• Dr. Buford is an Associate Professor in the UAB Department of Medicine, Division of Gerontology, Geriatrics & Palliative Care. He also serves as Associate Director for the UAB Center for Exercise Medicine and the NIH-funded Nathan Shock Center for the Basic Biology of Aging. Dr. Buford’s research utilizes clinical and pre-clinical models focused on preserving the health and independence of older adults, including leading multiple recent clinical trials related to exercise and mobility. He current has extensive NIH funding including two active R01 awards and has served on numerous grant peer-review committees including the NIH's Aging Systems and Geriatrics panel. He served as a co-investigator on the Phase 3 Lifestyle Interventions and Independence for Elders study and also serves as co-investigator for the NIH's Molecular Transducers of Physical Activity in Humans consortium funded by the NIH Common Fund. He is also actively involved in the NIH National Rehabilitation Research Resource to Enhance Clinical Trials housed at UAB.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Exercise and the Gut Microbiome: A Review of the Evidence, Potential Mechanisms, and Implications for Human HealthExercise and Sport Sciences Reviews.  47:75-85. 2019
    2019 Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.Journal of Clinical Medicine.  8. 2019
    2019 Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial.Journal of Clinical Medicine.  8. 2019
    2019 Mitochondrial DNA variants and pulmonary function in older personsExperimental Gerontology.  115:96-103. 2019
    2018 Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speedGeroscience.  40:497-511. 2018
    2018 Circadian rhythms, exercise, and cardiovascular healthJournal of Circadian Rhythms.  16. 2018
    2018 Composition and richness of the serum microbiome differ by age and link to systemic inflammationGeroscience.  40:257-268. 2018
    2018 Effect of physical activity on frailty: Secondary analysis of a randomized controlled trialAnnals of Internal Medicine.  168:309-316. 2018
    2018 Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults.Frontiers in Aging Neuroscience.  10:341. 2018
    2018 Nutrition and exercise in sarcopeniaCurrent Protein and Peptide Science.  19:649-667. 2018
    2017 Mobile Device Accuracy for Step Counting Across Age Groups.JMIR mHealth and uHealth.  5:e88. 2017
    2017 Metabolic costs of daily activity in older adults (Chores XL) study: Design and methodsContemporary Clinical Trials Communications.  6:1-8. 2017
    2017 Resveratrol and exercise to treat functional limitations in late life: Design of a randomized controlled trialContemporary Clinical Trials Communications.  6:58-63. 2017
    2017 Wearable technology to reduce sedentary behavior and CVD risk in older adults: Design of a randomized controlled trialContemporary Clinical Trials Communications.  6:122-126. 2017
    2017 Systemic inflammation, body composition, and physical performance in old community-dwellersJournal of Cachexia, Sarcopenia and Muscle.  8:69-77. 2017
    2017 Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE StudyArchives of Physical Medicine and Rehabilitation.  98:11-24.e3. 2017
    2016 Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: A randomized controlled trialClinical Interventions in Aging.  11:1797-1804. 2016
    2016 Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exerciseCanadian Journal of Applied Physiology.  42:68-76. 2016
    2016 Cardiovascular events in a physical activity intervention compared with a successful aging intervention: The LIFE study randomized trialJAMA Cardiology.  1:568-574. 2016
    2016 Hypertension and agingAgeing Research Reviews.  26:96-111. 2016
    2016 Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: Randomized clinical trial (LIFE study)BMJ.  352. 2016
    2015 Successful aging: Advancing the science of physical independence in older adultsAgeing Research Reviews.  24:304-327. 2015
    2015 Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE StudyExperimental Gerontology.  70:32-36. 2015
    2015 Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjectsBMC Immunology.  16. 2015
    2015 Kaatsu training to enhance physical function of older adults with knee osteoarthritis: Design of a randomized controlled trialControlled Clinical Trials.  43:217-222. 2015
    2015 Multi-modal intervention to reduce cardiovascular risk among hypertensive older adults: Design of a randomized clinical trialControlled Clinical Trials.  43:237-242. 2015
    2015 The renin–angiotensin system and prevention of age-related functional decline: where are we now?AGE.  37:1-11. 2015
    2014 Physical activity and resting pulse rate in older adults: Findings from a randomized controlled trialAmerican Heart Journal.  168:597-604. 2014
    2014 Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adultsJournal of applied physiology: respiratory, environmental and exercise physiology.  116:1481-1490. 2014
    2014 Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged malesEuropean Journal of Applied Physiology.  114:1321-1332. 2014
    2014 Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: A partial least squares-discriminant analysis approachFrontiers in Medicine.  1. 2014
    2013 Obesity and diabetes as accelerators of functional decline: Can lifestyle interventions maintain functional status in high risk older adults?Experimental Gerontology.  48:888-897. 2013
    2013 Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscleAGE.  35:1061-1075. 2013
    2012 Growth hormone responses to acute resistance exercise with vascular restriction in young and old menGrowth Hormone and IGF Research.  22:167-172. 2012
    2012 The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individualsAging Cell.  11:801-809. 2012
    2012 On muscle atrophy, aging, and diseaseJournal of applied physiology: respiratory, environmental and exercise physiology.  113:681. 2012
    2012 Age-related differences in lower extremity tissue compartments and associations with physical function in older adultsExperimental Gerontology.  47:38-44. 2012
    2011 The impact of behavioral intervention on obesity mediated declines in mobility function: Implications for longevityJournal of Aging Research.  2011. 2011
    2011 Erratum to: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats (Age DOI: 10.1007/s11357-010-9196-y)AGE.  33:185. 2011
    2011 Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway ratsAGE.  33:167-183. 2011
    2011 Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and functionAging Clinical and Experimental Research.  23:170-174. 2011
    2010 Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophyAgeing Research Reviews.  9:369-383. 2010
    2009 Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscleEuropean Journal of Applied Physiology.  107:463-471. 2009
    2009 Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscleCanadian Journal of Applied Physiology.  34:745-753. 2009
    2008 Impact of DHEA(S) and cortisol on immune function in aging: A brief reviewCanadian Journal of Applied Physiology.  33:429-433. 2008
    2008 Seasonal changes of body mass, body composition, and muscular performance in collegiate wrestlersInternational Journal of Sports Physiology and Performance.  3:176-184. 2008
    2007 Bilateral comparison of barbell kinetics and kinematics during a weightlifting competition.International Journal of Sports Physiology and Performance.  2:150-158. 2007


    Year Title Altmetric
    2008 Macronutrient intake for physical activity.  95-119. 2008

    Education And Training

  • Doctor of Philosophy in Exercise Physiology, Baylor University 2009
  • Master of Science in Kinesiology and Exercise Science, Oklahoma State University 2006
  • Bachelor of Science or Mathematics in Social Science Teacher Education, Oklahoma Baptist University 2004
  • Full Name

  • Thomas Buford