Positions

Overview

  • Dr. Wang is originally from China, and received his undergraduate education at Tsinghua University in Beijing, China (BS and B.Eng.) and graduate education at the University of Illinois at Chicago (MS) and the University of Wisconsin-Madison (PhD). At UW-Madison, Dr. Wang focused on studying kinetic protonation of enols, a classical physical organic chemistry topic, under the supervision of Professor Howard E. Zimmerman. He then joined Professor David Y. Gin at the University of Illinois-Urbana as a postdoctoral associate, working on natural product synthesis.

    In 2005, Dr. Wang started his independent academic career at UAB, focusing on discovery of novel organic reactions and development of new methodologies for application in organic synthesis, biochemical and biophysical research, medicinal chemistry, and materials science.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants 2019
    2019 Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant 2019
    2018 1-[3-(Diethylamino)phenyl]ethyl (DEAPE): A Photolabile Protecting Group for Hydroxyl and Carboxyl Groups 2018
    2018 Using the 3-Diethylaminobenzyl Group as a Photocage in Aqueous Solution 2018
    2017 Photochemical Cleavage of Benzylic C-O Bond Facilitated by an Ortho or Meta Amino Group 2017
    2017 Developing photolabile protecting groups based on the excited state meta effect 2017
    2016 Structurally Simple Benzylidene-Type Photolabile Diol Protecting Groups 2016
    2016 Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide 2016
    2016 Photochemical Cleavage of Benzylic C-N Bond to Release Amines 2016
    2015 ChemInform Abstract: Structurally Simple Benzyl-Type Photolabile Protecting Groups for Direct Release of Alcohols and Carboxylic Acids. 2015
    2015 Structurally Simple Benzyl-Type Photolabile Protecting Groups for Direct Release of Alcohols and Carboxylic Acids 2015
    2015 Photochemical Formation and Cleavage of C-N Bond 2015
    2013 Synthesis of QS-21-based immunoadjuvants 2013
    2013 ChemInform Abstract: Photolabile Protecting Groups. Structure and Reactivity 2013
    2013 Application of new photolabile protecting groups as photocleavable joints of block copolymers 2013
    2013 Mechanistic study of glycosylation using a prop-1-enyl donor 2013
    2013 Photolabile protecting groups: Structure and reactivity 2013
    2012 Development of hydrophilic photolabile hydroxyl protecting groups 2012
    2011 Oxidation with a photolabile carbonyl protecting group 2011
    2011 Development of trityl-based photolabile hydroxyl protecting groups 2011
    2011 Concise synthesis of Bacillus anthracis exosporium tetrasaccharide via two-stage activation of allyl glycosyl donor strategy 2011
    2011 Development of a photolabile carbonyl-protecting group toolbox 2011
    2010 Facile glycosylation strategy with two-stage activation of allyl glycosyl donors. Application to concise synthesis of Shigella flexneri serotype y O-antigen 2010
    2010 ChemInform Abstract: Facilitated Photochemical Cleavage of Benzylic C-O Bond. Application to Photolabile Hydroxyl-Protecting Group Design. 2010
    2010 Facilitated photochemical cleavage of benzylic C-O bond. Application to photolabile hydroxyl-protecting group design. 2010
    2010 Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivatives 2010
    2009 Photolabile carbonyl protecting group: A new tool for light-controlled release of anticancer agents 2009
    2009 Installation of photolabile carbonyl-protecting groups under neutral conditions without using any other chemical reagents 2009
    2008 Sequential removal of photolabile protecting groups for carbonyls with controlled wavelength 2008
    2007 Simple glycosylation reaction of allyl glycosides 2007
    2007 Application of the excited state meta effect in photolabile protecting group design 2007
    2007 Novel photolabile protecting group for carbonyl compounds. 2007

    Research Overview

  • Our ongoing research projects include (1) development of photolabile protecting groups (PPGs), (2) application of PPGs in synthesis, light-responsive smart materials, controlled release of biologically important compounds, and light-activated anticancer prodrugs, (3) application of new photochemical bond formation reactions in crosslinking macromolecules, labelling proteins, and tissue engineering, (4) development of new facile glycosylation methods, (5) synthesis of carbohydrate antigens for the development of carbohydrate-based vaccines, and (6) development of clinically relevant saponin-based vaccine adjuvants.

    Protecting groups are indispensable tools in organic chemistry. Among various protecting groups, photolabile protecting groups (PPGs) have very valuable and unique features: (1) they can be removed under mild conditions by light without using any chemical reagents; and (2) they are capable of releasing substrates in a spatially and temporally controlled manner. These advantages are attractive to both basic and applied sciences. We have developed a series of structurally simple and mechanistically novel PPGs for protection of various functional groups. These PPGs feature (1) ready access from inexpensive materials, (2) highly efficient, flexible, and diverse PPG installation approaches, (3) high deprotection efficiency (even with sunlight irradiation), (4) simple deprotection reaction conditions (compatible with air and water), (5) remarkable dark stability, (6) tunable photochemical property, and (7) flexible structural adjustment.

    We have also been pursuing step economy-oriented carbohydrate synthesis in solution phase for rapid access to oligosaccharides of biochemical and biomedical significance. We developed a new glycosylation method using only allyl glycosides as building blocks. Thus, in a one-pot fashion, an allyl glycoside is isomerized to the corresponding prop-1-enyl glycoside donor and its subsequent activation with NIS/TfOH in the presence of an allyl glycosyl acceptor leads to the formation of a new allyl glycoside. The new protocol could markedly simplify carbohydrate synthesis and improve overall synthetic efficiency in that it avoids laborious anomeric manipulations and intermediate purifications often encountered in conventional methods. This approach paves the way to rapid access to structurally well-defined natural/unnatural homogeneous oligo- and poly-saccharides for glycobiology research and development of carbohydrate-based drugs, vaccines, and diagnostic tools.

    Keywords - Organic Chemistry, Photochemistry, Carbohydrate Chemistry, Synthetic Methodology, Photoresponsive Materials, Synthetic Vaccines and Vaccine Adjuvants
  • Teaching Activities

  • CH730 - Physical Organic Chemistry (Fall Term 2019) 2019
  • CH439 - Spec Topics in Organic Chem (Spring Term 2019) 2019
  • CH739 - Spec Topics in Organic Chem (Spring Term 2019) 2019
  • CH730 - Physical Organic Chemistry (Fall Term 2018) 2018
  • CH631 - Org React and Their Mechanisms (Spring Term 2018) 2018
  • CH731 - Org Reactions and Mechanisms (Spring Term 2018) 2018
  • CH235 - Organic Chemistry I (Fall Term 2017) 2017
  • CH798 - Non-Dissertation Research (Fall Term 2017) 2017
  • CH235 - Organic Chemistry I (Fall Term 2016) 2016
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2016) 2016
  • CH731 - Org Reactions and Mechanisms (Spring Term 2016) 2016
  • CH237 - Organic Chemistry II (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH237R - Organic Chem II Recitation (Fall Term 2015) 2015
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2015) 2015
  • CH739 - Spec Topics in Organic Chem (Summer Term 2015) 2015
  • CH731 - Org Reactions and Mechanisms (Spring Term 2015) 2015
  • CH237 - Organic Chemistry II (Fall Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Fall Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Fall Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Fall Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Fall Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Fall Term 2014) 2014
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2014) 2014
  • CH237 - Organic Chemistry II (Summer Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Summer Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Summer Term 2014) 2014
  • CH237R - Organic Chem II Recitation (Summer Term 2014) 2014
  • CH235 - Organic Chemistry I (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235R - Organic Chemistry I Recitation (Spring Term 2014) 2014
  • CH235 - Organic Chemistry I (Fall Term 2013) 2013
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2013) 2013
  • CH235 - Organic Chemistry I (Summer Term 2013) 2013
  • CH235R - Organic Chemistry I Recitation (Summer Term 2013) 2013
  • CH235R - Organic Chemistry I Recitation (Summer Term 2013) 2013
  • CH235R - Organic Chemistry I Recitation (Summer Term 2013) 2013
  • CH235 - Organic Chemistry I (Spring Term 2013) 2013
  • CH731 - Org Reactions and Mechanisms (Spring Term 2013) 2013
  • CH235 - Organic Chemistry I (Fall Term 2012) 2012
  • CH535 - Organic Chem I for Grad Study (Fall Term 2012) 2012
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2012) 2012
  • CH739 - Spec Topics in Organic Chem (Summer Term 2012) 2012
  • CH235 - Organic Chemistry I (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH235R - Organic Chemistry I Recitation (Spring Term 2012) 2012
  • CH237 - Organic Chemistry II (Fall Term 2011) 2011
  • CH237R - Organic Chem II Recitation (Fall Term 2011) 2011
  • CH237R - Organic Chem II Recitation (Fall Term 2011) 2011
  • CH237R - Organic Chem II Recitation (Fall Term 2011) 2011
  • CH237R - Organic Chem II Recitation (Fall Term 2011) 2011
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2011) 2011
  • CH235 - Organic Chemistry I (Summer Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Summer Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Summer Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Summer Term 2011) 2011
  • CH235 - Organic Chemistry I (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH235R - Organic Chemistry I Recitation (Spring Term 2011) 2011
  • CH237 - Organic Chemistry II (Fall Term 2010) 2010
  • CH237R - Organic Chem II Recitation (Fall Term 2010) 2010
  • CH237R - Organic Chem II Recitation (Fall Term 2010) 2010
  • CH237R - Organic Chem II Recitation (Fall Term 2010) 2010
  • CH237R - Organic Chem II Recitation (Fall Term 2010) 2010
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2010) 2010
  • CH235 - Organic Chemistry I (Summer Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Summer Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Summer Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Summer Term 2010) 2010
  • CH739 - Spec Topics in Organic Chem (Summer Term 2010) 2010
  • CH235 - Organic Chemistry I (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH235R - Organic Chemistry I Recitation (Spring Term 2010) 2010
  • CH237 - Organic Chemistry II (Fall Term 2009) 2009
  • CH237R - Organic Chem II Recitation (Fall Term 2009) 2009
  • CH237R - Organic Chem II Recitation (Fall Term 2009) 2009
  • CH237R - Organic Chem II Recitation (Fall Term 2009) 2009
  • CH237R - Organic Chem II Recitation (Fall Term 2009) 2009
  • CH237R - Organic Chem II Recitation (Fall Term 2009) 2009
  • CH235 - Organic Chemistry I (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH235R - Organic Chemistry I Recitation (Spring Term 2009) 2009
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2008) 2008
  • CH235 - Organic Chemistry I (Summer Term 2008) 2008
  • CH739 - Spec Topics in Organic Chem (Summer Term 2008) 2008
  • CH107 - Introductory Chemistry II (Spring Term 2008) 2008
  • CH107 - Introductory Chemistry II (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Organic Chemistry, University of Wisconsin System : Madison 2002
  • Full Name

  • Pengfei Wang