Positions

Overview

  • Dr. Etty (Tika) Benveniste was the Founding Chair of the Department of Cell, Developmental and Integrative Biology (2012-2017). Benveniste served as Chair of the Department of Cell Biology (2000-2011). Benveniste also holds the Alma B. Maxwell-University of Alabama Health Services Foundation (UAHSF), Endowed Chair in Biomedical Research. In January 2015, Benveniste was appointed interim Senior Associate Dean for Research Administration at the University of Alabama at Birmingham (UAB) School of Medicine (SOM), and since September 1, 2015 was appointed to the permanent position. Benveniste also holds professorships in the UAB Departments of Neurobiology and Neurology. She is a member of multiple NIH study sections and chaired three different NIH Study Sections. During her postdoctoral studies, in the Department of Neurology at the University of California Los Angeles (UCLA), Benveniste initiated research on elucidating the mechanisms by which cells of the immune system and the central nervous system communicate and influence functionality, cytokine/chemokine production by glial cells, the effects of cytokines/chemokines on glial cell function, and the ability of glial cells to function as immune effector cells in the brain. This research continues to date. These studies have implications for autoimmune/neurodegenerative diseases such as Multiple Sclerosis and Parkinson’s Disease, and cancers such as brain tumors. Dr. Benveniste is well funded with three R01s and a T32; (1) RO1 CA-158534-01 “Targeting the JAK2/STAT-3 Pathway Signaling Axis in Glioma”; (2) RO1 NS57563-05A1 “Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation”; (3) R01 CA194414-01A1 "The Role of CK2 in Glioblastoma Development"; and (4) T32 NS48039 “Training Program in Brain Tumor Biology”. In addition, she holds grant awards from the National Multiple Sclerosis Society and the Michael J. Fox Foundation. Benveniste’s cancer studies are focused on brain tumor biology. The Benveniste laboratory is devoted to the study of neuroinflammation and the JAK/STAT and NF-kB signaling cascades. Benveniste has served on the editorial boards of multiple journals including The Journal of Immunology, Journal of Neuroscience, and Journal of Biological Chemistry and is currently on the editorial boards of the Journal of Neuro-Virology, Journal of Neuroinflammation, and ASN News. She was elected in 2009 as a Fellow of the American Association for the Advancement of Science (AAAS). Benveniste is also section editor for the Journal of Interferon and Cytokine Research (JICR) 2014-Present. With 27 years of peer-review panel experience, Benveniste continues as reviewer for such panels as the Michael J. Fox Foundation (2015), National Multiple Sclerosis Society (2015), and NIH Neurological Science and Disorders Committee C (2015). Benveniste’s committee experience spans 29 years. Benveniste continues to innovate as Chair, UAB Master’s Degree in Biomedical and Health Sciences (2014-Present) and Cancer Biology Undergraduate Degree (2014-Present). Dr. Benveniste has served as the Director, Graduate Program in Cell Biology (1995-2000) and as Founding Associate Dean, Office of Postdoctoral Education (1999-2001). She became Associate Director, Basic Science Research, Comprehensive Cancer Center, in 2006. She is the former co-director of the Cancer Cell Biology Program in the UAB’s Comprehensive Cancer Center. She is currently Past-President of the American Society for Neurochemistry (2015-2017), having served as President from 2013-2015. Benveniste warmly received the UAB Graduate School Dean’s Award for Excellence in Mentorship (2014).
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1.Journal of Immunology.  201:383-392. 2018
    2018 Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases.Clinical Immunology.  189:4-13. 2018
    2018 Protein Kinase CK2: An Emerging Regulator of Immunity.Immunology Today.  39:82-85. 2018
    2018 MicroRNA-31 is required for astrocyte specification.Glia.  66:987-998. 2018
    2017 Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.Experimental Neurology.  300:179-187. 2017
    2017 Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.Journal of Immunology.  198:4244-4254. 2017
    2017 Speaking out about gender imbalance in invited speakers improves diversity.Nature Immunology.  18:475-478. 2017
    2017 Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.Oncotarget.  8:18031-18049. 2017
    2017 Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells.Journal of Neuro-Oncology.  132:219-229. 2017
    2016 Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury.Experimental Neurology.  284:98-105. 2016
    2016 Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.AJP - Lung Cellular and Molecular Physiology.  311:L868-L880. 2016
    2016 Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses.Journal of Biological Chemistry.  291:15830-15840. 2016
    2016 Correction: SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation.Journal of Immunology.  197:387-389. 2016
    2016 Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.Journal of Neuroscience.  36:5144-5159. 2016
    2016 Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma.Oncotarget.  7:20621-20635. 2016
    2015 Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype.Journal of Immunology.  195:841-852. 2015
    2015 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma.Oncotarget.  6:17805-17816. 2015
    2015 SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.Cancer Immunology Research.  3:727-740. 2015
    2015 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAEJournal of Neuroinflammation2015
    2015 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.Journal of Neuroinflammation.  12:128. 2015
    2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.Nature Immunology.  16:286-295. 2015
    2015 Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.Critical Reviews in Immunology.  35:505-527. 2015
    2014 NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.Expert Review of Neurotherapeutics.  14:1293-1306. 2014
    2014 PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.Molecular and Cellular Biology.  34:3911-3925. 2014
    2014 Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells.Oncotarget.  5:6484-6496. 2014
    2014 Involvement of the janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis.Journal of Interferon and Cytokine Research.  34:577-588. 2014
    2014 Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.Journal of Immunology.  192:59-72. 2014
    2013 Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.Clinical Cancer Research.  19:6484-6494. 2013
    2013 Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.Cell Growth and Differentiation.  11:494-505. 2013
    2013 AMP-activated protein kinase restricts IFN-γ signaling.Journal of Immunology.  190:372-380. 2013
    2013 NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.PLoS ONE.  8:e78728. 2013
    2012 SOCS3 deficiency promotes M1 macrophage polarization and inflammation.Journal of Immunology.  189:3439-3448. 2012
    2012 Regulation of CCL20 expression in astrocytes by IL-6 and IL-17.Glia.  60:771-781. 2012
    2012 Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.Proceedings of the National Academy of Sciences.  109:5004-5009. 2012
    2012 ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro.Methods in Molecular Biology.  814:235-249. 2012
    2012 Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.PLoS ONE.  7:e50874. 2012
    2011 Therapeutic potential of AZD1480 for the treatment of human glioblastoma.Molecular Cancer Therapeutics.  10:2384-2393. 2011
    2011 IRE1-dependent activation of AMPK in response to nitric oxide.Molecular and Cellular Biology.  31:4286-4297. 2011
    2011 A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway.Blood.  118:156-166. 2011
    2011 Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production.Journal of Immunology.  186:6313-6318. 2011
    2011 An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas.Journal of Neuro-Oncology.  102:367-381. 2011
    2011 Viral exploitation of host SOCS protein functions.Journal of Virology.  85:1912-1921. 2011
    2011 Loss of the promyelocytic leukemia protein in gastric cancer: implications for IP-10 expression and tumor-infiltrating lymphocytes.PLoS ONE.  6:e26264. 2011
    2010 The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.Molecular and Cellular Biology.  30:5582-5596. 2010
    2010 Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid.Journal of Immunology.  185:5915-5925. 2010
    2010 Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages.Journal of Immunology.  185:2393-2404. 2010
    2010 IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia.Glia.  58:1082-1093. 2010
    2010 IL-17 enhancement of the IL-6 signaling cascade in astrocytes.Journal of Immunology.  184:4898-4906. 2010
    2010 NF-kappaB and STAT3 signaling in glioma: targets for future therapies.Expert Review of Neurotherapeutics.  10:575-586. 2010
    2009 The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.Oncogene.  28:3735-3745. 2009
    2009 ROLE OF SOCS PROTEINS IN GLIAL CELL FUNCTIONJournal of Neurochemistry.  110:212-212. 2009
    2009 SOCS1 and SOCS3 in the control of CNS immunity.Immunology Today.  30:392-400. 2009
    2009 TGF-beta promotes Th17 cell development through inhibition of SOCS3.Journal of Immunology.  183:97-105. 2009
    2009 The Effect of Human Cytomegalovirus Proteins PUL97 and PUL27 on Host Interferon ResponsesAntiviral Research.  82:A47-A47. 2009
    2009 CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells.Biological and Pharmaceutical Bulletin.  32:573-577. 2009
    2009 Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1.Journal of Cellular Physiology.  218:94-103. 2009
    2008 TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells.Biochemical and Biophysical Research Communications.  377:195-199. 2008
    2008 Transcriptional activation of human matrix metalloproteinase-9 gene expression by multiple co-activators.Journal of Molecular Biology.  383:945-956. 2008
    2008 The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes.Molecular and Cellular Biology.  28:6632-6645. 2008
    2008 Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes.Journal of Immunology.  181:3167-3176. 2008
    2008 Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes.Glia.  56:1250-1262. 2008
    2008 Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells.Biochemical and Biophysical Research Communications.  372:870-874. 2008
    2008 Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression.Clinical Cancer Research.  14:4694-4704. 2008
    2008 The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins.European Journal of Immunology.  38:2325-2336. 2008
    2008 Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas.Cell Growth and Differentiation.  6:675-684. 2008
    2008 Expression and function of SOCS proteins in astrocytesJournal of Neurochemistry.  104:10-10. 2008
    2008 IFN-beta-mediated inhibition of IL-8 expression requires the ISGF3 components Stat1, Stat2, and IRF-9.Journal of Interferon and Cytokine Research.  28:13-23. 2008
    2007 Type I interferons as anti-inflammatory mediators.Science's STKE : signal transduction knowledge environment.  2007:pe70. 2007
    2007 The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-beta on matrix metalloproteinase-9 expression.European Journal of Biochemistry.  274:6456-6468. 2007
    2007 Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia.Journal of Immunology.  179:5966-5976. 2007
    2007 Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha.Journal of Leukocyte Biology.  82:436-447. 2007
    2006 The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling.Proceedings of the National Academy of Sciences.  103:18715-18720. 2006
    2006 IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3.Journal of Immunology.  177:7761-7771. 2006
    2006 Mechanism of IFN-beta-mediated inhibition of IL-8 gene expression in astroglioma cells.Journal of Immunology.  177:822-830. 2006
    2006 IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia.Federation proceedings.  20:985-987. 2006
    2006 IFN-β-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microgliaFederation proceedings.  20. 2006
    2006 Divergent effects of oncostatin M on astroglioma cells: influence on cell proliferation, invasion, and expression of matrix metalloproteinases.Glia.  53:191-200. 2006
    2006 Erratum: Promotion of invasion and metastatic potential by Bcl-2 (Cancer Research (July 1, 2005) 65 (5554-5560))Cancer Research.  66:1250. 2006
    2005 LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia.Blood.  106:3114-3122. 2005
    2005 Interferon-gamma-activated STAT-1alpha suppresses MMP-9 gene transcription by sequestration of the coactivators CBP/p300.Journal of Leukocyte Biology.  78:515-523. 2005
    2005 Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2.Cancer Research.  65:5554-5560. 2005
    2005 Amphotericin-B-mediated reactivation of latent HIV-1 infection.Virology.  331:106-116. 2005
    2005 17beta-estradiol activation of the c-Jun N-terminal kinase pathway leads to down-regulation of class II major histocompatibility complex expression.Molecular Endocrinology -Baltimore-.  19:113-124. 2005
    2004 Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene.Journal of Biological Chemistry.  279:46326-46334. 2004
    2004 Oncostatin M: a pleiotropic cytokine in the central nervous system.Cytokine and Growth Factor Reviews.  15:379-391. 2004
    2004 Class II major histocompatibility complex transactivator (CIITA) inhibits matrix metalloproteinase-9 gene expression.Journal of Biological Chemistry.  279:38577-38589. 2004
    2004 17beta-Estradiol inhibits class II major histocompatibility complex (MHC) expression: influence on histone modifications and cbp recruitment to the class II MHC promoter.Molecular Endocrinology -Baltimore-.  18:1963-1974. 2004
    2004 Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.Glia.  47:9-20. 2004
    2004 Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription.Molecular and Cellular Biology.  24:5496-5509. 2004
    2004 Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.Antimicrobial Agents and Chemotherapy.  48:1652-1663. 2004
    2004 Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death.Cellular and Molecular Life Sciences.  61:1075-1081. 2004
    2004 Caspase-1 mediates Fas-induced apoptosis and is up-regulated by interferon-gamma in human astrocytoma cells.Journal of Neuro-Oncology.  67:167-176. 2004
    2004 Erratum: TRADD interacts with STAT1-α and influences interferon-γ signaling (Nature Immunology (2004) vol. 5 (199-207))Nature Immunology.  5:344. 2004
    2004 Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.Journal of Immunology.  172:2668-2677. 2004
    2004 TRADD interacts with STAT1-alpha and influences interferon-gamma signaling.Nature Immunology.  5:199-207. 2004
    2004 Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses.Brain Res Brain Res Rev.  44:65-81. 2004
    2004 Molecular regulation of CD40 gene expression in macrophages and microglia.Brain, Behavior, and Immunity.  18:7-12. 2004
    2003 Induction of intercellular adhesion molecule-1 by Fas ligation: proinflammatory roles of Fas in human astroglioma cells.Neuroscience Letters.  352:21-24. 2003
    2003 STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex.Journal of Immunology.  171:5313-5319. 2003
    2003 Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells.Oncogene.  22:8117-8124. 2003
    2003 CD154-CD40-induced reactivation of latent HIV-1 infection.Virology.  314:261-270. 2003
    2003 Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase-2 in astrocytes: synergy with interleukin-1beta, tumor necrosis factor-alpha, and bacterial lipopolysaccharide.Glia.  42:433-446. 2003
    2003 Chloroquine induces activation of nuclear factor-kappaB and subsequent expression of pro-inflammatory cytokines by human astroglial cells.Journal of Neurochemistry.  84:1266-1274. 2003
    2002 Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases.Journal of NeuroVirology.  8:496-512. 2002
    2002 Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency.Journal of Virology.  76:8776-8786. 2002
    2002 Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages.Journal of Immunology.  169:2354-2360. 2002
    2002 Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.Journal of Neuroscience.  22:5334-5343. 2002
    2002 Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.Journal of Biological Chemistry.  277:13796-13803. 2002
    2002 Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells.Molecular and Cellular Biology.  22:724-736. 2002
    2002 Fas engagement increases expression of interleukin-6 in human glioma cells.Journal of Neuro-Oncology.  56:13-19. 2002
    2002 Neurotoxic activity of the HIV-1 envelope glycoprotein: Activation ofprotein kinase C in rat astrocytesInternational Journal of Molecular Sciences.  3:1105-1116. 2002
    2001 TGF-beta1 up-regulates paxillin protein expression in malignant astrocytoma cells: requirement for a fibronectin substrate.Oncogene.  20:7976-7986. 2001
    2001 Immune function of astrocytes.Glia.  36:180-190. 2001
    2001 Immunological aspects of microglia: relevance to Alzheimer's disease.Neurochemistry International.  39:381-391. 2001
    2001 Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha.Journal of Immunology.  167:5150-5159. 2001
    2001 The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression.Journal of Immunology.  167:311-319. 2001
    2001 Fas-induced expression of chemokines in human glioma cells: involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase.Cancer Research.  61:3084-3091. 2001
    2001 Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules.Journal of Neuropathology and Experimental Neurology.  60:320-327. 2001
    2001 CXC chemokine receptor 4 expression and function in human astroglioma cells.Journal of Immunology.  166:2695-2704. 2001
    2001 IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein.Journal of Immunology.  166:2260-2269. 2001
    2001 Magnetic coupling between water and creatine protons in human brain and skeletal muscle, as measured using inversion transfer (1)H-MRS.NMR in Biomedicine.  14:1-4. 2001
    2001 Cloning of rat calcium-modulating cyclophilin ligand.DNA Sequence.  12:209-213. 2001
    2000 IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia.Journal of Immunology.  165:6235-6243. 2000
    2000 Transcriptional regulation of the human osteopontin promoter: functional analysis and DNA-protein interactions.Oncogene.  19:5801-5809. 2000
    2000 ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways.Journal of Immunology.  165:4658-4666. 2000
    2000 Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes.Journal of Virology.  74:9214-9221. 2000
    2000 gp120-induced alterations of human astrocyte function: Na(+)/H(+) exchange, K(+) conductance, and glutamate flux.American Journal of Physiology - Cell Physiology.  279:C700-C708. 2000
    2000 Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages.Journal of Biological Chemistry.  275:23674-23684. 2000
    2000 Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38.Journal of Neurochemistry.  75:563-575. 2000
    2000 Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins alphavbeta5 and alpha8beta1: modulation by the type 1 plasminogen activator inhibitor.Neuroscience Letters.  283:157-161. 2000
    2000 Differential regulation and function of Fas expression on glial cells.Journal of Immunology.  164:1277-1285. 2000
    1999 Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes.Journal of NeuroVirology.  5:678-684. 1999
    1999 Interleukin-6 expression and regulation in astrocytes.Journal of Neuroimmunology.  100:124-139. 1999
    1999 The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells.Journal of Biological Chemistry.  274:29130-29137. 1999
    1999 Regulation of MHC class II expression in the central nervous system.Microbes and Infection.  1:893-902. 1999
    1999 Adhesion molecule expression and regulation on cells of the central nervous system.Journal of Neuroimmunology.  98:77-88. 1999
    1999 Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor.Journal of Neuroscience.  19:5236-5244. 1999
    1999 IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes.Journal of Immunology.  162:4731-4739. 1999
    1999 Cytokine regulation of CC and CXC chemokine expression by human astrocytes.Journal of NeuroVirology.  5:82-94. 1999
    1999 IL-1 beta inhibits IFN-gamma-induced class II MHC expression by suppressing transcription of the class II transactivator gene.Journal of Immunology.  162:886-896. 1999
    1999 Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10.European Journal of Immunology.  29:1275-1285. 1999
    1998 Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-alpha and IFN-gamma.Journal of Immunology.  161:6664-6673. 1998
    1998 Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-kappaB and C/EBP isoforms.Journal of Neuroimmunology.  92:196-207. 1998
    1998 Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression.Journal of Immunology.  161:4992-4999. 1998
    1998 Cytokine actions in the central nervous system.Cytokine and Growth Factor Reviews.  9:259-275. 1998
    1998 Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta.European Journal of Immunology.  28:2537-2548. 1998
    1998 Kinase inhibitors abrogate IFN-gamma-induced class II transactivator and class II MHC gene expression in astroglioma cell lines.Journal of Neuroimmunology.  85:174-185. 1998
    1998 IL-1β mediated inhibition of IFN-γ induced class II MHC expression occurs by suppression of the class II transactivatorFederation proceedings.  12. 1998
    1998 Cleavage of membrane-associated ICAM-1 from astrocytes: involvement of a metalloprotease.Glia.  22:103-112. 1998
    1998 Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes.Glia.  22:171-179. 1998
    1997 Elevation of cyclic AMP levels in astrocytes antagonizes cytokine-induced adhesion molecule expression.Journal of Neurochemistry.  69:1438-1448. 1997
    1997 Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis.The Clinical investigator.  75:165-173. 1997
    1997 TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.Journal of Immunology.  158:2065-2075. 1997
    1997 Cytokines: influence on glial cell gene expression and function.Progress in allergy.  69:31-75. 1997
    1996 Induction of RANTES expression by astrocytes and astrocytoma cell lines.Journal of Neuroimmunology.  71:207-214. 1996
    1996 TGF-β mediated inhibition of class ii mhc expression occurs at the level of ciitaFederation proceedings.  10. 1996
    1996 Cell surface expression of tumor necrosis factor-alpha by activated rat astrocytesBMB Reports.  29:530-534. 1996
    1996 A 3' cis-acting element is involved in tumor necrosis factor-alpha gene expression in astrocytes.Journal of Biological Chemistry.  271:22383-22390. 1996
    1996 The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.Journal of Immunology.  157:1819-1822. 1996
    1996 Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.Journal of Immunology.  157:1559-1568. 1996
    1996 Cytokines in inflammatory brain lesions: helpful and harmful.Trends in Neurosciences.  19:331-338. 1996
    1996 Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta.Journal of Immunology.  157:892-900. 1996
    1996 HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells. Involvement of Janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways.Journal of Immunology.  156:1307-1314. 1996
    1996 Astrocytes and the AIDS dementia complex.Journal of Neuroaids.  1:111-131. 1996
    1996 Regulation of class II MHC expression.Critical Reviews in Immunology.  16:311-330. 1996
    1995 Second messenger systems in the regulation of cytokines and adhesion molecules in the central nervous system.Brain, Behavior, and Immunity.  9:304-314. 1995
    1995 TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.Federation proceedings.  9:1577-1584. 1995
    1995 Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6.Journal of Immunology.  155:1489-1501. 1995
    1995 Interleukin 1-beta- and tumor necrosis factor-alpha-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity.Glia.  14:267-278. 1995
    1995 Circulating adhesion molecules and inflammatory mediators in demyelination: a review.Neurology.  45:S22-S32. 1995
    1995 Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species.Neurology.  45:S16-S21. 1995
    1995 Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10.International Journal of Developmental Neuroscience.  13:341-349. 1995
    1995 HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes.American Journal of Physiology.  268:C1440-C1449. 1995
    1995 Inhibitory cytokines and cytokine inhibitors.Neurology.  45:S39-S43. 1995
    1995 Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta.Journal of Immunology.  154:2846-2854. 1995
    1995 Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.Journal of Immunology.  154:1888-1899. 1995
    1995 TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression.Journal of Immunology.  154:610-619. 1995
    1995 Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway.Advances in neuroimmunology.  5:261-269. 1995
    1995 Role of protein kinase C and tyrosine kinase activity in IFN-gamma-induced expression of the class II MHC gene.American Journal of Physiology.  268:C127-C137. 1995
    1994 Differential modulation of astrocyte cytokine gene expression by TGF-beta.Journal of Immunology.  153:5210-5221. 1994
    1994 Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-alpha-mediated class II MHC gene expression.Journal of Immunology.  153:4555-4564. 1994
    1994 Cytokines and HIV envelope glycoprotein gp120 stimulate Na+/H+ exchange in astrocytes.Journal of Biological Chemistry.  269:13811-13816. 1994
    1994 Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes.Journal of Neuroimmunology.  51:209-220. 1994
    1994 Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.Proceedings of the National Academy of Sciences.  91:494-498. 1994
    1994 Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha.Journal of Immunology.  152:841-850. 1994
    1994 Cytokine circuits in brain. Implications for AIDS dementia complex.Research publications - Association for Research in Nervous and Mental Disease.  72:71-88. 1994
    1994 gp120-mediated alterations in astrocyte ion transport.Advances in neuroimmunology.  4:175-179. 1994
    1993 Identification and characterization of a high-affinity granulocyte-macrophage colony-stimulating factor receptor on primary rat oligodendrocytes.Blood.  82:3279-3282. 1993
    1993 Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes.Gene.  132:227-236. 1993
    1993 Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine.Journal of Neuroimmunology.  45:137-145. 1993
    1993 Interleukin-1 and tumor necrosis factor-mediated regulation of C3 gene expression in human astroglioma cells.Glia.  7:225-236. 1993
    1992 Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.Journal of Immunology.  149:3894-3902. 1992
    1992 Tumor necrosis factor alpha response elements in the HLA-DRA promoter: identification of a tumor necrosis factor alpha-induced DNA-protein complex in astrocytes.Proceedings of the National Academy of Sciences.  89:11518-11522. 1992
    1992 Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa B-like nuclear protein.Journal of Neuroimmunology.  39:231-242. 1992
    1992 Interleukin-1 beta induction of TNF-alpha gene expression: involvement of protein kinase C.Journal of Cellular Physiology.  152:264-273. 1992
    1992 Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action.American Journal of Physiology.  263:C1-16. 1992
    1992 Interferon-gamma regulation of C3 gene expression in human astroglioma cells.Journal of Neuroimmunology.  38:275-282. 1992
    1992 Usage of primary cells to delineate IFN-gamma-responsive DNA elements in the HLA-DRA promoter and to identify a novel IFN-gamma-enhanced nuclear factor.Journal of Immunology.  148:3643-3651. 1992
    1992 Interleukin-1 beta induction of tumor necrosis factor-alpha gene expression in human astroglioma cells.Journal of Neuroimmunology.  36:179-191. 1992
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    1992 Enhancement of epidermal growth factor receptor expression on glioma cells by recombinant tumor necrosis factor alpha.Cancer Immunology, Immunotherapy.  34:370-376. 1992
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    1991 Changes induced in astrocyte cathepsin D by cytokines and leupeptin.Journal of Neurochemistry.  57:406-414. 1991
    1991 Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.Journal of Experimental Medicine.  173:801-811. 1991
    1990 Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-gamma and tumor necrosis factor-alpha.Journal of Neuroimmunology.  30:189-200. 1990
    1990 Induction and regulation of interleukin-6 gene expression in rat astrocytes.Journal of Neuroimmunology.  30:201-212. 1990
    1990 Tumor necrosis factor production and receptor expression by a human malignant glioma cell line, D54-MG.Journal of Neuroimmunology.  30:1-13. 1990
    1990 Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.Journal of Immunology.  144:2999-3007. 1990
    1989 Tumor necrosis factor-alpha enhances interferon-gamma-mediated class II antigen expression on astrocytes.Journal of Neuroimmunology.  25:209-219. 1989
    1989 Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytesInternational Immunology.  1:555. 1989
    1989 Monoclonal idiotypic and anti-idiotypic antibodies produced by immunization with peptides specified by a region of human myelin basic protein mRNA and its complement.Journal of Neuroimmunology.  22:157-166. 1989
    1989 Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytes.International Immunology.  1:219-228. 1989
    1989 Use of peptides encoded by complementary RNA for generating anti-idiotypic antibodies of predefined specificity.Methods in Enzymology.  178:63-74. 1989
    1988 Response of human glioblastoma cells to recombinant interleukin-2.Journal of Neuroimmunology.  17:301-314. 1988
    1988 Lymphokines and monokines in the neuroendocrine system.Progress in allergy.  43:84-120. 1988
    1988 Rat astrocyte proliferation by human B-cell growth factors.Annals of the New York Academy of Sciences.  540:392-395. 1988
    1987 Myelin basic protein-specific RNA levels in interleukin-2-stimulated oligodendrocytes.Journal of Neurochemistry.  49:1274-1279. 1987
    1987 Remyelination by oligodendrocytes stimulated by antiserum to spinal cord.Journal of Neuropathology and Experimental Neurology.  46:84-95. 1987
    1986 Stimulation of oligodendroglial proliferation and maturation by interleukin-2.Nature.  321:610-613. 1986
    1985 Purification and characterization of a human T-lymphocyte-derived glial growth-promoting factor.Proceedings of the National Academy of Sciences.  82:3930-3934. 1985
    1984 B-cell abnormalities in AIDS.New England Journal of Medicine.  310:258-259. 1984
    1983 Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome.Journal of Clinical Immunology.  3:359-367. 1983
    1983 The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders.Cellular Immunology.  80:105-114. 1983
    1983 T suppressor cells are required for the maintenance of the antigen-induced B-cell unresponsive state in humans.Journal of Clinical Immunology.  3:166-172. 1983
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    Chapter

    Year Title Altmetric
    2015 Protein kinase CK2 and dysregulated oncogenic inflammatory signaling pathways.  259-280. 2015
    2014 Inflammation and the pathophysiology of astrocytes in neurodegenerative diseases.  61-80. 2014
    2014 Cytokines.  921-925. 2014
    2013 Cytokine and Chemokine Receptors and Signaling 2013
    2001 Cerebrospinal fluid.  347-375. 2001

    Research Overview

  • Dr. Benveniste's research is directed toward understanding how the immune system and central nervous system (CNS) communicate with each other. Specifically, her laboratory is studying the function of shared cytokines/chemokines between cells of the immune and nervous systems. Astrocytes and microglia, the major glial cells of the CNS, have been shown to act as antigen-presenting cells in the CNS. Dr. Benveniste’s group is examining the mechanisms by which cytokines modulate class II major histocompatibility complex (MHC) and CD40 proteins on these cells, with a particular emphasis on delineating the transcriptional machinery that drives expression of these genes. The ability of astrocytes and microglia to secrete several immunoregulatory molecules (tumor necrosis factor, interleukin-6, macrophage chemotactic protein-1, interleukin-8) is also being studied, with an emphasis on the biological stimuli that induce these cytokines/chemokines, intracellular signaling events involved in the response, and the molecular mechanisms of gene regulation. These projects will provide a better understanding of how bidirectional communication occurs between the immune and nervous systems, and how these interactions affect the functionality of glial cells. These studies are also relevant to understanding the pathogenesis of several neurologic diseases such as multiple sclerosis, an autoimmune disease of the CNS, and HIV-1 associated dementia (HAD). Dr. Benveniste has also initiated studies to examine the role of MMPs and IL-8 in astroglioma migration and invasion, and how interferons inhibit these responses at the transcriptional level. In this line of research, her laboratory is examining how interferons inhibit MMP-9 and IL-8 gene expression by utilizing chromatin immunoprecipitation (ChIP) assays to examine the MMP-9 and IL-8 promoters in vivo. Recent studies in the laboratory are focused on the aberrant activation of two signal transduction pathways in astrogliomas; the JAK-STAT pathway and the NF-kB pathway. It is thought that the dysregulation of these signal transduction pathways contributes to the invasiveness of brain tumors, as well as angiogenic properties. As such, the group is exploring the therapeutic potential of inhibitors of the JAK-STAT and NF-kB pathways to treat brain tumor patients.
  • Principal Investigator On

  • Innate and Adaptive Immunity in Parkinson Disease - Project 2: Validating the JAK/STAT Pathway as a Novel Therapeutic Strategy in PD  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • HSF-GEF Research Acceleration Award - Benveniste  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2022
  • The Role of CK2 in Glioblastoma Development  awarded by National Cancer Institute/NIH/DHHS 2015 - 2020
  • Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2019
  • Training Program in Brain Tumor Biology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2019
  • Innate and Adaptive Immunity in Parkinson Disease - Project 2  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2017 - 2018
  • Targeting the JAK/STAT-3 Pathway Signaling Axis in Glioma  awarded by National Cancer Institute/NIH/DHHS 2012 - 2018
  • The Role of the JAK/STAT Pathway in Human Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2018
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2016
  • Collaborative MS Research Center Award  awarded by National Multiple Sclerosis Society 2009 - 2015
  • LKB1 and AMPK Signaling in Neuroinflammation  awarded by National Multiple Sclerosis Society 2012 - 2014
  • Determining the Molecular Mechanisms of Crosstalk Between the NF-kB and JAK/STAT-3 Signaling Pathways in Glioblastoma  awarded by American Brain Tumor Association 2012 - 2014
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2012 - 2014
  • Defining the Role of NF-kB in Promoting STAT3 Activation in Malignant Gliomas  awarded by SOUTHEASTERN BRAIN TUMOR FOUNDATION 2011 - 2013
  • Therapeutic Intervention of the JAK/STAT Pathway for Treatment of Neuroinflammation  awarded by National Multiple Sclerosis Society 2013
  • Training Program in Brain Tumor Biology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2013
  • Expression and Function of SOCS Proteins in Glial Cells - ARRA  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2012
  • TRADD as a Regulator of Cytokine Signaling in Glia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011
  • Mechanisms Regulating Functional Beta-Cell Recovery  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2009 - 2011
  • The Role of HIV Tat-Induced SOCS3 in HIV Associated Dementia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2009 - 2011
  • Expression and Function of SOCS Proteins in Glia  awarded by National Multiple Sclerosis Society 2006 - 2010
  • Investigator On

  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Comprehensive Cancer Center Core Support Grant - Adiministrative Core  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Sculpting Anti-tumor Immunity as an Approach to Treat Metastatic Breast Cancer  awarded by DOD - Department of Defense 2018 - 2021
  • Function of Protein Kinase CK2 in CD4+ T Cells and Autoimmune Disease  awarded by National Multiple Sclerosis Society 2017 - 2020
  • Ferritin Mediates Epithelial Cell-Macrophage Cross Talk in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Breast Tumor Tissue-Derived Hedgehog Morphogens Immunoedit the Polarization of Breast Cancer Associated Macrophages  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2014 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Microenvironmental Regulation of Glioblastoma Angiogenesis via CHD7  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Comprehensive Cancer Center Core Support Grant - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Active - Senior Leadership - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by MALLINCKRODT, INC. 2015
  • Negative Impact of RNA Destabilizer Tristetraprolin on Glioma Growth  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • PKC/MARCKS Pathway as a Target for Radiation Sensitization  awarded by American Society for Therapeutic Radiology and Oncology 2008 - 2013
  • Interrogation of Key Genomic Alterations in Glioblastoma Multiforme (GBM) for Identification of Molecular Pathways Critical to GBM Tumorigenesis and Progression  awarded by SOUTHERN RESEARCH INSTITUTE 2010 - 2012
  • Education And Training

  • Bachelor of Science or Mathematics in Biology, California State University System : Chico
  • Doctor of Philosophy in Immunology, University of California System : Los Angeles
  • Full Name

  • Tika Benveniste
  • Blazerid

  • tika