Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The AAA + ATPase Thorase is neuroprotective against ischemic injury.Journal of Cerebral Blood Flow and Metabolism.  271678X18769770. 2018
2017 Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.Science Translational Medicine.  9. 2017
2017 Generation and Characterization of SULT4A1 Mutant Mouse Models.Drug Metabolism and Disposition.  46:41-45. 2017
2017 Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.Journal of Cerebral Blood Flow and Metabolism.  37:1982-1993. 2017
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1Science.  354. 2016
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.Science.  354. 2016
2016 LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.Journal of Chemical Neuroanatomy.  76:90-97. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.Science.  353. 2016
2016 High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death.eNeuro.  3. 2016
2016 PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.Cancer Research.  76:4430-4442. 2016
2016 Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.eNeuro.  3. 2016
2015 Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.Proceedings of the National Academy of Sciences.  112:11696-11701. 2015
2014 Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.EMBO Journal.  33:2798-2813. 2014
2014 Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.EMBO Journal.  33:1548-1564. 2014
2014 Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.Proceedings of the National Academy of Sciences.  111:10209-10214. 2014
2014 Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.Cell.  157:472-485. 2014
2011 Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.Proceedings of the National Academy of Sciences.  108:14103-14108. 2011
2011 Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.Nature Medicine.  17:692-699. 2011
2011 Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).Science Signaling.  4:ra20. 2011
2011 Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.PLoS ONE.  6:e16706. 2011
2010 Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.Journal of Neurochemistry.  113:1012-1022. 2010
2009 Parthanatos, a messenger of death.Frontiers in Bioscience.  14:1116-1128. 2009
2007 Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain.Neuroscience.  148:198-211. 2007
2007 Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.Human Molecular Genetics.  16:223-232. 2007
2007 Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus.Neuroscience.  144:56-65. 2007
2006 Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.Proceedings of the National Academy of Sciences.  103:18314-18319. 2006
2006 Poly(ADP-ribose) (PAR) polymer is a death signal.Proceedings of the National Academy of Sciences.  103:18308-18313. 2006
2006 Localization of LRRK2 to membranous and vesicular structures in mammalian brain.Annals of Neurology.  60:557-569. 2006
2006 Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.Journal of Neuroscience.  26:3685-3696. 2006
2006 Blood-brain barrier permeability to the neuroprotectant oxyresveratrol.Neuroscience Letters.  393:113-118. 2006
2005 Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: cell death or survival.Brain Research.  1060:1-15. 2005
2004 Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia.Brain Research.  1017:98-107. 2004
2004 Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.Federation proceedings.  18:869-871. 2004

Education And Training

  • Doctor of Philosophy Level Degree in Neurobiology and Neurosciences, Otto-von-Guericke University Magdeburg
  • Full Name

  • Syed Shaida Andrabi
  • Blazerid

  • sandrabi