Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Neurobiology of Disease.  110:68-81. 2018
2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Molecular Brain.  10:32. 2017
2017 Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders: Randomized Controlled Trial Rationale and Protocol.JMIR Research Protocols.  6:e68. 2017
2016 Increased autophagic response in a population of metastatic breast cancer cells.Oncology Letters.  12:523-529. 2016
2016 Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson Disease.Analytical Chemistry.  88:1856-1863. 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy.  12:1-222. 2016
2015 HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse.Journal of Virology.  89:1024-1035. 2015
2014 Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice.Acta Neuropathologica Communications.  2:20. 2014
2014 ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.PLoS ONE.  9:e93257. 2014
2013 Autophagy Modulation in Disease Therapy: Where Do We Stand?Current Pathobiology Reports.  1:239-245. 2013
2013 MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.Journal of Neuroscience.  33:9592-9600. 2013
2013 Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth.Journal of Neuro-Oncology.  113:195-205. 2013
2013 A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.Molecular Cancer Therapeutics.  12:663-674. 2013
2013 HIV-specific CD8+ T cells from elite controllers are primed for survival.Journal of Virology.  87:5170-5181. 2013
2012 Rotenone inhibits autophagic flux prior to inducing cell death.ACS Chemical Neuroscience.  3:1063-1072. 2012
2012 Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis.Experimental and Molecular Pathology.  93:273-280. 2012
2012 Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics.Brain Research Bulletin.  88:43-57. 2012
2012 Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy.  8:445-544. 2012
2010 Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.Journal of Neurochemistry.  114:1193-1204. 2010
2010 Lysosome dysfunction triggers Atg7-dependent neural apoptosis.Journal of Biological Chemistry.  285:10497-10507. 2010
2009 Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Antioxidants and Redox Signaling.  11:481-496. 2009
2009 Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.Science.  323:124-127. 2009
2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
2008 Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain.Neuroscience.  155:818-832. 2008
2008 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.Autophagy.  4:151-175. 2008
2008 Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells.Cancer Research.  68:674-682. 2008
2008 Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging.Current Medicinal Chemistry.  15:404-414. 2008
2008 The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.Frontiers in Bioscience.  13:718-736. 2008
2007 Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.Autophagy.  3:474-476. 2007
2007 Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.Autophagy.  3:222-229. 2007
2007 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides.Journal of Biological Chemistry.  282:6324-6337. 2007
2007 Kainic acid induces early and transient autophagic stress in mouse hippocampus.Neuroscience Letters.  414:57-60. 2007
2007 Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.Journal of Neuroscience.  27:2081-2090. 2007
2007 p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis.Journal of Neuropathology and Experimental Neurology.  66:66-74. 2007
2006 Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells.Cell Death and Differentiation.  13:1506-1514. 2006
2006 Bcl-2 family and the central nervous system: from rheostat to real complex.Cell Death and Differentiation.  13:1299-1304. 2006
2006 Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection.Autophagy.  2:228-230. 2006
2006 Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.Molecular Pharmacology.  69:1125-1136. 2006
2005 Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses.American Journal of Pathology.  167:1473-1476. 2005
2005 Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications.Current Drug Targets -Cns and Neurological Disorders-.  4:25-39. 2005
2004 Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine.Journal of Neurochemistry.  89:602-612. 2004
2002 Erythropoietin receptor signalling is required for normal brain development.Development.  129:505-516. 2002
1998 Postnatal developmental regulation of neuronal nicotinic receptor subunit alpha 7 and multiple alpha 4 and beta 2 mRNA species in the rat.Developmental Brain Research.  109:67-75. 1998
1998 Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit alpha7, alpha4 and beta2 messenger RNAs in the postnatal rat brain.Neuroscience.  84:1151-1161. 1998
1997 Prenatal nicotine sex-dependently alters agonist-induced locomotion and stereotypy.Neurotoxicology and Teratology.  19:467-476. 1997
1996 Central and peripheral anatomy of nicotinic sitesMedicinal Chemistry Research.  6:444-464. 1996

Chapter

Year Title Altmetric
2012 Lysosome storage disorders on the brain: The autophagy lysosome pathway contributes to disease pathophysiology and may be utilized for therapeutic benefit.  331-354. 2012
2010 Apoptosis in Neurodegenerative Disease.  531-537. 2010

Education And Training

  • Doctor of Philosophy in Pharmacology and Toxicology, Virginia Commonwealth University
  • Full Name

  • John Shacka
  • Blazerid

  • shacka