Browse
Browse
Home
People
Organizations
Research
Events
Capability Map
Robert Welner Ph.D.
Assistant Professor
Close
E-mail
rwelner@uab.edu
Phone
205-975-3960
Visualizations
Co-author Network
Map of Science
Co-investigator Network
Robert Welner Ph.D.
Assistant Professor
Positions
Associate Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Assistant Professor (P)
,
Medicine - Hematology & Oncology
,
Department of Medicine
2016 -
Associate Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2016 -
Associate Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
2017 -
Associate Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2021
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates
.
Science Immunology
. 6.
2021
2020
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10
.
JCI insight
. 5.
2020
2020
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance
.
Blood
. 136:1735-1747.
2020
2020
Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes
.
JCI insight
. 5.
2020
2020
Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development
.
Immunity
. 52:1105-1118.e9.
2020
2019
Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths
.
Cell Reports
. 28:302-311.e5.
2019
2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
.
Journal of Clinical Investigation
. 129:2685-2701.
2019
2018
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
.
Nature Communications
. 9.
2018
2018
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
.
Nature Communications
. 9.
2018
2018
C/EBPγ is dispensable for steady-state and emergency granulopoiesis
2018
2017
ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα
.
Journal of Biological Chemistry
. 292:18924-18936.
2017
2017
Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment
.
International Journal of Hematology
. 105:566-577.
2017
2016
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
.
Science Translational Medicine
. 8:350ra104.
2016
2016
The second hit of DNA methylation
2016
2016
Multiple sclerosis: getting personal with induced pluripotent stem cells.
.
Cell Death and Disease
. 7:e2185.
2016
2016
Acetylation of C/EBPα inhibits its granulopoietic function
.
Nature Communications
. 7.
2016
2016
The DNA ligase IV syndrome R278H mutation impairs B lymphopoiesis via error-prone nonhomologous end-joining
.
Journal of Immunology
. 196:244-255.
2016
2015
Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia
.
Cell Stem Cell
. 17:611-623.
2015
2015
Multiple sclerosis: Getting personal with induced pluripotent stem cells
.
Cell Death and Disease
. 6.
2015
2015
Dissecting the role of aberrant DNA methylation in human leukaemia
.
Nature Communications
. 6.
2015
2015
Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells
.
Cancer Cell
. 27:671-681.
2015
2014
β-catenin contributes to lung tumor development induced by EGFR mutations
.
Cancer Research
. 74:5891-5902.
2014
2014
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
.
Blood
. 124:2391-2399.
2014
2014
9-1-1: HSCs respond to emergency calls
.
Cell Stem Cell
. 14:415-416.
2014
2014
Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry
.
PLoS ONE
. 9.
2014
2014
Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia
.
Cancer Cell
. 25:257.
2014
2013
Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia
.
Cancer Cell
. 24:575-588.
2013
2013
C/EBPΑ is required for development of dendritic cell progenitors
.
Blood
. 121:4073-4081.
2013
2013
Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells
.
Molecular Cell
. 49:934-946.
2013
2013
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells
.
Blood
. 121:1255-1264.
2013
2012
CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential
.
Blood
. 119:4889-4897.
2012
2011
Chronic exposure to a TLR ligand injures hematopoietic stem cells
.
Journal of Immunology
. 186:5367-5375.
2011
2010
Functional diversity of stem and progenitor cells with B-lymphopoietic potential
.
Immunological Reviews
. 237:10-21.
2010
2009
Asynchronous RAG-1 expression during B lymphopoiesis
.
Journal of Immunology
. 183:7768-7777.
2009
2009
A possible contribution of retinoids to regulation of fetal B lymphopoiesis
.
European Journal of Immunology
. 39:2515-2524.
2009
2009
A differentiation pathway for B1 cells in adult bone marrow
2009
2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions
.
Blood
. 113:1016-1026.
2009
2008
Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection
.
Blood
. 112:3753-3761.
2008
2008
Evolving views on the genealogy of B cells
.
Nature Reviews Immunology
. 8:95-106.
2008
2008
CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system
.
Journal of Immunology
. 180:1098-1106.
2008
2008
Retinoids accelerate B lineage lymphoid differentiation
.
Journal of Immunology
. 180:138-145.
2008
2007
Stem Cells on Patrol
.
Cell
. 131:842-844.
2007
2007
Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kit
Hi
CD62L
+
lymphoid progenitors
.
Blood
. 109:4825-4831.
2007
2007
Early lymphopoiesis in adult bone marrow
.
Inmunología
. 26:135-144.
2007
2006
Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential
.
Journal of Immunology
. 177:2880-2887.
2006
2006
Life before the pre-B cell receptor checkpoint: Specification and commitment of primitive lymphoid progenitors in adult bone marrow
.
Seminars in Immunology
. 18:2-11.
2006
2005
Age-related loss of bone marrow pre-B- and immature B-lymphocytes in the autoimmune-prone flaky skin mutant mice
.
Autoimmunity
. 38:399-408.
2005
2005
In vitro differentiation and measurement of B cell progenitor activity in culture.
2005
2005
Isolation of prolymphocytes from bone marrow and fetal liver.
2005
2005
Lymphoid progenitors and primary routes to becoming cells of the immune system
.
Current Opinion in Immunology
. 17:100-107.
2005
2005
Measurement of natural killer cell progenitor activity in culture.
2005
2004
Hyperactivation and proliferation of lymphocytes from the spleens of flaky skin (fsn) mutant mice
.
Autoimmunity
. 37:227-235.
2004
2002
Antinuclear autoantibodies in flaky skin (fsn) mutant mice
.
Autoimmunity
. 35:175-181.
2002
Research
Principal Investigator On
Private Grant
awarded by
HEAT BIOLOGICS
2020 - 2024
Role of Bone Marrow Tregs in Maintaining Stromal Cell Function
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2020 - 2024
Functional Consequences of Stem and Progenitor Cell Heterogeneity
awarded by
BETH ISRAEL DEACONESS MEDICAL CENTER
2017 - 2022
Targeting Leukemic Cells Through Oncogene-independent Signaling Pathways
awarded by
American Society of Hematology ^
2018 - 2019
Investigator On
Leukemia Stem Cell Regulation and Resistance
awarded by
National Cancer Institute/NIH/DHHS
2021 - 2026
Pregnancy-Specific Mechanisms Regulating Beta-Cell Proliferation and Mass
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2020 - 2025
Microenvironmental Regulation Of Leukemia Stem Cells
awarded by
National Cancer Institute/NIH/DHHS
2019 - 2024
Collapsing the Tumor-Supportive Immune Portfolio of Breast Cancer to Achieve Durable Reduction of Metastasis
awarded by
DOD - Department of Defense
2019 - 2022
Teaching
Teaching Activities
GBSC700 - Journal Clubs (Spring Term 2020)
2020
GBSC700 - Journal Clubs (Fall Term 2019)
2019
GBSC700 - Journal Clubs (Spring Term 2019)
2019
GBSC700 - Journal Clubs (Fall Term 2018)
2018
GBSC700 - Journal Clubs (Spring Term 2018)
2018
GBS747 - Special Topics (Fall Term 2017)
2017
Background
Education And Training
Doctor of Philosophy in Microbiological Sciences and Immunology,
University of Oklahoma
2007
Master of Science in Medical Basic Sciences,
University of Maine System : University of Southern Maine
2002
Contact
Full Name
Robert
Welner