Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The AAA + ATPase Thorase is neuroprotective against ischemic injuryJournal of Cerebral Blood Flow and Metabolism.  39:1836-1848. 2019
2019 SULT4A1 protects against oxidative-stress induced mitochondrial dysfunction in neuronal cellsDrug Metabolism and Disposition.  47:949-953. 2019
2018 Short communication generation and characterization of SULT4A1 mutant mouse modelsDrug Metabolism and Disposition.  46:41-45. 2018
2017 Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by PerampanelScience Translational Medicine.  9. 2017
2017 Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosisJournal of Cerebral Blood Flow and Metabolism.  37:1982-1993. 2017
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1Science.  354. 2016
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1Science.  354. 2016
2016 LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicityJournal of Chemical Neuroanatomy.  76:90-97. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 High-content genome-wide rnai screen reveals ccr3 as a key mediator of neuronal cell deatheNeuro.  3. 2016
2016 PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasisCancer Research.  76:4430-4442. 2016
2016 Adult conditional knockout of PGC-1α leads to loss of dopamine neuronseNeuro.  3. 2016
2015 Parkin loss leads to Paris-dependent declines in mitochondrial mass and respirationProceedings of the National Academy of Sciences.  112:11696-11701. 2015
2014 Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteinsEMBO Journal.  33:1548-1564. 2014
2014 Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysisProceedings of the National Academy of Sciences.  111:10209-10214. 2014
2014 Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in parkinson's diseaseCell.  157:472-485. 2014
2014 Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brainEMBO Journal.  33:2798-2813. 2014
2011 Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damageProceedings of the National Academy of Sciences.  108:14103-14108. 2011
2011 Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell deathNature Medicine.  17:692-699. 2011
2011 Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)Science Signaling.  4. 2011
2011 Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activationPLoS ONE.  6. 2011
2010 Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemiaJournal of Neurochemistry.  113:1012-1022. 2010
2009 Parthanatos, A messenger of deathFrontiers in Bioscience.  14:1116-1128. 2009
2007 Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brainNeuroscience.  148:198-211. 2007
2007 Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicityHuman Molecular Genetics.  16:223-232. 2007
2007 Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleusNeuroscience.  144:56-65. 2007
2006 Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell deathProceedings of the National Academy of Sciences.  103:18314-18319. 2006
2006 Poly(ADP-ribose) (PAR) polymer is a signalProceedings of the National Academy of Sciences.  103:18308-18313. 2006
2006 Localization of LRRK2 to membranous and vesicular structures in mammalian brainAnnals of Neurology.  60:557-569. 2006
2006 Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathyJournal of Neuroscience.  26:3685-3696. 2006
2006 Blood-brain barrier permeability to the neuroprotectant oxyresveratrolNeuroscience Letters.  393:113-118. 2006
2005 Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: Cell death or survivalBrain Research.  1060:1-15. 2005
2004 Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemiaBrain Research.  1017:98-107. 2004
2004 Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.Federation proceedings.  18:869-871. 2004

Education And Training

  • Doctor of Philosophy Level Degree in Neurobiology and Neurosciences, Otto-von-Guericke University Magdeburg 2005
  • Full Name

  • Syed Shaida Andrabi