Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Temperature-responsive nanogel multilayers of poly(N-vinylcaprolactam) for topical drug delivery.Journal of Colloid and Interface Science.  506:589-602. 2017
2017 Bone regeneration from human mesenchymal stem cells on porous hydroxyapatite-PLGA-collagen bioactive¬†polymer¬†scaffolds.Bio-Medical Materials and Engineering.  28:671-685. 2017
2016 Development of gellan gum containing formulations for transdermal drug delivery: Component evaluation and controlled drug release using temperature responsive nanogels.International Journal of Pharmaceutics.  509:465-476. 2016
2016 Mechanical properties and osteogenic potential of hydroxyapatite-PLGA-collagen biomaterial for bone regeneration.Journal of Biomaterials Science, Polymer Edition.  27:1139-1154. 2016
2016 Exercise Medicine for Osteoarthritis: Research Strategies to Maximize Effectiveness.Arthritis Care and Research.  68:288-291. 2016
2015 Transient Growth Factor Stimulation Improves Chondrogenesis in Static Culture and Under Dynamic Conditions in a Novel Shear and Perfusion BioreactorCellular and Molecular Bioengineering.  8:267-277. 2015
2015 Transient Growth Factor Stimulation Improves Chondrogenesis in Static Culture and Under Dynamic Conditions in a Novel Shear and Perfusion BioreactorCellular and Molecular Bioengineering2015
2015 Novel synthesis and characterization of a collagen-based biopolymer initiated by hydroxyapatite nanoparticles.Acta Biomaterialia.  15:181-190. 2015
2015 Novel synthesis and characterization of a collagen-based biopolymer initiated by hydroxyapatite nanoparticlesActa Biomaterialia.  15:181-190. 2015
2014 Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivo.Biofabrication.  6:035019. 2014
2009 Protocol Development for Vitrification of Tissue-Engineered Cartilage.Bioprocessing Journal.  8:29-36. 2009
2008 Hemodynamics and inflammatory mediators regulate sickle erythrocyte adhesion to endothelial cellsBiorheology.  45:62-62. 2008
2006 Histamine increases sickle erythrocyte adherence to endothelium.British Journal of Haematology.  132:512-522. 2006
2005 Endothelial cell-smooth muscle cell co-culture in a perfusion bioreactor system.Annals of Biomedical Engineering.  33:920-928. 2005
2004 Sickle cell adhesion depends on hemodynamics and endothelial activation.Journal of Laboratory and Clinical Medicine.  144:260-267. 2004
2004 Effect of low oxygen tension on tissue-engineered cartilage construct development in the concentric cylinder bioreactor.Tissue Engineering -Larchmont-.  10:825-832. 2004
2004 Perfusion bioreactor for small diameter tissue-engineered arteries.Tissue Engineering -Larchmont-.  10:930-941. 2004
2003 Elevated endothelial cAMP reduces cell adhesion molecule expression on and sickle erythrocyte adhesion to TNF-alpha stimulated human dermal microvascular endothelium.Blood.  102:82A-82A. 2003
2003 Histamine promotes sickle erythrocyte adherence to endothelium under flow through stimulation of H-2 and H-4 via nitric oxide synthase signaling.Blood.  102:259A-259A. 2003
2003 Shear stress modulation of cytokine-induced sickle cell adherence to endothelium.Blood.  102:264A-264A. 2003
2003 Inflammatory mediators promote strong sickle cell adherence to endothelium under venular flow conditions.American Journal of Hematology.  73:215-224. 2003
2003 Concentric cylinder bioreactor for production of tissue engineered cartilage: effect of seeding density and hydrodynamic loading on construct development.Biotechnology Progress.  19:510-521. 2003
2002 Microcirculatory effects of Poloxamer 188 in transgenic sickle cell mice.Blood.  100:664A-664A. 2002
2002 Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering.Biotechnology Progress.  18:951-963. 2002
2002 Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusion.American Journal of Hematology.  70:216-227. 2002
2001 Transgenic mice expressing exclusively HbS are more susceptible to endotoxin and desmopressin challenge.Blood.  98:488A-488A. 2001
2001 Bioreactor for the scalable production of engineered cartilage construcs.ACS National Meeting Book of Abstracts.  221:U146-U146. 2001
2001 Characterization of the mechanical and chemical environment in a cartilage bioreactor using computational fluid dynamics.ACS National Meeting Book of Abstracts.  221:U145-U146. 2001
2001 Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.Pediatric Pathology and Molecular Medicine.  20:47-72. 2001
2000 Microcirculatory effects of blocking cell adhesion molecules in transgenic sickle cell mice.Blood.  96:528A-528A. 2000
2000 Microcirculatory effects of blocking cell adhesion molecules in transgenic sickle cell mice.Circulation.  102:307-307. 2000
1999 Bioreactor for development of tissue engineered cartilage constructsAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  42:131-132. 1999
1999 Effect of shear stresses on cardiac leaflet fibroblastsAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  42:205-206. 1999
1999 Screening of antisickling agents by the new systematic multi-level analysis protocol developed at the sickle cell disease reference laboratory.Blood.  94:199A-199A. 1999
1999 Sickle red blood cell (SRBC) adherence to endothelial cells (EC) is regulated by hemodynamics and receptor affinity.Blood.  94:675A-675A. 1999
1998 Effect of fluid-mechanical and chemical environments on cell function and tissue growth: Experimental and modeling studiesAmerican Society of Mechanical Engineerings, Bioengineering Division (Publication) BED.  40:55-59. 1998
1998 Prosthesis-induced hemolysis: mechanisms and quantification of shear stress.Journal of Heart Valve Disease.  7:376-386. 1998
1998 Short report: Plasmodium falciparum: cytoadherence to alpha(v)beta3 on human microvascular endothelial cells.American Journal of Tropical Medicine and Hygiene.  59:77-79. 1998
1998 RBC adhesion to cremaster endothelum in mice with abnormal hemoglobin is increased by topical endotoxin.Annals of the New York Academy of Sciences.  850:391-393. 1998
1998 Endothelial cells in physiology and in the pathophysiology of vascular disorders.Blood.  91:3527-3561. 1998
1997 Erythrocyte adhesion to cremaster endotheilum in mice with abnormal hemoglobin is increased by topical endotoxin.Blood.  90:1960-1960. 1997
1997 Plasmodium falciparum: soluble thrombospondin increases cytoadherence of parasitized erythrocytes to human microvascular endothelium under shear flow conditions.Experimental Parasitology.  87:69-72. 1997
1996 Phorbol ester stimulation increases sickle erythrocyte adherence to endothelium: a novel pathway involving alpha 4 beta 1 integrin receptors on sickle reticulocytes and fibronectin.Blood.  88:4348-4358. 1996
1996 Continuous recirculating contact enhances adhesion of sickle red blood cells to endothelial cells.Blood.  88:27-27. 1996
1996 Inhibition of plasma-mediated sickle erythrocyte adherence to microvascular endothelium by poloxamer compounds.Blood.  88:24-24. 1996
1996 Sickle red blood cell adherence to vascular endothelium is more tenacious in confined flow channelsBlood.  88:23-23. 1996
1996 Tenacity of sickle red blood cell (SRBC) endothelial cell (EC) adherence is augmented under hemodynamic shear and by involvement of multiple adhesion pathways.Blood.  88:2585-2585. 1996
1996 Inhibition of plasma-mediated adherence of sickle erythrocytes to microvascular endothelium by conformationally constrained RGD-containing peptides.American Journal of Hematology.  53:92-98. 1996
1996 Hemodynamic modulation of monocytic cell adherence to vascular endothelium.Annals of Biomedical Engineering.  24:382-393. 1996
1996 Molecular basis of sickle cell-endothelial cell interactions.Current opinion in hematology.  3:118-124. 1996
1996 A novel method for quantification of surgical gown permeabilityASTM Special Technical Publication.  1237:123-130. 1996
1995 Increased tenacity of sickle erythrocyte-endothelial cell adherence by involvement of multiple receptor-ligand interactionsBlood.  86:1180-1180. 1995
1995 Double-stranded RNA induces sickle erythrocyte adherence to endothelium: a potential role for viral infection in vaso-occlusive pain episodes in sickle cell anemia.Blood.  85:2945-2950. 1995
1995 PHORBOL ESTER ACTIVATION OF ALPHA(4)BETA(1) INTEGRINS ON SICKLE RETICULOCYTES INCREASES RED-CELL ADHERENCE TO ENDOTHELIUMFederation proceedings.  9:A846-A846. 1995
1995 DUAL MODULATION OF MONOCYTE ADHERENCE TO VASCULAR ENDOTHELIUM BY SHEAR-STRESSFederation proceedings.  9:A35-A35. 1995
1995 INDUCTION OF ENDOTHELIAL ADHESION MOLECULE EXPRESSION BY SICKLE CELLS - A POSSIBLE MECHANISM FOR INCREASED BY VASCULAR-DISEASEFederation proceedings.  9:A541-A541. 1995
1994 IN-VITRO COMPARISON OF KNOWN MECHANISMS OF SICKLE ERYTHROCYTE ADHERENCE TO ENDOTHELIUM - BIOPHYSICAL STUDIES TO PREDICT THE RELATIVE IMPORTANCE OF COMPETING ADHERENCE PATHWAYS IN-VIVOBlood.  84:A407-A407. 1994
1994 SHORT-TERM CONTACT WITH SICKLE ERYTHROCYTES INHIBITS SHEAR-INDUCED ELONGATION OF ARTERIAL ENDOTHELIUMBlood.  84:A407-A407. 1994
1994 SICKLE ERYTHROCYTES STIMULATED WITH PHORBOL ESTER ADHERE TO ENDOTHELIUM VIA ACTIVATED ALPHA-4-BETA-1 INTEGRIN ON SICKLE RETICULOCYTES AND FIBRONECTIN ON ENDOTHELIUMBlood.  84:A408-A408. 1994
1994 INCREASED MONOCYTE ADHERENCE TO ENDOTHELIAL-CELLS (ECS) EXPOSED TO LOW SHEAR-STRESS IS VIA A VCAM-1/ALPHA-4-BETA-1 MEDIATED MECHANISMFederation proceedings.  8:A322-A322. 1994
1993 PLASMA ENHANCEMENT OF SICKLE RED-BLOOD-CELL (RBC) ADHERENCE TO MICROVASCULAR ENDOTHELIAL-CELLS (MEC) MEDIATED BY INTEGRIN RECEPTORS CAN BE INHIBITED BY CONFORMATIONALLY CONSTRAINED RGD PEPTIDESBlood.  82:A353-A353. 1993
1993 SICKLE RED-BLOOD-CELLS (RBC) INDUCE EXPRESSION OF CELL-ADHESION MOLECULES ON HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS (HUVEC)Blood.  82:A352-A352. 1993
1993 STIMULATION OF SICKLE ERYTHROCYTES WITH PHORBOL ESTER PROMOTES ADHERENCE TO ENDOTHELIUM - A POTENTIAL ROLE FOR ACTIVATED VLA-4 (ALPHA-4-BETA-1) ON SICKLE RETICULOCYTESBlood.  82:A352-A352. 1993
1993 SYNTHETIC DOUBLE-STRANDED-RNA INCREASES ADHERENCE OF SICKLE RED-BLOOD-CELLS (SRBC) TO HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS (HUVEC) VIA ALPHA-4-BETA-1 - VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) PATHWAYBlood.  82:A352-A352. 1993
1993 Prolonged contact with blood alters surgical gown permeability.American Journal of Infection Control.  21:249-256. 1993
1993 Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium.Blood.  82:1891-1899. 1993
1993 Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion.Blood.  81:2137-2143. 1993
1993 SICKLE RETICULOCYTES EXPRESS CD36 AND ALPHA-4-BETA-1 WHICH MEDIATE THEIR BINDING TO ENDOTHELIAL-CELLSClinical research.  41:A262-A262. 1993
1993 Cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelium is regulatable by cytokines and phorbol ester.Journal of Infectious Diseases.  167:698-703. 1993
1993 Unusually large von Willebrand factor multimers preferentially promote young sickle and nonsickle erythrocyte adhesion to endothelial cells.American Journal of Hematology.  42:284-292. 1993
1992 Sickle erythrocyte adherence to large vessel and microvascular endothelium under physiologic flow is qualitatively different.Journal of Laboratory and Clinical Medicine.  120:538-545. 1992
1992 Plasmodium fragile: cytoadherence of parasitized rhesus monkey erythrocytes to human endothelial cells under shear flow conditions.Experimental Parasitology.  74:228-231. 1992
1992 CYTOADHERENCE OF PLASMODIUM-FALCIPARUM PARASITIZED RED-BLOOD-CELLS (PRBC) TO HUMAN MICROVASCULAR ENDOTHELIAL-CELL (MEC) CD36 AND ICAM-1 IS STRAIN-SPECIFIC AND REGULATABLEFederation proceedings.  6:A1892-A1892. 1992
1992 Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro.Journal of Immunology.  148:78-83. 1992
1991 Abnormal adhesion of sickle red blood cells to human microvascular endothelial cells. A potential role for the plasma milieu in the initiation of vaso-occlusion in sickle cell diseaseAnnals of Biomedical Engineering.  19:580. 1991
1991 Blood permeability of non-woven surgical gownsAnnals of Biomedical Engineering.  19:605. 1991
1991 Cytoadherence of Plasmodium falciparum-infected erythrocytes to human umbilical vein and human dermal microvascular endothelial cells under shear conditions.American Journal of Tropical Medicine and Hygiene.  45:578-586. 1991
1991 ABNORMAL ADHESION OF SICKLE ERYTHROCYTES TO HUMAN MICROVASCULAR ENDOTHELIAL-CELLS IS DUE TO RED-CELL FACTORS AND COLLAGEN-BINDING PLASMA-PROTEINSFederation proceedings.  5:A528-A528. 1991
1987 Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow.Journal of Clinical Investigation.  80:905-910. 1987

Teaching Activities

  • EGR481 - Interdisciplinary Project Lab (Fall Term 2018) 2018
  • HC111 - Honors Seminar in Engineering (Fall Term 2018) 2018
  • EGR481 - Interdisciplinary Project Lab (Summer Term 2018) 2018
  • EGR301 - Honors Research I (Fall Term 2017) 2017
  • HC111 - Honors Seminar in Engineering (Fall Term 2017) 2017
  • EGR490 - Special Topics in (Area) (Summer Term 2017) 2017
  • BME490 - Special Topic in BME (Fall Term 2016) 2016
  • EGR301 - Honors Research I (Fall Term 2016) 2016
  • EGR490 - Special Topics in (Area) (Fall Term 2016) 2016
  • HC111 - Honors Seminar in Engineering (Fall Term 2016) 2016
  • BME799 - Dissertation Research (Spring Term 2016) 2016
  • BME490 - Special Topic in BME (Fall Term 2015) 2015
  • BME799 - Dissertation Research (Fall Term 2015) 2015
  • HC111 - Honors Seminar in Engineering (Fall Term 2015) 2015
  • BME799 - Dissertation Research (Summer Term 2015) 2015
  • BME350 - Biological Transport Phenomena (Spring Term 2015) 2015
  • BME491 - Individual Study in BME (Spring Term 2015) 2015
  • BME799 - Dissertation Research (Spring Term 2015) 2015
  • BME408 - Biofluids (Fall Term 2014) 2014
  • BME491 - Individual Study in BME (Fall Term 2014) 2014
  • BME495 - Honors Research II (Fall Term 2014) 2014
  • BME508 - Biofluids (Fall Term 2014) 2014
  • BME799 - Dissertation Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Summer Term 2014) 2014
  • BME799 - Dissertation Research (Summer Term 2014) 2014
  • BME350 - Biological Transport Phenomena (Spring Term 2014) 2014
  • BME494 - Honors Research I (Spring Term 2014) 2014
  • BME798 - Non-Dissertation Research (Spring Term 2014) 2014
  • BME698 - Non-Thesis Research (Fall Term 2013) 2013
  • BME798 - Non-Dissertation Research (Fall Term 2013) 2013
  • BME798 - Non-Dissertation Research (Summer Term 2013) 2013
  • BME350 - Biological Transport Phenomena (Spring Term 2013) 2013
  • BME495 - Honors Research II (Spring Term 2013) 2013
  • BME798 - Non-Dissertation Research (Spring Term 2013) 2013
  • BME495 - Honors Research II (Fall Term 2012) 2012
  • BME798 - Non-Dissertation Research (Fall Term 2012) 2012
  • BME799 - Dissertation Research (Fall Term 2012) 2012
  • BME494 - Honors Research I (Summer Term 2012) 2012
  • BME698 - Non-Thesis Research (Summer Term 2012) 2012
  • BME799 - Dissertation Research (Summer Term 2012) 2012
  • BME350 - Biological Transport Phenomena (Spring Term 2012) 2012
  • BME494 - Honors Research I (Spring Term 2012) 2012
  • BME798 - Non-Dissertation Research (Spring Term 2012) 2012
  • BME698 - Non-Thesis Research (Fall Term 2011) 2011
  • BME798 - Non-Dissertation Research (Fall Term 2011) 2011
  • BME798 - Non-Dissertation Research (Summer Term 2011) 2011
  • BME350 - Biological Transport Phenomena (Spring Term 2011) 2011
  • BME491 - Individual Study in (Area) (Spring Term 2011) 2011
  • BME690 - Special Topics in (Area) (Spring Term 2011) 2011
  • BME798 - Non-Dissertation Research (Spring Term 2011) 2011
  • BME401 - Undergraduate BME Seminar (Fall Term 2010) 2010
  • BME496 - BME Honors Seminar (Fall Term 2010) 2010
  • BME601 - Biomedical Engineering Seminar (Fall Term 2010) 2010
  • BME698 - Non-Thesis Research (Fall Term 2010) 2010
  • BME701 - Biomedical Engineering Seminar (Fall Term 2010) 2010
  • BME798 - Non-Dissertation Research (Fall Term 2010) 2010
  • BME495 - Honors Research II (Summer Term 2010) 2010
  • BME699 - Masters Thesis Research (Summer Term 2010) 2010
  • BME798 - Non-Dissertation Research (Summer Term 2010) 2010
  • BME011 - UG Coop/Intership in BME (Spring Term 2010) 2010
  • BME350 - Biological Transport Phenomena (Spring Term 2010) 2010
  • BME401 - Undergraduate BME Seminar (Spring Term 2010) 2010
  • BME495 - Honors Research II (Spring Term 2010) 2010
  • BME496 - BME Honors Seminar (Spring Term 2010) 2010
  • BME601 - Biomedical Engineering Seminar (Spring Term 2010) 2010
  • BME699 - Masters Thesis Research (Spring Term 2010) 2010
  • BME701 - Biomedical Engineering Seminar (Spring Term 2010) 2010
  • BME401 - Undergraduate BME Seminar (Fall Term 2009) 2009
  • BME495 - Honors Research II (Fall Term 2009) 2009
  • BME496 - BME Honors Seminar (Fall Term 2009) 2009
  • BME601 - Biomedical Engineering Seminar (Fall Term 2009) 2009
  • BME698 - Non-Thesis Research (Fall Term 2009) 2009
  • BME699 - Masters Thesis Research (Fall Term 2009) 2009
  • BME701 - Biomedical Engineering Seminar (Fall Term 2009) 2009
  • BME798 - Non-Dissertation Research (Fall Term 2009) 2009
  • BME494 - Honors Research I (Summer Term 2009) 2009
  • BME698 - Non-Thesis Research (Summer Term 2009) 2009
  • BME699 - Masters Thesis Research (Summer Term 2009) 2009
  • BME401 - Undergraduate BME Seminar (Spring Term 2009) 2009
  • BME496 - BME Honors Seminar (Spring Term 2009) 2009
  • BME601 - Biomedical Engineering Seminar (Spring Term 2009) 2009
  • BME691 - Individual Study in (Area) (Spring Term 2009) 2009
  • BME698 - Non-Thesis Research (Spring Term 2009) 2009
  • BME701 - Biomedical Engineering Seminar (Spring Term 2009) 2009
  • BME494 - Honors Research I (Fall Term 2008) 2008
  • BME698 - Non-Thesis Research (Fall Term 2008) 2008
  • BME699 - Masters Thesis Research (Fall Term 2008) 2008
  • BME698 - Non-Thesis Research (Summer Term 2008) 2008
  • BME699 - Masters Thesis Research (Summer Term 2008) 2008
  • BME401 - Undergraduate BME Seminar (Spring Term 2008) 2008
  • BME496 - BME Honors Seminar (Spring Term 2008) 2008
  • BME601 - Biomedical Engineering Seminar (Spring Term 2008) 2008
  • BME698 - Non-Thesis Research (Spring Term 2008) 2008
  • BME701 - Biomedical Engineering Seminar (Spring Term 2008) 2008
  • BME350 - Biological Transport Phenomena (Fall Term 2007) 2007
  • BME401 - Undergraduate BME Seminar (Fall Term 2007) 2007
  • BME496 - BME Honors Seminar (Fall Term 2007) 2007
  • BME601 - Biomedical Engineering Seminar (Fall Term 2007) 2007
  • BME698 - Non-Thesis Research (Fall Term 2007) 2007
  • BME701 - Biomedical Engineering Seminar (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Chemical Engineering, Rice University
  • Full Name

  • Timothy Wick
  • Blazerid

  • tmwick