Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Best practices for generating and using alpha-synuclein pre-formed fibrils to model Parkinson's disease in rodentsJournal of Parkinson's Disease.  8:303-322. 2018
2018 Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s diseaseProceedings of the National Academy of Sciences.  115:E2634-E2643. 2018
2017 LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.Molecular Therapy : Nucleic Acids.  8:508-519. 2017
2017 Effects of α-synuclein on axonal transportNeurobiology of Disease.  105:321-327. 2017
2017 α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic NeurodegenerationNeurobiology of Disease.  105:84-98. 2017
2016 How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Journal of Neurochemistry.  131-155. 2016
2016 G2019s-LRRK2 expression augments α-synuclein sequestration into inclusions in neuronsJournal of Neuroscience.  36:7415-7427. 2016
2016 MicroRNA-155 regulates alpha-synuclein-induced inflammatory responses in models of Parkinson diseaseJournal of Neuroscience.  36:2383-2390. 2016
2016 Invisible KillersMovement Disorders.  31:44-44. 2016
2015 Trophic factors for Parkinson's disease: To live or let dieMovement Disorders.  30:1715-1724. 2015
2015 Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegenerationJournal of Biological Chemistry.  290:19433-19444. 2015
2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocketJournal of Biological Chemistry.  289:32937-32951. 2014
2014 Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsJournal of Comparative Neurology.  522:2465-2480. 2014
2014 Abrogation of α-synuclein -mediated dopaminergic neurodegeneration in LRRK2-deficient ratsProceedings of the National Academy of Sciences.  111:9289-9294. 2014
2014 Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregatesNature Protocols.  9:2135-2146. 2014
2014 Formation of α-synuclein lewy neurite-like aggregates in axons impedes the transport of distinct endosomesCell regulation.  25:4010-4023. 2014
2013 Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neuronsJournal of Neuroscience.  33:10154-10164. 2013
2013 Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagyJournal of Biological Chemistry.  288:15194-15210. 2013
2011 Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.Neuron.  72:57-71. 2011
2010 Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brainJournal of Biological Chemistry.  285:28708-28714. 2010
2005 Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane trafficCell regulation.  16:4495-4508. 2005
2004 Immunohistochemical localization of proteins in the nervous system.Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].  Chapter 1. 2004
2003 Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout MiceMolecular Pharmacology.  64:1309-1316. 2003
2003 Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient miceAnnals of Neurology.  53:788-796. 2003
2003 Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout micePharmacology Biochemistry and Behavior.  74:977-986. 2003

Education And Training

  • Doctor of Philosophy in Neuroscience, Emory University 2003
  • Bachelor of Science or Mathematics, Franklin & Marshall College 1993
  • Full Name

  • Laura Volpicelli-Daley