Selected Publications

Academic Article

Year Title Altmetric
2021 E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fatesScience Immunology.  6. 2021
2020 Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10JCI insight.  5. 2020
2020 Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenanceBlood.  136:1735-1747. 2020
2020 Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetesJCI insight.  5. 2020
2020 Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell DevelopmentImmunity.  52:1105-1118.e9. 2020
2019 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation PathsCell Reports.  28:302-311.e5. 2019
2019 SIRT1 regulates metabolism and leukemogenic potential in CML stem cellsJournal of Clinical Investigation.  129:2685-2701. 2019
2018 The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammationNature Communications.  9. 2018
2018 The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemiaNature Communications.  9. 2018
2018 C/EBPγ is dispensable for steady-state and emergency granulopoiesis 2018
2017 ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPαJournal of Biological Chemistry.  292:18924-18936. 2017
2017 Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironmentInternational Journal of Hematology.  105:566-577. 2017
2016 Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expressionScience Translational Medicine.  8:350ra104. 2016
2016 The second hit of DNA methylation 2016
2016 Multiple sclerosis: getting personal with induced pluripotent stem cells.Cell Death and Disease.  7:e2185. 2016
2016 Acetylation of C/EBPα inhibits its granulopoietic functionNature Communications.  7. 2016
2016 The DNA ligase IV syndrome R278H mutation impairs B lymphopoiesis via error-prone nonhomologous end-joiningJournal of Immunology.  196:244-255. 2016
2015 Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid LeukemiaCell Stem Cell.  17:611-623. 2015
2015 Multiple sclerosis: Getting personal with induced pluripotent stem cellsCell Death and Disease.  6. 2015
2015 Dissecting the role of aberrant DNA methylation in human leukaemiaNature Communications.  6. 2015
2015 Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor CellsCancer Cell.  27:671-681. 2015
2014 β-catenin contributes to lung tumor development induced by EGFR mutationsCancer Research.  74:5891-5902. 2014
2014 The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cellsBlood.  124:2391-2399. 2014
2014 9-1-1: HSCs respond to emergency callsCell Stem Cell.  14:415-416. 2014
2014 Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometryPLoS ONE.  9. 2014
2014 Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid LeukemiaCancer Cell.  25:257. 2014
2013 Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid LeukemiaCancer Cell.  24:575-588. 2013
2013 C/EBPΑ is required for development of dendritic cell progenitorsBlood.  121:4073-4081. 2013
2013 Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem CellsMolecular Cell.  49:934-946. 2013
2013 In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cellsBlood.  121:1255-1264. 2013
2012 CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potentialBlood.  119:4889-4897. 2012
2011 Chronic exposure to a TLR ligand injures hematopoietic stem cellsJournal of Immunology.  186:5367-5375. 2011
2010 Functional diversity of stem and progenitor cells with B-lymphopoietic potentialImmunological Reviews.  237:10-21. 2010
2009 Asynchronous RAG-1 expression during B lymphopoiesisJournal of Immunology.  183:7768-7777. 2009
2009 A possible contribution of retinoids to regulation of fetal B lymphopoiesisEuropean Journal of Immunology.  39:2515-2524. 2009
2009 A differentiation pathway for B1 cells in adult bone marrow 2009
2009 Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisionsBlood.  113:1016-1026. 2009
2008 Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infectionBlood.  112:3753-3761. 2008
2008 Evolving views on the genealogy of B cellsNature Reviews Immunology.  8:95-106. 2008
2008 CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous systemJournal of Immunology.  180:1098-1106. 2008
2008 Retinoids accelerate B lineage lymphoid differentiationJournal of Immunology.  180:138-145. 2008
2007 Stem Cells on PatrolCell.  131:842-844. 2007
2007 Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitorsBlood.  109:4825-4831. 2007
2007 Early lymphopoiesis in adult bone marrowInmunología.  26:135-144. 2007
2006 Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potentialJournal of Immunology.  177:2880-2887. 2006
2006 Life before the pre-B cell receptor checkpoint: Specification and commitment of primitive lymphoid progenitors in adult bone marrowSeminars in Immunology.  18:2-11. 2006
2005 Age-related loss of bone marrow pre-B- and immature B-lymphocytes in the autoimmune-prone flaky skin mutant miceAutoimmunity.  38:399-408. 2005
2005 In vitro differentiation and measurement of B cell progenitor activity in culture. 2005
2005 Isolation of prolymphocytes from bone marrow and fetal liver. 2005
2005 Lymphoid progenitors and primary routes to becoming cells of the immune systemCurrent Opinion in Immunology.  17:100-107. 2005
2005 Measurement of natural killer cell progenitor activity in culture. 2005
2004 Hyperactivation and proliferation of lymphocytes from the spleens of flaky skin (fsn) mutant miceAutoimmunity.  37:227-235. 2004
2002 Antinuclear autoantibodies in flaky skin (fsn) mutant miceAutoimmunity.  35:175-181. 2002

Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Oklahoma 2007
  • Master of Science in Medical Basic Sciences, University of Maine System : University of Southern Maine 2002
  • Full Name

  • Robert Welner