Oxalate is a common component of kidney stones. The theme of Dr. Fargue's research is in understanding the mechanisms underlying oxalate metabolism in healthy subjects and in patients with kidney stone disease. The initial focus has been on a rare hereditary form of oxalate kidney stones, called primary hyperoxaluria, both from a clinical perspective and basic science perspective. Dr. Fargue's recent research includes investigating mechanisms underlying calcium oxalate kidney stones.