Positions

Overview

  • Dr. Szul's broad research background and training has been rooted in membrane trafficking and molecular mechanisms that regulate the delivery of proteins to their cellular destination. Since his transition to the Division of Pulmonary, Allergy, and Critical Care Medicine, his research interests have evolved into two overlapping fields; first: to understand the mechanisms of secretion of key enzymes involved in chronic lung inflammation (MMP9, PE, LTA4H); and secondly: to map out the role that single nucleotide polymorphism (SNP) in combination with conventional cigarettes/e-cigarettes plays on expression and activity of these enzymes.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.  Biochemical and Biophysical Research Communications.  517:691-696. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.  Cell.  176:113-126.e15. 2019
    2019 Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema.  American Journal of Respiratory Cell and Molecular Biology.  61:560-566. 2019
    2018 Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.  JCI insight.  3. 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway Epithelia.  American Journal of Respiratory and Critical Care Medicine.  197:632-643. 2018
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes.  American Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor.  Journal of Cystic Fibrosis.  15:67-73. 2016
    2016 Genetic regulation of expression of leukotriene A4 hydrolase.  Ers Monograph.  2. 2016
    2014 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.  American Journal of Respiratory and Critical Care Medicine.  190:51-61. 2014
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.  European Respiratory Journal.  43:1086-1096. 2014
    2013 The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).  Journal of Biological Chemistry.  288:11532-11545. 2013
    2012 Identification of a functional domain within the p115 tethering factor that is required for Golgi ribbon assembly and membrane trafficking.  Journal of Cell Science.  125:1896-1909. 2012
    2011 Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.  Journal of Biological Chemistry.  286:36898-36906. 2011
    2011 COPII and COPI traffic at the ER-Golgi interface.  News in Physiological Sciences.  26:348-364. 2011
    2011 ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization..  Cellular Logistics.  1:139-154. 2011
    2011 The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila..  Cellular Logistics.  1:69-76. 2011
    2007 Activation of ADP-ribosylation factor regulates biogenesis of the ATP7A-containing trans-Golgi network compartment and its Cu-induced trafficking.  American Journal of Physiology - Cell Physiology.  293. 2007
    2007 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.  Journal of Cell Science.  120:3929-3940. 2007
    2006 On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo.  Cell regulation.  17:2996-3008. 2006
    2005 Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.  Traffic.  6:374-385. 2005
    2003 Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlin.  Human Genetics.  113:406-416. 2003
    2003 ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1.  Cell regulation.  14:2250-2261. 2003

    Research Overview

  • Dr. Szul's broad research background and training has been rooted in membrane trafficking and molecular mechanisms that regulate the delivery of proteins to their cellular destination. Since his arrival at the Division of Pulmonary, Allergy, and Critical Care Medicine, his research interests have evolved into two overlapping fields; first: to understand the mechanisms of secretion of various enzymes involved in chronic lung inflammation (MMP9, PE, LTA4H); and secondly: to map out the role that single nucleotide polymorphism (SNP) in combination with conventional cigarettes/e-cigarettes plays on expression and activity of these enzymes.

    • Principal Investigator On

    Investigator On

    Full Name

  • Tomasz Szul