Positions

Overview

  • My lab aims to understand virus structure and the structure-function relationships involved in the processes of viral replication, including virus-host interactions, capsid structure and polynucleotide synthesis. Toward this goal, we have used structural techniques (cryo-electron microscopy, x-ray crystallography and small angle x-ray scattering) alongside biochemistry and classical virology techniques to study viral proteins from negative strand RNA viruses (NSV: influenza A, mumps, rabies virus, VSV) and retroviruses (HIV). This dual approach has been successful in producing near atomic-level snapshots of many complex protein assemblies as well as enabling a fast-track to novel biological discovery and new experimental design. Professionally, my expertise in structural biology has lead to my collaboration with investigators locally, nationally and internationally on viral, bacterial, human and murine targets.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 RNA synthesis and capping by nonsegmented negative strand RNA viral polymerases: Lessons from a prototypic virusFrontiers in Microbiology.  10. 2019
    2019 The emerging role of complement proteins as a target for therapy of IgA nephropathyFrontiers in Immunology.  10. 2019
    2017 A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes riskDiabetes.  66:2019-2032. 2017
    2014 1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosisActa Crystallographica Section F: Structural Biology Communications.  70:414-417. 2014
    2012 Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-GAnnals of the Rheumatic Diseases.  71:777-784. 2012
    2012 Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolismDiabetologia.  55:331-339. 2012
    2011 Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1American Journal of Human Genetics.  89:619-627. 2011
    2011 Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriersHuman Genetics.  130:685-699. 2011
    2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesDiabetes.  60:2624-2634. 2011
    2011 Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: The candidate gene association resource (CARe)Investigative Ophthalmology and Visual Science.  52:7593-7602. 2011
    2008 MAST3: A novel IBD risk factor that modulates TLR4 signalingGenes and Immunity.  9:602-612. 2008
    2007 A second major histocompatibility complex susceptibility locus for multiple sclerosisAnnals of Neurology.  61:228-236. 2007
    2006 A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands 2006
    2006 Resolution improvement of X-ray diffraction data of crystals of a vesicular stomatitis virus nucleocapsid protein oligomer complexed with RNAActa Crystallographica Section D: Biological Crystallography.  62:498-504. 2006
    2006 Purification, crystallization and preliminary X-ray crystallographic analysis of the nucleocapsid protein of Bunyamwera virus 2006
    2004 Crystallization and preliminary X-ray analysis of a proteinase-K-resistant domain within the phosphoprotein of vesicular stomatitis virus (Indiana)Acta Crystallographica Section D: Biological Crystallography.  60:2087-2090. 2004
    2004 Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairsHuman Molecular Genetics.  13:763-770. 2004
    2003 Expression, purification, crystallization of fragments from the C-terminal region of DFF45/ICADActa Crystallographica Section D: Biological Crystallography.  59:1323-1326. 2003
    2000 Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility lociAmerican Journal of Human Genetics.  66:1863-1870. 2000
    1998 Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16Gastroenterology.  115:1062-1065. 1998
    1998 Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33American Journal of Human Genetics.  63:1086-1094. 1998

    Chapter

    Year Title Altmetric
    2011 Assembly of vesicular stomatitis virus.  175-192. 2011

    Research Overview

  • The targets of my current NIH funded research are to understand the processes of NSV polynucleotide synthesis from the view of the template (a complex between the viral genome and the nucleocapsid) as well as the polymerase machinery (a complex between the L protein, P protein and potentially host factors).
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 2002
  • Bachelor of Science or Mathematics in Biology, University of Alabama in Huntsville 1994
  • Full Name

  • Todd Green