Selected Publications

Academic Article

Year Title Altmetric
2019 O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.Laboratory Investigation.  99:260-270. 2019
2019 Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer.OncoImmunology.  8:1548241. 2019
2018 Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer.Carcinogenesis.  39:1165-1175. 2018
2018 Prognostic Significance of Lymphovascular Space Invasion in the Absence of Lymph Node Metastases in Early-Stage Endometrial Cancer.International Journal of Gynecological Cancer.  28:890-894. 2018
2018 Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.Oncotarget.  9:19459. 2018
2018 Evaluating the use of external beam radiation alone in the management of cervix cancerJournal of Radiotherapy in Practice.  17:37-43. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.Oncogene.  37:1610-1623. 2018
2017 Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.Clinical and Experimental Metastasis.  34:443-447. 2017
2017 Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model.Scientific Reports.  7:14167. 2017
2017 Current practice in total-body irradiation: results of a Canada-wide survey.Current Oncology.  24:181-186. 2017
2017 Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.Scientific Reports.  7:40773. 2017
2017 Developing Cures: Targeting Ontogenesis in Cancer.Trends Cancer.  3:126-136. 2017
2017 Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival.PLoS ONE.  12:e0189662. 2017
2016 Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.Oncotarget.  7:86803-86815. 2016
2016 Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.Oncotarget.  7:53984-53996. 2016
2016 Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination.International Journal of Cancer.  139:491-500. 2016
2016 Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer.Oncotarget.  7:17991-18005. 2016
2016 Pulmonary toxicity following total body irradiation for acute lymphoblastic leukaemia: The Ottawa Hospital Cancer Centre (TOHCC) experienceJournal of Radiotherapy in Practice.  15:54-60. 2016
2015 Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.Gastroenterology.  149:1825-1836.e5. 2015
2015 The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer.Cancers.  7:1333-1348. 2015
2015 N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells.Scientific Reports.  5:11995. 2015
2015 The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart.PLoS ONE.  10:e0132607. 2015
2014 microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer.Molecular Cancer.  13:200. 2014
2014 Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Cancer Letters.  349:8-14. 2014
2014 Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.Gynecologic Oncology.  134:112-120. 2014
2014 Nonclassical hedgehog-GLI signaling and its clinical implications.International Journal of Cancer.  135:1-6. 2014
2014 Role of osteopontin in the pathophysiology of cancer.Collagen and related research.  37:131-141. 2014
2014 Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.Oncogene.  33:2620-2628. 2014
2014 E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.Proceedings of the National Academy of Sciences.  111:6834-6839. 2014
2014 Effect of niclosamide on basal-like breast cancers.Molecular Cancer Therapeutics.  13:800-811. 2014
2014 NMI and EMT.Oncoscience.  1:476-477. 2014
2013 Pain assessment during conscious sedation for cervical cancer high-dose-rate brachytherapyCurrent Oncology.  20. 2013
2013 Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.Journal of Biological Chemistry.  288:11824-11833. 2013
2012 Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs.Oncogene.  31:4979-4986. 2012
2012 DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.Oncogene.  31:4472-4483. 2012
2012 Assessing patient outcomes after palliative radiotherapy using image-guided intensity-modulated radiotherapy.Clinical Oncology.  24:e125. 2012
2012 Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.FEBS Letters.  586:3429-3434. 2012
2012 Does multimodal analgesia premedication improve the management of carcinoma cervix brachytherapy?Pain Research and Management.  17:353-354. 2012
2012 Micro-RNA-632 downregulates DNAJB6 in breast cancer.Laboratory Investigation.  92:1310-1317. 2012
2012 Effects of radiation and total androgen blockade on serum hemoglobin, testosterone, and erythropoietin in patients with localized prostate cancerCurrent Oncology.  19. 2012
2012 Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.Oncogene.  31:3370-3380. 2012
2012 DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.Biochemical Journal.  444:573-580. 2012
2012 Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.Experimental Cell Research.  318:1086-1093. 2012
2012 Dickkopf1: a tumor suppressor or metastasis promoter?International Journal of Cancer.  130:1477-1483. 2012
2012 The expanding proteome of the molecular chaperone HSP90.Cell Cycle.  11:1301-1308. 2012
2012 Location, location, location: The BRMS1 protein and melanoma progressionBMC Medicine.  10. 2012
2012 Location, location, location: the BRMS1 protein and melanoma progression.BMC Medicine.  10:19. 2012
2012 Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.PLoS ONE.  7:e34374. 2012
2012 The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer.International Journal of Breast Cancer.  2012:298623. 2012
2012 The influence of the cancer microenvironment on the process of metastasis.International Journal of Breast Cancer.  2012:756257. 2012
2011 Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation.Journal of Biological Chemistry.  286:40376-40385. 2011
2011 Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.Cell Growth and Differentiation.  9:1165-1174. 2011
2011 Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis.Journal of Biological Chemistry.  286:9612-9622. 2011
2011 Recent advances in anti-angiogenic therapy of cancer.Oncotarget.  2:122-134. 2011
2010 Oncology residents' perspectives on communication skills and shared decision making.Journal of Cancer Education.  25:474-477. 2010
2010 Rapid palliative radiotherapy: Comparing IG-IMRT with more conventional approachesJournal of Radiotherapy in Practice.  9:143-148. 2010
2010 DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.Journal of Biological Chemistry.  285:24686-24694. 2010
2010 Evaluating contemporary radiotherapy approaches in the primary treatment of cervical cancer.International Journal of Gynecological Cancer.  20:1087-1091. 2010
2010 Functional characterization of the progestagen-associated endometrial protein gene in human melanoma.Journal of Cellular and Molecular Medicine.  14:1432-1442. 2010
2010 Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin.Journal of Cellular and Molecular Medicine.  14:1693-1706. 2010
2010 Comparison of favorable early-stage hodgkin's lymphoma treatments: a single-institution review.International Journal of Radiation Oncology - Biology - Physics.  76:1166-1170. 2010
2010 Osteopontin: an effector and an effect of tumor metastasis.Current Molecular Medicine.  10:71-81. 2010
2010 Elevated osteopontin levels in metastatic melanoma correlate with epigenetic silencing of breast cancer metastasis suppressor 1.Oncology.  78:75-86. 2010
2010 Exploring cancer treatment decision-making by patients: A descriptive studyCurrent Oncology.  17:85-93. 2010
2009 Longitudinal assessments of quality of life in endometrial cancer patients: effect of surgical approach and adjuvant radiotherapy.International Journal of Radiation Oncology - Biology - Physics.  75:795-802. 2009
2009 The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.Journal of Biological Chemistry.  284:22888-22897. 2009
2009 Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth.International Journal of Cancer.  125:556-564. 2009
2009 Emerging role of nuclear protein 1 (NUPR1) in cancer biology.Cancer and Metastasis Reviews.  28:225-232. 2009
2009 Total scalp radiation using image-guided IMRT for progressive cutaneous T cell lymphoma.British Journal of Radiology.  82:e122-e125. 2009
2009 Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma.Clinical and Experimental Metastasis.  26:739-749. 2009
2009 Multi-faceted role of HSP40 in cancer.Clinical and Experimental Metastasis.  26:559-567. 2009
2009 The emerging role of IG-IMRT for palliative radiotherapy: A single-institution experienceCurrent Oncology.  16:40-45. 2009
2008 High-technology palliative radiotherapy using image-guided intensity-modulated radiotherapy.Clinical Oncology.  20:718-720. 2008
2008 Decision making in oncology: a review of patient decision aids to support patient participation.CA: A Cancer Journal for Clinicians.  58:293-304. 2008
2008 Contemporary management of stage I testicular seminoma: A survey of Canadian radiation oncologistsCurrent Oncology.  15:3-7. 2008
2008 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.Current Cancer Drug Targets.  8:421-430. 2008
2008 The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.BMC Medical Genomics.  1:13. 2008
2008 Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.BBA - Biochimica et Biophysica Acta.  1782:259-270. 2008
2008 On-line rapid palliation using helical tomotherapy: a prospective feasibility study.Radiotherapy and Oncology.  87:116-118. 2008
2008 Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.Journal of Biological Chemistry.  283:7438-7444. 2008
2008 BRMS1Targeted Protein Database 1.  22093. 2008
2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer.Clinical and Experimental Metastasis.  25:753-763. 2008
2008 Global comparative gene expression analysis of melanoma patient samples, derived cell lines and corresponding tumor xenografts.Cancer Genomics and Proteomics.  5:1-35. 2008
2008 Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer.Breast Cancer Research.  10:R22. 2008
2008 Palliative radiotherapy knowledge among community family physicians and nurses.Journal of Cancer Education.  23:156-160. 2008
2007 Primary vaginal cancer treated with concurrent chemoradiation using Cis-platinum.International Journal of Radiation Oncology - Biology - Physics.  69:746-750. 2007
2007 Rac1 activity regulates proliferation of aggressive metastatic melanoma.Experimental Cell Research.  313:3832-3839. 2007
2007 Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.Molecular Cancer.  6:6. 2007
2006 Awareness and use of the Rapid Palliative Radiotherapy Program by family physicians in Eastern Ontario: A surveyCurrent Oncology.  13. 2006
2006 How should we describe the benefits of palliative radiotherapy?Current Oncology.  13:230-234. 2006
2006 The preferred treatment for stage I seminoma: a survey of Canadian radiation oncologists.Clinical Oncology.  18:696-699. 2006
2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.Biochemical and Biophysical Research Communications.  348:1429-1435. 2006
2006 Effective palliative radiotherapy for symptomatic recurrent or residual ovarian cancer.Gynecologic Oncology.  102:204-209. 2006
2006 Palliative radiotherapy for recurrent granulosa cell tumor of the ovary: a report of 3 cases with radiological evidence of response.Gynecologic Oncology.  102:406-410. 2006
2006 Treatment of stage I seminoma: a 15-year review.Urologic Oncology: Seminars and Original Investigations.  24:180-183. 2006
2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1).Cancer Letters.  235:260-265. 2006
2006 Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435.Clinical and Experimental Metastasis.  23:123-133. 2006
2005 Radiotherapy basics for family physicians. Potent tool for symptom relief.Canadian Family Physician.  51:1496-1501. 2005
2005 Radiotherapy for the treatment of primary vaginal cancer.Radiotherapy and Oncology.  77:133-136. 2005
2005 Evaluating changes in stage I seminoma management: a single institution review.Canadian Journal of Urology.  12:2738-2744. 2005
2005 Radical radiotherapy for cervix cancer: the effect of waiting time on outcome.International Journal of Radiation Oncology - Biology - Physics.  61:1071-1077. 2005
2005 Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells.Cancer Research.  65:713-717. 2005
2004 Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells.International Journal of Cancer.  111:693-697. 2004
2004 Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.Journal of Biological Chemistry.  279:1562-1569. 2004
2004 A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.Clinical and Experimental Metastasis.  21:119-128. 2004
2004 Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells.Clinical and Experimental Metastasis.  21:149-157. 2004
2004 Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12.International Journal of Cancer.  108:15-22. 2004
2003 A cost-outcome analysis of long-term adjuvant goserelin in addition to radiotherapy for locally advanced prostate cancer.Urologic Oncology: Seminars and Original Investigations.  21:171-177. 2003
2002 Geographic delivery models for radiotherapy services.Australasian Radiology.  46:290-294. 2002
2002 Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1.Mammalian Genome.  13:289-292. 2002
2002 Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1.Experimental Cell Research.  273:229-239. 2002
2002 Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1).International Journal of Cancer.  97:15-20. 2002
2002 Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.Clinical and Experimental Metastasis.  19:95-105. 2002
2001 A cost-outcome analysis of adjuvant postmastectomy locoregional radiotherapy in high-risk postmenopausal breast cancer patients.International Journal of Radiation Oncology - Biology - Physics.  50:1376. 2001
2001 Metastasis suppression in prostate cancer.Cancer and Metastasis Reviews.  20:279-286. 2001
2001 Palliative care educational needs of family physicians.Journal of Palliative Care.  17:277-280. 2001
2001 Radiotherapy education among family physicians and residents.Journal of Cancer Education.  16:134-138. 2001
2000 A cost-outcome analysis of adjuvant postmastectomy locoregional radiotherapy in premenopausal node-positive breast cancer patients.International Journal of Radiation Oncology - Biology - Physics.  48:977-982. 2000
2000 Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.Cancer Research.  60:2764-2769. 2000
2000 Analysis of mechanisms underlying BRMS1 suppression of metastasis.Clinical and Experimental Metastasis.  18:683-693. 2000
1999 Production and evaluation of low-cost patient education videos using digital imageryJournal of Cancer Education.  14:204-207. 1999
1999 Staging investigations in patients with breast cancer: the role of bone scans and liver imaging.Archives of Surgery -New York-.  134:551-553. 1999
1999 Prognosis, treatment, and recurrence of breast cancer for women attending or not attending the Screening Mammography Program of British Columbia.Breast Cancer Research and Treatment.  54:73-81. 1999
1998 The development and production of radiotherapy patient education videos using computer-based digital imagery.International Journal of Radiation Oncology - Biology - Physics.  41:485. 1998


Year Title Altmetric
2017 Mechanisms and functions of spatial protein quality control.  Ed. 86.  2017

Education And Training

  • Doctor of Philosophy Level Degree in Molecular Biology, Indian Institute of Technology/Bombay
  • Full Name

  • Rajeev Samant