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Sonia Fargue
Assistant Professor
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E-mail
sfargue@uab.edu
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Sonia Fargue
Assistant Professor
Positions
Assistant Professor (P)
,
Urology
,
School of Medicine
2015 -
Associate Scientist (C)
,
Nephrology Research & Training Center
,
General Clinical Research Center
2018 -
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2020 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
Effect of alanine supplementation on oxalate synthesis
2021
2020
End points for clinical trials in primary hyperoxaluria
.
Clinical Journal of the American Society of Nephrology
. 15:1056-1065.
2020
2020
Future treatments for hyperoxaluria
.
Current Opinion in Urology
. 30:171-176.
2020
2020
The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria
2020
2019
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity
2019
2018
Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluria
.
Journal of the American Society of Nephrology
. 29:1615-1623.
2018
2016
High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1
.
Scientific Reports
. 6.
2016
2016
Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay
2016
2016
MP67-02 THE EFFECT OF ALANINE ON CELL VIABILITY AND AGT ACTIVITY IN TRANSFORMED CHINESE HAMSTER OVARY CELLS
2016
2016
MP67-03 MITOCHONDRIAL IMPLICATIONS OF GLYCOLATE METABOLISM IN PRIMARY HYPEROXALURIA
2016
2016
Metabolism of
13
C
5
-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase
2016
2015
MP34-04 INHIBITION OF GLYCOLATE OXIDASE REDUCES URINARY OXALATE EXCRETION IN A MOUSE MODEL OF PRIMARY HYPEROXALURIA TYPE 1
2015
2015
Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening
.
ASSAY and Drug Development Technologies
. 13:16-24.
2015
2015
A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5′UTR causing primary hyperoxaluria type II
2015
2015
Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine: Glyoxylate aminotransferase causing primary hyperoxaluria type I
.
Human Molecular Genetics
. 24:5500-5511.
2015
2014
Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1
2014
2014
Factors influencing clinical outcome in patients with primary hyperoxaluria type 1
.
Kidney International
. 86:1074-1076.
2014
2013
Multiple mechanisms of action of pyridoxine in primary hyperoxaluria type 1
2013
2013
Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele
.
Journal of Biological Chemistry
. 288:2475-2484.
2013
2012
The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase
2012
2012
Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment.
.
Nephrology Dialysis Transplantation
. 27:1729-1736.
2012
2011
Hyperoxalurie primitive de type 1 : expérience française
.
Néphrologie and Thérapeutique
. 7:289-289.
2011
2011
Primary hyperoxaluria
.
Néphrologie and Thérapeutique
. 7:249-259.
2011
2011
Primary hyperoxaluria.
.
International Journal of Nephrology
. 2011:864580.
2011
2011
Screening for NPHS2 mutations may help predict FSGS recurrence after transplantation
.
Journal of the American Society of Nephrology
. 22:579-585.
2011
2010
Tacrolimus nephrotoxicity: Beware of the association of diarrhea, drug interaction and pharmacogenetics
.
Pediatric Nephrology
. 25:965-969.
2010
2010
Genotype-phenotype correlation in primary hyperoxaluria type 1: The p.Gly170Arg AGXT mutation is associated with a better outcome
.
Kidney International
. 77:443-449.
2010
2010
Bone metabolism in oxalosis: A single-center study using new imaging techniques and biomarkers
.
Pediatric Nephrology
. 25:1081-1089.
2010
2010
Primary hyperoxaluria type 1: Strategy for organ transplantation
.
Current Opinion in Organ Transplantation
. 15:590-593.
2010
2009
Survey of First-Year Medical Students to Assess Their Knowledge and Attitudes Toward Organ Transplantation and Donation
.
Transplantation Proceedings
. 41:634-638.
2009
2009
Disease recurrence in paediatric renal transplantation
.
Pediatric Nephrology
. 24:2097-2108.
2009
2009
Effect of conservative treatment on the renal outcome of children with primary hyperoxaluria type 1
.
Kidney International
. 76:767-773.
2009
2008
Hyperuricemia after liver transplantation in children
.
Pediatric Transplantation
. 12:847-853.
2008
2007
New treatment strategies for proliferative lupus nephritis: Keep children in mind!
.
Lupus
. 16:684-691.
2007
2006
Primary hyperoxaluria type 1: Still challenging!
.
Pediatric Nephrology
. 21:1075-1081.
2006
2006
Hyperoxalurie primitive
.
EMC - Néphrologie
. 1:1-10.
2006
Chapter
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Year
Title
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2009
Primary Hyperoxaluria
. 1069-1079.
2009
Research
Principal Investigator On
Glycolate Metabolism and Kidney Oxalate
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
Investigator On
Private Grant
awarded by
ALNYLAM PHARMACEUTICALS, INC.
2019 - 2020
Metabolism Associated with Hyperoxaluria and Calcium Oxalate Stone Disease
awarded by
UROLOGY CARE FOUNDATION
2014 - 2016
Background
Education And Training
Doctor of Philosophy,
University of London - University College London
2012
Contact
Full Name
Sonia
Fargue