Positions

Overview

  • Jessy Deshane received her PhD in Biochemistry and Molecular Genetics from University of Alabama at Birmingham under the mentorship of Dr. Anupam Agarwal. After completing her post-doctoral training in Immunology with Dr. David Chaplin, in Department of Microbiology, she joined the faculty of the Division of Pulmonary, Allergy, and Critical Care Medicine in the Department of Medicine in 2011 as an Assistant Professor. Dr. Deshane is committed to an academic career combining basic and translational research with an emphasis on inflammatory diseases of the airway. Research in Dr. Deshane’s laboratory is focused on myeloid-derived regulatory cells (MDRCs) and their immunoregulatory roles in chronic inflammatory lung diseases. Dr. Deshane is particularly interested in delineating mechanisms underlying the differentiation, activation, metabolism and function of MDRCs. Her group recently reported that a subset of reactive oxygen species (ROS)-producing MDRCs exacerbate T cell responses and airway hyper-reactivity in mice. They recently characterized human MDRC subsets in bronchoalveolar lavage of asthmatics.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.American Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.Cell Reports.  25:1938-1952.e5. 2018
    2018 Fibronectin on the Surface of Extracellular Vesicles Mediates Fibroblast Invasion.American Journal of Respiratory Cell and Molecular Biology2018
    2018 Author Correction: Metformin reverses established lung fibrosis in a bleomycin model.Nature Medicine.  24:1627. 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin model.Nature Medicine.  24:1121-1127. 2018
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.Scientific Reports.  8:10340. 2018
    2018 Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5.Journal of Immunology.  201:278-295. 2018
    2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells.Redox Biology.  18:54-64. 2018
    2017 Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.PLoS Pathogens.  13:e1006582. 2017
    2017 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients.The Journal of heart transplantation2017
    2017 Exosomes in immunoregulation of chronic lung diseases.Allergy.  72:534-544. 2017
    2016 Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment.Oncotarget.  7:75407-75424. 2016
    2016 Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions.Toxicology and Applied Pharmacology.  308:46-58. 2016
    2016 Prostate cancer-derived cathelicidin-related antimicrobial peptide facilitates macrophage differentiation and polarization of immature myeloid progenitors to protumorigenic macrophages.Prostate.  76:624-636. 2016
    2016 AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-Induced Lung Injury.Molecular Medicine.  21:937-950. 2016
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.Immunity.  44:582-596. 2016
    2016 PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia.Journal of Immunology.  196:2239-2248. 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.AJP - Lung Cellular and Molecular Physiology.  310:L328-L336. 2016
    2015 SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.Cancer Immunology Research.  3:727-740. 2015
    2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.International Journal of Oncology.  46:1079-1088. 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease.Journal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.Laboratory Investigation.  94:1312-1325. 2014
    2014 Refractory asthma: mechanisms, targets, and therapy.Allergy.  69:817-827. 2014
    2014 Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury.Journal of Immunology.  192:4795-4803. 2014
    2014 The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer.OncoImmunology.  3:e27401. 2014
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways.Cancer Research.  73:6609-6620. 2013
    2013 Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.Molecular Medicine.  19:387-398. 2013
    2013 Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.Toxicology and Applied Pharmacology.  272:879-887. 2013
    2013 A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism.Gene Therapy.  20:733-741. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer.Cancer Research.  73:672-682. 2013
    2012 Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.American Journal of Respiratory Cell and Molecular Biology.  46:790-796. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.Molecular Medicine.  18:659-668. 2012
    2011 AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils.Federation proceedings.  25:4358-4368. 2011
    2011 Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection.Infection and Immunity.  79:3966-3977. 2011
    2011 Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness.Mucosal Immunology.  4:503-518. 2011
    2011 Inhibition of neutrophil apoptosis by PAI-1.AJP - Lung Cellular and Molecular Physiology.  301:L247-L254. 2011
    2011 Elevated levels of NO are localized to distal airways in asthma.Free Radical Biology and Medicine.  50:1679-1688. 2011
    2010 Follicular dendritic cell makes environmental sense.Immunity.  33:2-4. 2010
    2010 Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.Journal of Biological Chemistry.  285:16476-16486. 2010
    2010 Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model.Brain, Behavior, and Immunity.  24:153-159. 2010
    2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.Journal of Biological Chemistry.  283:18032-18039. 2008
    2008 Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis.Circulation.  117:231-241. 2008
    2007 Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis.Circulation Research.  100:1703-1711. 2007
    2007 2D gel proteomics: An approach to study age-related differences in protein abundance or isoform complexity in biological samplesMethods in Molecular Biology.  371:349-391. 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism.Journal of Experimental Medicine.  204:605-618. 2007
    2007 2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples.Methods in Molecular Biology.  371:349-391. 2007
    2006 Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds.Life Sciences.  78:2060-2065. 2006
    2005 Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.Proceedings of the National Academy of Sciences.  102:7251-7256. 2005
    2005 The case for well-conducted experiments to validate statistical protocols for 2D gels: different pre-processing = different lists of significant proteins.BMC Biotechnology.  5:7. 2005
    2005 Heme oxygenase-1 expression in disease states.Acta Biochimica Polonica.  52:273-284. 2005
    2004 Proteomics analysis of rat brain protein modulations by grape seed extract.Journal of Agricultural and Food Chemistry.  52:7872-7883. 2004
    2003 Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2.Journal of Biological Chemistry.  278:4135-4144. 2003
    2001 Eradication of c-erbB-2-Positive Ovarian Cancer Cells Mediated by Intracellular Expression of Anti-c-erbB-2 Antibody.Methods in Molecular Medicine.  39:757-768. 2001
    1998 Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5.Journal of Biological Chemistry.  273:19183-19189. 1998
    1998 The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv.The Clinical investigator.  76:451-458. 1998
    1998 CD5 regulates Casein Kinase 2 (CK2) by direct interaction with the holoenzymeFederation proceedings.  12. 1998
    1997 An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2.Gene Therapy.  4:317-322. 1997
    1997 Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapy.Gynecologic Oncology.  64:378-385. 1997
    1997 A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow.Human Gene Therapy.  8:157-170. 1997
    1997 Gene therapy and ovarian cancer: a review.Obstetrics and Gynecology.  89:145-155. 1997
    1996 erbB-2 knockout employing an intracellular single-chain antibody (sFv) accomplishes specific toxicity in erbB-2-expressing lung cancer cells.American Journal of Respiratory Cell and Molecular Biology.  15:348-354. 1996
    1996 Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity.Clinical Cancer Research.  2:1089-1095. 1996
    1996 Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosis.Cancer Gene Therapy.  3:89-98. 1996
    1995 Targeted tumor killing via an intracellular antibody against erbB-2.Journal of Clinical Investigation.  96:2980-2989. 1995
    1995 Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody.Gynecologic Oncology.  59:8-14. 1995
    1995 Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.Cancer Research.  55:2024-2028. 1995
    1994 Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines.Gene Therapy.  1:332-337. 1994

    Research Overview

  • Dr. Deshane’s current research interests are to study effects of MDRCs on post-translational oxidative and nitrative modifications of self-peptides. This study is based the hypothesis that these modified self-proteins are recognized as non-tolerized neo-antigens and stimulate Th responses that underlie the immunopathology of asthma. Furthermore, her lab investigates how environmental pollutants such as tobacco smoke would impact MDRC function and contribute to exacerbation of inflammation in asthmatic smokers. These studies will provide insight into the role of MDRC in tobacco related pathology of the lung. Dr. Deshane’s group also studies the function of these myeloid-lineage cells in anti-tumor immunity. They have developed novel therapeutic strategies to target these immunoregulatory cells to enhance anti-tumor immunity for lung cancer; in parallel, they seek to understand molecular signatures of the tumor microenvironment (TME). Their innovative therapeutic strategy targets Indoleamine 2, 3- dioxygenase (IDO), an enzyme that regulates tryptophan metabolism in the TME and suppresses the function of these regulatory myeloid cells. This novel strategy has distinct advantages over existing immunotherapy strategies targeting CTLA-4 and PD-1/PDL-1 in that it overrides the IDO resistance associated with current immunotherapy strategies. Dr. Deshane’s group investigates the mechanisms by which this therapeutic strategy induces metabolic reprogramming in the TME involving IDO and the nutrient sensing metabolic signaling pathways. They also seek to translate these findings in human studies to investigate efficacy of combination chemotherapy strategies in targeting these cells and amino acid metabolism pathways in lung cancer patients.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Alabama at Birmingham
  • Master of Life Sciences in Biology, University of Alabama in Huntsville
  • Full Name

  • Jessy Deshane
  • Blazerid

  • treena