Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 CaMK4 is a downstream effector of the a1G T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells 2021
2021 The role of pseudomonas aeruginosa virulence factors in cytoskeletal dysregulation and lung barrier dysfunction.  Toxins.  13. 2021
2019 Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cells.  Pulmonary Pharmacology and Therapeutics.  55:5-16. 2019
2019 α 1G T-type calcium channel determines the angiogenic potential of pulmonary microvascular endothelial cells 2019
2019 NLRX1 regulation following acute mitochondrial injury.  Frontiers in Immunology.  10. 2019
2014 Transcriptional regulation of α1H T-type calcium channel under hypoxia 2014
2014 A unique pulmonary microvascular endothelial cell niche revealed by weibel-palade bodies and Griffonia simplicifolia.  Pulmonary Circulation.  4:111-115. 2014
2014 The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entry.  Pulmonary Circulation.  4:116-127. 2014
2013 TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells.  Physiological Reports.  1. 2013
2013 Regulation of store-operated calcium entry by FK506-binding immunophilins.  Cell Calcium.  53:275-285. 2013
2012 Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.  Journal of Clinical Investigation.  122:4218-4230. 2012
2012 KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells 2012
2012 Orai1 determines calcium selectivity of an endogenous trpc heterotetramer channel.  Circulation Research.  110:1435-1444. 2012
2012 Lung endothelial Ca 2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.  American Journal of Respiratory and Critical Care Medicine.  185:160-170. 2012
2010 Effect of hypernatremia on injury caused by energy deficiency: Role of T-type Ca2+ channel 2010
2010 α1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium 2010
2010 New developments in lung endothelial heterogeneity: Von willebrand factor, P-selectin, and the weibel-palade body.  Seminars in Thrombosis and Hemostasis.  36:301-308. 2010
2009 A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation 2009
2009 Ca2+ entry via α1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium 2009
2008 Quantum dots - Utilization in TEM.  Microscopy and Microanalysis.  14:702-703. 2008
2008 Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.  Circulation Research.  102:966-974. 2008
2008 T-type Ca2+ channel expression in human esophageal carcinomas: A functional role in proliferation.  Cell Calcium.  43:49-58. 2008
2007 Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeability.  Journal of Biological Chemistry.  282:34801-34808. 2007
2007 Cav3.1 (α1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells 2007
2006 T-type calcium channels in pulmonary vascular endothelium.  Microcirculation.  13:645-656. 2006
2005 Activation of the endothelial store-operated ISOC Ca 2+ channel requires interaction of protein 4.1 with TRPC4.  Circulation Research.  97:1164-1172. 2005
2005 Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability determinants of the vascular leak site.  Circulation Research.  96:856-863. 2005
2005 Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.  Circulation Research.  96:864-872. 2005
2005 Reversal of hyperglycemic preconditioning by angiotensin II: Role of calcium transport 2005
2005 Is there a role for T-type Ca2+ channel in glioma cell proliferation? (multiple letter).  Cell Calcium.  38:593-595. 2005
2005 The low-voltage-activated calcium channel CAV3.1 controls proliferation of human pulmonary artery myocytes.  Chest.  128:581S-582S. 2005
2004 Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes.  Microvascular Research.  67:139-151. 2004
2003 CaV3.1 (α1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation.  Circulation Research.  93:346-353. 2003
2003 On the endothelial cell ISOC.  Cell Calcium.  33:323-336. 2003
2001 Essential control of an endothelial cell ISOC by the spectrin membrane skeleton 2001
2001 Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway.  The FASEB Journal.  15:1727-1738. 2001
2000 Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cells.  Journal of Biological Chemistry.  275:18887-18896. 2000
2000 A mibefradil metabolite is a potent intracellular blocker of L-type Ca2+ currents in pancreatic β-cells.  Journal of Pharmacology and Experimental Therapeutics.  292:939-943. 2000
2000 Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells.  Diabetes.  49:59-64. 2000

Chapter

Year Title Altmetric
2015 Regulation of t-type ca2+ channels by intercellular and intracellular signals.  19-35. 2015
2009 Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels.  129-142. 2009
2005 Receptor-operated Ca2+ channels.  99-124. 2005
2005 Transient receptor potential cation channels and store-operated Ca2+ channels.  125-146. 2005

Research Overview

  • Lung endothelial cell calcium channels
    Lung endothelial cell barrier integrity
    Lung endothelial cell activation and pro-inflammatory phenotype
    Lung endothelial cell angioproliferative phenotype and idiopathic pulmonary arterial hypertension
    Lung endothelial cell and hypoxic pulmonary vasoconstriction

    • Principal Investigator On

    Education And Training

  • Medical College of Georgia, Georgia Regents University Department of Anesthesiology and Perioperstive Medicine, Internship
  • Department of Internal Medicine, The Second Affiliated Hospital of Henan Medical University Internal Medicine, Residency
  • Medical College of Geogia at Augusta University Department of Anesthesiology and Perioperstive Medicine, Residency
  • University of South Alabama College of Medicine Department of Pharmacology, Postdoctoral Fellowship
  • Master of Science in Health Professions and Related Clinical Sciences, Zhengzhou University 1992
  • Doctor of Medicine, Zhengzhou University 1986

    • Awards And Honors

    Full Name

  • Songwei Wu