Positions

Overview

  • Dr. Wang is originally from China, and received his undergraduate education at Tsinghua University in Beijing, China (BS and B.Eng.) and graduate education at the University of Illinois at Chicago (MS) and the University of Wisconsin-Madison (PhD). At UW-Madison, Dr. Wang focused on studying kinetic protonation of enols, a classical physical organic chemistry topic, under the supervision of Professor Howard E. Zimmerman. He then joined Professor David Y. Gin at the University of Illinois-Urbana as a postdoctoral associate, working on natural product synthesis.

    In 2005, Dr. Wang started his independent academic career at UAB, focusing on discovery of novel organic reactions and development of new methodologies for application in organic synthesis, biochemical and biophysical research, medicinal chemistry, and materials science.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants.ACS Infectious Diseases2019
    2019 Synthesis and Evaluation of a QS-17/18-Based Vaccine AdjuvantJournal of Medicinal Chemistry.  62:1669-1676. 2019
    2018 1-[3-(Diethylamino)phenyl]ethyl (DEAPE): A Photolabile Protecting Group for Hydroxyl and Carboxyl GroupsJournal of Organic Chemistry.  83:10736-10742. 2018
    2018 Using the 3-Diethylaminobenzyl Group as a Photocage in Aqueous SolutionJournal of Organic Chemistry.  83:7459-7466. 2018
    2017 Photochemical Cleavage of Benzylic C-O Bond Facilitated by an Ortho or Meta Amino GroupJournal of Organic Chemistry.  82:7309-7316. 2017
    2017 Developing photolabile protecting groups based on the excited state meta effectJournal of Photochemistry and Photobiology A: Chemistry.  335:300-310. 2017
    2016 Structurally Simple Benzylidene-Type Photolabile Diol Protecting GroupsOrganic Letters.  18:5396-5399. 2016
    2016 Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing TrisaccharideJournal of Organic Chemistry.  81:9560-9566. 2016
    2016 Photochemical Cleavage of Benzylic C-N Bond to Release AminesJournal of Organic Chemistry.  81:6195-6200. 2016
    2015 ChemInform Abstract: Structurally Simple Benzyl-Type Photolabile Protecting Groups for Direct Release of Alcohols and Carboxylic Acids.ChemInform.  46:no-no. 2015
    2015 Structurally Simple Benzyl-Type Photolabile Protecting Groups for Direct Release of Alcohols and Carboxylic AcidsOrganic Letters.  17:2114-2117. 2015
    2015 Photochemical Formation and Cleavage of C-N BondOrganic Letters.  17:170-172. 2015
    2013 Synthesis of QS-21-based immunoadjuvantsJournal of Organic Chemistry.  78:11525-11534. 2013
    2013 ChemInform Abstract: Photolabile Protecting Groups. Structure and ReactivityChemInform.  44:no-no. 2013
    2013 Application of new photolabile protecting groups as photocleavable joints of block copolymersChemical Communications.  49:9636-9638. 2013
    2013 Mechanistic study of glycosylation using a prop-1-enyl donorJournal of Organic Chemistry.  78:1858-1863. 2013
    2013 Photolabile protecting groups: Structure and reactivityAsian Journal of Organic Chemistry.  2:452-464. 2013
    2012 Development of hydrophilic photolabile hydroxyl protecting groupsPhotochemical & Photobiological Sciences Photochemical and Photobiological Sciences.  11:514-517. 2012
    2011 Oxidation with a photolabile carbonyl protecting groupJournal of Organic Chemistry.  76:8955-8961. 2011
    2011 Development of trityl-based photolabile hydroxyl protecting groupsJournal of Organic Chemistry.  76:5873-5881. 2011
    2011 Concise synthesis of Bacillus anthracis exosporium tetrasaccharide via two-stage activation of allyl glycosyl donor strategyTetrahedron Letters.  52:3912-3915. 2011
    2011 Development of a photolabile carbonyl-protecting group toolboxJournal of Organic Chemistry.  76:2040-2048. 2011
    2010 Facile glycosylation strategy with two-stage activation of allyl glycosyl donors. Application to concise synthesis of Shigella flexneri serotype y O-antigenJournal of the Chemical Society, Perkin Transactions 1.  8:4322-4328. 2010
    2010 ChemInform Abstract: Facilitated Photochemical Cleavage of Benzylic C-O Bond. Application to Photolabile Hydroxyl-Protecting Group Design.ChemInform.  41:no-no. 2010
    2010 Facilitated photochemical cleavage of benzylic C-O bond. Application to photolabile hydroxyl-protecting group design.Chemical Communications.  46:1514-1516. 2010
    2010 Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivativesTetrahedron Letters.  51:600-601. 2010
    2009 Photolabile carbonyl protecting group: A new tool for light-controlled release of anticancer agentsEuropean Journal of Organic Chemistry.  2055-2058. 2009
    2009 Installation of photolabile carbonyl-protecting groups under neutral conditions without using any other chemical reagentsEuropean Journal of Organic Chemistry.  208-211. 2009
    2008 Sequential removal of photolabile protecting groups for carbonyls with controlled wavelengthJournal of Organic Chemistry.  73:6152-6157. 2008
    2007 Simple glycosylation reaction of allyl glycosidesJournal of Organic Chemistry.  72:5870-5873. 2007
    2007 Application of the excited state meta effect in photolabile protecting group designOrganic Letters.  9:2831-2833. 2007
    2007 Novel photolabile protecting group for carbonyl compounds.Organic Letters.  9:1533-1535. 2007

    Research Overview

  • Our ongoing research projects include (1) development of photolabile protecting groups (PPGs), (2) application of PPGs in synthesis, light-responsive smart materials, controlled release of biologically important compounds, and light-activated anticancer prodrugs, (3) application of new photochemical bond formation reactions in crosslinking macromolecules, labelling proteins, and tissue engineering, (4) development of new facile glycosylation methods, (5) synthesis of carbohydrate antigens for the development of carbohydrate-based vaccines, and (6) development of clinically relevant saponin-based vaccine adjuvants.

    Protecting groups are indispensable tools in organic chemistry. Among various protecting groups, photolabile protecting groups (PPGs) have very valuable and unique features: (1) they can be removed under mild conditions by light without using any chemical reagents; and (2) they are capable of releasing substrates in a spatially and temporally controlled manner. These advantages are attractive to both basic and applied sciences. We have developed a series of structurally simple and mechanistically novel PPGs for protection of various functional groups. These PPGs feature (1) ready access from inexpensive materials, (2) highly efficient, flexible, and diverse PPG installation approaches, (3) high deprotection efficiency (even with sunlight irradiation), (4) simple deprotection reaction conditions (compatible with air and water), (5) remarkable dark stability, (6) tunable photochemical property, and (7) flexible structural adjustment.

    We have also been pursuing step economy-oriented carbohydrate synthesis in solution phase for rapid access to oligosaccharides of biochemical and biomedical significance. We developed a new glycosylation method using only allyl glycosides as building blocks. Thus, in a one-pot fashion, an allyl glycoside is isomerized to the corresponding prop-1-enyl glycoside donor and its subsequent activation with NIS/TfOH in the presence of an allyl glycosyl acceptor leads to the formation of a new allyl glycoside. The new protocol could markedly simplify carbohydrate synthesis and improve overall synthetic efficiency in that it avoids laborious anomeric manipulations and intermediate purifications often encountered in conventional methods. This approach paves the way to rapid access to structurally well-defined natural/unnatural homogeneous oligo- and poly-saccharides for glycobiology research and development of carbohydrate-based drugs, vaccines, and diagnostic tools.

    Keywords - Organic Chemistry, Photochemistry, Carbohydrate Chemistry, Synthetic Methodology, Photoresponsive Materials, Synthetic Vaccines and Vaccine Adjuvants
  • Teaching Activities

  • missing activity 2019
  • missing activity 2019
  • missing activity 2018
  • missing activity 2018
  • missing activity 2018
  • missing activity 2017
  • missing activity 2017
  • missing activity 2016
  • missing activity 2016
  • missing activity 2016
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2015
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2014
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2013
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2012
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2011
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2010
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2009
  • missing activity 2008
  • missing activity 2008
  • missing activity 2008
  • missing activity 2008
  • missing activity 2007
  • Education And Training

  • Doctor of Philosophy in Organic Chemistry, University of Wisconsin System : Madison 2002
  • Full Name

  • Pengfei Wang