Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.European Journal of Immunology.  49:918-927. 2019
2019 Evaluation of the ELITe InGenius PCR platform for detection of Mycoplasma pneumoniaeJournal of Clinical Microbiology.  57. 2019
2019 Mycoplasma pneumoniae Carriage with De Novo Macrolide-Resistance and Breakthrough PneumoniaPediatrics.  144. 2019
2018 Quantitative Thresholds Enable Accurate Identification of Clostridium difficile Infection by the Luminex xTAG Gastrointestinal Pathogen Panel.Journal of Clinical Microbiology.  56. 2018
2017 Current and Emerging Molecular Tests for Human Papillomavirus-Related Neoplasia in the Genomic Era.Journal of Molecular Diagnostics.  19:366-377. 2017
2016 Clinical Significance of Commensal Gram-Positive Rods Routinely Isolated from Patient Samples.Journal of Clinical Microbiology.  54:2928-2936. 2016
2016 Closing the Brief Case: Recurrent Granulomatous Mastitis Due to Corynebacterium kroppenstedtii.Journal of Clinical Microbiology.  54:2212. 2016
2016 The Brief Case: Recurrent Granulomatous Mastitis Due to Corynebacterium kroppenstedtii.Journal of Clinical Microbiology.  54:1938-1941. 2016
2016 Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.Virulence.  7:465-476. 2016
2015 Erratum: Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2Nature Immunology.  16:214-214. 2015
2014 Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.Journal of Immunology.  192:3319-3327. 2014
2014 Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses.Glycobiology.  24:262-271. 2014
2014 Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.Nature Immunology.  15:143-151. 2014
2014 Fatal metacestode infection in Bornean orangutan caused by unknown Versteria species.Emerging Infectious Diseases.  20:109-113. 2014
2013 The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo.Journal of Immunology.  191:2581-2588. 2013
2013 Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers.PLoS ONE.  8:e64867. 2013
2013 Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.PLoS Pathogens.  9:e1003436. 2013
2012 Fungal antioxidant pathways promote survival against neutrophils during infection.Journal of Clinical Investigation.  122:2482-2498. 2012
2012 The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models.Cytokine.  58:107-111. 2012
2011 Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium.Journal of Infectious Diseases.  204:942-950. 2011
2011 Co-regulation of {beta}-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa.Journal of Medical Microbiology.  60:147-156. 2011
2010 Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.PLoS Pathogens.  6:e1000976. 2010
2008 Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.Journal of Medical Microbiology.  57:809-813. 2008

Book

Year Title Altmetric
2010 Encyclopedia of the Eye 2010

Research Overview

  • Development of novel molecular assays to more accurately diagnose infectious diseases. Utilizing model systems to identify key mediators of microbial detection and killing by phagocytic cells.
  • Principal Investigator On

  • Private Grant  awarded by MFLUIDX, INC. 2019 - 2021
  • Private Grant  awarded by IMMUNO-MYCOLOGICS, INC. 2019 - 2020
  • Private Grant  awarded by SPEEDX PTY. LTD. 2019
  • Full Name

  • Sixto Leal