Selected Publications

Academic Article

Year Title Altmetric
2017 Mechanical loading regulates organization of the actin cytoskeleton and column formation in postnatal growth plate.Cell regulation.  28:1862-1870. 2017
2016 Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.BONE.  97:54-64. 2016
2016 TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.Scientific Reports.  6:38616. 2016
2016 SOX9 protein is stabilized by TGF-β and regulates PAPSS2 mRNA expression in chondrocytes.Osteoarthritis and Cartilage.  25:332-340. 2016
2016 Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.PLoS Genetics.  12:e1006217. 2016
2016 An investigation on wind turbine resonant vibrationsWind Energy.  19:847-859. 2016
2016 Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.Nature Communications.  7:11024. 2016
2016 Erratum: The Tunguska event and Cheko lake origin: Dendrochronological analysis (International Journal of Astrobiology (2014) DOI: 10.1017/S1473550414000445)International Journal of Astrobiology.  15:33. 2016
2015 Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.Annals of the New York Academy of Sciences.  1335:78-99. 2015
2014 Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation.Journal of Bone and Mineral Research.  29:2653-2665. 2014
2014 Erg cooperates with TGF-β to control mesenchymal differentiation.Experimental Cell Research.  328:410-418. 2014
2014 Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells.Cilia.  3:4. 2014
2014 Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.Journal of Biomechanics.  47:579-582. 2014
2014 Chondrocyte-specific knockout of Cbfβ reveals the indispensable function of Cbfβ in chondrocyte maturation, growth plate development and trabecular bone formation in mice.International Journal of Biological Sciences.  10:861-872. 2014
2014 Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors.PLoS ONE.  9:e113247. 2014
2013 Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation.Developmental Biology.  382:27-37. 2013
2013 Ift88 regulates Hedgehog signaling, Sfrp5 expression, and β-catenin activity in post-natal growth plate.Journal of Orthopaedic Research.  31:350-356. 2013
2013 WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells.PLoS ONE.  8:e58329. 2013
2012 PDGF mediates TGFβ-induced migration during development of the spinous process.Developmental Biology.  365:110-117. 2012
2012 Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage.Arthritis Research.  14:R49. 2012
2012 Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.Osteoarthritis and Cartilage.  20:152-161. 2012
2011 Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation.Biology of Reproduction.  85:907-915. 2011
2011 TMJ development and growth require primary cilia function.Journal of Dental Research.  90:988-994. 2011
2011 Wnt5a as an effector of TGFβ in mammary development and cancer.Journal of Mammary Gland Biology and Neoplasia.  16:157-167. 2011
2011 Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.Human Molecular Genetics.  20:271-285. 2011
2011 Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development.Cells Tissues Organs.  194:161-165. 2011
2011 TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.Gastroenterology.  140:242-253. 2011
2010 Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues.Journal of Histochemistry and Cytochemistry.  58:857-870. 2010
2010 Inhibiting breast cancer progression by exploiting TGFbeta signaling.Current Drug Targets.  11:1089-1102. 2010
2010 Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc.BMC Developmental Biology.  10:29. 2010
2010 PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.EMBO Journal.  29:956-968. 2010
2009 Tgfbr2 is required for development of the skull vault.Developmental Biology.  334:481-490. 2009
2009 TGF-beta promotes Th17 cell development through inhibition of SOCS3.Journal of Immunology.  183:97-105. 2009
2009 Roles of the primary cilium component Polaris in synchondrosis development.Journal of Dental Research.  88:545-550. 2009
2009 Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype.Breast Cancer Research.  11:R19. 2009
2008 Role of intraflagellar transport and primary cilia in skeletal development.The Anatomical record. Supplement : an offical publication of the American Association of Anatomists.  291:1049-1061. 2008
2008 Role for primary cilia in the regulation of mouse ovarian function.Developmental Dynamics.  237:2053-2060. 2008
2008 Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung.AJP - Lung Cellular and Molecular Physiology.  295:L86-L95. 2008
2008 Cilia involvement in patterning and maintenance of the skeleton.Current Topics in Developmental Biology.  85:303-332. 2008
2007 Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth.Development.  134:3929-3939. 2007
2007 Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints.Developmental Biology.  310:304-316. 2007
2007 Intraflagellar transport in skeletal development.The Journal of Musculoskeletal and Neuronal Interactions.  7:302-303. 2007
2007 Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.Development.  134:2159-2169. 2007
2007 Development of the post-natal growth plate requires intraflagellar transport proteins.Developmental Biology.  305:202-216. 2007
2007 C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways.BMC Developmental Biology.  7:18. 2007
2007 Intraflagellar transport is essential for endochondral bone formation.Development.  134:307-316. 2007
2006 Tgfbr2 regulates the maintenance of boundaries in the axial skeleton.Developmental Biology.  296:363-374. 2006
2006 Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.Journal of applied physiology: respiratory, environmental and exercise physiology.  100:564-571. 2006
2006 Transforming growth factor-beta signaling helps specify tumor type in DMBA and hormone-induced mammary cancers.Differentiation.  74:40-52. 2006
2005 Mouse models of transforming growth factor beta impact in breast development and cancer.Endocrine-Related Cancer.  12:749-760. 2005
2005 Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification.Journal of Bone and Mineral Research.  20:1011-1021. 2005
2005 Co-ordination of TGF-beta and FGF signaling pathways in bone organ cultures.Mechanisms of Development.  122:557-571. 2005
2005 TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma.Developmental Biology.  279:58-72. 2005
2004 Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones.Developmental Biology.  276:124-142. 2004
2004 Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture.Developmental Dynamics.  230:685-699. 2004
2004 Prolactin and transforming growth factor-beta signaling exert opposing effects on mammary gland morphogenesis, involution, and the Akt-forkhead pathway.Molecular Endocrinology -Baltimore-.  18:1171-1184. 2004
2003 TGF-beta signaling in human skeletal and patterning disorders.Birth Defects Research Part C: Embryo Today: Reviews.  69:333-351. 2003
2003 TGF-β mammary gland development and breast cancerBreast Disease.  18:61-73. 2003
2002 Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone.Osteoarthritis and Cartilage.  10:482-490. 2002
2002 TGFβ2 mediates the effects of Hedgehog on hypertrophic differentiation and PTHrP expressionDevelopment.  129:1913-1924. 2002
2001 Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development.Mechanisms of Development.  109:13-26. 2001
2001 The perichondrium plays an important role in mediating the effects of TGF-beta1 on endochondral bone formation.Developmental Dynamics.  221:311-321. 2001
2001 Antagonistic effects of TGFbeta1 and BMP-6 on skin keratinocyte differentiation.Experimental Cell Research.  263:265-273. 2001
1999 Transforming growth factor-beta in development and diseaseBiotecnología Aplicada.  16:205-218. 1999
1999 Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation.Journal of Cell Biology.  145:783-794. 1999
1999 Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching.Cell regulation.  10:1221-1234. 1999
1998 Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.Cell Growth and Differentiation.  9:229-238. 1998
1997 Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.Journal of Cell Biology.  139:541-552. 1997
1996 Regulation of differentiation by TGF-beta.Current Opinion in Genetics and Development.  6:581-586. 1996
1996 Tumor suppressor genes in the TGF-beta signaling pathway?Nature Medicine.  2:390-391. 1996
1995 pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ cultures.Development.  121:3057-3066. 1995
1994 TGF beta 1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures.Development.  120:2153-2161. 1994
1994 TGF beta regulation of cell proliferation.Princess Takamatsu Symp.  24:250-263. 1994


Year Title Altmetric
2014 Development of the intervertebral disc.  33-51. 2014

Principal Investigator On

  • Mechanisms Of Growth Plate Organization In Response To Mechanical Load  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2020
  • Mechanisms Regulating Afferent Innervation in the Dental Pulp  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2020
  • Mechanism of Tgfbr2 in Chondroprotection  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • TGF-beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Chondrocytic Cilia and Mechano-Sensation  awarded by United States - Israel Binational Science Foundation 2012 - 2016
  • Wnt5a and TGF-beta in Mammary Development and Cancer  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • Sox9 in TGF-Mediated Maintenance of beta Chondrocyte Phenotype  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2014
  • Orchestration of Breast Cancer Osteolytic Bone Metastasis by MIF  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2014
  • TGF-Beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2007 - 2013
  • Primary Cilia in Breast Cancer Progression  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2009 - 2011
  • The Mechanism of Tgfbr2 Action in Joint Degeneration  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2011
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Pennsylvania State System of Higher Education
  • Full Name

  • Rosa Serra
  • Blazerid

  • rserra