Positions

Overview

  • Laura Timares is an Associate Professor in the Division of Hematology-Oncology in the School of Medicine who recently transferred (2017) from Department of Dermatology at the University of Alabama at Birmingham (UAB). She obtained both her undergraduate (BA Biology) and graduate degrees (Ph.D., Microbiology and Immunology School of Medicine) from the University of California at Los Angeles (UCLA). Her postdoctoral training at the California Institute of Technology (1991-1993) and Cedars Sinai Medical Center/UCLA (1993-1996) developed her interest in genetic engineering of transplantable cells and their translational application in treating liver diseases and diabetes.  After joining the University of Texas, Southwestern Medical Center at Dallas (UTSW) (1996), she became faculty in the Department of Medicine in the Center for Biomedical Inventions.  There she studied the role of transfected dendritic cells in skin generated by topical genetic immunization and characterized their role as inducers of vaccine immunity.  She was recruited to the University of Alabama in Birmingham (UAB) in the Department of Dermatology (1999) where she continued her research on cutaneous immunology with a focus on the development of prophylactic skin cancer vaccines. In the Division of Heme-Onc, she is currently applying her expertise toward understanding the role of human mucosal immunology in heterosexual HIV transmission.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2017 CD151 expression is associated with a hyperproliferative T cell phenotypeJournal of Immunology.  199:3336-3347. 2017
    2017 IL-23 Inhibits Melanoma Development by Augmenting DNA repair and modulating T cell subpopulationsJournal of Immunology.  198:950-961. 2017
    2016 A murine model for the development of melanocytic nevi and their progression to melanomaMolecular Carcinogenesis.  55:646-658. 2016
    2015 Erratum: Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor (Cancer Gene Therapy (2013) 20 (445-452) DOI: 10.1038/cgt.2013.39)Cancer Gene Therapy.  22:222. 2015
    2015 Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutationsJournal of Immunology.  194:2683-2695. 2015
    2015 In vivo suppression of heat shock protein (HSP)27 and HSP70 accelerates DMBA-induced skin carcinogenesis by inducing antigenic unresponsiveness to the initiating carcinogenic chemicalJournal of Immunology.  194:4796-4803. 2015
    2015 MC1R, eumelanin and pheomelanin: Their role in determining the susceptibility to skin cancerPhotochemistry and Photobiology.  91:188-200. 2015
    2014 Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma developmentJournal of Dermatological Science.  75:121-132. 2014
    2012 Inflammasome activation of IL-1 family mediators in response to cutaneous photodamagePhotochemistry and Photobiology.  88:1111-1125. 2012
    2012 CD40-targeted adenoviral cancer vaccines: The long and winding road to the clinicJournal of Gene Medicine.  14:416-427. 2012
    2011 Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathwayMolecular Carcinogenesis.  50:516-527. 2011
    2010 HIV antigen incorporation within adenovirus hexon hypervariable 2 for a novel HIV vaccine approachPLoS ONE.  5. 2010
    2010 Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosisCancer Research.  70:6566-6576. 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunityJournal of Immunology.  184:442-451. 2010
    2009 A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivoVaccine.  27:7116-7124. 2009
    2009 Strategies to overcome host immunity to adenovirus vectors in vaccine developmentExpert Review of Vaccines.  8:761-777. 2009
    2008 A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosisJournal of Immunology.  181:3077-3088. 2008
    2008 Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesisCancer Research.  68:3924-3930. 2008
    2008 DNA damage, apoptosis and Langerhans cells - Activators of UV-induced immune tolerancePhotochemistry and Photobiology.  84:422-436. 2008
    2007 Acquired and innate immunity to polyaromatic hydrocarbonsToxicology and Applied Pharmacology.  224:308-312. 2007
    2007 17β-Estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhageMolecular Immunology.  44:3317-3323. 2007
    2006 CD4 T cell-induced, bid-dependent apoptosis of cutaneous dendritic cells regulates T cell expansion and immune responsesJournal of Immunology.  177:5956-5967. 2006
    2006 Fluorescence of sunscreens adsorbed to dielectric nanospheres: Parallels to optical behavior on HaCat cells and skinPhotochemistry and Photobiology.  82:1557-1565. 2006
    2004 A library-selected, langerhans cell-targeting peptide enhances an immune responseDNA (Mary Ann Liebert, Inc.).  23:742-752. 2004
    2004 Adenovirus-mediated gene delivery to dendritic cells.Methods in Molecular Biology.  246:139-154. 2004
    2003 Drug-inducible, dendritic cell-based genetic immunizationJournal of Immunology.  170:5483-5490. 2003
    2002 Long-term insulin independence following repeated islet transplantation in totally pancreatectomized diabetic pigsCell Transplantation.  11:55-66. 2002
    2001 Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cellsImmunogenetics.  53:455-467. 2001
    1998 Quantitative analysis of the immunopotency of genetically transfected dendritic cellsProceedings of the National Academy of Sciences.  95:13147-13152. 1998
    1996 Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulusTransplantation.  62:588-593. 1996
    1996 Ultrastructure, enzymatic, and transport properties of the PICM-19 bipotent liver cell lineExperimental Cell Research.  225:22-34. 1996
    1996 Differential secretion of TNF-α and IFN-γ by human peripheral blood-derived NK subsets and association with functional maturationJournal of Clinical Immunology.  16:46-54. 1996
    1996 Fulminant hepatic failure in rats: Survival and effect on blood chemistry and liver regenerationHepatology.  24:1452-1459. 1996
    1995 Automated liver cell processing facilitates large scale isolation and purification of porcine hepatocytesASAIO Journal.  41:155-161. 1995
    1995 Teleost fish islets: A potential source of endocrine tissue for the treatment of diabetesJournal of Surgical Research.  58:583-591. 1995
    1994 Automated large-scale production of porcine hepatocytes for bioartificial liver supportTransplantation Proceedings.  26:3505-3506. 1994
    1994 Qualitative and quantitative analysis of subpopulations of cytotoxic effector cells by flow cytometryJournal of lipid mediators and cell signalling.  9:19-25. 1994
    1993 Killer cell recruitment and renewal capacity of purified cytolytic and noncytolytic human peripheral blood natural killer cell subsetsJournal of Immunology.  150:320-329. 1993
    1993 Natural killer cell subsets: Maturation, differentiation and regulationNatural Immunity.  12:194-208. 1993
    1990 Purification and characterization of cytolytic and noncytolytic human natural killer cell subsetsProceedings of the National Academy of Sciences.  87:6063-6067. 1990
    1989 The in vivo depletion of Vβ17a+T cells results in the inhibition of reticulum cell sarcoma growth in SJL/J mice. Evidence for the use of anticlonotypic antibody therapy in the control of malignancyJournal of Immunology.  143:1387-1395. 1989
    1988 The SJL/J T cell response to both spontaneous and transplantable syngeneic reticulum cell sarcoma is mediated predominantly by the vβ17a+ T cell clonotypeJournal of Experimental Medicine.  168:1553-1562. 1988
    1987 Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. II. Normal antibody-dependent cellular cytotoxicity (ADCC) mediated by effector cells defective in natural killer (NK) cytotoxicityJournal of Immunology.  139:55-60. 1987
    1986 Analysis of lymphocyte-target conjugates by flow cytometry. I. Discrimination between killer and non-killer lymphocytes bound to targets and sorting of conjugates containing one or multiple lymphocytesNatural immunity and cell growth regulation.  5:221-237. 1986
    1985 The use of flow cytometry for the separation of T lymphocyte-target conjugates and analysis of cell mediated cytotoxicity (CMC)Federation proceedings.  44. 1985
    1984 Mechanism of cell-mediated cytotoxicity at the single cell level. VI. Direct assessment of the cytotoxic potential of human peripheral blood non-lytic effector-target cell conjugatesJournal of Immunology.  132:594-598. 1984
    1984 Role of soluble cytotoxic factors in antibody dependent cellular cytotoxicity (ADCC)Federation proceedings.  43. 1984

    Chapter

    Year Title Altmetric
    2012 Host defenses in the skin.  228-238. 2012

    Education And Training

  • Doctor of Philosophy in Immunology, University of California System : Los Angeles 1990
  • Full Name

  • Laura Timares