Positions

Overview

  • William R. Carroll, M.D., the George W. Barber Jr. Endowed Professor and widely-recognized leader in the field of head and neck oncology, has been named the chair of the Department of Otolaryngology in the UAB School of Medicine.

    Carroll has served the department as its interim chair since the Department was established by the UA System Board of Trustees in October 2015. He took the role in a permanent basis on February 15, 2017.

    The Department of Otolaryngology at UAB is a world-class practice, with 15 full-time faculty performing more than 3,600 surgeries per year. The program’s clinical services include head and neck oncology, otology/neurotology, sinus and skull base disorders, facial plastics and reconstruction, laryngology, salivary gland disorders and sleep apnea.

    Otolaryngology is also home to a growing residency program to train future physicians through five years of comprehensive surgical training, as well as specialized fellowship programs in rhinology and head and neck oncology.

    Carroll joined the UAB faculty in 1996, was named section director for head and neck oncology in 2004 and became director of the Head and Neck Oncology Fellowship Training Program in 2008. Prior to his role as interim department chair, he served as interim division director. Dr. Carroll has published more than 150 manuscripts in scientific journals, authored 14 book chapters, served in numerous leadership positions in national and regional professional societies and committees, and often participates in national academic/clinical meetings as a featured presenter.

    He began his career at Medical College of Georgia where he earned his medical degree before beginning his postdoctoral training in Otolaryngology Head and Neck Surgery at the University of Michigan. Prior to joining the UAB faculty as an associate professor of surgery, Carroll served as assistant professor of surgery at the University of Michigan Hospitals and as section chief of otolaryngology at the VA Hospital in Ann Arbor.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Head and neck cancer survivors' preferences for and evaluations of a post-treatment dietary intervention 2019
    2019 Feasibility Outcomes of a Pilot Randomized Clinical Trial to Increase Cruciferous and Green Leafy Vegetable Intake in Posttreatment Head and Neck Cancer Survivors 2019
    2019 Outcomes and cost implications of microvascular reconstructions of the head and neck 2019
    2019 Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer * 2019
    2019 Assessment of the Reliability of the Fiberoptic Endoscopic Evaluation of Swallowing as an Outcome Measure in Patients Undergoing Revision Anterior Cervical Discectomy and Fusion 2019
    2019 Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions 2019
    2018 Oral and pharyngeal cancer risk associated with occupational carcinogenic substances: Systematic review 2018
    2018 First-line treatment of widely metastatic BRAF-mutated salivary duct carcinoma with combined BRAF and MEK inhibition 2018
    2018 Higher carbohydrate intake is associated with increased risk of all-cause and disease-specific mortality in head and neck cancer patients: results from a prospective cohort study 2018
    2018 Utility of the Surgical Apgar Score in Head and Neck Squamous Cell Carcinoma 2018
    2018 Utility of the Modified Surgical Apgar Score in a Head and Neck Cancer Population 2018
    2018 Voice and swallowing outcomes following reoperative anterior cervical discectomy and fusion with a 2-team surgical approach 2018
    2017 Fluorescence Imaging for Cancer Screening and Surveillance 2017
    2017 Reconstruction of midface defects with the osteocutaneous radial forearm flap: Evaluation of long term outcomes including patient reported quality of life 2017
    2017 Retraction to: Worst Pattern Of Invasion and occult cervical metastases for oral squamous carcinoma: Update on impact of adjuvant rt for low-stage high-risk oral squamous cancer (Head & Neck, (2017), 10.1002/hed.24754) 2017
    2017 Sensitivity and specificity of cetuximab-IRDye800CW to identify regional metastatic disease in head and neck cancer 2017
    2017 Effects of an Unlabeled Loading Dose on Tumor-Specific Uptake of a Fluorescently Labeled Antibody for Optical Surgical Navigation 2017
    2017 Laser-assisted indocyanine green dye angiography for postoperative fistulas after salvage laryngectomy 2017
    2017 Effect of Overlapping Operations on Outcomes in Microvascular Reconstructions of the Head and Neck 2017
    2017 Characterizing the utility and limitations of repurposing an open-field optical imaging device for fluorescence-guided surgery in head and neck cancer patients 2017
    2017 DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery 2017
    2017 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study. 2017
    2017 Oncologic Procedures Amenable to Fluorescence-guided Surgery 2017
    2017 Worst Pattern Of Invasion and occult cervical metastases for oral squamous carcinoma 2017
    2016 Long-term results of a phase I/II trial of the addition of celecoxib to chemoradiotherapy for locally advanced or recurrent squamous cell carcinoma of the head-and-neck 2016
    2016 Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx 2016
    2016 Outcomes after surgical salvage for recurrent oropharyngeal squamous cell carcinoma 2016
    2016 Recurrent laryngeal nerve injury following reoperative anterior cervical discectomy and fusion: A meta-analysis 2016
    2016 Photoimmunotherapy of residual disease after incomplete surgical resection in head and neck cancer models 2016
    2016 Fluorescence imaging to localize head and neck squamous cell carcinoma for enhanced pathological assessment 2016
    2016 An extended toboggan technique for resection of substernal thyroid goiters 2016
    2016 Parotid gland metastasis in Merkel cell carcinoma of the head and neck: A series of 14 cases 2016
    2016 Smoking Cessation and Electronic Cigarette Use among Head and Neck Cancer Patients 2016
    2015 Early oral tongue squamous cell carcinoma sampling of margins from tumor bed and worse local control 2015
    2015 [<sup>99m</sup>Tc]Tilmanocept Accurately Detects Sentinel Lymph Nodes and Predicts Node Pathology Status in Patients with Oral Squamous Cell Carcinoma of the Head and Neck: Results of a Phase III Multi-institutional Trial 2015
    2015 Safety and tumor specificity of cetuximab-IRDye800 for surgical navigation in head and neck cancer 2015
    2015 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: A comparative study 2015
    2015 Phase I dose-escalating trial of Escherichia coli purine nucleoside phosphorylase and fludarabine gene therapy for advanced solid tumors 2015
    2015 Working to eliminate cancer health disparities from tobacco: A review of the National Cancer Institute's community networks program 2015
    2015 Survival trends in hypopharyngeal cancer: A population-based review 2015
    2015 A ratiometric threshold for determining presence of cancer during fluorescence-guided surgery 2015
    2015 Intraoperative nerve monitoring and vocal cord paralysis: Controlling bias: In reply to Nguyen and wang 2015
    2015 The protective effect of p16 INK4a in oral cavity carcinomas: p16 Ink4A dampens tumor invasion-integrated analysis of expression and kinomics pathways 2015
    2015 Transoral robotic surgery for oropharyngeal and tongue cancer in the united states 2015
    2014 African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated carcinogenesis 2014
    2014 Intraluminal negative pressure wound therapy for optimizing pharyngeal reconstruction 2014
    2014 Assessment of Erlotinib as Adjuvant Chemoprevention in High-Risk Head and Neck Cancer Patients 2014
    2014 Examining national outcomes after thyroidectomy with nerve monitoring 2014
    2014 Hardware removal after osseous free flap reconstruction 2014
    2014 Harmonic Scalpel versus electrocautery and surgical clips in head and neck free-flap harvesting 2014
    2014 Head and neck cutaneous squamous cell carcinoma requiring parotidectomy: Prognostic indicators and treatment selection 2014
    2014 Negative pressure wound therapy in head and neck surgery 2014
    2014 Transoral robotic versus open surgical approaches to oropharyngeal squamous cell carcinoma by human papillomavirus status 2014
    2013 Perceptions of harm to health from cigarettes, blunts, and marijuana among young adult African American men 2013
    2013 Validation of the Risk Model: High-Risk Classification and Tumor Pattern of Invasion Predict Outcome for Patients with Low-Stage Oral Cavity Squamous Cell Carcinoma 2013
    2013 Patterns of prophylactic gastrostomy tube placement in head and neck cancer patients: A consideration of the significance of social support and practice variation 2013
    2013 Hemorrhage after transoral robotic-assisted surgery 2013
    2013 Microvascular anastomotic coupler assessment in head and neck reconstruction 2013
    2013 Outcomes in head and neck reconstruction by surgical site and donor site 2013
    2013 Sternoclavicular joint surgery: How far does danger lurk below? 2013
    2013 Learning curve for transoral robotic surgery: A 4-year analysis 2013
    2013 Phase 1 study of erlotinib plus radiation therapy in patients with advanced cutaneous squamous cell carcinoma 2013
    2013 Increased likelihood of long-term gastrostomy tube dependence in head and neck cancer survivors without partners 2013
    2013 Locoregional failure and the risk of distant metastasis after modern radiotherapy for head and neck cancer 2013
    2013 Salvage surgery for recurrent cancers of the oropharynx comparing TORS with standard open surgical approaches 2013
    2012 Prognostic significance of thyroid or cricoid cartilage invasion in laryngeal or hypopharyngeal cancer treated with organ preserving strategies 2012
    2012 Assessment and incidence of salivary leak following laryngectomy 2012
    2012 Transoral robotic surgery: A multicenter study to assess feasibility, safety, and surgical margins 2012
    2012 Use of recombinant bone morphogenetic protein 2 in free flap reconstruction for osteonecrosis of the mandible 2012
    2012 Social networking and professionalism in otolaryngology residency applicants 2012
    2012 CD147 expression in advanced cutaneous squamous cell carcinoma 2012
    2012 Reconstruction of scalp defects with the radial forearm free flap 2012
    2012 EGFR expression in advanced head and neck cutaneous squamous cell carcinoma 2012
    2012 Free flap reconstruction of lateral mandibular defects: Indications and outcomes 2012
    2012 The need for further evaluation of objective parameters of swallowing function after transoral robotic surgery: Reply 2012
    2012 Gastrostomy tube placement and use in patients with head and neck cancer 2012
    2012 Incidence and outcomes of stricture formation postlaryngectomy 2012
    2012 Outcomes of intubation in difficult airways due to head and neck pathology 2012
    2012 Patterns of blunt use among rural young adult African-American men 2012
    2012 Successful closure of pharyngo-cutaneous and phayryngo-tracheal fistulas using removable hypopharyngeal stent after laryngectomy for laryngeal carcinoma 2012
    2011 Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening 2011
    2011 Novel neoadjuvant immunotherapy regimen safety and survival in head and neck squamous cell cancer 2011
    2011 Disruption of the AKT pathway inhibits metastasis in an orthotopic model of head and neck squamous cell carcinoma 2011
    2011 Functional and survival outcomes in patients undergoing total glossectomy compared with total laryngoglossectomy 2011
    2011 Impact of average weekly dose of radiation during radiotherapy alone or chemoradiotherapy in head and neck cancer 2011
    2011 Patient-perceived and objective functional outcomes following transoral robotic surgery for early oropharyngeal carcinoma 2011
    2011 Utility of CT surveillance for primary site recurrence of squamous cell carcinoma of the head and neck 2011
    2011 Examination of laryngoesophageal dysfunction-free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx 2011
    2011 CD147 expression in advanced cutaneous squamous cell carcinoma 2011
    2011 Tobacco use among rural African American young adult males 2011
    2011 Primary versus delayed tracheoesophageal puncture for laryngopharyngectomy with free flap reconstruction 2011
    2011 Closure of post-laryngectomy pharyngocutaneous fistulae 2011
    2011 Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: A comprehensive review and call for evidence-based medicine 2011
    2011 Outcomes of recurrent head and neck cutaneous squamous cell carcinoma. 2011
    2010 Anti-EMMPRIN treatment of HNSCC in an ex vivo model 2010
    2010 Transoral robotic-assisted surgery for head and neck squamous cell carcinoma: One- and 2-year survival analysis 2010
    2010 Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model 2010
    2010 Disruptions in the organization of meal preparation and consumption among older cancer patients and their family caregivers 2010
    2010 Outcomes following temporal bone resection 2010
    2010 Functional outcomes of fibula and osteocutaneous forearm free flap reconstruction for segmental mandibular defects 2010
    2010 Robotic-assisted surgery for primary or recurrent oropharyngeal carcinoma 2010
    2010 Outcomes of salvage surgery with free flap reconstruction for recurrent oral and oropharyngeal cancer 2010
    2010 Management of the N0 neck in recurrent laryngeal squamous cell carcinoma 2010
    2009 Barriers to early detection and treatment of head and neck squamous cell carcinoma in African American men 2009
    2009 Outcomes of intubation in difficult airways due to head and neck pathology 2009
    2009 The contribution of social factors to undereating in older adults with cancer 2009
    2009 Postoperative reirradiation for mucosal head and neck squamous cell carcinomas 2009
    2009 Functional outcomes after transoral robotic surgery for head and neck cancer 2009
    2009 Functional outcomes following secondary free flap reconstruction of the head and neck 2009
    2009 Factors Associated With Long-Term Dysphagia After Definitive Radiotherapy for Locally Advanced Head-and-Neck Cancer 2009
    2009 Cancer of the tonsil presenting as central nervous system metastasis: A case report 2009
    2009 Robot-assisted surgery for upper aerodigestive tract neoplasms 2009
    2008 Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome 2008
    2008 Interim obturator retained by an extraoral device: A clinical report 2008
    2008 Zygomaticomaxillary buttress reconstruction of midface defects with the osteocutaneous radial forearm free flap 2008
    2008 Fistula analysis after radial forearm free flap reconstruction of hypopharyngeal defects 2008
    2008 Locoregionally Advanced Head and Neck Cancer Treated With Primary Radiotherapy: A Comparison of the Addition of Cetuximab or Chemotherapy and the Impact of Protocol Treatment 2008
    2008 Evolution of a paradigm for free tissue transfer reconstruction of lateral temporal bone defects 2008
    2008 Pretreatment swallowing exercises improve swallow function after chemoradiation 2008
    2007 Free tissue transfer to manage salvage laryngectomy defects after organ preservation failure 2007
    2006 In vivo detection of head and neck cancer orthotopic xenografts by immunofluorescence 2006
    2006 Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life 2006
    2005 Use of negative pressure dressings in head and neck reconstruction 2005
    2005 Preemptive vessel dilator cricothyrotomy aids in the management of upper airway obstruction 2005
    2004 Simplifying head and neck microvascular reconstruction 2004
    2004 Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts 2004
    2004 Malignant carotid body tumor 2004
    2004 Pectoralis Major Myocutaneous Flap vs Revascularized Free Tissue Transfer: Complications, Gastrostomy Tube Dependence, and Hospitalization 2004
    2003 A 2-Phase Screening Process for Patients with Wegener's Granulomatosis: A Pilot Study 2003
    2003 Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck 2003
    2003 Use of the endoscopic microdebrider in the management of airway obstruction from laryngotracheal carcinoma 2003
    2001 Head and neck: Editorial 2001
    2001 Head and neck: Letter to the editor [1] (multiple letters) 2001
    2001 Malt lymphoma presenting as a cystic salivary gland mass 2001
    2001 MALT lymphoma presenting as a cystic salivary gland mass. 2001
    2001 Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands 2001
    2001 Motion-specific laryngeal reinnervation using muscle-nerve-muscle neurotization 2001
    2001 Selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization 2001
    2000 Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. 2000
    2000 Ischemia/reperfusion injury in microvascular surgery 2000
    1999 Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector 1999
    1999 The pathogenesis of vascular thrombosis and its impact in microvascular surgery 1999
    1999 Retargeting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma 1999
    1998 Functional results of primary closure vs flaps in oropharyngeal reconstruction: A prospective study of speech and swallowing 1998
    1997 Effects of implantable biomaterials on radiation dosimetry 1997
    1997 Planned early neck dissection before radiation for persistent neck nodes after induction chemotherapy 1997
    1997 CaN19 expression in benign and malignant hyperplasias of the skin and oral mucosa: Evidence for a role in regenerative differentiation 1997
    1997 Otologic manifestations of vertebral artery dissection 1997
    1997 Repair of a complete glottic-subglottic stenosis with a fibular osseocutaneous free flap 1997
    1996 Chemotherapy followed by accelerated fractionated radiation for larynx preservation in patients with advanced laryngeal cancer 1996
    1996 Intraoperative fire with electrocautery 1996
    1996 Preoperative vascular imaging for the fibular osteocutaneous flap 1996
    1996 Recurrence of head and neck cancer after surgery or irradiation: Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses 1996
    1995 Atypical myosin heavy chain in rat laryngeal muscle 1995
    1995 Perilesional interleukin-2 in the VX-2 carcinoma in rabbits: A preliminary investigation 1995
    1994 Analysis of recurrence, complications, and functional results with free jejunal flaps 1994
    1994 Hemilaryngectomy for Glottic Carcinoma After Radiation Therapy Failure 1994
    1994 The Platysma Myocutaneous Flap: Indications and Caveats 1994
    1993 Branchiogenic carcinoma 1993
    1993 Ionized serum calcium levels following combined treatment for cancer of the head and neck 1993
    1993 Olfactory neuroblastoma: The results of modern treatment approaches at the University of Michigan 1993
    1992 Extracapsular Spread and the Perineural Extension of Squamous Cell Cancer in the Cervical Plexus 1992
    1992 Lateral Arm Free Flap in Head and Neck Reconstruction 1992
    1992 Monitoring of Revascularized Jejunal Autografts 1992
    1991 Palatal inclusion cyst: An unusual complication of uvulopalatopharyngoplasty 1991
    1991 Primary Adenocarcinoma of the Temporal Bone: A Case With 40-Year Follow-up 1991
    1991 Spontaneous CSF Rhinorrhea: An Unusual Presentation of a Pituitary Adenoma 1991
    1990 The Cutaneous Scapular Free Flap in Head and Neck Reconstruction 1990
    1990 The free scapular flap for head and neck reconstruction 1990
    1989 Soft Tissue Reconstruction and Augmentation of the Face with Free Flaps 1989

    Chapter

    Year Title Altmetric
    2018 Surgery for cancer of the oral cavity.  334-344. 2018
    2012 Surgery for cancer of the oral cavity 2012

    Research Overview

  • Head and neck oncology
    Transoral robotic assisted surgery (TORS)
    Clinical trials in head and neck oncology
  • Investigator On

  • Private Grant  awarded by SKYLINE BIOSCIENCES LLC 2019 - 2022
  • Private Grant  awarded by CELGENE CORPORATION 2019 - 2022
  • Private Grant  awarded by IMAGINAB 2019 - 2021
  • Development, Implementation, and Evaluation of a Smoking Cessation Intervention Tailored to Rural Young Adult African American Men: Toward Scalability  awarded by National Cancer Institute/NIH/DHHS 2018 - 2020
  • Private Grant  awarded by ELI LILLY AND COMPANY 2016 - 2020
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2015 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2014 - 2019
  • Imaging Guided Surgery Using Fluorescently Labeled Cetuximab  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • ACRIN 6685: A Multicenter Trial of FDG-PET/CT Staging of Head and Neck Cancer and its Impact on the N0 Neck Surgical Treatment in Head and Neck Cancer Patients(R10-151)  awarded by American College of Radiology Imaging Network 2014 - 2017
  • Private Grant  awarded by SUCAMPO PHARMACEUTICALS 2016
  • Food and Eating Behaviors of Head and Neck Cancer Patients  awarded by National Cancer Institute/NIH/DHHS 2012 - 2016
  • Private Grant  awarded by NOVADAQ TECHNOLOGIES, INC. 2015 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by PNP THERAPEUTICS, INC. 2011 - 2016
  • Private Grant  awarded by LICOR, INC. 2014 - 2015
  • Private Grant  awarded by NOVADAQ TECHNOLOGIES, INC. 2013 - 2015
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC. 2013 - 2014
  • Tissue Resource Site (TSS) in Support of the The Cancer Genome Atlas (TCGA) Program - Admin Core  awarded by SAIC - FREDERICK 2013 - 2014
  • PET/CT Staging of Head & Neck Cancer and its Impact on the NO Neck Surgical Treatment (R10-151)  awarded by American College of Radiology Imaging Network 2011 - 2014
  • Education And Training

  • St. Joseph Mercy Health System, Internship 1986
  • University of Michigan Hospitals & Health Centers, Residency 1990
  • Full Name

  • William Carroll