Positions

Overview

  • Anne Theibert received her Ph.D. from The Johns Hopkins University School of Medicine in 1985. She is an Professor of Neurobiology, and Adjunct Assistant Professor of Cell Biology and Physiology and Biophysics.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2016 The endosome localized Arf-GAP AGAP1 modulates dendritic spine morphology downstream of the neurodevelopmental disorder factor dysbindinFrontiers in Cellular Neuroscience.  10. 2016
    2009 Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: Fundamental roles in neurodevelopmental disorders associated with mental retardation and autismJournal of Neurodevelopmental Disorders.  1:185-196. 2009
    2009 Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutationsNeurobiology of Disease.  34:199-211. 2009
    2008 Consensus nomenclature for the human ArfGAP domain-containing proteinsJournal of Cell Biology.  182:1039-1044. 2008
    2007 The neuronal Arf GAP centaurin α1 modulates dendritic differentiationJournal of Cell Science.  120:2683-2693. 2007
    2004 The Arf6 GAP centaurin α-1 is a neurolonal actin-binding protein which also functions via GAP-independent activity to regulate te actin cytoskeletonCytobiologie.  83:541-554. 2004
    2002 Regulation of inositol phospholipid binding and signaling through syndecan-4Journal of Biological Chemistry.  277:49296-49303. 2002
    2002 Functions of PI 3-kinase in development of the nervous systemInternational Journal of Developmental Neuroscience.  20:187-197. 2002
    2001 Casein Kinase I Associates with Members of the Centaurin-α Family of Phosphatidylinositol 3,4,5-Trisphosphate-binding ProteinsJournal of Biological Chemistry.  276:18757-18764. 2001
    2001 Cytohesins and centaurins: Mediators of PI 3-kinase regulated Arf signalingTrends in Biochemical Sciences.  26:220-221. 2001
    2000 Cocaine inhibition of neuronal differentiation in NGF-induced PC12 cells is independent of ras signalingInternational Journal of Developmental Neuroscience.  18:765-772. 2000
    2000 Cytohesins and centaurins: Mediators of PI 3-kinase-regulated Arf signalingTrends in Biochemical Sciences.  25:489-495. 2000
    2000 Restructuring of focal adhesion plaques by PI 3-kinase: Regulation by PtdIns (3,4,5)-P3 binding to α-actininJournal of Cell Biology.  150:627-641. 2000
    2000 Cocaine inhibits NGF-induced PC12 cells differentiation through D1-type dopamine receptorsBrain Research.  869:85-97. 2000
    1999 Regulation of AMP deaminase by phosphoinositidesJournal of Biological Chemistry.  274:25701-25707. 1999
    1999 GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitroCell regulation.  10:581-596. 1999
    1998 Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brainNeurobiology of Aging.  19:385-391. 1998
    1998 Novel developmentally regulated phosphoinositide binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeastEMBO Journal.  17:4004-4017. 1998
    1998 Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5- bisphosphate coordinately regulate protein kinase C activityJournal of Biological Chemistry.  273:10624-10629. 1998
    1998 Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinaseJournal of Biological Chemistry.  273:1755-1763. 1998
    1998 C-fos mediates cocaine inhibition of NGF-induced PC12 cell differentiationMolecular Genetics and Metabolism.  64:62-69. 1998
    1998 Cocaine-inhibited neuronal differentiation in NGF-induced PC12 cells and altered C-fos expression are reversed by C-fos antisense oligonucleotideAnnals of the New York Academy of Sciences.  846:427-430. 1998
    1996 Identification and cloning of centaurin-α. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brainJournal of Biological Chemistry.  271:18859-18868. 1996
    1996 Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinaseJournal of Cell Science.  109:289-300. 1996
    1992 Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2Biochemical and Biophysical Research Communications.  187:158-163. 1992
    1992 Photoaffinity labeling and characterization of isolated inositol 1,3,4,5- tetrakisphosphate- and inositol hexakisphosphate-binding proteinsJournal of Biological Chemistry.  267:9071-9079. 1992
    1991 Tethered IP 3 . Synthesis and Biochemical Applications of the 1-O-(3-Aminopropyl) Ester of Inositol 1,4,5-TrisphosphateJournal of the American Chemical Society.  113:1822-1825. 1991
    1991 Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: Isolation and characterization from rat brainProceedings of the National Academy of Sciences.  88:3165-3169. 1991
    1990 Solubilization and separation of inositol 1,3,4,5-tetrakisphosphate- and inositol 1,4,5-trisphosphate-binding proteins and metabolizing enzymes in rat brainBiochemical Journal.  267:441-445. 1990
    1988 Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calciumProceedings of the National Academy of Sciences.  85:8747-8750. 1988
    1988 Identification and Ligand-Induced Modification of the cAMP Receptor in DictyosteliumMethods in Enzymology.  159:267-278. 1988
    1988 Receptor G‐Protein Interactions in the Development of DictyosteliumBotanica acta : Berichte der Deutschen Botanischen Gesellschaft = journal of the German Botanical Society.  101:123-127. 1988
    1987 Demonstration of inositol 1,3,4,5-tetrakisphosphate receptor bindingBiochemical and Biophysical Research Communications.  148:1283-1289. 1987
    1987 Transmembrane Signaling in DictyosteliumMethods in Cell Biology.  28:299-331. 1987
    1986 Cell-cell interactions in the development of DictyosteliumAmerican Zoologist.  26:549-552. 1986
    1986 Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformantsNature.  323:340-343. 1986
    1986 Surface receptor-mediated activation of adenylate cyclase in dictyostelium. Regulation by guanine nucleotides in wild-type cells and aggregation deficient mutantsJournal of Biological Chemistry.  261:15121-15125. 1986
    1986 Cell-cell interactions in the development of Dictyostelium.Developmental biology (New York, N.Y. : 1985).  3:261-281. 1986
    1986 The specificity of the cAMP receptor mediating activation of adenylate cyclase in Dictyostelium discoideumDevelopmental Biology.  114:529-533. 1986
    1985 Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideumJournal of Biological Chemistry.  260:1757-1764. 1985
    1984 Specific photoaffinity labeling of the cAMP surface receptor in Dictyostelium discoideumJournal of Biological Chemistry.  259:12318-12321. 1984
    1984 Adenosine and its derivatives inhibit the cAMP signaling response in Dictyostelium discoideumDevelopmental Biology.  106:166-173. 1984
    1983 Cyclic 3',5'-AMP relay in Dictyostelium discoideum: Adaptation is independent of activation of adenylate cyclaseJournal of Cell Biology.  97:173-177. 1983

    Research Overview

  • Many diseases are linked to dysregulation of second messenger signaling cascades. One important second messenger system is the phosphoinositide (PI) system, in which inositol lipids function as second messengers and cofactors for many cellular activities stimulated by growth and trophic factors, hormones, cytokines, and neurotransmitters. My research focuses on investigating the intracellular targets for several of the PI second messengers in the nervous system. We are particularly interested in the function of PtdInsP3 in neurons and glia, since we have demonstrated that this lipid is required for cells to extend processes, termed neurites, in response to trophic factors and extracellular matrix. Neurites eventually form mature axons and dendrites, which contact each other at synapses, and allow for information transfer between neurons. Using biochemical and molecular techniques, we have isolated and cloned several novel phosphoinositide receptors from brain. One of these receptors is involved in regulating vesicle trafficking and the actin cytoskeleton, two activities which are involved in neurite outgrowth and new synapse formation. Studies are underway to determine the role of these receptors in neuronal development and synapse formation, and the molecular mechanisms which regulate receptor expression, targeting to intracellular compartments, and modulation of activity. Several potential homologues of these receptors are present in the genetically tractable organism, Saccharomyces cerevisiae, which allows us to use yeast genetics to complement the biochemical and molecular approaches in dissecting the function of these brain phosphoinositide receptors.
  • Teaching Activities

  • NBL355 - Mech of Syn Trans (Spring Term 2019) 2019
  • NBL356 - From Systems to Cog Neuro (Spring Term 2019) 2019
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2019) 2019
  • NBL610 - Molecular Bio of the Neuron (Spring Term 2019) 2019
  • NBL355 - Mech of Syn Trans (Fall Term 2018) 2018
  • NBL356 - From Systems to Cog Neuro (Fall Term 2018) 2018
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2018) 2018
  • NBL355 - Mech of Syn Trans (Spring Term 2018) 2018
  • NBL356 - From Systems to Cog Neuro (Spring Term 2018) 2018
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2018) 2018
  • NBL355 - Mech of Syn Trans (Fall Term 2017) 2017
  • NBL356 - From Systems to Cog Neuro (Fall Term 2017) 2017
  • NBL355 - Cellular & Molecular Neuro (Spring Term 2017) 2017
  • NBL356 - From Systems to Cog Neuro (Spring Term 2017) 2017
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2017) 2017
  • PY355 - Cellular & Molecular Neuro (Spring Term 2017) 2017
  • PY356 - From Systems to Cog Neuro (Spring Term 2017) 2017
  • NBL355 - Cellular & Molecular Neuro (Fall Term 2016) 2016
  • NBL356 - From Systems to Cog Neuro (Fall Term 2016) 2016
  • PY355 - Cellular & Molecular Neuro (Fall Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL355 - Neuro Mech of Syn Trans (Spring Term 2016) 2016
  • NBL356 - Neuro Mech of Sen Mov & Cog (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2016) 2016
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2016) 2016
  • PY355 - Introduction to Neuroscience (Spring Term 2016) 2016
  • PY401 - Neuroscience Seminar (Spring Term 2016) 2016
  • NBL355 - Neuro Mech of Syn Trans (Fall Term 2015) 2015
  • NBL356 - Neuro Mech of Sen Mov & Cog (Fall Term 2015) 2015
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2015) 2015
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2015) 2015
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2015) 2015
  • PY355 - Introduction to Neuroscience (Fall Term 2015) 2015
  • PY401 - Neuroscience Seminar (Fall Term 2015) 2015
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2015) 2015
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2015) 2015
  • NBL355 - Introduction to Neuroscience (Spring Term 2015) 2015
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2015) 2015
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2015) 2015
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2015) 2015
  • PY355 - Introduction to Neuroscience (Spring Term 2015) 2015
  • PY401 - Neuroscience Seminar (Spring Term 2015) 2015
  • NBL330 - Neuro: Brain Function & Dysfun (Fall Term 2014) 2014
  • NBL356 - Intro to Neuroscience II (Fall Term 2014) 2014
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2014) 2014
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2014) 2014
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2014) 2014
  • PY401 - Neuroscience Seminar (Fall Term 2014) 2014
  • VIS429 - Intro to Neurobiology (Fall Term 2014) 2014
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2014) 2014
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2014) 2014
  • NBL355 - Introduction to Neuroscience (Spring Term 2014) 2014
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2014) 2014
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2014) 2014
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2014) 2014
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2014) 2014
  • PY355 - Introduction to Neuroscience (Spring Term 2014) 2014
  • PY401 - Neuroscience Seminar (Spring Term 2014) 2014
  • NBL356 - Intro to Neuroscience II (Fall Term 2013) 2013
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2013) 2013
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2013) 2013
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2013) 2013
  • PY401 - Neuroscience Seminar (Fall Term 2013) 2013
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2013) 2013
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2013) 2013
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2013) 2013
  • NBL355 - Introduction to Neuroscience (Spring Term 2013) 2013
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2013) 2013
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2013) 2013
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2013) 2013
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2013) 2013
  • PY355 - Introduction to Neuroscience (Spring Term 2013) 2013
  • PY401 - Neuroscience Seminar (Spring Term 2013) 2013
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2012) 2012
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2012) 2012
  • NBL780 - Selected Topics in NeuroBiol I (Fall Term 2012) 2012
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2012) 2012
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2012) 2012
  • PY401 - Neuroscience Seminar (Fall Term 2012) 2012
  • PY460 - Advanced Nero:Molecules to Min (Fall Term 2012) 2012
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2012) 2012
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2012) 2012
  • NBL355 - Introduction to Neuroscience (Spring Term 2012) 2012
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2012) 2012
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2012) 2012
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2012) 2012
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2012) 2012
  • PY355 - Introduction to Neuroscience (Spring Term 2012) 2012
  • PY401 - Neuroscience Seminar (Spring Term 2012) 2012
  • GBS731 - Principles of Cell Neuroscie (Fall Term 2011) 2011
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2011) 2011
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2011) 2011
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2011) 2011
  • PY401 - Neuroscience Seminar (Fall Term 2011) 2011
  • PY460 - Advanced Nero:Molecules to Min (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2011) 2011
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2011) 2011
  • VIS429 - Intro to Neurobiology (Summer Term 2011) 2011
  • NBL355 - Introduction to Neuroscience (Spring Term 2011) 2011
  • NBL700 - Intro Cellular & Molec Neuro (Spring Term 2011) 2011
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2011) 2011
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2011) 2011
  • PY355 - Introduction to Neuroscience (Spring Term 2011) 2011
  • GBS731 - Principles of Cell Neuroscie (Fall Term 2010) 2010
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2010) 2010
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2010) 2010
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2010) 2010
  • PY401 - Neuroscience Seminar (Fall Term 2010) 2010
  • PY442 - Princ Cell Neurosci Mod II (Fall Term 2010) 2010
  • PY443 - Princ Cell Neurosci Module III (Fall Term 2010) 2010
  • STH299 - Interdisciplinary Seminar (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2010) 2010
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2010) 2010
  • CMB754 - CMB V Cell & Mole Neuroscience (Spring Term 2010) 2010
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2010) 2010
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2010) 2010
  • PY355 - Introduction to Neuroscience (Spring Term 2010) 2010
  • NBL780 - Selected Topics in NeuroBiol I (Fall Term 2009) 2009
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2009) 2009
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2009) 2009
  • STH299 - Interdisciplinary Seminar (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2009) 2009
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2009) 2009
  • CMB754 - CMB V Cell & Mole Neuroscience (Spring Term 2009) 2009
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2009) 2009
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2009) 2009
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2008) 2008
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2008) 2008
  • NEUR712 - Princ of Cell Neurosci-Mod II (Fall Term 2008) 2008
  • STH299 - Interdisciplinary Seminar (Fall Term 2008) 2008
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008) 2008
  • NBL798 - Non-Dis Res Neurobio (Summer Term 2008) 2008
  • NBL799 - Dissertation Res Neurobiology (Summer Term 2008) 2008
  • CMB754 - CMB V Cell & Mole Neuroscience (Spring Term 2008) 2008
  • NBL798 - Non-Dis Res Neurobio (Spring Term 2008) 2008
  • NBL799 - Dissertation Res Neurobiology (Spring Term 2008) 2008
  • NBL798 - Non-Dis Res Neurobio (Fall Term 2007) 2007
  • NBL799 - Dissertation Res Neurobiology (Fall Term 2007) 2007
  • NEUR712 - Princ of Cell Neurosci-Mod II (Fall Term 2007) 2007
  • NEUR713 - Princ of Cell Neurosci Mod III (Fall Term 2007) 2007
  • STH299 - Interdisciplinary Seminar (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Johns Hopkins University 1985
  • Full Name

  • Anne Theibert
  • Fax

  • 205-935-7394