Positions

Overview

  • Dr. Hauptfeld-Dolejsek attended the Charles University in Prague, where she obtained a Masters Degree, in Experimental Zoology; PhD in Embryology and Candidate of Science in Molecular Biology.

    She became Board certified for Human Histocompatibility and Immunogenetics D(ABHI) in US by American Society for Histocompatibility and Immunogenetics.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigensImmunogenetics.  71:479-487. 2019
    2018 Impact of high-dose steroid premedication on the outcome of myeloablative T-cell replete haploidentical peripheral blood stem cell transplantBone Marrow Transplantation.  53:1345-1348. 2018
    2018 Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantationAmerican Journal of Transplantation.  18:2189-2199. 2018
    2016 Outcomes in Simultaneous Liver Kidney Transplants in the Setting of a Positive Crossmatch: A Single Center ExperienceClinical Transplants.  32:119-125. 2016
    2015 Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failureAmerican Journal of Transplantation.  15:1615-1622. 2015
    1994 Continued mapping of chromosome 2 genesImmunogenetics.  40:21-26. 1994
    1992 The evolutionary origin of the HLA-DR3 haplotypeImmunogenetics.  35:263-271. 1992
    1991 Production of marked prolongation of islet xenograft survival (rat to mouse) by local release of mouse and rat antilymphocyte sera at transplant siteDiabetes.  40:482-485. 1991
    1989 Antigenic properties of 36 new H-2 congenic strains and 4 independently derived strains, W10LT, DDD, BZH, and FMImmunogenetics.  30:132-136. 1989
    1989 Immune response gene control of the mouse antibody responses to human creatine kinase-MM and the lactate dehydrogenase-1 enzymesImmunogenetics.  30:128-131. 1989
    1989 Production of H-2 class II (Ia. 7) antibody is under Ir gene controlImmunogenetics.  30:126-127. 1989
    1989 Induction of Ia antigen expression on murine islet parenchymal cells does not diminish islet allograft survivalAmerican Journal of Pathology.  134:237-242. 1989
    1988 Tumor necrosis factor enhances interferon-induced Ia antigen expression on murine islet parenchymal cellsAmerican Journal of Pathology.  130:427-430. 1988
    1987 Induction of class II MHC antigens on human and rodent islet parenchymal cells in vitro.Diabetologia.  30:441. 1987
    1986 Interferon-mediated induction of Ia antigen expression on isolated murine whole islets and dispersed islet cellsDiabetes.  35:1174-1177. 1986
    1986 The effect of cyclosporin-A, low-temperature culture, and anti-Ia antibodies on prevention of rejection of rat islet allograftsDiabetes.  35:83-88. 1986
    1985 Monoclonal antibodies to mouse antigens - II. Characterization of thirty-one anti-14 reagentsImmunogenetics.  21:193-197. 1985
    1984 Monoclonal antibodies to mouse MHC antigens - I. Serologic characterization of ten anti-H-2 and anti-Ia reagentsImmunogenetics.  19:169-173. 1984
    1984 Characterization of monoclonal anti-I-J reagentsFederation proceedings.  43. 1984
    1984 Three subpopulations of Ia+cells within murine islets of LangerhansFederation proceedings.  43. 1984
    1982 Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibodyImmunogenetics.  15:41-52. 1982
    1979 Evidence for partial defect in stem cell function induced in mice by neonatal thymectomyImmunology Letters.  1:133-136. 1979
    1976 Histocompatibility-2 system in wild mice - III. mixed lymphocyte reaction and cell-mediated lymphocytotoxicity with t-bearing miceImmunogenetics.  3:489-497. 1976
    1976 Ia Antigens: Their Serology, Molecular Relationships, and their role in Allograft ReactionsImmunological Reviews.  30:83-100. 1976
    1975 Evidence for a fifth (G) region in the H-2 complex of the mouseImmunogenetics.  2:141-150. 1975
    1974 Evidence for a third, Ir-associated histocompatibility region in the H-2 complex of the mouseImmunogenetics.  1:45-56. 1974
    1974 Production of anti‐H‐2 antibodies in thymectomized miceEuropean Journal of Immunology.  4:41-44. 1974

    Research Overview

  • Dr.Hauptfeld-Dolejsek over four decades has been interested in defining the structure and function of the histocompatibility gene products which are fundamental in immunologic mechanisms. When she arrived to US, she joined Dr. Jan Klein in Michigan, where her research focused on the murine major histocompatibility system. In his laboratory, they discovered Ia antigens, later renamed as class II antigens. After 30 years in defining the structure and function of the MHC gene products in mice, she transferred her interest to a human MHC, because of its remarkable genetic and functional homology and feasibility to apply that knowledge to human.


    Keywords: HLA, crossmatching, Histocompatibility; Solid organ transplantation, deceased and living donors; bone marrow /HSC transplantation, related and unrelated
  • Education And Training

  • Doctor of Science in Molecular Genetics, 1996
  • Doctor of Philosophy in Zoology / Animal Biology, Charles University in Prague 1968
  • Full Name

  • Vera Hauptfeld-Dolejsek