Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Verapamil and beta cell function in adults with recent-onset type 1 diabetes.Nature Medicine.  24:1108-1112. 2018
2018 Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP.Current Opinion in Endocrinology and Diabetes.  25:75-80. 2018
2017 miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.Diabetes.  67:256-264. 2017
2017 Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory ResponsesACS Biomaterials Science and Engineering.  3:2110-2119. 2017
2016 Keeping tabs on fructose.eLife.  5. 2016
2016 Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop.Molecular Metabolism.  5:1208-1215. 2016
2016 miR-204 Targets PERK and Regulates UPR Signaling and β-Cell Apoptosis.Molecular Endocrinology -Baltimore-.  30:917-924. 2016
2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.AJP - Heart and Circulatory Physiology.  311:H64-H75. 2016
2016 Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study.Diabetes Research and Clinical Practice.  115:115-121. 2016
2016 Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.Journal of Biological Chemistry.  291:8428-8439. 2016
2015 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice.BBA - Biochimica et Biophysica Acta.  1861:1579-1595. 2015
2015 β-Cell MicroRNAs: Small but Powerful.Diabetes.  64:3631-3644. 2015
2014 MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.Journal of Biological Chemistry.  289:36275-36283. 2014
2014 Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell.Molecular Endocrinology -Baltimore-.  28:1211-1220. 2014
2014 Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop.Molecular Endocrinology -Baltimore-.  28:674-680. 2014
2014 Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.Journal of Biological Chemistry.  289:11807-11815. 2014
2014 Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix.International Journal of Nanomedicine.  9 Suppl 1:13-21. 2014
2013 Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.Nature Medicine.  19:1141-1146. 2013
2013 FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells.Journal of Biological Chemistry.  288:23194-23202. 2013
2012 Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.Molecular Pharmacology.  82:541-549. 2012
2012 Preventing β-cell loss and diabetes with calcium channel blockers.Diabetes.  61:848-856. 2012
2010 Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein.Journal of Biological Chemistry.  285:3997-4005. 2010
2010 Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Diabetes.  59:440-447. 2010
2009 Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.Journal of Biological Chemistry.  284:16898-16905. 2009
2009 Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein.AJP - Endocrinology and Metabolism.  296:E1133-E1139. 2009
2008 Lack of TXNIP protects beta-cells against glucotoxicity.Biochemical Society Transactions.  36:963-965. 2008
2008 Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.Federation proceedings.  22:3581-3594. 2008
2008 Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.Diabetes.  57:938-944. 2008
2008 HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus.AJP - Endocrinology and Metabolism.  294:E558-E567. 2008
2007 Exenatide blocks JAK1-STAT1 in pancreatic beta cells.Metabolism.  56:915-918. 2007
2007 A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.Cell Metabolism.  5:221-227. 2007
2006 Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity.Arteriosclerosis, Thrombosis, and Vascular Biology.  26:2666-2672. 2006
2006 An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells.Archives internationales de physiologie, de biochimie et de biophysique.  112:189-218. 2006
2006 Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose.Biochemistry.  45:11047-11051. 2006
2006 Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein.Biochemical and Biophysical Research Communications.  346:1067-1074. 2006
2005 Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein.Biochemical and Biophysical Research Communications.  336:770-778. 2005
2005 Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.Endocrinology.  146:2397-2405. 2005
2005 Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance.Molecular Endocrinology -Baltimore-.  19:794-803. 2005
2004 Resistin serum levels in type 1 diabetes pre- and post-islet transplantation.Metabolism.  53:403-404. 2004
2004 Insulinomas and expression of an insulin splice variant.Lancet.  363:363-367. 2004
2003 Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas.Surgery.  134:982-987. 2003
2003 Resistin is expressed in pancreatic islets.Biochemical and Biophysical Research Communications.  310:641-645. 2003
2002 Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway.Endocrinology.  143:3695-3698. 2002
2002 A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets.Endocrinology.  143:2541-2547. 2002
2001 Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.Journal of Biological Chemistry.  276:34948-34957. 2001
2001 Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.EMBO Journal.  20:2326-2337. 2001
2001 A multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition.Cold Spring Harbor Symposia on Quantitative Biology.  66:403-415. 2001
2000 Discovery of a lipodystrophy gene: one answer, one hundred questions.European Journal of Endocrinology.  143:565-567. 2000
2000 A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.Genes and Development.  14:2534-2546. 2000
1999 Hope for insulin mimetic oral antidiabetic drugs.European Journal of Endocrinology.  141:561-562. 1999
1999 The crucial role of a phosphatase in insulin resistance and obesity.European Journal of Endocrinology.  141:323-324. 1999
1998 Insulin receptor substrate-2--a new candidate gene for NIDDM?European Journal of Endocrinology.  139:263-264. 1998
1998 [Chylothorax as the initial manifestation of malignant Hodgkin lymphoma].PRAXIS.  87:690-693. 1998
1998 Effects of glucagon-like peptide 1 (7-36 amide) on glucose kinetics during somatostatin-induced suppression of insulin secretion in healthy men.Hormone Research.  49:221-225. 1998
1997 The role of glucagon-like peptide 1 in the regulation of glucose homeostasis and satiety.European Journal of Endocrinology.  137:220-221. 1997
1997 Absence of short-term effects of glucagon-like peptide-1 and of hyperglycemia on plasma leptin levels in man.Metabolism.  46:723-725. 1997
1997 Short-term effects of glucagon-like peptide 1 (7-36 amide) on leucine kinetics in healthy volunteers.Clinical Nutrition.  16:101-102. 1997
1997 Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man.European Journal of Clinical Investigation.  27:10-16. 1997
1996 Insulin-independent effects of glucagon-like peptide 1 (7-36 amide) (glp-1) on glucose kinetics in manFederation proceedings.  10. 1996
1996 The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.Endocrinology.  137:4499-4502. 1996
1996 Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis.European Journal of Endocrinology.  134:541-542. 1996

Principal Investigator On

  • UAB Diabetes Research Center - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Development of An Early Diagnostic Biomarker and Novel Treatment Strategy for T1D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • TXNIP Regulation of Endogenous Beta Cell Mass  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Repurposing of Verapamil as a Beta Cell Survival Therapy in T1D  awarded by Juvenile Diabetes Research Foundation International 2014 - 2019
  • Targeting TXNIP to Enhance Beta Cell Mass in T1D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2018
  • TXNIP Regulation of Endogenous Beta Cell Mass  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2017
  • Identification of a TXNIP-Regulated microRNA Involved in Insulin Production  awarded by American Diabetes Association, Inc. 2012 - 2015
  • Promote Beta-Cell Survival by Blocking TXNIP: Role of Calcium Channel Blocker  awarded by Juvenile Diabetes Research Foundation International 2010 - 2014
  • TXNIP Regulation of Endogenous Beta Cell Mass  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2013
  • Islet Cell Growth and Function: The Role of Thioredoxin-Interacting Protein  awarded by American Diabetes Association, Inc. 2010 - 2012
  • Education And Training

  • Doctor of Medicine, University of Basel
  • Full Name

  • Anath Shalev
  • Blazerid

  • shalev