Positions

Overview

  • Dr. Thannickal is Professor of Medicine and the Ben Vaughan Branscomb Chair of Medicine in Respiratory Disease at the University of Alabama at Birmingham (UAB). Following his fellowship training at Tufts University School of Medicine, he has held faculty positions at Tufts, University of Michigan and UAB, where he currently serves as director of the Division of Pulmonary, Allergy, and Critical Care Medicine. Under his leadership, the division has grown to over 65 faculty members and expanded its research and educational programs, including the institution of a highly successful NIH T32 Training Program in Lung Biology and Translational Medicine. Dr. Thannickal is an elected member of Association of American Physicians, and received the American Thoracic Society (ATS) Recognition Award for Scientific Accomplishments in 2016. He has served on the ATS Research Training Fellowship Committee (2005-2006), Scientific Advisory Committee (2011-2013), Awards Committee (2012-2013) and the RCMB Working Group on Aging (2013-2015). He has been a strong advocate for increasing research funding on behalf of the ATS and the NIH, including providing congressional testimony on Capitol Hill.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages. 2019
    2019 NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis 2019
    2019 Update in Pulmonary Fibrosis 2018 2019
    2019 Identification of an emphysema- associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts 2019
    2019 Remember Me? The Bone Marrow in Pulmonary Fibrosis. 2019
    2019 Modeling Fibrosis in 3D Organoids Reveals New Epithelial Restraints on Fibroblasts. 2019
    2019 FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury 2019
    2019 The Aging Lung and Idiopathic Pulmonary Fibrosis 2019
    2019 Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury 2019
    2019 Fibronectin on the surface of extracellular vesicles mediates fibroblast invasion 2019
    2019 Pulmonary fibrosis: "idiopathic" is not "cryptogenic" 2019
    2019 Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury 2019
    2019 Developmental pathways in the pathogenesis of lung fibrosis 2019
    2019 Idiopathic interstitial pneumonia or idiopathic interstitial pneumonitis: what's in a name? 2019
    2019 Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling 2019
    2019 SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury 2019
    2019 Betting on novel treatments for asthma: Bromodomain 4 inhibitors 2019
    2019 Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts 2019
    2019 Mechanisms for the resolution of organ fibrosis 2019
    2019 NADPH oxidases and aging models of lung fibrosis 2019
    2019 Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis 2019
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics 2018
    2018 Extracellular matrix in lung development, homeostasis and disease 2018
    2018 Ambulatory oxygen and quality of life in interstitial lung disease 2018
    2018 Erratum to: Metformin reverses established lung fibrosis in a bleomycin model (Nature Medicine, (2018), 24, 8, (1121-1127), 10.1038/s41591-018-0087-6) 2018
    2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells 2018
    2018 Reversing mechanoinductive DSP expression by CRISPR/dCas9–mediated epigenome editing 2018
    2018 Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctional 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin model 2018
    2018 Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis? 2018
    2018 Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli 2018
    2018 Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria 2018
    2018 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients 2018
    2018 Idiopathic pulmonary fibrosis: idiopathic no more? 2018
    2018 Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury. 2018
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation 2018
    2018 What's in a name? That which we call IPF, by any other name would act the same 2018
    2017 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation. 2017
    2017 The lung likes the little fella miR-29 2017
    2017 Mitochondrial dysfunction in pulmonary fibrosis 2017
    2017 The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop 2017
    2017 Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells 2017
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease 2017
    2017 Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis 2017
    2017 DNA methylation regulated gene expression in organ fibrosis 2017
    2017 Measures of frailty in chronic lung diseases 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β 2017
    2017 An official American thoracic society workshop report: Use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs 2017
    2017 Exosomes in immunoregulation of chronic lung diseases 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions 2017
    2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathway 2017
    2017 MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. 2017
    2017 Epigenetic regulation of caveolin-1 gene expression in lung fibroblasts 2017
    2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin 2017
    2017 Transforming growth factor 1 (TGF1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis 2017
    2017 Transforming growth factor β1 (TGF β1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts 2017
    2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanism 2016
    2016 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis 2016
    2016 Redox mechanisms in age-related lung fibrosis 2016
    2016 Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis 2016
    2016 Alveolar epithelial disintegrity in pulmonary fibrosis 2016
    2016 Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis 2016
    2016 A bundled care approach to patients with idiopathic pulmonary fibrosis improves transplant-free survival 2016
    2016 Matrix remodeling in pulmonary fibrosis and emphysema 2016
    2016 MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation 2016
    2016 The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury 2016
    2016 Oxidative modifications of protein tyrosyl residues are increased in plasma of human subjects with interstitial lung disease 2016
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis 2016
    2016 Getting to the core of fibrosis: Targeting redox imbalance in aging 2016
    2016 Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where to Now? 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma 2016
    2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections 2016
    2016 Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment 2016
    2016 Novel mechanisms for the antifibrotic action of nintedanib 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis 2015
    2015 Systemic sclerosis-associated fibrosis: An accelerated aging phenotype? 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiation 2015
    2015 The idiopathic pulmonary fibrosis clinical research network (IPFnet): Diagnostic and adjudication processes 2015
    2015 Use of ECMO in the management of severe acute respiratory distress syndrome: A survey of academic medical centers in the United States 2015
    2015 The code of non-coding RNAs in lung fibrosis 2015
    2015 Noninvasive imaging of experimental lung fibrosis 2015
    2015 Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across species 2015
    2015 SMAD-independent down-regulation of caveolin-1 by TGF-β: Effects on proliferation and survival of myofibroblasts 2015
    2015 The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages 2015
    2015 Blue Journal Conference: Aging and susceptibility to lung disease 2015
    2015 Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence 2015
    2015 Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice 2015
    2015 Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis 2015
    2015 Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism 2015
    2014 Extracorporeal membrane oxygenation for acute respiratory failure in adults: The need for pulmonary INTERMACS 2014
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis 2014
    2014 Wnt/b-Catenin and transforming growth factor-B signaling in pulmonary fibrosis: A case for antagonistic pleiotropy? 2014
    2014 Wnt/β-catenin and transforming growth factor-β signaling in pulmonary fibrosis. A case for antagonistic pleiotropy? 2014
    2014 MiR-27a regulates inflammatory response of macrophages by targeting IL-10 2014
    2014 Negative regulation of NADPH oxidase 4 by Hydrogen peroxide-inducible clone 5 (Hic-5) protein 2014
    2014 NADPH oxidases in lung health and disease 2014
    2014 Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice 2014
    2014 A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β 2014
    2014 Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance 2014
    2014 Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop report 2014
    2014 Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis 2014
    2014 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients 2014
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness 2014
    2014 Fibrosis: Ultimate and proximate causes 2014
    2014 Matrix biology of idiopathic pulmonary fibrosis: A workshop report of the national heart, lung, and blood institute 2014
    2014 The human long noncoding RNA lnc-IL7R regulates the inflammatory response 2014
    2014 Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis 2014
    2013 MiR-125a-5p regulates differential activation of macrophages and inflammation 2013
    2013 Mechanistic links between aging and lung fibrosis 2013
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways 2013
    2013 Heritability of pulmonary function estimated from pedigree and whole-genome markers 2013
    2013 Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts 2013
    2013 Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials 2013
    2013 MiR-145 regulates myofibroblast differentiation and lung fibrosis 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688)) 2013
    2013 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury 2013
    2013 HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4 2013
    2013 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis 2013
    2013 Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stress 2013
    2013 Host responses in tissue repair and fibrosis 2013
    2012 Vascular peroxidase 1 catalyzes the formation of hypohalous acids: Characterization of its substrate specificity and enzymatic properties 2012
    2012 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle action filaments during myofibroblast differentiation 2012
    2012 Lactate, a novel trigger of transforming growth factor- βactivation in idiopathic pulmonary fibrosis 2012
    2012 Altered DNA methylation profile in idiopathic pulmonary fibrosis 2012
    2012 Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction 2012
    2012 miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis 2012
    2012 Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice 2012
    2012 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid 2012
    2012 Targeting NOX enzymes in pulmonary fibrosis 2012
    2012 Update in diffuse parenchymal lung disease 2011 2012
    2012 Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling 2012
    2012 Biological insights from clinical trials and networks 2012
    2012 Participation of miR-200 in pulmonary fibrosis 2012
    2012 A randomized Trial of recombinant human granulocyte-macrophage colony stimulating factor for Patients with acute lung injury 2012
    2012 Mechanisms of pulmonary fibrosis: role of activated myofibroblasts and NADPH oxidase. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. 2012
    2011 Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis 2011
    2011 Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling 2011
    2011 Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions 2011
    2011 miR-29 is a major regulator of genes associated with pulmonary fibrosis 2011
    2011 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis 2011
    2011 Cell plasticity in lung injury and repair: Report from an NHLBI Workshop, April 19-20, 2010 2011
    2011 Elevated levels of NO are localized to distal airways in asthma 2011
    2011 Nonresolving fibrotic disorders: Idiopathic pulmonary fibrosis as a paradigm of impaired tissue regeneration 2011
    2011 Hecker, Crowe and Thannickal reply: 2011
    2011 Lung stem cells: Looking beyond the hype 2011
    2011 Reversible differentiation of myofibroblasts by MyoD 2011
    2010 Aging, antagonistic pleiotropy and fibrotic disease 2010
    2010 A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis 2010
    2010 miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis 2010
    2010 Caveolin-1 regulates dorsoventral patterning through direct interaction with β-catenin in zebrafish 2010
    2010 Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of plasminogen activator inhibitor 1 in fibroblasts 2010
    2010 Challenges in translating preclinical studies to effective drug therapies in idiopathic pulmonary fibrosis 2010
    2010 Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis 2010
    2009 Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways 2009
    2009 Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema 2009
    2009 Innovative approaches to the therapy of fibrosis 2009
    2009 Endothelin-1 and transforming growth factor-β1 independently induce fibroblast resistance to apoptosis via AKT activation 2009
    2009 NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury 2009
    2009 Oxygen in the evolution of complex life and the price we pay 2009
    2009 Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells 2009
    2009 Update in diffuse parenchymal lung disease 2008 2009
    2009 Insulin-Like growth factor-i receptor blockade improves outcome in mouse model of lung injury 2009
    2009 NOX enzymes and pulmonary disease. 2009
    2008 Idiopathic pulmonary fibrosis: A disorder of lung regeneration? 2008
    2008 Protein kinase inhibitors in the treatment of pulmonary fibrosis 2008
    2008 Transforming growth factor β1 induces αvβ3 integrin expression in human lung fibroblasts via a β3 integrin-, c-Src-, and p38 MAPK-dependent pathway 2008
    2008 PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis 2008
    2008 Plasminogen activation-induced pericellular fibronectin proteolysis promotes fibroblast apoptosis 2008
    2007 Current and emerging drugs for idiopathic pulmonary fibrosis 2007
    2007 PGE2 inhibition of TGF-β1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling 2007
    2007 Lung cells from neonates show a mesenchymal stem cell phenotype 2007
    2007 Idiopathic interstitial pneumonia: Do community and academic physicians agree on diagnosis? 2007
    2007 Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts 2007
    2007 Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts 2007
    2007 Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: Implications for treatment of fibrotic diseases 2007
    2007 The myofibroblast: One function, multiple origins 2007
    2006 Epithelial-mesenchymal interactions in pulmonary fibrosis 2006
    2006 Idiopathic interstitial pneumonia: A clinicopathological perspective 2006
    2006 Idiopathic pulmonary fibrosis: Preface 2006
    2006 Idiopathic pulmonary fibrosis: New concepts in pathogenesis and implications for drug therapy 2006
    2006 Evolving concepts of apoptosis in idiopathic pulmonary fibrosis 2006
    2006 Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype 2006
    2006 Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome 2006
    2006 Classification of interstitial pneumonias: What do gene expression profiles tell us? 2006
    2005 Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin 2005
    2005 Emerging drugs for idiopathic pulmonary fibrosis 2005
    2005 Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts 2005
    2005 Bone Marrow-Derived Cells in the Pathogenesis of Lung Fibrosis. 2005
    2005 CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury 2005
    2005 Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury 2005
    2004 Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection 2004
    2004 STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection 2004
    2004 Idiopathic pulmonary fibrosis: Emerging concepts on pharmacotherapy 2004
    2004 Idiopathic pulmonary fibrosis: Pathogenesis and therapeutic approaches 2004
    2004 Mechanisms of pulmonary fibrosis 2004
    2004 Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-gamma ligands. 2004
    2004 Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-γ ligands 2004
    2004 Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor 2004
    2004 Peroxisome proliferator-activated receptor-γ activation inhibits tumor progression in non-small-cell lung cancer 2004
    2003 Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis 2003
    2003 Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation 2003
    2003 Integrin α4β1 regulates migration across basement membranes by lung fibroblasts: A role for phosphatase and tensin homologue deleted on chromosome 10 2003
    2003 Fibroblastic foci in usual interstitial pneumonia: Idiopathic versus collagen vascular disease 2003
    2003 Myofibroblast differentiation by transforming growth factor-β1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase 2003
    2003 The paradox of reactive oxygen species: Injury, signaling, or both? 2003
    2003 The paradox of reactive oxygen species: injury, signaling, or both? 2003
    2001 Oxidative Protein Cross-linking Reactions Involving L-Tyrosine in Transforming Growth Factor-β1-stimulated Fibroblasts 2001
    2001 H2O2 production by myofibroblasts is dependent on Src kinase(s) and actin cytoskeletal regulation 2001
    2000 Reactive oxygen species in cell signaling 2000
    2000 Reactive oxygen species in cell signaling. 2000
    2000 Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-β1 2000
    2000 Transforming growth factor-β1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor 2000
    1998 Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-β1 (TGF-β1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts 1998
    1998 Tyrosine phosphorylation regulates H2O2 production in lung fibroblasts stimulated by transforming growth factor β1 1998
    1998 Tyrosine phosphorylation regulates H_2O_2 production in lung fibroblasts stimulated by transforming growth factor beta1 1998
    1996 Transforming growth factor-βl induces macrophage-colony stimulating factor via a signaling pathway involving a flavinlinked oxidase and h,o 1996
    1995 Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor β1 1995
    1995 Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines 1995
    1995 Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane. 1995
    1994 Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension. 1994
    1994 Glutathione deficiency in human disease 1994
    1994 Regulation of endothelial cell xanthine dehydrogenase/xanthine oxidase gene expression by oxygen tension 1994
    1993 Enhanced rate of H 2 O 2 release from bovine pulmonary artery endothelial cells induced by TGF-β1 1993
    1993 Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TFG-beta1 1993
    1993 Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1. 1993
    1993 Mechanism of basal and transforming growth factor beta 1 stimulated H2O2 release by endothelial cells. 1993

    Chapter

    Year Title Altmetric
    2015 Fibroblast biology in idiopathic pulmonary fibrosis.  99-117. 2015
    2014 Signaling Networks Controlling Cellular Senescence.  67-83. 2014
    2006 Interstitial Lung Disease: Idiopathic Pulmonary Fibrosis.  440-448. 2006

    Research Overview

  • Dr. Thannickal’s research is focused on cellular and molecular mechanisms of lung repair and regeneration. Active studies involve elucidating mechanisms of cellular senescence, oxidative stress and aging in the context of chronic lung diseases, in concert with the development of therapeutics and biomarkers for complex lung diseases. His research program is funded by the National Institutes of Health and the U.S. Department of Veterans Affairs.
  • Principal Investigator On

  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2023
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Core A: Administrative and Biostatistical Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2023
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Project Two: Redox Regulation of Metabolic Reprogramming in Activated Myofibroblasts  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2023
  • Protein o,o’-Dityrosine Cross-Linking in Lung Injury and Wound Healing  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • Training Program in Lung Biology and Translational Medicine  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2020
  • Rheumatic Diseases Research Core Centers - P&F 8: Development of Monoclonal Antibodies Against NOX4 for Studies/Treatment of Rheumatic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Myofibroblast Senescence in Pulmonary Fibrosis  awarded by National Institute on Aging/NIH/DHHS 2014 - 2019
  • IPA - Sirtuins in Lung Aging and Fibrosis (Jianhua Zhang)  awarded by VETERANS ADMINISTRATION 2015 - 2018
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease: Core A - Administrative and Biostatistics Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease: Project 3 - NOX4 as a Therapeutic Target in IPF  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • Private Grant  awarded by GENKYOTEX SA 2016 - 2017
  • Private Grant  awarded by BIOGEN IDEC, INC. 2014 - 2016
  • Training Program in Lung Biology and Translational Medicine  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2015
  • Rho-Kinase Pathway in Pulmonary Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2014
  • Oxidants and TGF-beta in Myofibroblast Differentiation/Survival  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2009 - 2013
  • Mass Spectrometry-Based Biomarker Discovery  awarded by University of Michigan 2009 - 2013
  • Investigator On

  • Program on Cellular Metabolism and Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2023
  • Environmental Cadmium and COPD  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center - P&F Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • AMPK in the Development and Resolution of Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2022
  • Targeting Matrix Stiffness in Lung Fibrosis Associated with Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Cardiac Mesenchymal Stem Cells and Myocardial Fibrosis: Role of Platelet Derived Growth Factor Receptor Signaling  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Histone H4 Lysine16 Acetylation in Aging and Lung Fibrosis  awarded by National Institute on Aging/NIH/DHHS 2016 - 2021
  • Myeloid-Derived Regulatory Cells in Asthma  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Mucus Matters: Mucociliary Physiology in Pulmonary Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2021
  • Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry (IPF_Pro) and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype Prospective Outcomes (ILD-PRO) Registry  awarded by Duke University 2019 - 2020
  • Fibroblast Growth Factor 23/Klotho Crosstalk and Airway Epithelial Senescence in COPD  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • The Role of Biomechanical Signaling in Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • PAI-1 and Aging-Related Susceptibility to Lung Fibrosos  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry (IPF_Pro)  awarded by Duke University 2014 - 2018
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease: Core B - Animal and Therapeutics Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • Private Grant  awarded by FIBROGEN, INC. 2013 - 2018
  • RT-SQuARED-M Method to Study the Precise Role of Mitochondria in the Oxidative Damage Caused by Environmental Toxins  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2015 - 2018
  • Private Grant  awarded by Genentech 2013 - 2018
  • Mitochondrial UCP2 in Age-Related Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017
  • Private Grant  awarded by FIBROGEN, INC. 2010 - 2017
  • Role of Mechanosensitive ITGA6 in Myofibroblast Invasion and Lung Fibrosis  awarded by American Heart Association (Southeast Affiliate) 2014 - 2017
  • miR-21 and Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2016
  • Differentiation of Regulatory Myeloid-Derived Cells by Reactive Oxygen Species  awarded by PARKER B. FRANCIS FOUNDATION 2013 - 2016
  • Private Grant  awarded by Gilead Sciences 2013 - 2016
  • Private Grant  awarded by INTERMUNE, INC. 2008 - 2015
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2014 - 2015
  • Private Grant  awarded by MedImmune 2014 - 2015
  • Second-Hand Smoke and Myeloid Cells in Asthma  awarded by Flight Attendant Medical Research Institute 2011 - 2014
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2013 - 2014
  • Private Grant  awarded by MedImmune 2013 - 2014
  • Private Grant  awarded by VERILOGUE, INC. 2013
  • Private Grant  awarded by Gilead Sciences 2013
  • Teaching Overview

  • Dr. Thannickal has a passion for mentoring and team-building; trainees from his laboratory have moved on to independent careers at academic institutions around the U.S., including the University of Michigan, Indiana University, University of California-San Francisco, and the University of Arizona.
  • Full Name

  • Victor Thannickal