Positions

Overview

  • Dr. Thannickal is Professor of Medicine and the Ben Vaughan Branscomb Chair of Medicine in Respiratory Disease at the University of Alabama at Birmingham (UAB). Following his fellowship training at Tufts University School of Medicine, he has held faculty positions at Tufts, University of Michigan and UAB, where he currently serves as director of the Division of Pulmonary, Allergy, and Critical Care Medicine. Under his leadership, the division has grown to over 65 faculty members and expanded its research and educational programs, including the institution of a highly successful NIH T32 Training Program in Lung Biology and Translational Medicine. Dr. Thannickal is an elected member of Association of American Physicians, and received the American Thoracic Society (ATS) Recognition Award for Scientific Accomplishments in 2016. He has served on the ATS Research Training Fellowship Committee (2005-2006), Scientific Advisory Committee (2011-2013), Awards Committee (2012-2013) and the RCMB Working Group on Aging (2013-2015). He has been a strong advocate for increasing research funding on behalf of the ATS and the NIH, including providing congressional testimony on Capitol Hill.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Fibronectin on the surface of extracellular vesicles mediates fibroblast invasionAmerican Journal of Respiratory Cell and Molecular Biology.  60:279-288. 2019
    2019 Pulmonary fibrosis: "idiopathic" is not "cryptogenic"European Respiratory Journal.  53. 2019
    2019 Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injuryJCI insight.  4. 2019
    2019 Developmental pathways in the pathogenesis of lung fibrosisMolecular Aspects of Medicine.  65:56-69. 2019
    2019 Idiopathic interstitial pneumonia or idiopathic interstitial pneumonitis: what's in a name?European Respiratory Journal.  53. 2019
    2019 Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signalingDevelopment.  146. 2019
    2019 SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.JCI insight.  4. 2019
    2019 Betting on novel treatments for asthma: Bromodomain 4 inhibitorsAmerican Journal of Respiratory Cell and Molecular Biology.  60:7-8. 2019
    2019 Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  60:49-57. 2019
    2019 Mechanisms for the resolution of organ fibrosisNews in Physiological Sciences.  34:43-55. 2019
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
    2018 Extracellular matrix in lung development, homeostasis and diseaseCollagen and related research.  73:77-104. 2018
    2018 Ambulatory oxygen and quality of life in interstitial lung diseaseLancet Respiratory Medicine.  6:730-731. 2018
    2018 Erratum to: Metformin reverses established lung fibrosis in a bleomycin model (Nature Medicine, (2018), 24, 8, (1121-1127), 10.1038/s41591-018-0087-6)Nature Medicine.  24:1627. 2018
    2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cellsRedox Biology.  18:54-64. 2018
    2018 Reversing mechanoinductive DSP expression by CRISPR/dCas9–mediated epigenome editingAmerican Journal of Respiratory and Critical Care Medicine.  198:599-609. 2018
    2018 Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctionalAmerican Journal of Respiratory Cell and Molecular Biology.  59:135-136. 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin modelNature Medicine.  24:1121-1131. 2018
    2018 Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis?Expert Review of Respiratory Medicine.  12:441-443. 2018
    2018 Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuliRespiratory Research.  19. 2018
    2018 Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteriaPLoS Pathogens.  14. 2018
    2018 What's in a name? That which we call IPF, by any other name would act the sameEuropean Respiratory Journal.  51. 2018
    2018 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipientsThe Journal of heart transplantation.  37:206-216. 2018
    2018 Idiopathic pulmonary fibrosis: idiopathic no more?Lancet Respiratory Medicine.  6:84-85. 2018
    2018 Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury.Frontiers in Genetics.  9:418. 2018
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activationJournal of Biological Chemistry.  293:1218-1228. 2018
    2017 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.Journal of Biological Chemistry.  293:1218-1228. 2017
    2017 The lung likes the little fella miR-29American Journal of Respiratory Cell and Molecular Biology.  57:637-638. 2017
    2017 Mitochondrial dysfunction in pulmonary fibrosisAnnals of the American Thoracic Society.  14:S383-S388. 2017
    2017 The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA WorkshopJournals of Gerontology, Series A.  72:1492-1500. 2017
    2017 Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem CellsDevelopmental Cell.  43:48-59.e5. 2017
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung diseaseAging Cell.  16:1114-1124. 2017
    2017 Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosisJournal of Immunology.  199:1596-1605. 2017
    2017 DNA methylation regulated gene expression in organ fibrosisBBA - Molecular Basis of Disease.  1863:2389-2397. 2017
    2017 Measures of frailty in chronic lung diseasesAnnals of the American Thoracic Society.  14:1266-1267. 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-βAJP - Lung Cellular and Molecular Physiology.  312:L926-L935. 2017
    2017 An official American thoracic society workshop report: Use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  56:667-679. 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugsJCI insight.  2. 2017
    2017 Exosomes in immunoregulation of chronic lung diseasesAllergy.  72:534-544. 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctionsAJP - Lung Cellular and Molecular Physiology.  312:L415-L424. 2017
    2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathwayJournal of Biological Chemistry.  292:3029-3038. 2017
    2017 MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescenceAmerican Journal of Respiratory Cell and Molecular Biology.  56:168-178. 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.JCI insight.  2:e91377. 2017
    2017 Epigenetic regulation of caveolin-1 gene expression in lung fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  56:50-61. 2017
    2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentinAJP - Lung Cellular and Molecular Physiology.  313:L80-L91. 2017
    2017 Transforming growth factor 1 (TGF1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosisJournal of Biological Chemistry.  292:10490-10519. 2017
    2017 Transforming growth factor β1 (TGF β1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblastsJournal of Biological Chemistry.  292:10465-10489. 2017
    2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanismPLoS ONE.  11. 2016
    2016 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary FibrosisScientific Reports.  6. 2016
    2016 Redox mechanisms in age-related lung fibrosisRedox Biology.  9:67-76. 2016
    2016 Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosisNature Communications.  7. 2016
    2016 Alveolar epithelial disintegrity in pulmonary fibrosisAJP - Lung Cellular and Molecular Physiology.  311:185-191. 2016
    2016 Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung FibrosisAmerican Journal of Pathology.  186:1712-1723. 2016
    2016 A bundled care approach to patients with idiopathic pulmonary fibrosis improves transplant-free survivalRespiratory Medicine.  115:33-38. 2016
    2016 Matrix remodeling in pulmonary fibrosis and emphysemaAmerican Journal of Respiratory Cell and Molecular Biology.  54:751-760. 2016
    2016 MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiationAmerican Journal of Respiratory Cell and Molecular Biology.  54:843-852. 2016
    2016 The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injuryFederation proceedings.  30:2135-2150. 2016
    2016 Oxidative modifications of protein tyrosyl residues are increased in plasma of human subjects with interstitial lung diseaseAmerican Journal of Respiratory and Critical Care Medicine.  193:861-866. 2016
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary FibrosisImmunity.  44:582-596. 2016
    2016 Getting to the core of fibrosis: Targeting redox imbalance in agingAnnals of translational medicine.  4. 2016
    2016 Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where to Now?Drugs.  76:291-300. 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthmaAJP - Lung Cellular and Molecular Physiology.  310:L328-L336. 2016
    2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infectionsAJP - Lung Cellular and Molecular Physiology.  311:L928-L940. 2016
    2016 Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironmentOncotarget.  7:75407-75424. 2016
    2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  192:1462-1474. 2015
    2015 Systemic sclerosis-associated fibrosis: An accelerated aging phenotype?Current Opinion in Rheumatology.  27:571-576. 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiationJournal of Biological Chemistry.  290:25427-25438. 2015
    2015 The idiopathic pulmonary fibrosis clinical research network (IPFnet): Diagnostic and adjudication processesChest.  148:1034-1042. 2015
    2015 Use of ECMO in the management of severe acute respiratory distress syndrome: A survey of academic medical centers in the United StatesASAIO Journal.  61:556-563. 2015
    2015 The code of non-coding RNAs in lung fibrosisCellular and Molecular Life Sciences.  72:3507-3519. 2015
    2015 Noninvasive imaging of experimental lung fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  53:8-13. 2015
    2015 Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across speciesPLoS ONE.  10. 2015
    2015 SMAD-independent down-regulation of caveolin-1 by TGF-β: Effects on proliferation and survival of myofibroblastsPLoS ONE.  10. 2015
    2015 The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophagesJournal of Biological Chemistry.  290:46-55. 2015
    2015 Blue Journal Conference: Aging and susceptibility to lung diseaseAmerican Journal of Respiratory and Critical Care Medicine.  191:261-269. 2015
    2015 Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescenceFree Radical Biology and Medicine.  79:197-205. 2015
    2015 Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated miceAJP - Lung Cellular and Molecular Physiology.  309:L280-L292. 2015
    2015 Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosisExperimental Gerontology.  61:62-75. 2015
    2015 Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolismJournal of Immunology.  194:6082-6089. 2015
    2014 Extracorporeal membrane oxygenation for acute respiratory failure in adults: The need for pulmonary INTERMACSAmerican Journal of Respiratory and Critical Care Medicine.  190:1321-1322. 2014
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosisJournal of Pharmacology and Experimental Therapeutics.  351:87-95. 2014
    2014 Wnt/b-Catenin and transforming growth factor-B signaling in pulmonary fibrosis: A case for antagonistic pleiotropy?American Journal of Respiratory and Critical Care Medicine.  190:129-131. 2014
    2014 Wnt/β-catenin and transforming growth factor-β signaling in pulmonary fibrosis. A case for antagonistic pleiotropy?American Journal of Respiratory and Critical Care Medicine.  190:129-131. 2014
    2014 MiR-27a regulates inflammatory response of macrophages by targeting IL-10Journal of Immunology.  193:327-334. 2014
    2014 Negative regulation of NADPH oxidase 4 by Hydrogen peroxide-inducible clone 5 (Hic-5) proteinJournal of Biological Chemistry.  289:18270-18278. 2014
    2014 NADPH oxidases in lung health and diseaseAntioxidants and Redox Signaling.  20:2838-2853. 2014
    2014 Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in miceEuropean Respiratory Journal.  43:1448-1458. 2014
    2014 A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-βGene.  540:62-67. 2014
    2014 Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalanceScience Translational Medicine.  6. 2014
    2014 Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop reportAmerican Journal of Respiratory and Critical Care Medicine.  189:214-222. 2014
    2014 Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosisRespiratory Medicine.  108:181-188. 2014
    2014 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patientsClinical and Translational Science.  7:336-341. 2014
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsivenessLaboratory Investigation.  94:1312-1325. 2014
    2014 Fibrosis: Ultimate and proximate causesJournal of Clinical Investigation.  124:4673-4677. 2014
    2014 Matrix biology of idiopathic pulmonary fibrosis: A workshop report of the national heart, lung, and blood instituteAmerican Journal of Pathology.  184:1643-1651. 2014
    2014 The human long noncoding RNA lnc-IL7R regulates the inflammatory responseEuropean Journal of Immunology.  44:2085-2095. 2014
    2014 Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosisFederation proceedings.  28:1122-1131. 2014
    2013 MiR-125a-5p regulates differential activation of macrophages and inflammationJournal of Biological Chemistry.  288:35428-35436. 2013
    2013 Mechanistic links between aging and lung fibrosisBiogerontology.  14:609-615. 2013
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
    2013 Heritability of pulmonary function estimated from pedigree and whole-genome markersFrontiers in Genetics.  4. 2013
    2013 Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblastsInternational Journal of Molecular Sciences.  14:19605-19617. 2013
    2013 Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trialsRespiratory Research.  14. 2013
    2013 MiR-145 regulates myofibroblast differentiation and lung fibrosisFederation proceedings.  27:2382-2391. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injuryAmerican Journal of Pathology.  182:1239-1247. 2013
    2013 HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4AJP - Lung Cellular and Molecular Physiology.  304. 2013
    2013 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosisJournal of Clinical Investigation.  123:1096-1108. 2013
    2013 Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophagesJournal of Immunology.  190:2273-2281. 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stressRedox Biology.  1:8-16. 2013
    2013 Host responses in tissue repair and fibrosisAnnual Review of Pathology: Mechanisms of Disease.  8:241-276. 2013
    2012 Vascular peroxidase 1 catalyzes the formation of hypohalous acids: Characterization of its substrate specificity and enzymatic propertiesFree Radical Biology and Medicine.  53:1954-1959. 2012
    2012 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle action filaments during myofibroblast differentiationAJP - Lung Cellular and Molecular Physiology.  303. 2012
    2012 Lactate, a novel trigger of transforming growth factor- βactivation in idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  186:701-703. 2012
    2012 Altered DNA methylation profile in idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  186:525-535. 2012
    2012 Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransductionAmerican Journal of Respiratory Cell and Molecular Biology.  47:340-348. 2012
    2012 miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosisFederation proceedings.  26:3790-3799. 2012
    2012 Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in miceAmerican Journal of Respiratory Cell and Molecular Biology.  47:28-36. 2012
    2012 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acidInfection and Immunity.  80:2528-2537. 2012
    2012 Targeting NOX enzymes in pulmonary fibrosisCellular and Molecular Life Sciences.  69:2365-2371. 2012
    2012 Update in diffuse parenchymal lung disease 2011American Journal of Respiratory and Critical Care Medicine.  186:24-29. 2012
    2012 Recent developments in myofibroblast biology: Paradigms for connective tissue remodelingAmerican Journal of Pathology.  180:1340-1355. 2012
    2012 Biological insights from clinical trials and networksAmerican Journal of Respiratory and Critical Care Medicine.  185:475-476. 2012
    2012 Participation of miR-200 in pulmonary fibrosisAmerican Journal of Pathology.  180:484-493. 2012
    2012 A randomized Trial of recombinant human granulocyte-macrophage colony stimulating factor for Patients with acute lung injuryCritical Care Medicine.  40:90-97. 2012
    2012 Mechanisms of pulmonary fibrosis: role of activated myofibroblasts and NADPH oxidase.Fibrogenesis & Tissue Repair.  5:S23. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.Molecular Medicine.  18:659-668. 2012
    2011 Relaxin Regulates Myofibroblast Contractility and Protects against Lung FibrosisAmerican Journal of Pathology.  179:2751-2765. 2011
    2011 Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signalingFree Radical Biology and Medicine.  51:1271-1288. 2011
    2011 Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactionsFree Radical Biology and Medicine.  51:1445-1453. 2011
    2011 miR-29 is a major regulator of genes associated with pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  45:287-294. 2011
    2011 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosisDrugs.  71:981-1001. 2011
    2011 Cell plasticity in lung injury and repair: Report from an NHLBI Workshop, April 19-20, 2010Proceedings of the American Thoracic Society.  8:215-222. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 Nonresolving fibrotic disorders: Idiopathic pulmonary fibrosis as a paradigm of impaired tissue regenerationAmerican Journal of the Medical Sciences.  341:431-434. 2011
    2011 Hecker, Crowe and Thannickal reply:Nature Medicine.  17:32-33. 2011
    2011 Lung stem cells: Looking beyond the hypeNature Medicine.  17:788. 2011
    2011 Reversible differentiation of myofibroblasts by MyoDExperimental Cell Research.  317:1914-1921. 2011
    2010 Aging, antagonistic pleiotropy and fibrotic diseaseThe International journal of biochemistry.  42:1398-1400. 2010
    2010 A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosisNew England Journal of Medicine.  363:620-628. 2010
    2010 miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosisJournal of Experimental Medicine.  207:1589-1597. 2010
    2010 Caveolin-1 regulates dorsoventral patterning through direct interaction with β-catenin in zebrafishDevelopmental Biology.  344:210-223. 2010
    2010 Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of plasminogen activator inhibitor 1 in fibroblastsJournal of Biological Chemistry.  285:16239-16247. 2010
    2010 Challenges in translating preclinical studies to effective drug therapies in idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  181:532-533. 2010
    2010 Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  181:254-263. 2010
    2009 Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathwaysFederation proceedings.  23:4317-4326. 2009
    2009 Mesenchymal cell fate and phenotypes in the pathogenesis of emphysemaCOPD: Journal of Chronic Obstructive Pulmonary Disease.  6:201-210. 2009
    2009 Innovative approaches to the therapy of fibrosisCurrent Opinion in Rheumatology.  21:649-655. 2009
    2009 Endothelin-1 and transforming growth factor-β1 independently induce fibroblast resistance to apoptosis via AKT activationAmerican Journal of Respiratory Cell and Molecular Biology.  41:484-493. 2009
    2009 NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injuryNature Medicine.  15:1077-1081. 2009
    2009 Oxygen in the evolution of complex life and the price we payAmerican Journal of Respiratory Cell and Molecular Biology.  40:507-510. 2009
    2009 Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cellsAntioxidants and Redox Signaling.  11:747-764. 2009
    2009 Update in diffuse parenchymal lung disease 2008American Journal of Respiratory and Critical Care Medicine.  179:439-444. 2009
    2009 Insulin-Like growth factor-i receptor blockade improves outcome in mouse model of lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  179:212-219. 2009
    2009 NOX enzymes and pulmonary disease.Antioxidants and Redox Signaling.  11:2505-2516. 2009
    2008 Idiopathic pulmonary fibrosis: A disorder of lung regeneration?American Journal of Respiratory and Critical Care Medicine.  178:663-665. 2008
    2008 Protein kinase inhibitors in the treatment of pulmonary fibrosisCurrent Medicinal Chemistry.  15:2632-2640. 2008
    2008 Transforming growth factor β1 induces αvβ3 integrin expression in human lung fibroblasts via a β3 integrin-, c-Src-, and p38 MAPK-dependent pathwayJournal of Biological Chemistry.  283:12898-12908. 2008
    2008 PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosisAJP - Lung Cellular and Molecular Physiology.  294. 2008
    2008 Plasminogen activation-induced pericellular fibronectin proteolysis promotes fibroblast apoptosisAmerican Journal of Respiratory Cell and Molecular Biology.  38:78-87. 2008
    2007 Current and emerging drugs for idiopathic pulmonary fibrosisExpert Opinion on Emerging Drugs.  12:627-646. 2007
    2007 PGE2 inhibition of TGF-β1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signalingAJP - Lung Cellular and Molecular Physiology.  293. 2007
    2007 Lung cells from neonates show a mesenchymal stem cell phenotypeAmerican Journal of Respiratory and Critical Care Medicine.  175:1158-1164. 2007
    2007 Idiopathic interstitial pneumonia: Do community and academic physicians agree on diagnosis?American Journal of Respiratory and Critical Care Medicine.  175:1054-1060. 2007
    2007 Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allograftsJournal of Clinical Investigation.  117:989-996. 2007
    2007 Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblastsCellular Signalling.  19:761-771. 2007
    2007 Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: Implications for treatment of fibrotic diseasesJournal of Pharmacology and Experimental Therapeutics.  321:35-44. 2007
    2007 The myofibroblast: One function, multiple originsAmerican Journal of Pathology.  170:1807-1816. 2007
    2006 Epithelial-mesenchymal interactions in pulmonary fibrosisSeminars in Respiratory and Critical Care Medicine.  27:600-612. 2006
    2006 Idiopathic interstitial pneumonia: A clinicopathological perspectiveSeminars in Respiratory and Critical Care Medicine.  27:569-573. 2006
    2006 Idiopathic pulmonary fibrosis: PrefaceSeminars in Respiratory and Critical Care Medicine.  27:567-568. 2006
    2006 Idiopathic pulmonary fibrosis: New concepts in pathogenesis and implications for drug therapyAmerican Journal of Respiratory Medicine.  5:325-342. 2006
    2006 Evolving concepts of apoptosis in idiopathic pulmonary fibrosisProceedings of the American Thoracic Society.  3:350-356. 2006
    2006 Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotypeJournal of Proteome Research.  5:1143-1154. 2006
    2006 Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndromeAJP - Lung Cellular and Molecular Physiology.  290. 2006
    2006 Classification of interstitial pneumonias: What do gene expression profiles tell us?American Journal of Respiratory and Critical Care Medicine.  173:141-142. 2006
    2005 Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberinCancer Research.  65:10881-10890. 2005
    2005 Emerging drugs for idiopathic pulmonary fibrosisExpert Opinion on Emerging Drugs.  10:707-727. 2005
    2005 Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblastsFederation proceedings.  19:854-856. 2005
    2005 Bone Marrow-Derived Cells in the Pathogenesis of Lung Fibrosis.Current Respiratory Medicine Reviews.  1:69-76. 2005
    2005 CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injuryAmerican Journal of Pathology.  166:675-684. 2005
    2005 Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injuryAmerican Journal of Pathology.  166:367-375. 2005
    2004 Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infectionAmerican Journal of Respiratory and Critical Care Medicine.  170:1331-1339. 2004
    2004 STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infectionJournal of Immunology.  173:4075-4083. 2004
    2004 Idiopathic pulmonary fibrosis: Emerging concepts on pharmacotherapyExpert Opinion on Pharmacotherapy.  5:1671-1686. 2004
    2004 Idiopathic pulmonary fibrosis: Pathogenesis and therapeutic approachesDrugs.  64:405-430. 2004
    2004 Mechanisms of pulmonary fibrosisAnnual Review of Medicine.  55:395-417. 2004
    2004 Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-gamma ligands.AJP - Lung Cellular and Molecular Physiology.  286:L613-L619. 2004
    2004 Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-γ ligandsAJP - Lung Cellular and Molecular Physiology.  286. 2004
    2004 Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth FactorJournal of Biological Chemistry.  279:1359-1367. 2004
    2004 Peroxisome proliferator-activated receptor-γ activation inhibits tumor progression in non-small-cell lung cancerOncogene.  23:100-108. 2004
    2003 Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosisJournal of Pathology.  201:343-354. 2003
    2003 Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate ElevationAmerican Journal of Respiratory Cell and Molecular Biology.  29:537-544. 2003
    2003 Integrin α4β1 regulates migration across basement membranes by lung fibroblasts: A role for phosphatase and tensin homologue deleted on chromosome 10American Journal of Respiratory and Critical Care Medicine.  168:436-442. 2003
    2003 Fibroblastic foci in usual interstitial pneumonia: Idiopathic versus collagen vascular diseaseAmerican Journal of Respiratory and Critical Care Medicine.  167:1410-1415. 2003
    2003 Myofibroblast differentiation by transforming growth factor-β1 is dependent on cell adhesion and integrin signaling via focal adhesion kinaseJournal of Biological Chemistry.  278:12384-12389. 2003
    2003 The paradox of reactive oxygen species: Injury, signaling, or both?AJP - Lung Cellular and Molecular Physiology.  284. 2003
    2003 The paradox of reactive oxygen species: injury, signaling, or both?AJP - Lung Cellular and Molecular Physiology.  284:L24-L25. 2003
    2001 Oxidative Protein Cross-linking Reactions Involving L-Tyrosine in Transforming Growth Factor-β1-stimulated FibroblastsJournal of Biological Chemistry.  276:17437-17441. 2001
    2001 H2O2 production by myofibroblasts is dependent on Src kinase(s) and actin cytoskeletal regulationChest.  120:32S-33S. 2001
    2000 Reactive oxygen species in cell signalingAJP - Lung Cellular and Molecular Physiology.  279. 2000
    2000 Reactive oxygen species in cell signaling.AJP - Lung Cellular and Molecular Physiology.  279:L1005-L1028. 2000
    2000 Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-β1Federation proceedings.  14:1741-1748. 2000
    2000 Transforming growth factor-β1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factorJournal of Biological Chemistry.  275:27650-27656. 2000
    1998 Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-β1 (TGF-β1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblastsBiochemical and Biophysical Research Communications.  251:437-441. 1998
    1998 Tyrosine phosphorylation regulates H2O2 production in lung fibroblasts stimulated by transforming growth factor β1Journal of Biological Chemistry.  273:23611-23615. 1998
    1996 Transforming growth factor-βl induces macrophage-colony stimulating factor via a signaling pathway involving a flavinlinked oxidase and h,oJournal of Investigative Medicine.  44. 1996
    1995 Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor β1Journal of Biological Chemistry.  270:30334-30338. 1995
    1995 Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokinesJournal of Clinical Investigation.  96:60-68. 1995
    1995 Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane.American Journal of Respiratory Cell and Molecular Biology.  12:41-49. 1995
    1994 Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension.American Journal of Physiology.  266:L163-L171. 1994
    1994 Glutathione deficiency in human diseaseJournal of Nutritional Biochemistry.  5:218-226. 1994
    1994 Regulation of endothelial cell xanthine dehydrogenase/xanthine oxidase gene expression by oxygen tensionAmerican Journal of Physiology.  266. 1994
    1993 Enhanced rate of H 2 O 2 release from bovine pulmonary artery endothelial cells induced by TGF-β1American Journal of Physiology.  265. 1993
    1993 Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TFG-beta1American Journal of Physiology.  265. 1993
    1993 Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1.American Journal of Physiology.  265:L622-L626. 1993
    1993 Mechanism of basal and transforming growth factor beta 1 stimulated H2O2 release by endothelial cells.Transactions of the Association of American Physicians.  106:179-186. 1993

    Chapter

    Year Title Altmetric
    2015 Fibroblast biology in idiopathic pulmonary fibrosis.  99-117. 2015
    2014 Signaling Networks Controlling Cellular Senescence.  67-83. 2014

    Research Overview

  • Dr. Thannickal’s research is focused on cellular and molecular mechanisms of lung repair and regeneration. Active studies involve elucidating mechanisms of cellular senescence, oxidative stress and aging in the context of chronic lung diseases, in concert with the development of therapeutics and biomarkers for complex lung diseases. His research program is funded by the National Institutes of Health and the U.S. Department of Veterans Affairs.
  • Teaching Overview

  • Dr. Thannickal has a passion for mentoring and team-building; trainees from his laboratory have moved on to independent careers at academic institutions around the U.S., including the University of Michigan, Indiana University, University of California-San Francisco, and the University of Arizona.
  • Full Name

  • Victor Thannickal