Positions

Overview

  • Dr. Barnes was trained in Chemistry and Biochemistry in the UK. He joined UAB in 1977 and pursued research on bile acids and latterly polyphenols, particularly soy isoflavones. He was promoted to Associate Professor (with tenure) in 1985 and Full Professor in 1994. He has received NIH support from several areas to pursue the conjugation of bile acids, the chemistry, biochemistry and physiology of polyphenols, the underlying chemistry of lens cataracts and the use of omics approaches in biomedical research. He was the Associate Director of the Purdue UAB Botanicals Center for Age Related Disease (2000-2010) and the UAB Center for Nutrient Gene Interaction (2002-2011). He was an elected member of the National Advisory Council for the Center for Complementary and Alternate Medicine (2007-2010) and the NIH Council of Councils (2010-2012). He was the Director of the NIH funded Workshop in Metabolomics (2012-2018). He received the 2012 Distinguished Faculty Award and in 2018 became a Distinguished Professor of Pharmacology and Toxicology.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolismAJP - Renal Physiology.  316:F414-F425. 2019
    2019 Droplets and Bubbles: Solidification of Sulphide-rich Vapour-saturated Orthocumulates in the Norilsk-Talnakh Ni-Cu-PGE Ore-bearing IntrusionsJournal of Petrology.  60:269-300. 2019
    2019 Evidence for dyke-parallel shear during syn-intrusion fracturingEarth and Planetary Science Letters.  507:119-130. 2019
    2019 Growth history of sphalerite in a modern sea floor hydrothermal chimney revealed by electron backscattered diffractionEconomic Geology.  114:165-176. 2019
    2019 Time scales and length scales in magma flow pathways and the origin of magmatic Ni–Cu–PGE ore depositsGeoscience Frontiers.  10:77-87. 2019
    2019 Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acidsOcular Surface2019
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
    2018 Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasiaAJP - Lung Cellular and Molecular Physiology.  315:L810-L815. 2018
    2018 Plume-lithosphere interaction at craton margins throughout Earth historyTectonophysics.  746:678-694. 2018
    2018 Sulfide-silicate textures in magmatic Ni-Cu-PGE sulfide ore deposits: Massive, semi-massive and sulfide-matrix breccia oresOre Geology Reviews.  101:629-651. 2018
    2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
    2018 Morphology and particle size distribution of olivines and sulphides in the jinchuan Ni-Cu sulphide deposit: Evidence for sulphide percolation in a crystal mushJournal of Petrology.  59:1701-1730. 2018
    2018 A revised oxygen barometry in sulfide-saturated magmas and application to the Permian magmatic Ni–Cu deposits in the southern Central Asian Orogenic BeltMineralium Deposita.  53:731-755. 2018
    2018 Timing, geochemistry and tectonic setting of Ni-Cu sulfide-associated intrusions of the Halls Creek Orogen, Western AustraliaLithos.  314-315:425-446. 2018
    2018 Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell cultureRedox Biology.  17:59-69. 2018
    2018 Ruthenium in chromite as indicator for magmatic sulfide liquid equilibration in mafic-ultramafic systemsOre Geology Reviews.  97:152-170. 2018
    2018 The Archean Fortescue large igneous province: A result of komatiite contamination by a distinct Eo-Paleoarchean crustPrecambrian Research.  310:365-390. 2018
    2018 Blade-shaped dikes and nickel sulfide deposits: A model for the emplacement of ore-bearing small intrusionsEconomic Geology.  113:789-798. 2018
    2018 Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarctionJournal of Molecular and Cellular Cardiology.  118:70-80. 2018
    2018 Textural development in sulfide-matrix ore breccias in the Aguablanca Ni-Cu deposit, Spain, revealed by X-ray fluorescence microscopyOre Geology Reviews.  95:849-862. 2018
    2018 Two distinct origins for Archean greenstone beltsEarth and Planetary Science Letters.  487:106-116. 2018
    2018 Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylationAmerican Journal of Respiratory Cell and Molecular Biology.  58:378-390. 2018
    2018 A relic of the Mozambique Ocean in south-east TanzaniaPrecambrian Research.  305:386-426. 2018
    2018 A mechanism for chromite growth in ophiolite complexes: Evidence from 3D high-resolution X-ray computed tomography images of chromite grains in Harold's Grave chromitite in the Shetland ophioliteMineralogical Magazine.  82:457-470. 2018
    2018 Absorbent materials to collect urine can affect proteomics and metabolomic biomarker concentrationsClinical Chemistry and Laboratory Medicine2018
    2018 Corrigendum to “Rapid mineralogical and geochemical characterization of the Fisher East nickel sulphide prospects, Western Australia, using hyperspectral and pXRF data” [Ore Geol. Rev. 90 (2017) 371–387]Ore Geology Reviews2018
    2018 Evaluation of a ketogenic diet for improvement of neurological recovery in individuals with acute spinal cord injury: a pilot, randomized safety and feasibility trial.Spinal Cord Series and Cases.  4:88. 2018
    2018 Introduction to the Special Issue dedicated to the work and memory of Professor Hazel Margaret Prichard (1954-2017)Mineralogical Magazine.  82:453-456. 2018
    2018 Platinum-group element and gold contents of arsenide and sulfarsenide minerals associated with Ni and Au deposits in Archean greenstone beltsMineralogical Magazine.  82:625-647. 2018
    2017 Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibitionPLoS ONE.  12. 2017
    2017 Dedication to Professor Hazel Prichard BSc, PhD, MBA (1954–2017)Geochimica et Cosmochimica Acta.  216:312-313. 2017
    2017 Genesis of the Huangshannan high-Ni tenor magmatic sulfide deposit in the Eastern Tianshan, northwest China: Constraints from PGE geochemistry and Os–S isotopesOre Geology Reviews.  90:591-606. 2017
    2017 Paragenesis of multiple platinum-group mineral populations in Shetland ophiolite chromitite: 3D X-ray tomography and in situ Os isotopesGeochimica et Cosmochimica Acta.  216:314-334. 2017
    2017 Primary stratigraphic controls on ore mineral assemblages in the Wannaway komatiite-hosted nickel-sulfide deposit, Kambalda camp, Western AustraliaOre Geology Reviews.  90:634-666. 2017
    2017 Rapid mineralogical and geochemical characterisation of the Fisher East nickel sulphide prospects, Western Australia, using hyperspectral and pXRF dataOre Geology Reviews.  90:371-387. 2017
    2017 Simplifying drill-hole domains for 3D geochemical modelling: An example from the Kevitsa Ni-Cu-(PGE) depositOre Geology Reviews.  90:388-398. 2017
    2017 Textural development in sulfide-matrix ore breccias in the Voisey's Bay Ni-Cu-Co deposit, Labrador, CanadaOre Geology Reviews.  90:414-438. 2017
    2017 Thermomechanical erosion of ore-hosting embayments beneath komatiite lava channels: Textural evidence from Kambalda, Western AustraliaOre Geology Reviews.  90:446-464. 2017
    2017 Erratum to: Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent diet: Irradiation modifies the content of animal diet (Journal of Mass Spectrometry, (2017), 52, 8, (507-516), 10.1002/jms.3950)Journal of Mass Spectrometry.  52:707. 2017
    2017 Detailed Investigation and Comparison of the XCMS and MZmine 2 Chromatogram Construction and Chromatographic Peak Detection Methods for Preprocessing Mass Spectrometry Metabolomics DataAnalytical Chemistry.  89:8689-8695. 2017
    2017 One Step Forward for Reducing False Positive and False Negative Compound Identifications from Mass Spectrometry Metabolomics Data: New Algorithms for Constructing Extracted Ion Chromatograms and Detecting Chromatographic PeaksAnalytical Chemistry.  89:8696-8703. 2017
    2017 Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent dietJournal of Mass Spectrometry.  52:507-516. 2017
    2017 Lower Levels of Cervicovaginal Tryptophan Are Associated with Natural Clearance of Chlamydia in WomenJournal of Infectious Diseases.  215:1888-1892. 2017
    2017 2.7 Ga plume associated VHMS mineralization in the Eastern Goldfields Superterrane, Yilgarn Craton: Insights from the low temperature and shallow water, Ag-Zn-(Au) Nimbus depositPrecambrian Research.  291:119-142. 2017
    2017 Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neuronsRedox Biology.  11:73-81. 2017
    2017 Magmatic sulfide ore depositsElements.  13:89-95. 2017
    2017 Origin of platinum deposits in layered intrusions by in situ crystallization: Evidence from undercutting Merensky Reef of the Bushveld ComplexJournal of Petrology.  58:715-762. 2017
    2017 Role of degassing of the Noril'sk nickel deposits in the Permian-Triassic mass extinction eventProceedings of the National Academy of Sciences.  114:2485-2490. 2017
    2017 Small molecules, both dietary and endogenous, influence the onset of lens cataractsExperimental Eye Research.  156:87-94. 2017
    2017 Sulfide-silicate textures in magmatic Ni-Cu-PGE sulfide ore deposits: Disseminated and net-textured oresAmerican Mineralogist.  102:473-506. 2017
    2017 Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemiaJournal of Leukocyte Biology.  101:531-542. 2017
    2017 Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signalingScientific Reports.  7. 2017
    2017 The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smokeAmerican Journal of Respiratory Cell and Molecular Biology.  56:99-108. 2017
    2016 Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factorsGenes and Immunity.  17:400-405. 2016
    2016 An Elevated Perspective: Dyke-Related Fracture Networks Analysed with Uav PhotogrammetryActa Geologica Sinica -Chinese Edition-.  90:54-55. 2016
    2016 Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophilsRedox Biology.  9:57-66. 2016
    2016 Interspinifex Ni sulfide ore from the coronet shoot, Kambalda: Characterization using Microbeam X-ray fluorescence mapping and 3-D X-ray computed tomographyEconomic Geology.  111:1509-1517. 2016
    2016 Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cellsFood and Function.  7:4012-4019. 2016
    2016 Review of lithogeochemical exploration tools for komatiite-hosted Ni-Cu-(PGE) depositsJournal of Geochemical Exploration.  168:1-19. 2016
    2016 A molecular and isotopic study of palaeoenvironmental conditions through the middle Cambrian in the Georgina Basin, central AustraliaEarth and Planetary Science Letters.  447:21-32. 2016
    2016 Petrogenesis and Ni-Cu sulphide potential of mafic-ultramafic rocks in the Mesoproterozoic Fraser Zone within the Albany-Fraser Orogen, Western AustraliaPrecambrian Research.  281:27-46. 2016
    2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:535-548. 2016
    2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:ii-iii. 2016
    2016 3D textural evidence for the formation of ultra-high tenor precious metal bearing sulphide microdroplets in offset reefs: An extreme example from the Platinova Reef, Skaergaard Intrusion, GreenlandLithos.  256-257:55-74. 2016
    2016 Carboxy-terminal mutations of bile acid CoA: N-acyltransferase alter activity and substrate specificityJournal of Lipid Research.  57:1133-1143. 2016
    2016 Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseJournal of Proteome Research.  15:2265-2282. 2016
    2016 The mineral system approach applied to magmatic Ni–Cu–PGE sulphide depositsOre Geology Reviews.  76:296-316. 2016
    2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  461-475. 2016
    2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  51:ii-iii. 2016
    2016 Poikilitic textures, heteradcumulates and zoned orthopyroxenes in the Ntaka Ultramafic Complex, Tanzania: Implications for crystallization mechanisms of oikocrystsJournal of Petrology.  57:1171-1198. 2016
    2016 Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imagingAJP - Renal Physiology.  310:F1136-F1147. 2016
    2016 Effect of n-3 and n-6 polyunsaturated fatty acids on microsomal P450 steroidogenic enzyme activities and in vitro cortisol production in adrenal tissue from yorkshire boarsEndocrinology.  157:1512-1521. 2016
    2016 Hydrothermal remobilisation around a deformed and remobilised komatiite-hosted Ni-Cu-(PGE) deposit, Sarah’s Find, Agnew Wiluna greenstone belt, Yilgarn Craton, Western AustraliaMineralium Deposita.  51:369-388. 2016
    2016 Primary cumulus platinum minerals in the Monts de Cristal Complex, Gabon: magmatic microenvironments inferred from high-definition X-ray fluorescence microscopyContributions to Mineralogy and Petrology.  171:1-18. 2016
    2016 Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolismFree Radical Biology and Medicine.  91:143-153. 2016
    2016 Effects of hydrous alteration on the distribution of base metals and platinum group elements within the Kevitsa magmatic nickel sulphide depositOre Geology Reviews.  72:128-148. 2016
    2016 Evidence of lateral thermomechanical erosion of basalt by Fe-Ni-Cu sulfide melt at Kambalda, Western AustraliaGeology.  44:1047-1050. 2016
    2016 Trafficking and function of the cystic fibrosis transmembrane conductance regulator: A complex network of posttranslational modificationsAJP - Lung Cellular and Molecular Physiology.  311:L719-L733. 2016
    2015 Dynamics of magmatic sulphide droplets during transport in silicate melts and implications for magmatic sulphide ore formationJournal of Petrology.  56:2445-2472. 2015
    2015 Cholesterol-independent suppression of lymphocyte activation, autoimmunity, and glomerulonephritis by apolipoprotein A-I in normocholesterolemic lupus-prone miceJournal of Immunology.  195:4685-4698. 2015
    2015 Evolution of a ~2.7Ga large igneous province: A volcanological, geochemical and geochronological study of the Agnew Greenstone Belt, and new regional correlations for the Kalgoorlie Terrane (Yilgarn Craton, Western Australia)Precambrian Research.  270:334-368. 2015
    2015 Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseasesClinical Epigenetics.  7. 2015
    2015 Platinum group elements in mantle melts and mantle samplesLithos.  232:395-417. 2015
    2015 A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: application to small vertebrate lens imagingFresenius' Journal of Analytical Chemistry.  407:2311-2320. 2015
    2015 Peroxiredoxin-2 recycling is inhibited during erythrocyte storageAntioxidants and Redox Signaling.  22:294-307. 2015
    2015 Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor CellsJournal of Neuropathology and Experimental Neurology.  74:568-586. 2015
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
    2015 Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: A randomized crossover trial<sup>1,2</sup>American Journal of Clinical Nutrition.  102:695-703. 2015
    2015 Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarctionAJP - Heart and Circulatory Physiology.  308:H269-H280. 2015
    2014 Fecal bacterial community changes associated with isoflavone metabolites in postmenopausal women after soy bar consumptionPLoS ONE.  9. 2014
    2014 Improved high sensitivity analysis of polyphenols and their metabolites by nano-liquid chromatography-mass spectrometryArchives of Biochemistry and Biophysics.  559:3-11. 2014
    2014 Dietary acrylamide and human cancer: A systematic review of literatureNutrition and Cancer.  66:774-790. 2014
    2014 Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (Dietary versus Intestinal Production) in ovariectomized ratsJournal of Agricultural and Food Chemistry.  62:1294-1300. 2014
    2014 S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsyNutrition Research.  34:116-125. 2014
    2014 Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membraneOncotarget.  5:1382-1389. 2014
    2014 Is midtrimester vitamin D status associated with spontaneous preterm birth and preeclampsia?American Journal of Perinatology.  31:541-546. 2014
    2014 Petrogenesis of the ~2.77 ga Monts de Cristal complex, Gabon: Evidence for direct precipitation of Pt-arsenides from basaltic magmaJournal of Petrology.  56:285-1308. 2014
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cellsAJP - Endocrinology and Metabolism.  305. 2013
    2013 Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cellsAJP - Renal Physiology.  305. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Utility of prehospital quantitative end tidal CO2?Prehospital and Disaster Medicine.  28:87-93. 2013
    2013 Nitration of Hsp90 induces cell deathProceedings of the National Academy of Sciences.  110. 2013
    2013 MRMPath and MRMutation, facilitating discovery of mass transitions for proteotypic peptides in biological pathways using a bioinformatics approachAdvances in Bioinformatics.  2013. 2013
    2013 Isoflavone metabolism in domestic cats (Felis catus): Comparison of plasma metabolites detected after ingestion of two different dietary forms of genistein and daidzeinJournal of Animal Science.  91:1295-1306. 2013
    2013 Temporal patterns of tyrosine nitration in embryo heart developmentFree Radical Biology and Medicine.  55:101-108. 2013
    2013 Simultaneous quantification of F2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometryJournal of chromatography. B, Biomedical sciences and applications.  913-914:161-168. 2013
    2013 Effect of soy isoflavone supplementation on menopausal quality of lifeMenopause.  20:443-447. 2013
    2013 In nutrition, can we 'see' what is good for us?Advances in Nutrition.  4. 2013
    2013 Ovariectomy lowers urine levels of unconjugated (+)-catechin, (-)-epicatechin, and their methylated metabolites in rats fed grape seed extractHormone Molecular Biology and Clinical Investigation.  16:129-138. 2013
    2013 Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouseRedox Biology.  1:381-386. 2013
    2012 A chain reaction approach to modelling gene pathwaysTranslational cancer research.  1:61-73. 2012
    2012 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acidInfection and Immunity.  80:2528-2537. 2012
    2012 Effect of soy isoflavone supplementation on nitric oxide metabolism and blood pressure in menopausal womenAmerican Journal of Clinical Nutrition.  95:1487-1494. 2012
    2012 The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular functionAntioxidants and Redox Signaling.  17:1580-1589. 2012
    2012 Purification of CFTR for mass spectrometry analysis: Identification of palmitoylation and other post-translational modificationsProtein Engineering -Oxford-.  25:7-14. 2012
    2011 Dietary isoflavone absorption, excretion, and metabolism in captive cheetahs (Acinonyx jubatus)Journal of Zoo and Wildlife Medicine.  42:658-670. 2011
    2011 Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemiaBlood.  118:4902-4909. 2011
    2011 Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effectsMenopause.  18:923-931. 2011
    2011 Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brainPLoS ONE.  6. 2011
    2011 The role of soy isoflavones in menopausal health: Report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010)Menopause.  18:732-753. 2011
    2011 Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometryJournal of Agricultural and Food Chemistry.  59:6682-6688. 2011
    2011 Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy: Kang X, Zhang Q, Wang S, et al (Cancer Hosp of Harbin Med Univ, China) CMAJ 182:1857-1862, 2010Breast Diseases.  22:184-185. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrinInfection and Immunity.  79:2440-2450. 2011
    2011 Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteersJournal of Clinical Anesthesia.  23:218-223. 2011
    2011 The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systemsFood and Function.  2:235-244. 2011
    2011 Clinical outcomes of a 2-y soy isoflavone supplementation in menopausal womenAmerican Journal of Clinical Nutrition.  93:356-367. 2011
    2011 Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f ratExperimental Eye Research.  92:120-127. 2011
    2010 Isoflavones and PPAR signaling: A critical target in cardiovascular, metastatic, and metabolic diseasePPAR Research2010
    2010 Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: Potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescueAmerican Journal of Respiratory Cell and Molecular Biology.  43:607-616. 2010
    2010 xxCredit where credit is dueScientist -Philadelphia-.  24. 2010
    2010 Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/F Rat lensesInvestigative Ophthalmology & Visual Science.  51:5153-5161. 2010
    2010 Role of phytoestrogens in cancer therapyPlanta Medica.  76:1132-1142. 2010
    2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognitionJournal of Biological Chemistry.  285:20860-20869. 2010
    2010 Cautions and research needs identified at the equol, soy, and menopause research leadership conferenceJournal of Nutrition.  140. 2010
    2010 The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J miceObesity Research.  18:995-999. 2010
    2010 Simultaneous determination of 11 phytoestrogens in human serum using a 2 min liquid chromatography/tandem mass spectrometry methodJournal of chromatography. B, Biomedical sciences and applications.  878:994-1002. 2010
    2010 The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food productsLymphatic Research and Biology.  8:89-98. 2010
    2010 A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzein as a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathwayJournal of Neuroscience.  30:739-748. 2010
    2010 A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomesMolecular Therapy.  18:1606-1614. 2010
    2009 Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiencyLaboratory Investigation.  89:1348-1354. 2009
    2009 Soy isoflavone supplementation and bone mineral density in menopausal women: A 2-y multicenter clinical trialAmerican Journal of Clinical Nutrition.  90:1433-1439. 2009
    2009 Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized ratsJournal of Nutrition.  139:1908-1913. 2009
    2009 Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive ratsJournal of Agricultural and Food Chemistry.  57:7268-7273. 2009
    2009 Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extractPhytomedicine.  16:233-243. 2009
    2009 Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using 41Ca methodologyJournal of Clinical Endocrinology and Metabolism.  94:3798-3805. 2009
    2009 Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometryPhytomedicine.  16:65-71. 2009
    2008 A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serumJournal of chromatography. B, Biomedical sciences and applications.  876:219-224. 2008
    2008 The metal-rich portions of the phase system Cu-Fe-Pd-S at 1000°C, 900°C and 725°C: Implications for mineralization in the Skaergaard intrusionMineralogical Magazine.  72:941-951. 2008
    2008 2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomesJournal of Proteome Research.  7:4638-4650. 2008
    2008 Nutritional Genomics, Polyphenols, Diets, and Their Impact on DieteticsJournal of The American Dietetic Association.  108:1888-1895. 2008
    2008 Proteomic analysis of mouse hypothalamus under simulated microgravityNeurochemical Research.  33:2335-2341. 2008
    2008 High-resolution mass spectrometry analysis of protein oxidations and resultant loss of functionBiochemical Society Transactions.  36:1037-1044. 2008
    2008 Effect of cranberry juice concentrate on chemically-induced urinary bladder cancersOncology Reports.  19:1565-1570. 2008
    2008 Evaluating statistical methods using plasmode data sets in the age of massive public databases: An illustration using false discovery ratesPLoS Genetics.  4. 2008
    2008 Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenalJournal of Lipid Research.  49:282-294. 2008
    2008 UV-A-induced structural and functional changes in human lens deamidated αB-crystallinMolecular Vision.  14:234-248. 2008
    2008 Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductasesBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1781:16-25. 2008
    2007 Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal womenFertility and Sterility.  88:1609-1617. 2007
    2007 Metabolism and bioavailability of flavonoids in chemoprevention: Current analytical strategies and future prospectusMolecular Pharmaceutics.  4:846-864. 2007
    2007 Active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: Mapping of modified sites by fourier transform-ion cyclotron resonance mass spectrometryChemical Research in Toxicology.  20:1260-1268. 2007
    2007 Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicityBiochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1773:1116-1123. 2007
    2007 Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liverJournal of Lipid Research.  48:1305-1315. 2007
    2007 2D gel proteomics: An approach to study age-related differences in protein abundance or isoform complexity in biological samplesMethods in Molecular Biology.  371:349-391. 2007
    2007 Assessment of dietary isoflavone intake among middle-aged Chinese menJournal of Nutrition.  137:1011-1016. 2007
    2007 Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometryBiomedical Chromatography.  21:410-414. 2007
    2007 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 Cells by tyrosine-containing peptidesJournal of Biological Chemistry.  282:6324-6337. 2007
    2007 Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARγJournal of Nutrition.  137:351-356. 2007
    2007 Identification of isoflavone glycosides in pueraria lobata cultures by tandem mass spectrometryPhytochemical Analysis.  18:50-59. 2007
    2007 Soy isoflavones do not affect bone resorption in postmenopausal women: A dose-response study using a novel approach with41CaJournal of Clinical Endocrinology and Metabolism.  92:577-582. 2007
    2006 Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female ratsJournal of Nutrition.  136:2975-2979. 2006
    2006 In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomicsProteomics.  6:5805-5814. 2006
    2006 Mass spectrometric proteomics profiles of in vivo tumor secretomes: Capillary ultrafiltration sampling of regressive tumor massesProteomics.  6:6107-6116. 2006
    2006 In the postgenomic era, can high-dimensional analyses deliver the answers we're looking for?Journal of Nutrition.  136. 2006
    2006 Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplementsLife Sciences.  78:2054-2059. 2006
    2006 Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compoundsLife Sciences.  78:2060-2065. 2006
    2006 In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomicsChromatographic reviews.  1109:144-151. 2006
    2006 Proteomic analysis of mice hippocampus in simulated microgravity environmentJournal of Proteome Research.  5:548-553. 2006
    2006 Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomicsMolecular and Cellular Proteomics.  5:523-532. 2006
    2006 A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stressFree Radical Biology and Medicine.  40:459-468. 2006
    2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell functionJournal of Immunology.  176:1375-1385. 2006
    2006 Reliability and validity of an assessment of usual phytoestrogen consumption (United States)Cancer Causes and Control.  17:85-93. 2006
    2006 A proposed metric for assessing the measurement quality of individual microarraysBMC Bioinformatics.  7. 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisArthritis and Rheumatism.  54:343-355. 2006
    2005 Contrasting effects of puerarin and daidzin on glucose homeostasis in miceJournal of Agricultural and Food Chemistry.  53:8760-8767. 2005
    2005 The case for strategic international alliances to harness nutritional genomics for public and personal healthBritish Journal of Nutrition.  94:623-632. 2005
    2005 Prospective highlights of functional skin proteomicsMass Spectrometry Reviews.  24:647-660. 2005
    2005 Sources of variation in Affymetrix microarray experimentsBMC Bioinformatics.  6. 2005
    2005 Revealing anti-inflammatory mechanisms of soy isoflavones by flow: Modulation of leukocyte-endothelial cell interactionsAJP - Heart and Circulatory Physiology.  289. 2005
    2005 Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation productsJournal of Mass Spectrometry.  40:916-923. 2005
    2005 Induction of cell proliferation, micronuclei and hyperdiploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal ratsEnvironmental and Molecular Mutagenesis.  46:43-52. 2005
    2005 Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in Caucasian menJournal of Nutrition.  135:1400-1406. 2005
    2005 Comparative effect of soy protein, soy isoflavones, and 17β-estradiol on bone metabolism in adult ovariectomized ratsJournal of Bone and Mineral Research.  20:828-839. 2005
    2005 Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain?International Journal of Obesity.  29:443-446. 2005
    2005 Bile acid coenzyme A: Amino acid N-acyltransferase in the amino acid conjugation of bile acidsMethods in Enzymology.  400:374-394. 2005
    2005 Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids.Methods in Enzymology.  400:374-394. 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsAmerican Journal of Pathology.  167:705-719. 2005
    2005 Current progress in the use of traditional medicines and nutraceuticalsCurrent Opinion in Plant Biology.  8:324-328. 2005
    2005 Metabolism of phytoestrogen conjugatesMethods in Enzymology.  400:316-342. 2005
    2005 Synthesis of bile acid coenzyme A thioesters in the amino acid conjugation of bile acidsMethods in Enzymology.  400:360-373. 2005
    2004 Proteomics analysis of rat brain protein modulations by grape seed extractJournal of Agricultural and Food Chemistry.  52:7872-7883. 2004
    2004 Excitement and realities in microarray analysis of the biological effects of polyphenolsPharmaceutical Biology.  42:94-101. 2004
    2004 Mass spectrometric methods for the determination of flavonoids in biological samplesFree Radical Biology and Medicine.  37:1324-1350. 2004
    2004 Modification of cytochrome c by 4-hydroxy-2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adductsJournal of The American Society for Mass Spectrometry.  15:1136-1147. 2004
    2004 Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometryJournal of Agricultural and Food Chemistry.  52:3708-3712. 2004
    2004 Inulin Effects on Bioavailability of Soy Isoflavones and Their Calcium Absorption Enhancing AbilityJournal of Agricultural and Food Chemistry.  52:2827-2831. 2004
    2004 Dietary Phytoestrogens Increase Metabolic Resistance (Cold Tolerance) in Long-Chain Acyl-CoA Dehydrogenase-Deficient MiceJournal of Nutrition.  134:1028-1031. 2004
    2004 Soy Isoflavones-Phytoestrogens and What Else?Journal of Nutrition.  134. 2004
    2004 Nutriproteomics: Identifying the molecular targets of nutritive and non-nutritive components of the dietBMB Reports.  37:59-74. 2004
    2004 Foreword from the editorsNutrition.  20:1. 2004
    2004 Individual differences in the response to ingested nutrients.Nutrition.  20:1. 2004
    2004 Proteomics and mass spectrometry in nutrition researchNutrition.  20:155-165. 2004
    2003 Erratum: Identification of Novel Interactions in HIV-1 Capsid Protein Assembly by High-resolution Mass Spectrometry (Journal of Molecular Biology (2003) 325 (759-772))Journal of Molecular Biology.  334:1133. 2003
    2003 Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant propertiesFree Radical Biology and Medicine.  35:1417-1430. 2003
    2003 Rat liver bile acid CoA:amino acid N-acyltransferase: Expression, characterization, and peroxisomal localizationJournal of Lipid Research.  44:2242-2249. 2003
    2003 Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitriteBiochemistry.  42:9906-9914. 2003
    2003 Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometryJournal of Agricultural and Food Chemistry.  51:4213-4218. 2003
    2003 DING, a genistein target in human breast cancer: a protein without a gene.Journal of Nutrition.  133:2497S-2501S. 2003
    2003 Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: A novel class of biological metabolitesJournal of Mass Spectrometry.  38:764-771. 2003
    2003 Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerizationJournal of Biological Chemistry.  278:4194-4204. 2003
    2003 Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometryJournal of Molecular Biology.  325:759-772. 2003
    2003 A design and statistical perspective on microarray gene expression studies in nutrition: The need for playful creativity and scientific hard-mindednessNutrition.  19:997-1000. 2003
    2003 Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoidsJournal of Allergy and Clinical Immunology.  112:1064-1071. 2003
    2002 Conserved residues in the putative catalytic triad of human bile acid coenzyme A:Amino acid N-acyltransferaseJournal of Biological Chemistry.  277:47270-47275. 2002
    2002 Bromination, Chlorination, and Nitration of IsoflavonoidsACS Symposium Series.  807:251-261. 2002
    2002 Molecular cloning and expression of rat liver bile acid CoA ligaseJournal of Lipid Research.  43:2062-2071. 2002
    2002 High throughput two-dimensional blue-native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexesProteomics.  2:969-977. 2002
    2002 High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes.Proteomics.  2:969-977. 2002
    2002 Effect of soy protein on endogenous hormones in postmenopausal womenAmerican Journal of Clinical Nutrition.  75:145-153. 2002
    2002 Review of the methods used in the determination of phytoestrogensJournal of chromatography. B, Biomedical sciences and applications.  777:3-28. 2002
    2001 Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavengingFree Radical Biology and Medicine.  31:1570-1581. 2001
    2001 Novel fatty acid esters of p-coumaryl alcohol in epicuticular wax of apple fruitJournal of Agricultural and Food Chemistry.  49:3787-3792. 2001
    2001 Heterogeneity of O-glycosylation in the hinge region of human IgA1Molecular Immunology.  37:1047-1056. 2001
    2001 Soy isoflavonoids and cancer - Metabolism at the target siteMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  480-481:121-127. 2001
    2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
    2001 Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta.Biochemical Society Transactions.  29:216-222. 2001
    2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-444. 2001
    2001 Hydrogen-deuterium exchange as a probe of folding and assembly in viral capsidsJournal of Molecular Biology.  306:389-396. 2001
    2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
    2001 Oestrogens and their promiscuous receptors: Confronting realityBiochemical Society Transactions.  29:231-236. 2001
    2001 Re-Os isotopic study of komatiitic volcanism and magmatic sulfide formation in the Southern Abitibi Greenstone Belt, Ontario, CanadaCanadian Mineralogist.  39:473-490. 2001
    2001 Role of phytochemicals in prevention and treatment of prostate cancerEpidemiologic Reviews.  23:102-105. 2001
    2001 The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigenJournal of Urology, The.  165:294-300. 2001
    2000 Retention and changes of soy isoflavones and carotenoids in immature soybean seeds (edamame) during processingJournal of Agricultural and Food Chemistry.  48:6061-6069. 2000
    2000 The role of isoflavones in menopausal health: Consensus opinion of the North American Menopause SocietyMenopause.  7:215-229. 2000
    2000 Biochemical structural analysis of the lantibiotic mutacin IIJournal of Biological Chemistry.  275:15845-15850. 2000
    2000 Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/α-tocopherol than α-tocopherol/ascorbateJournal of Biological Chemistry.  275:10812-10818. 2000
    2000 Beyond ERα and ERβ: Estrogen receptor binding is only part of the isoflavone storyJournal of Nutrition.  130. 2000
    2000 The enzymatic formation of novel bile acid primary amidesArchives of Biochemistry and Biophysics.  374:107-117. 2000
    2000 Assessing phytoestrogen exposure in epidemiologic studies: Development of a database (United States)Cancer Causes and Control.  11:289-298. 2000
    2000 Isoflavonoids and chronic disease: Mechanisms of actionBioFactors.  12:209-215. 2000
    1999 Chlorination and nitration of soy isoflavonesArchives of Biochemistry and Biophysics.  368:265-275. 1999
    1999 Antioxidant properties of phytoestrogensJournal of Medicinal Food.  2:163-166. 1999
    1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ionChemical Research in Toxicology.  12:83-92. 1999
    1998 Tyrosine kinase inhibitor effects on avian osteoclastic acid transport.American Journal of Clinical Nutrition.  68:1369S-1374S. 1998
    1998 Nitration of unsaturated fatty acids by nitric oxide-derived reactive speciesMethods in Enzymology.  301:454-470. 1998
    1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
    1998 Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategyApplied and Environmental Microbiology.  64:2335-2340. 1998
    1998 Evolution of the health benefits of soy isoflavonesProceedings of the Society for Experimental Biology and Medicine.  217:386-392. 1998
    1998 Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in ratsProceedings of the Society for Experimental Biology and Medicine.  217:358-364. 1998
    1998 HPLC-mass spectrometry analysis of isoflavonesProceedings of the Society for Experimental Biology and Medicine.  217:254-262. 1998
    1998 Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.American Journal of Clinical Nutrition.  68:1418S-1425S. 1998
    1998 Phytoestrogens and breast cancerBaillieres Clinical Endocrinology and Metabolism.  12:559-579. 1998
    1997 Characterization of purified bile acid coenzyme A synthetase (BAS) from rat liver microsomesFederation proceedings.  11. 1997
    1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
    1997 Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomesArchives of Biochemistry and Biophysics.  348:15-24. 1997
    1997 Structure and activity of the lantibiotic mutacin II. Evidence for two domains?Protein Engineering -Oxford-.  10:87. 1997
    1997 The chemopreventive properties of soy isoflavonoids in animal models of breast cancerBreast Cancer Research and Treatment.  46:169-179. 1997
    1997 Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-LJournal of Neurochemistry.  69:1945-1953. 1997
    1997 Intestinal uptake and biliary excretion of the isoflavone genistein in ratsJournal of Nutrition.  127:1260-1268. 1997
    1997 Cloning, expression, and chromosomal localization of mouse liver bile acid CoA:amino acid N-acyltransferaseJournal of Lipid Research.  38:1139-1148. 1997
    1997 Urinary phytoestrogen levels in young women from a multiethnic populationCancer Epidemiology, Biomarkers and Prevention.  6:339-345. 1997
    1997 Phyto-oestrogens and breast cancerLancet.  350:971-972. 1997
    1996 Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cellsCell Growth and Differentiation.  7:1345-1351. 1996
    1996 Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal womenCancer Epidemiology, Biomarkers and Prevention.  5:785-794. 1996
    1996 Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in ratsCarcinogenesis.  17:1451-1457. 1996
    1996 Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized ratsJournal of Cellular Biochemistry.  61:629-637. 1996
    1996 Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats.Journal of Cellular Biochemistry.  61:629-637. 1996
    1996 Detection of modified amino acids in lantibiotic peptide mutacin II by chemical derivatization and electrospray ionization-mass spectroscopic analysisAnalytical Biochemistry.  236:358-360. 1996
    1996 Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometryClinica Chimica Acta.  247:121-142. 1996
    1996 Peroxynitrite-dependent tryptophan nitrationChemical Research in Toxicology.  9:390-396. 1996
    1996 Selective detection and site-analysis of O-GlcNAc-modified glycopeptides by β-elimination and tandem electrospray mass spectrometryAnalytical Biochemistry.  234:38-49. 1996
    1996 The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin ACarcinogenesis.  17:1861-1869. 1996
    1995 Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: Termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivativesArchives of Biochemistry and Biophysics.  324:15-25. 1995
    1995 Genistein suppresses mammary cancer in ratsCarcinogenesis.  16:2833-2840. 1995
    1995 Antioxidant and Antipromotional Effects of the Soybean Isoflavone GenisteinProceedings of the Society for Experimental Biology and Medicine.  208:124-130. 1995
    1995 Biochemical Targets of the Isoflavone Genistein in Tumor Cell LinesProceedings of the Society for Experimental Biology and Medicine.  208:103-108. 1995
    1995 Imaging biliary lipid secretion in the rat: Ultrastructural evidence for vesiculation of the hepatocyte canalicular membraneJournal of Lipid Research.  36:2147-2163. 1995
    1995 Neonatal Genistein Chemoprevents Mammary CancerProceedings of the Society for Experimental Biology and Medicine.  208:120-123. 1995
    1995 Rationale for the use of genistein‐containing soy matrices in chemoprevention trials for breast and prostate cancerJournal of Cellular Biochemistry.  59:181-187. 1995
    1994 Isoflavones and Their Conjugates in Soy Foods: Extraction Conditions and Analysis by HPLC-Mass SpectrometryJournal of Agricultural and Food Chemistry.  42:2466-2474. 1994
    1994 Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N- acyltransferaseJournal of Biological Chemistry.  269:19375-19379. 1994
    1994 Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivativesJournal of Biological Chemistry.  269:26066-26075. 1994
    1994 Potential role of dietary isoflavones in the prevention of cancerAdvances in Experimental Medicine and Biology.  354:135-147. 1994
    1994 Role of bile salt hydrophobicity in hepatic microtubule-dependent bile salt secretionJournal of Lipid Research.  35:1738-1748. 1994
    1994 Soy intake and cancer risk: A review of the in vitro and in vivo dataNutrition and Cancer.  21:113-131. 1994
    1994 Ultrastructural localization of a fluorinated bile salt in hepatocytesLaboratory Investigation.  71:42-51. 1994
    1993 Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylationProstate.  22:335-345. 1993
    1993 Genistein, Daidzein, and Their β-Glycoside Conjugates: Antitumor Isoflavones in Soybean Foods from American and Asian DietsJournal of Agricultural and Food Chemistry.  41:1961-1967. 1993
    1993 Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin.Anticancer Research.  13:229-236. 1993
    1993 Identification of bile acid coenzyme A synthetase in rat kidneyJournal of Lipid Research.  34:95-99. 1993
    1993 Inhibition of tumor promoter-Induced hydrogen peroxide formation in vitro and in vivo by genisteinNutrition and Cancer.  20:1-12. 1993
    1993 Purification and Properties of a Human Platelet Inositol 1,4,5-Trisphosphate 3-KinaseArchives of Biochemistry and Biophysics.  303:412-420. 1993
    1992 Bioactivation of 7‐hydroxymethyl‐12‐ methyibenz[a]anthracene by rat liver bile acid sulfotransferase IJournal of biochemical toxicology.  7:241-248. 1992
    1992 Clinical apnea as an early manifestation of Pneumocystis carinii pneumonia in an infant with perinatal HIV-1 infection.Journal of the National Medical Association.  84:79-80. 1992
    1992 Differential intestinal deconjugation of taurine and glycine bile acid N- acyl amidates in ratsAmerican Journal of Physiology.  262. 1992
    1992 Distribution of sulphides and pge within the porphyritic websterite zone of the Munni Munni Complex, Western AustraliaAustralian Journal of Earth Sciences.  39:289-302. 1992
    1992 Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats. Potential relevance to toxicity pattern of 5-fluorouracilDrug Metabolism and Disposition.  20:113-119. 1992
    1991 Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance geneBiochemical and Biophysical Research Communications.  179:661-667. 1991
    1991 Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liverJournal of Biological Chemistry.  266:10227-10233. 1991
    1991 The role of soy products in reducing risk of cancerJNCI: Journal of the National Cancer Institute.  83:541-546. 1991
    1991 Disposition and metabolism of 2-fluoro-β-alanine conjugates of bile acids following secretion into bileBBA - Molecular Basis of Disease.  1096:179-186. 1991
    1991 A comparative study of bile acid CoA:Amino acid:N-acyltransferase (BAT) from four mammalian speciesComparative Biochemistry and Physiology - B: Comparative Biochemistry.  100:131-136. 1991
    1991 Bile Acid Conjugation Pattern in the Isolated Perfused Rat Liver During Infusion of an Amino Acid FormulationJournal of Parenteral and Enteral Nutrition.  15:303-306. 1991
    1991 Identification of bile acid-CoA:amino acid N-acyltransferase in rat kidneyBiochemical Journal.  280:821-824. 1991
    1990 2-Fluoro-β-alanine, a previously unrecognized substrate for bile acid coenzyme A:Amino acid:N-acyltransferase from human liverBiochemical Pharmacology.  40:1241-1246. 1990
    1990 Phosphorylation by protein kinase C inactivates an inositol 1,4,5-trisphosphate 3-kinase purified from human plateletsBiochemical and Biophysical Research Communications.  170:1371-1376. 1990
    1990 Biological properties of the 2-fluoro-β-alanine conjugates of cholic acid and chenodeoxycholic acid in the isolated perfused rat liverBiochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1054:21-25. 1990
    1990 Soybeans inhibit mammary tumors in models of breast cancer.Progress in clinical and biological research.  347:239-253. 1990
    1989 Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedureAnalytical Biochemistry.  182:360-365. 1989
    1989 Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: Purification, N-terminal amino acid sequence, and kinetic propertiesJournal of Lipid Research.  30:529-540. 1989
    1988 Formation of Conjugates of 2-Fluoro-β-alanine and Bile Acids during the Metabolism of 5-Fluorouracil and 5-Fluoro-2-deoxyuridine in the Isolated Perfused Rat LiverCancer Research.  48:2010-2014. 1988
    1987 Enantiomeric composition analysis of amphetamine and methamphetamine by chiral phase high-performance liquid chromatography-mass spectrometryChromatographic reviews.  398:239-246. 1987
    1987 Metabolism of 5-flourouracil to an N-cholyl-2-fluoro-β-alanine conjugate: Previously unrecognized role for bile acids in drug conjugationProceedings of the National Academy of Sciences.  84:5439-5443. 1987
    1987 Structure of the Dysprosium-Glycocholate Complex in Submicellar Aqueous Solution: Paramagnetic Mapping by Proton Nuclear Magnetic Resonance Spectroscopy. An Approximation for the Intrinsic “Bound” Relaxation Rates in the Case of Nondilute Paramagnetic SystemsBiochemistry.  26:6785-6792. 1987
    1986 Evidence for an ordered reaction mechanism for bile salt:3'phosphoadenosine-5'-phosphosulfate: Sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholateJournal of Lipid Research.  27:1111-1123. 1986
    1986 Biologic properties of cell lines derived from canine mammary carcinomasJNCI: Journal of the National Cancer Institute.  77:783-792. 1986
    1986 NMR Studies of the Binding of Sodium and Calcium Ions to the Bile Salts Glycocholate and Taurocholate in Dilute Solution, as Probed by the Paramagnetic Lanthanide DysprosiumJournal of the American Chemical Society.  108:7082-7089. 1986
    1985 Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5β-cholanoic acidJournal of Lipid Research.  26:1068-1078. 1985
    1984 Aggregation patterns of bile salts: Crystal structure of calcium cholate chloride heptahydrateJournal of Lipid Research.  25:791-798. 1984
    1984 Autonomous cholesterol biosynthesis in murine hepatoma. A receptor defect with normal coated pitsCancer.  54:1562-1568. 1984
    1984 Bile Salt Micelles: Nuclear Magnetic Resonance Spectroscopy and Crystallographic StudiesHepatology.  4:98S-102S. 1984
    1983 Alkaline butanol extraction of bile salt and steroid sulfate esters: Application to the assay of sulfotransferasesAnalytical Biochemistry.  133:470-475. 1983
    1982 Flash heater derivatization of unconjugated bile acids using trimethylanilinium hydroxide. Rapid analysis by capillary gas-liquid chromatographyJournal of Chromatography - Biomedical Applications.  231:155-160. 1982
    1982 Evidence for heterogeneity of hepatic bile salt sulfotransferases in female hamsters and ratsBBA - Proteins and Proteomics.  704:353-360. 1982
    1982 High resolution nuclear magnetic resonance spectroscopy of bile salts: individual proton assignments for sodium cholate in aqueous solution at 400 MHzJournal of Lipid Research.  23:161-170. 1982
    1982 Streptozotocin-induced diabetes stimulates bile salt sulfation in male ratsGastroenterology.  82:1013. 1982
    1981 Syndromatic hepatic ductular hypoplasia (arteriohepatic dysplasia) - A clinical and hepatic histologic study of three patientsDigestive Diseases and Sciences.  26:485-497. 1981
    1981 EFFECTS OF SPIRONOLACTONE ON SERUM BILE ACIDSClinical and Experimental Pharmacology and Physiology.  8:87-88. 1981
    1981 Postnatal physiologic hypercholemia in both premature and full-term infantsJournal of Clinical Investigation.  68:775-782. 1981
    1980 Improved enzymatic assays for bile acids using resazurin and nadh oxidoreductase from Clostridium kluyveriClinica Chimica Acta.  102:241-245. 1980
    1980 Determination of the pool size and synthesis rate of bile acids by measurements in blood of patients with liver diseaseClinical Science.  58:485-492. 1980
    1980 Preparation and characterisation of permethylated derivatives of bile acids, and their application to gas chromatographic analysisJournal of Chromatography - Biomedical Applications.  183:269-276. 1980
    1980 Stoichiometry of the nadh-oxidoreductase reaction for dehydrogenase determinationsClinica Chimica Acta.  107:149-154. 1980
    1979 Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamstersJournal of Lipid Research.  20:952-959. 1979
    1979 Modification of d-galactosamine-induced liver injury in the rat by spironolactonePharmacology.  18:235-240. 1979
    1979 Radiolabeled bile acid clearance in control subjects and patients with liver diseaseClinical Science.  57:499-508. 1979
    1979 The effect of bile duct ligation on hepatic bile acid sulfotransferase activity in the hamsterBiochemical medicine.  22:165-174. 1979
    1978 Bile acids in portal bloodGastroenterology.  74:964-965. 1978
    1978 Serum disappearance of cholylglycine (CG)Gastroenterology.  74:1006. 1978
    1977 A simplified procedure for the isolation of bile acids from serum based on a batch extraction with the non ionic resin Amberlite XAD 7Annals of Clinical Biochemistry.  14:235-239. 1977
    1977 Evidence for renal control of urinary excretion of bile acids and bile acid sulphates in the cholestatic syndromeClinical science and molecular medicine.  52:51-65. 1977
    1977 Assessment of the plasma disappearance of cholyl-l-14C-glycine as a test of hepatocellular diseaseGut.  18:697-702. 1977
    1977 Bile acids in liver disease associated with inflammatory bowel diseaseDigestion.  15:469-481. 1977
    1977 The role of tubular reabsorption in the renal excretion of bile acidsBiochemical Journal.  166:65-73. 1977
    1976 Effect of Fasting and lleal Resection on the Concentration of Deoxycholic Acid in Rat Portal BloodProceedings of the Society for Experimental Biology and Medicine.  152:292-297. 1976
    1975 Bile acid metabolism in chronic bowel disease: determinations in gallbladder bile, portal blood, and peripheral bloodGut.  16:393-394. 1975
    1975 Diagnostic value of serum bile acid estimations in liver diseaseJournal of Clinical Pathology.  28:506-509. 1975
    1973 Proceedings: The diagnostic value of postprandial bile salt estimations in patients with liver disease.Gut.  14:819. 1973
    1973 Total and unconjugated bile acids in rat portal blood following intestinal resection.Clinical Science.  45. 1973

    Chapter

    Year Title Altmetric
    2013 Uptake and Metabolism of Dietary Proanthocyanidins.  553-560. 2013
    2009 Recent advances in traditional medicines and dietary supplements.  533-546. 2009
    2006 Soy Isoflavones.  559-571. 2006
    2006 Genistein and Polyphenols in the Study of Cancer Prevention: Chemistry, Biology, Statistics, and Experimental Design.  305-329. 2006
    2005 Nutriproteomics approach to understanding dementia-relevant brain protein changes in response to grape seed extract, a dietary antioxidant.  457-480. 2005
    2004 Proteomics: Examining the effects of processing on food proteins.  483-516. 2004
    2003 The importance of in vivo metabolism of polyphenols and their biological actions.  51-59. 2003

    Research Overview

  • I have had a longstanding interest in metabolism and enzymology and the enterohepatic circulation of endogenous and exogenous metabolites. Because of early training in hepatobiliary diseases, this led to studies on bile acid metabolism and purification of the enzymes catalyzing their formation. A second strong area of research has been the roles of polyphenols in health and disease, with a particular emphasis on soy isoflavones. Over the past decade, I have been pursuing the basis of lens cataract formation in the lens. An overarching theme for these research areas has been the pathways of metabolism and the utilization of mass spectrometry for their study. This had led to a strong interest in metabolomics and training in this re-emerging discipline.
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Imperial College London 1972
  • Bachelor's Level Degree in Chemistry, University of Surrey 1967
  • Full Name

  • Stephen Barnes
  • Fax

  • 205-934-6944