Positions

Overview

  • My lab focusses on identifying the heritable component of a wide range of cardiovascular diseases including atherosclerosis and peripheral artery disease. To this end, we utilize publicly available genome-wide genetic and bioinformatics resources in conjunction with in vitro and in vivo approaches to discover the implicated gene and the associated signaling pathway.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.
    CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.Circulation Research.  118:230-240.
    Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease.
    Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.PLoS Genetics.  11:e1005155.
    De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.PLoS Genetics.  12:e1005963.
    Expression and functional activity of four myocardin isoforms.Gene.  464:1-10.
    Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locusPLoS Genetics.  14.
    Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.
    Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.Journal of Biological Chemistry.  287:2459-2467.
    Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.
    Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.Nature Nanotechnology.  15:154-161.
    Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation.Circulation.  137:750-753.
    The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.JACC: Basic to Translational Science.  2:209-211.

    Research Overview

  • Cardiovascular disease, vascular biology, atherosclerosis, peripheral artery disease, signal transduction, angiogenesis, genetics, smooth muscle biology, gene transcription, translational research
  • Education And Training

  • Stanford University School of Medicine Surgery, Postdoctoral Research
  • Doctor of Philosophy in Pharmacology, University of Rochester 2014
  • Master of Sciences or Mathematics in Pharmacology, University of Rochester 2011
  • Bachelor of Science or Mathematics in Medical Basic Sciences/Other, Rochester Institute of Technology 2006
  • Full Name

  • Vivek Nanda