Selected Publications

Academic Article

Year Title Altmetric
2019 Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cellsPulmonary Pharmacology and Therapeutics.  55:5-16. 2019
2019 α1G T-type Calcium Channel Determines the Angiogenic Potential of Pulmonary Microvascular Endothelial Cells.American Journal of Physiology - Cell Physiology2019
2014 Transcriptional regulation of α1H T-type calcium channel under hypoxia.American Journal of Physiology - Cell Physiology.  307:C648-C656. 2014
2014 A unique pulmonary microvascular endothelial cell niche revealed by Weibel-Palade bodies and Griffonia simplicifolia.Pulmonary Circulation.  4:110-115. 2014
2014 The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entry.Pulmonary Circulation.  4:116-127. 2014
2013 TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells.Physiological Reports.  1:e00121. 2013
2013 Regulation of store-operated calcium entry by FK506-binding immunophilins.Cell Calcium.  53:275-285. 2013
2012 Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.Journal of Clinical Investigation.  122:4218-4230. 2012
2012 KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells.BBA - Biochimica et Biophysica Acta.  1823:1666-1675. 2012
2012 Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel.Circulation Research.  110:1435-1444. 2012
2012 Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.American Journal of Respiratory and Critical Care Medicine.  185:160-170. 2012
2010 Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca2+ channel.American Journal of Physiology - Cell Physiology.  299:C289-C297. 2010
2010 Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.AJP - Lung Cellular and Molecular Physiology.  299:L86-L97. 2010
2010 New developments in lung endothelial heterogeneity: Von Willebrand factor, P-selectin, and the Weibel-Palade body.Seminars in Thrombosis and Hemostasis.  36:301-308. 2010
2009 A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation.Oncology Reports.  22:1229-1235. 2009
2009 Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.AJP - Lung Cellular and Molecular Physiology.  297:L650-L657. 2009
2008 Quantum dots - Utilization in TEMMicroscopy and Microanalysis.  14:702-703. 2008
2008 Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.Circulation Research.  102:966-974. 2008
2008 T-type Ca2+ channel expression in human esophageal carcinomas: a functional role in proliferation.Cell Calcium.  43:49-58. 2008
2007 Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeability.Journal of Biological Chemistry.  282:34801-34808. 2007
2007 Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells.AJP - Lung Cellular and Molecular Physiology.  292:L833-L844. 2007
2006 T-type calcium channels in pulmonary vascular endothelium.Microcirculation.  13:645-656. 2006
2005 Is there a role for T-type Ca2+ channel in glioma cell proliferation?Cell Calcium.  38:593-595. 2005
2005 The low-voltage-activated calcium channel CAV3.1 controls proliferation of human pulmonary artery myocytes.Chest.  128:581S-582S. 2005
2005 Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.Circulation Research.  97:1164-1172. 2005
2005 Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability: determinants of the vascular leak site.Circulation Research.  96:856-863. 2005
2005 Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.Circulation Research.  96:864-872. 2005
2005 Reversal of hyperglycemic preconditioning by angiotensin II: role of calcium transport.AJP - Heart and Circulatory Physiology.  288:H1965-H1975. 2005
2004 Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes.Microvascular Research.  67:139-151. 2004
2003 Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation.Circulation Research.  93:346-353. 2003
2003 On the endothelial cell I(SOC).Cell Calcium.  33:323-336. 2003
2001 Essential control of an endothelial cell ISOC by the spectrin membrane skeleton.Journal of Cell Biology.  154:1225-1233. 2001
2001 Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway.Federation proceedings.  15:1727-1738. 2001
2000 Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cells.Journal of Biological Chemistry.  275:18887-18896. 2000
2000 A mibefradil metabolite is a potent intracellular blocker of L-type Ca(2+) currents in pancreatic beta-cells.Journal of Pharmacology and Experimental Therapeutics.  292:939-943. 2000
2000 Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells.Diabetes.  49:59-64. 2000


Year Title Altmetric
2015 Regulation of t-type ca2+channels by intercellular and intracellular signals.  19-35. 2015
2009 Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels.  129-142. 2009
2005 Receptor-operated Ca2+ channels.  99-124. 2005
2005 Transient receptor potential cation channels and store-operated Ca2+ channels.  125-146. 2005

Research Overview

  • Lung endothelial cell calcium channels
    Lung endothelial cell barrier integrity
    Lung endothelial cell activation and pro-inflammatory phenotype
    Lung endothelial cell angioproliferative phenotype and idiopathic pulmonary arterial hypertension
    Lung endothelial cell and hypoxic pulmonary vasoconstriction
  • Principal Investigator On

    Full Name

  • Songwei Wu