Positions

Overview

  • Dr. Etty (Tika) Benveniste was the Founding Chair of the Department of Cell, Developmental and Integrative Biology (2012-2017). Benveniste served as Chair of the Department of Cell Biology (2000-2011). Benveniste also holds the Alma B. Maxwell-University of Alabama Health Services Foundation (UAHSF), Endowed Chair in Biomedical Research. In January 2015, Benveniste was appointed interim Senior Associate Dean for Research Administration at the University of Alabama at Birmingham (UAB) School of Medicine (SOM), and since September 1, 2015 was appointed to the permanent position. Benveniste also holds professorships in the UAB Departments of Neurobiology and Neurology. She is a member of multiple NIH study sections and chaired three different NIH Study Sections.

    During her postdoctoral studies, in the Department of Neurology at the University of California Los Angeles (UCLA), Benveniste initiated research on elucidating the mechanisms by which cells of the immune system and the central nervous system communicate and influence functionality, cytokine/chemokine production by glial cells, the effects of cytokines/chemokines on glial cell function, and the ability of glial cells to function as immune effector cells in the brain. This research continues to date. These studies have implications for autoimmune/neurodegenerative diseases such as Multiple Sclerosis and Parkinson’s Disease, and cancers such as brain tumors.

    Dr. Benveniste is well funded with three R01s and a T32; (1) RO1 CA-158534-01 “Targeting the JAK2/STAT-3 Pathway Signaling Axis in Glioma”; (2) RO1 NS57563-05A1 “Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation”; (3) R01 CA194414-01A1 "The Role of CK2 in Glioblastoma Development"; and (4) T32 NS48039 “Training Program in Brain Tumor Biology”. In addition, she holds grant awards from the National Multiple Sclerosis Society and the Michael J. Fox Foundation. Benveniste’s cancer studies are focused on brain tumor biology. The Benveniste laboratory is devoted to the study of neuroinflammation and the JAK/STAT and NF-kB signaling cascades.

    Benveniste has served on the editorial boards of multiple journals including The Journal of Immunology, Journal of Neuroscience, and Journal of Biological Chemistry and is currently on the editorial boards of the Journal of Neuro-Virology, Journal of Neuroinflammation, and ASN News. She was elected in 2009 as a Fellow of the American Association for the Advancement of Science (AAAS). Benveniste is also section editor for the Journal of Interferon and Cytokine Research (JICR) 2014-Present. With 27 years of peer-review panel experience, Benveniste continues as reviewer for such panels as the Michael J. Fox Foundation (2015), National Multiple Sclerosis Society (2015), and NIH Neurological Science and Disorders Committee C (2015). Benveniste’s committee experience spans 29 years. Benveniste continues to innovate as Chair, UAB Master’s Degree in Biomedical and Health Sciences (2014-Present) and Cancer Biology Undergraduate Degree (2014-Present).

    Dr. Benveniste has served as the Director, Graduate Program in Cell Biology (1995-2000) and as Founding Associate Dean, Office of Postdoctoral Education (1999-2001). She became Associate Director, Basic Science Research, Comprehensive Cancer Center, in 2006. She is the former co-director of the Cancer Cell Biology Program in the UAB’s Comprehensive Cancer Center. She is currently Past-President of the American Society for Neurochemistry (2015-2017), having served as President from 2013-2015. Benveniste warmly received the UAB Graduate School Dean’s Award for Excellence in Mentorship (2014).

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Tissue-Resident Macrophages Promote Renal Cystic Disease 2019
    2019 Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production 2019
    2018 Gender Inequities in the Multiple Sclerosis Community: A Call for Action 2018
    2018 CK2 controls Th17 and regulatory T cell differentiation through inhibition of FoxO1 2018
    2018 MicroRNA-31 is required for astrocyte specification 2018
    2018 Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases 2018
    2018 Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease 2018
    2018 Protein Kinase CK2: An Emerging Regulator of Immunity 2018
    2017 Protein kinase CK2 controls the fate between Th17 cell and regulatory T cell differentiation 2017
    2017 Speaking out about gender imbalance in invited speakers improves diversity 2017
    2017 Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells 2017
    2017 Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo 2017
    2016 Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury 2016
    2016 Attenuation of PKR-like ER Kinase (PERK) signaling selectively controls endoplasmic reticulum stress-induced inflammation without compromising immunological responses 2016
    2016 Erratum: SOCS3 deficiency promotes M1 macrophage polarization and inflammation (Journal of Immunology (2012) 189 (3439-3448)) 2016
    2016 Inhibition of the JAK/STAT pathway protects against α-synuclein-induced neuroinflammation and dopaminergic neurodegeneration 2016
    2016 Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma 2016
    2016 Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury 2016
    2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cells 2015
    2015 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE 2015
    2015 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE 2015
    2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iT reg cell balance 2015
    2015 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma 2015
    2015 Opportunities for translation from the bench: Therapeutic intervention of the JAK/STAT pathway in neuroinflammatory diseases 2015
    2015 Preferential recruitment of neutrophils into the cerebellum and brainstem contributes to the atypical experimental autoimmune encephalomyelitis phenotype 2015
    2014 Involvement of the Janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis 2014
    2014 NF-κB and STAT3 in glioblastoma: Therapeutic targets coming of age 2014
    2014 Perk-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation 2014
    2014 Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breas cancer cells 2014
    2014 Therapeutic efficacy of suppressing the JAK/STAT pathway in multiple models of experimental autoimmune encephalomyelitis 2014
    2013 Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma 2013
    2013 NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma 2013
    2013 Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells 2013
    2013 AMP-activated protein kinase restricts IFN-γ signaling 2013
    2012 Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3 2012
    2012 SOCS3 deficiency promotes M1 macrophage polarization and inflammation 2012
    2012 Regulation of CCL20 expression in astrocytes by IL-6 and IL-17 2012
    2012 Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation 2012
    2012 ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro 2012
    2011 Therapeutic potential of AZD1480 for the treatment of human glioblastoma 2011
    2011 IRE1-dependent activation of AMPK in response to nitric oxide 2011
    2011 Loss of the promyelocytic leukemia protein in gastric cancer: Implications for IP-10 expression and tumor-infiltrating lymphocytes 2011
    2011 ACK2-dependent mechanism for activation of the JAK-STAT signaling pathway 2011
    2011 Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production 2011
    2011 An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas 2011
    2011 Viral exploitation of host SOCS protein functions 2011
    2010 The adaptor protein TRIP6 antagonizes fas-induced apoptosis but promotes its effect on cell migration 2010
    2010 Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid 2010
    2010 Suppressor of cytokine signaling 3 inhibits antiviral IFN-β signaling to enhance HIV-1 replication in macrophages 2010
    2010 IL-27 inhibits OSM-mediated TNF-α and iNOS gene expression in microglia 2010
    2010 IL-17 enhancement of the IL-6 signaling cascade in astrocytes 2010
    2010 NF-κB and STAT3 signaling in glioma: Targets for future therapies 2010
    2009 The prolyl isomerase Pin1 regulates the NF-B signaling pathway and interleukin-8 expression in glioblastoma 2009
    2009 ROLE OF SOCS PROTEINS IN GLIAL CELL FUNCTION 2009
    2009 SOCS1 and SOCS3 in the control of CNS immunity 2009
    2009 TGF-β promotes Th17 cell development through inhibition of SOCS3 2009
    2009 The Effect of Human Cytomegalovirus Proteins PUL97 and PUL27 on Host Interferon Responses 2009
    2009 CXCL12-Mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells 2009
    2009 Thrombospondin-1-Induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1 2009
    2008 TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells 2008
    2008 Transcriptional Activation of Human Matrix Metalloproteinase-9 Gene Expression by Multiple Co-activators 2008
    2008 The ING4 tumor suppressor attenuates NF-κB activity at the promoters of target genes 2008
    2008 Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes 2008
    2008 Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes 2008
    2008 Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells 2008
    2008 Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: Implications for STAT-3 activation and gene expression 2008
    2008 The IFN-γ-induced transcriptional program of the CIITA gene is inhibited by statins 2008
    2008 Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas 2008
    2008 Expression and function of SOCS proteins in astrocytes 2008
    2008 IFN-β-mediated inhibition of IL-8 expression requires the ISGF3 components Stat1, Stat2, and IRF-9 2008
    2007 The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-β on matrix metalloproteinase-9 expression 2007
    2007 Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia 2007
    2007 Simvastatin inhibits IFN-γ-induced CD40 gene expression by suppressing STAT-1α 2007
    2007 Type I interferons as anti-inflammatory mediators. 2007
    2006 The promyelocytic leukemia protein functions as a negative regulator of IFN-γ signaling 2006
    2006 IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3 2006
    2006 Mechanism of IFN-β-mediated inhibition of IL-8 gene expression in astroglioma cells 2006
    2006 IFN-β-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia 2006
    2006 Divergent effects of oncostatin M on astroglioma cells: Influence on cell proliferation, invasion, and expression of matrix metalloproteinases 2006
    2006 Erratum: Promotion of invasion and metastatic potential by Bcl-2 (Cancer Research (July 1, 2005) 65 (5554-5560)) 2006
    2006 IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia. 2006
    2005 LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia 2005
    2005 Interferon-γ-activated STAT-1α suppresses MMP-9 gene transcription by sequestration of the coactivators CBP/p300 2005
    2005 Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2 2005
    2005 Amphotericin-B-mediated reactivation of latent HIV-1 infection 2005
    2005 17β-Estradiol activation of the c-Jun N-terminal kinase pathway leads to down-regulation of class II major histocompatibility complex expression 2005
    2004 Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene 2004
    2004 Oncostatin M: A pleiotropic cytokine in the central nervous system 2004
    2004 Class II major histocompatibility complex transactivator (CIITA) inhibits matrix metalloproteinase-9 gene expression 2004
    2004 17β-estradiol inhibits class ii major histocompatibility complex (MHC) expression: Influence on histone modifications and CBP recruitment to the class II MHC promoter 2004
    2004 Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells 2004
    2004 Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription 2004
    2004 Bis-Anthracycline Antibiotics Inhibit Human Immunodeficiency Virus Type 1 Transcription 2004
    2004 Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death 2004
    2004 Caspase-1 mediates Fas-induced apoptosis and is up-regulated by interferon-γ in human astrocytoma cells 2004
    2004 Erratum: TRADD interacts with STAT1-α and influences interferon-γ signaling (Nature Immunology (2004) vol. 5 (199-207)) 2004
    2004 Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1β-Induced IL-6 Expression 2004
    2004 TRADD interacts with STAT1-α and influences interferon-γ signaling 2004
    2004 Fas ligand/Fas system in the brain: Regulator of immune and apoptotic responses 2004
    2004 Molecular regulation of CD40 gene expression in macrophages and microglia 2004
    2003 Induction of intercellular adhesion molecule-1 by Fas ligation: Proinflammatory roles of Fas in human astroglioma cells 2003
    2003 STAT-1α and IFN-γ as Modulators of TNF-α Signaling in Macrophages: Regulation and Functional Implications of the TNF Receptor 1:STAT-1α Complex 2003
    2003 Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells 2003
    2003 CD154-CD40-induced reactivation of latent HIV-1 infection 2003
    2003 Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase-2 in astrocytes: Synergy with interleukin-1β, tumor necrosis factor-α, and bacterial lipopolysaccharide 2003
    2003 Chloroquine induces activation of nuclear factor-κB and subsequent expression of pro-inflammatory cytokines by human astroglial cells 2003
    2002 Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases 2002
    2002 Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages 2002
    2002 Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency 2002
    2002 Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia 2002
    2002 Critical role of tumor necrosis factor-α and NF-κB in interferon-γ-induced CD40 expression in microglia/macrophages 2002
    2002 Fas engagement increases expression of interleukin-6 in human glioma cells 2002
    2002 Neurotoxic activity of the HIV-1 envelope glycoprotein: Activation ofprotein kinase C in rat astrocytes 2002
    2002 Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells 2002
    2001 Cloning of rat calcium-modulating cyclophilin ligand 2001
    2001 TGF-β1 up-regulates paxillin protein expression in malignant astrocytoma cells: Requirement for a fibronectin substrate 2001
    2001 Immune function of astrocytes 2001
    2001 Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-γ and IFN-β: Critical role of STAT-1α 2001
    2001 The Smad3 protein is involved in TGF-β inhibition of class II transactivator and class II MHC expression 2001
    2001 Magnetic coupling between water and creatine protons in human brain and skeletal muscle, as measured using inversion transfer 1H-MRS 2001
    2001 Fas-induced expression of chemokines in human glioma cells: Involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase 2001
    2001 CXC chemokine receptor 4 expression and function in human astroglioma cells 2001
    2001 IFN-γ regulation of class II transactivator promoter IV in macrophages and microglia: Involvement of the suppressors of cytokine signaling-1 protein 2001
    2001 Immunological aspects of microglia: Relevance to Alzheimer's disease 2001
    2001 Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules 2001
    2000 IL-4-activated STAT-6 inhibits IFN-γ-induced CD40 gene expression in macrophages/microglia 2000
    2000 Transcriptional regulation of the human osteopontin promoter: Functional analysis and DNA-protein interactions 2000
    2000 ICAM-1-induced expression of proinflammatory cytokines in astrocytes: Involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways 2000
    2000 gp120-Induced alterations of human astrocyte function: Na+/H+ exchange, K+ conductance, and glutamate flux 2000
    2000 Oncostatin M regulation of interleukin-6 expression in astrocytes: Biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38 2000
    2000 Involvement of STAT-1 and Ets family members interferon-γ induction of CD40 transcription in microglia/macrophages 2000
    2000 Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins αvβ5 and α8β1: Modulation by the type 1 plasminogen activator inhibitor 2000
    2000 Differential regulation and function of Fas expression on glial cells 2000
    2000 Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 Tat in astrocytes 2000
    1999 The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells 1999
    1999 Adhesion molecule expression and regulation on cells of the central nervous system 1999
    1999 Interleukin-6 (IL-6) production by astrocytes: Autocrine regulation by IL-6 and the soluble IL-6 receptor 1999
    1999 IFN-γ regulation of the type IV class II transactivator promoter in astrocytes 1999
    1999 IL-1β inhibits IFN-γ-induced class II MHC expression by suppressing transcription of the class II transactivator gene 1999
    1999 Class II transactivator and class II MHC gene expression in microglia: Modulation by the cytokines TGF-β, IL-4, IL-13 and IL-10 1999
    1999 Cytokine regulation of CC and CXC chemokine expression by human astrocytes 1999
    1999 Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes 1999
    1999 Interleukin-6 expression and regulation in astrocytes 1999
    1999 Regulation of MHC class II expression in the central nervous system 1999
    1998 Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-α and IFN-γ1 1998
    1998 Cytokine actions in the central nervous system 1998
    1998 Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-κB and C/EBP isoforms 1998
    1998 Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression 1998
    1998 Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β 1998
    1998 Kinase inhibitors abrogate IFN-γ-induced class II transactivator and class II MHC gene expression in astroglioma cell lines 1998
    1998 IL-1β mediated inhibition of IFN-γ induced class II MHC expression occurs by suppression of the class II transactivator 1998
    1998 Cleavage of membrane-associated ICAM-1 from astrocytes: Involvement of a metalloprotease 1998
    1998 Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes 1998
    1997 Cytokines: Influence on glial cell gene expression and function 1997
    1997 Elevation of cyclic AMP levels in astrocytes antagonizes cytokine- induced adhesion molecule expression 1997
    1997 Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis 1997
    1997 TGF-β Suppresses IFN-γ Induction of Class II MHC Gene Expression by Inhibiting Class II Transactivator Messenger RNA Expression 1997
    1996 Induction of RANTES expression by astrocytes and astrocytoma cell lines 1996
    1996 TGF-β mediated inhibition of class ii mhc expression occurs at the level of ciita 1996
    1996 Cell surface expression of tumor necrosis factor-alpha by activated rat astrocytes 1996
    1996 Regulation of class II MHC expression 1996
    1996 A 3' cis-acting element is involved in tumor necrosis factor-α gene expression in astrocytes 1996
    1996 The Central Nervous System as an Immunocompetent Organ: Role of Glial Cells in Antigen Presentation 1996
    1996 Stat1α Expression Is Involved in IFN-γ Induction of the Class II Transactivator and Class II MHC Genes 1996
    1996 Stimulus-specific inhibition of intercellular adhesion molecule-1 gene expression by TGF-β 1996
    1996 HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells: Involvement of janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways 1996
    1996 Cytokines in inflammatory brain lesions: Helpful and harmful 1996
    1995 TNF-α- and IFN-γ-mediated signal transduction pathways: Effects on glial cell gene expression and function 1995
    1995 Astrocytes and the aids dementia complex 1995
    1995 HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes 1995
    1995 Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines 1995
    1995 Circulating adhesion molecules and inflammatory mediators in demyelination: A review 1995
    1995 Class II MHC gene expression in microglia: Regulation by the cytokines IFN-γ, TNF-α, and TGF-β 1995
    1995 Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species 1995
    1995 Differential regulation of astrocyte TNF-α expression by the cytokines TGF-β, IL-6 and IL-10 1995
    1995 Inhibitory cytokines and cytokine inhibitors 1995
    1995 Intercellular adhesion molecule-1 gene expression by glial cells: Differential mechanisms of inhibition by IL-10 and IL-6 1995
    1995 Interleukin 1‐β‐ and tumor necrosis factor‐α‐mediated regulation of ICAM‐1 gene expression in astrocytes requires protein kinase C activity 1995
    1995 Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway 1995
    1995 Role of protein kinase C and tyrosine kinase activity in IFN-γ-induced expression of the class II MHC gene 1995
    1995 Second messenger systems in the regulation of cytokines and adhesion molecules in the central nervous system 1995
    1995 TGF-β suppression of IFN-γ-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-γ enhanced factor X expression 1995
    1994 Differential modulation of astrocyte cytokine gene expression by TGF-β 1994
    1994 Characterization of astrocyte nuclear proteins involved in IFN-γ- and TNF-α-mediated class II MHC gene expression 1994
    1994 Cytokines and HIV envelope glycoprotein gp120 stimulate Na+/H+ exchange in astrocytes 1994
    1994 Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: Implications for AIDS dementia complex 1994
    1994 Signal transduction pathways mediating astrocyte IL-6 induction by IL-1β and tumor necrosis factor-α 1994
    1994 Cytokine circuits in brain. Implications for AIDS dementia complex. 1994
    1994 Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes 1994
    1994 gp120-mediated alterations in astrocyte ion transport 1994
    1993 Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes 1993
    1993 Identification and characterization of a high-affinity granulocyte- macrophage colony-stimulating factor receptor on primary rat oligodendrocytes 1993
    1993 Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine 1993
    1993 Interleukin‐1 and tumor necrosis factor‐mediated regulation of C3 gene expression in human astroglioma cells 1993
    1992 Tumor necrosis factor α response elements in the HLA-DRA promoter: Identification of a tumor necrosis factor α-induced DNA-protein complex in astrocytes 1992
    1992 Role of protein kinase C activity in tumor necrosis factor-α gene expression: Involvement at the transcriptional level 1992
    1992 Enhancement of epidermal growth factor receptor expression on glioma cells by recombinant tumor necrosis factor α 1992
    1992 Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein 1992
    1992 Cytokines: Influence on glial cell gene expression and function 1992
    1992 Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action 1992
    1992 Interferon-gamma regulation of C3 gene expression in human astroglioma cells 1992
    1992 Interleukin-1β induction of tumor necrosis factor-alpha gene expression in human astroglioma cells 1992
    1992 Interleukin‐1β induction of TNF‐α gene expression: Involvement of protein kinase C 1992
    1992 Usage of primary cells to delineate IFN-γ-responsive DNA elements in the HLA-DRA promoter and to identify a novel IFN-γ-enhanced nuclear factor 1992
    1991 Interferon-γ-induced astrocyte class II major histocompatibility complex gene expression is associated with both protein kinase C activation and Na+ entry 1991
    1991 Changes Induced in Astrocyte Cathepsin D by Cytokines and Leupeptin 1991
    1991 Differential tumor necrosis factor α expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains 1991
    1990 Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α 1990
    1990 Induction and regulation of interleukin-6 gene expression in rat astrocytes 1990
    1990 Tumor necrosis factor production and receptor expression by a human malignant glioma cell line, D54-MG 1990
    1990 Tumor necrosis factor-α production by astrocytes. Induction by lipopolysaccharide, IFN-γ, and IL-1β 1990
    1989 Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytes 1989
    1989 Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytes 1989
    1989 Monoclonal idiotypic and anti-idiotypic antibodies produced by immunization with peptides specified by a region of human myelin basic protein mRNA and its complement 1989
    1989 Tumor necrosis factor-α enhances interferon-γ-mediated class II antigen expression on astrocytes 1989
    1989 Use of peptides encoded by complementary RNA for generating anti-idiotypic antibodies of predefined specificity 1989
    1988 Lymphokines and monokines in the neuroendocrine system 1988
    1988 Rat Astrocyte Proliferation by Human B‐Cell Growth Factors 1988
    1988 Response of human glioblastoma cells to recombinant interleukin-2 1988
    1987 Myelin Basic Protein‐Specific RNA Levels in Interleukin‐2‐Stimulated Oligodendrocytes 1987
    1987 Remyelination by oligodendrocytes stimulated by antiserum to spinal cord 1987
    1986 Stimulation of oligodendroglial proliferation and maturation by interleukin-2 1986
    1985 Purification and characterization of a human T-lymphocyte-derived glial growth-promoting factor 1985
    1984 B-Cell Abnormalities in AIDS 1984
    1983 Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome 1983
    1983 T suppressor cells are required for the maintenance of the antigen-induced B-cell unresponsive state in humans 1983
    1983 The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders 1983
    1982 THE SELECTIVE ROLE OF MEMBRANE IgG IN THE ANTIGEN‐INDUCED INHIBITION OF HUMAN IN VITRO ANTIBODY PRODUCTION 1982
    1982 The selective role of membrane IgG in the antigen-induced inhibition of human in vitro antibody synthesis 1982
    1980 Funtional properties of human T cells bearing Fc receptors for IgA. I. Mitogen responsiveness, mixed lymphocyte culture reactivity, and helper activity for B cell immunoglobulin production 1980

    Book

    Year Title Altmetric
    2005 Cytokines and the CNS 2005

    Chapter

    Year Title Altmetric
    2015 Protein kinase CK2 and dysregulated oncogenic inflammatory signaling pathways.  259-280. 2015
    2014 Inflammation and the pathophysiology of astrocytes in neurodegenerative diseases.  61-80. 2014
    2014 Cytokines.  921-925. 2014
    2013 Cytokine and Chemokine Receptors and Signaling 2013
    2001 Cerebrospinal fluid.  347-375. 2001

    Research Overview

  • Dr. Benveniste's research is directed toward understanding how the immune system and central nervous system (CNS) communicate with each other. Specifically, her laboratory is studying the function of shared cytokines/chemokines between cells of the immune and nervous systems. Astrocytes and microglia, the major glial cells of the CNS, have been shown to act as antigen-presenting cells in the CNS. Dr. Benveniste’s group is examining the mechanisms by which cytokines modulate class II major histocompatibility complex (MHC) and CD40 proteins on these cells, with a particular emphasis on delineating the transcriptional machinery that drives expression of these genes. The ability of astrocytes and microglia to secrete several immunoregulatory molecules (tumor necrosis factor, interleukin-6, macrophage chemotactic protein-1, interleukin-8) is also being studied, with an emphasis on the biological stimuli that induce these cytokines/chemokines, intracellular signaling events involved in the response, and the molecular mechanisms of gene regulation. These projects will provide a better understanding of how bidirectional communication occurs between the immune and nervous systems, and how these interactions affect the functionality of glial cells. These studies are also relevant to understanding the pathogenesis of several neurologic diseases such as multiple sclerosis, an autoimmune disease of the CNS, and HIV-1 associated dementia (HAD). Dr. Benveniste has also initiated studies to examine the role of MMPs and IL-8 in astroglioma migration and invasion, and how interferons inhibit these responses at the transcriptional level. In this line of research, her laboratory is examining how interferons inhibit MMP-9 and IL-8 gene expression by utilizing chromatin immunoprecipitation (ChIP) assays to examine the MMP-9 and IL-8 promoters in vivo. Recent studies in the laboratory are focused on the aberrant activation of two signal transduction pathways in astrogliomas; the JAK-STAT pathway and the NF-kB pathway. It is thought that the dysregulation of these signal transduction pathways contributes to the invasiveness of brain tumors, as well as angiogenic properties. As such, the group is exploring the therapeutic potential of inhibitors of the JAK-STAT and NF-kB pathways to treat brain tumor patients.

    • Principal Investigator On

  • Innate and Adaptive Immunity in Parkinson Disease - Project 2: Validating the JAK/STAT Pathway as a Novel Therapeutic Strategy in PD  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • HSF-GEF Research Acceleration Award - Benveniste  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2022
  • The Role of CK2 in Glioblastoma Development  awarded by National Cancer Institute/NIH/DHHS 2015 - 2020
  • Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2020
  • Private Grant  awarded by Pfizer Pharmaceuticals 2019 - 2020
  • Investigating the Phenotype of B-Cells in Peripheral Blood of PD Patients  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2020
  • Training Program in Brain Tumor Biology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2019
  • Innate and Adaptive Immunity in Parkinson Disease - Project 2  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2017 - 2018
  • Targeting the JAK/STAT-3 Pathway Signaling Axis in Glioma  awarded by National Cancer Institute/NIH/DHHS 2012 - 2018
  • The Role of the JAK/STAT Pathway in Human Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2018
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2016
  • Collaborative MS Research Center Award  awarded by National Multiple Sclerosis Society 2009 - 2015
  • LKB1 and AMPK Signaling in Neuroinflammation  awarded by National Multiple Sclerosis Society 2012 - 2014
  • Determining the Molecular Mechanisms of Crosstalk Between the NF-kB and JAK/STAT-3 Signaling Pathways in Glioblastoma  awarded by American Brain Tumor Association 2012 - 2014
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2012 - 2014
  • Defining the Role of NF-kB in Promoting STAT3 Activation in Malignant Gliomas  awarded by SOUTHEASTERN BRAIN TUMOR FOUNDATION 2011 - 2013
  • Therapeutic Intervention of the JAK/STAT Pathway for Treatment of Neuroinflammation  awarded by National Multiple Sclerosis Society 2013
  • Training Program in Brain Tumor Biology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2013
  • Expression and Function of SOCS Proteins in Glial Cells - ARRA  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2012
  • TRADD as a Regulator of Cytokine Signaling in Glia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011
  • Mechanisms Regulating Functional Beta-Cell Recovery  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2009 - 2011
  • The Role of HIV Tat-Induced SOCS3 in HIV Associated Dementia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2009 - 2011
  • Expression and Function of SOCS Proteins in Glia  awarded by National Multiple Sclerosis Society 2006 - 2010

    • Investigator On

  • Measuring Neuroinflammation in Chronic Fatigue Syndrome with Whole-brain Magnetic Resonance Spectroscopy  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2019 - 2024
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Sculpting Anti-tumor Immunity as an Approach to Treat Metastatic Breast Cancer  awarded by DOD - Department of Defense 2018 - 2021
  • Function of Protein Kinase CK2 in CD4+ T Cells and Autoimmune Disease  awarded by National Multiple Sclerosis Society 2017 - 2020
  • Ferritin Mediates Epithelial Cell-Macrophage Cross Talk in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Adiministrative Core  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Breast Tumor Tissue-Derived Hedgehog Morphogens Immunoedit the Polarization of Breast Cancer Associated Macrophages  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2014 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Microenvironmental Regulation of Glioblastoma Angiogenesis via CHD7  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Comprehensive Cancer Center Core Support Grant - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Active - Senior Leadership - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by MALLINCKRODT, INC. 2015
  • Negative Impact of RNA Destabilizer Tristetraprolin on Glioma Growth  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • PKC/MARCKS Pathway as a Target for Radiation Sensitization  awarded by American Society for Therapeutic Radiology and Oncology 2008 - 2013
  • Interrogation of Key Genomic Alterations in Glioblastoma Multiforme (GBM) for Identification of Molecular Pathways Critical to GBM Tumorigenesis and Progression  awarded by SOUTHERN RESEARCH INSTITUTE 2010 - 2012

    • Full Name

  • Tika Benveniste