Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major. 2017
2017 Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia 2017
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2013 Erythropoiesis in the absence of adult hemoglobin 2013
2011 Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development 2011
2010 Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology 2010
2009 Preclinical transfusion-dependent humanized mouse model of β thalassemia major 2009
2009 Humanized mouse model of Cooley's anemia 2009
2007 JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells 2007
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cells 2006
2004 A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin 2004
2004 Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. 2004
2003 Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells 2003
2003 Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization 2003
2002 Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
2001 Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene 2001
2000 Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention 2000
2000 Human β-globin gene promoter element regulates human β-globin gene developmental specificity 2000
1998 Knockout-transgenic mouse models of human hemoglobinopathies 1998
1998 Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene 1998
1997 Knockout-transgenic mouse model of sickle cell disease 1997
1995 Mouse model of human β0 thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells 1995
1994 Preparation of recombinant hemoglobin in transgenic mice 1994
1991 Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice 1991
1990 A Transgenic Mouse Model for Human Sickle Cell Disease 1990
1990 Human sickle hemoglobin in transgenic mice 1990
1990 Human γ- To β-globin gene switching in transgenic mice 1990
1990 Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody 1990
1989 A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. 1989
1989 DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice. 1989
1989 High-level erythroid expression of human α-globin genes in transgenic mice 1989
1989 Synthesis of functional human hemoglobin in transgenic mice 1989

Teaching Activities

  • GBS748 - Special Topics (Fall Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2019) 2019
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBS784 - Stem Cell Biology (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2018) 2018
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS784 - Stem Cell Biology (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBS784 - Stem Cell Biology (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2016) 2016
  • GBS784 - Stem Cell Biology (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Fall Term 2015) 2015
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015) 2015
  • GBS784 - Stem Cell Biology (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Fall Term 2014) 2014
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2014) 2014
  • GBS784 - Stem Cell Biology (Spring Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2013) 2013
  • GBS784 - Stem Cell Biology (Spring Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2012) 2012
  • OBHS111 - Fundamentals Dent/Optometry I (Fall Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2012) 2012
  • GBS784 - Stem Cell Biology (Spring Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2011) 2011
  • GBS784 - Stem Cell Biology (Spring Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2010) 2010
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2009) 2009
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2008) 2008
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2008) 2008
  • BMG798 - Non-Dissertation Research (Spring Term 2008) 2008
  • BMG799 - Dissertation Research (Spring Term 2008) 2008
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2007) 2007
  • BMG798 - Non-Dissertation Research (Fall Term 2007) 2007
  • BMG799 - Dissertation Research (Fall Term 2007) 2007
  • Full Name

  • Thomas Ryan