Positions

Overview

  • From 2004-10 Dr. Rich was UAB Senior Vice President for Medicine and Dean of the School of Medicine and from 2004-16 served as Professor of Medicine, Microbiology and (since 2012) Medical Education. From 2011-14 he was Faculty Accreditation Lead for reaccreditation of the School of Medicine. From 2014-16 he developed and then served as founding Director of the university-wide UAB Center for Interprofessional Education and Simulation. Dr. Rich was a member of the faculty of Baylor College of Medicine from 1973-98 and from 1990-98 he also served as Vice President and Dean of Research at Baylor. He was an Investigator of the Howard Hughes Medical Institute from 1977-91 and from 1998-04 he was Executive Associate Dean for Research and Strategic Initiatives at Emory University School of Medicine.

    From 2003-08 Dr. Rich was Editor-in-Chief of The Journal of Immunology. Other appointments to editorial boards have included The Journal of Experimental Medicine, The Journal of Infectious Diseases, The Journal of Clinical Immunology and Clinical and Experimental Immunology. He is also the founding Editor-in-Chief of a comprehensive textbook Clinical Immunology: Principles and Practice; the 5th edition of the book is scheduled for publication in 2018. He has authored or co-authored more than 200 articles and chapters in scientific journals and books. His research focused on cellular and molecular interactions between antigen presenting cells and T lymphocytes, including definition of interactions of superantigens with T cell receptors for antigen and discovery of the molecular basis of peptide binding and functional specialization of a major histocompatibility class Ib molecule.

    Dr. Rich is Past President and Past Chairman of the Board of Directors of the Federation of American Societies for Experimental Biology. He is also Past President of the Clinical Immunology Society. He was Vice President of the American Academy of Allergy Asthma and Immunology, Chair of its Professional Education Council, Chair of the Basic and Clinical Immunology Interest Section and a member of its Board of Directors. He served as a member of two NIH Study Sections (as chair of one) and on the Boards of Directors of the American Board of Allergy and Immunology (also as chair) and the American Board of Internal Medicine. He was a Councilor of the American Clinical and Climatological Association and a member of the Council of the American Association of Immunologists, for which he also chaired the committees on Clinical Immunology and Public Affairs.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2006 From whence we come (happy birthday to us) 2006
    2004 Rediscovering the pillars 2004
    2003 Cotton rat Sihi-M3 is a minimally oligomorphic Mhc I-b molecule that binds the chemotactic peptide fMLF under stringent conditions: Evidence that positive selection drives inter-species diversity of residues interacting with the termini of short peptides 2003
    2003 Hyperconservation of the N-formyl peptide binding site of M3: Evidence that M3 is an old eutherian molecule with conserved recognition of a pathogen-associated molecular pattern 2003
    2003 Benefit versus risk 2003
    2003 The baton is passed 2003
    2002 Hyperconservation of the putative antigen recognition site of the MHC class I-b molecule TL in the subfamily murinae: Evidence that thymus leukemia antigen is an ancient mammalian gene 2002
    2002 Science policy: The NIH budget in the "Postdoubling" era 2002
    2001 Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling 2001
    2001 Exogenous peptides enter the endoplasmic reticulum of TAP-deficient cells and induce the maturation of nascent MHC class I molecules 2001
    2001 Exogenous peptides enter the endoplasmic reticulum of TAP-deficient cells and induce the maturation of nascent MHC class I molecules. 2001
    2001 Superantigen recognition by γδ T cells: SEA recognition site for human Vγ2 T cell receptors 2001
    2000 Heterogeneity of RAMA-S cell line: Derivatives of RAMA-S cells lacking H2-Kb and H2-Db expression 2000
    2000 Immunization with f-Met peptides induces immune reactivity against Mycobacterium tuberculosis 2000
    1998 Binding specificity of a class II-restricted hepatitis B epitope by DR molecules from responder and nonresponder vaccine recipients 1998
    1998 Structural dichotomy of Staphylococcal enterotoxin C superantigens leading to MHC class II-independent activation of T lymphocytes 1998
    1998 Intercellular adhesion molecule-1 and leukocyte function-associated antigen-3 provide costimulation for superantigen-induced T lymphocyte proliferation in the absence of a specific presenting molecule 1998
    1998 The future of allergy practice: An academician's perspective 1998
    1996 Altered Orientation of Streptococcal Superantigen (SSA) on HLA-DR1 Allows Unconventional Regions to Contribute to SSA Vβ Specificity 1996
    1996 Chimeric β2m·h-2m3 single chain: a model for studying the functions of an mhc class i-b molecule 1996
    1996 MHC class IB molecule, Qa-1b, presents a proteinaseresistant hydrophobic antigen from mycobacteria 1996
    1996 Transplantation of the n-formyl pocket of H-2M3 to K b 1996
    1996 Species-Dependent Post-Translational Modification and Position 2 Allelism: Effects on Streptococcal Superantigen SSA Structure and Vβ Specificity 1996
    1996 Phylogenetic distribution of streptococcal superantigen SSA allelic variants provides evidence for horizontal transfer of ssa within Streptococcus pyogenes 1996
    1996 Residues near the amino and carboxyl termini of staphylococcal enterotoxin E independently mediate TCR Vβ-specific interactions 1996
    1996 Justifying a mechanism-based specialty. 1996
    1996 Practice parameters for the diagnosis and management of immunodeficiency. The Clinical and Laboratory Immunology Committee of the American Academy of Allergy, Asthma, and Immunology (CLIC-AAAAI) 1996
    1996 H2-M3wt-restricted, Listeria monocytogenes-specific CD8 T cells recognize a novel, hydrophobic, protease-resistant, periodate-sensitive antigen 1996
    1996 Major histocompatibility complex class ii-independent presentation of staphylococcal enterotoxins to humant cells 1996
    1996 N terminal allelism and species-dependent modification alter streptococcal superantigen vβ-specificity 1996
    1996 Practice parameters for the diagnosis and management of immunodeficiency 1996
    1995 H-2M3a violates the paradigm for major histoeompatibility complex class I peptide binding 1995
    1995 Peptides from the amino-terminus of mouse mitochondrially encoded NADH dehydrogenase subunit 1 are potent chemoattractants 1995
    1995 Whither clinical immunology? 1995
    1994 Characterization and distribution of insertion sequence IS1239 in Streptococcus pyogenes 1994
    1994 Antigen presentation by major histocompatibility complex class I-b molecules 1994
    1994 Availability of endogenous peptides limits expression of an M3a-Ld major histocompatibility complex class I chimera 1994
    1994 Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells 1994
    1994 Health care reform: Implications for biomedical research 1994
    1994 Long-term inositol phosphate release, but not tyrosine kinase activity, correlates with IL-2 secretion and NF-AT induction in anti-CD3-activated peripheral human T lymphocytes 1994
    1994 Molecular characterization and phylogenetic distribution of the streptococcal superantigen gene (ssa) from Streptococcus pyogenes 1994
    1993 Differential amino-terminal anchors for peptide binding to H-2M3a or H-2Kb and H-2Db1 1993
    1993 Localization of a site on bacterial superantigens that determines T cell receptor β chain specificity 1993
    1993 A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C 1993
    1993 Intravenous IgG: Supertherapy for superantigens? 1993
    1993 Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins 1993
    1992 Biochemical specificity of H-2M3a: Stereospecificity and space-filling requirements at position 1 maintain N-formyl peptide binding 1992
    1992 Kinetics of killing by monoclonal cytotoxic T lymphocytes. I. Colorimetric detection of cryptic CTL determinants on adherent target cells and survivorship analysis 1992
    1992 Dual roles for class II major histocompatibility complex molecules in staphylococcal enterotoxin-induced cytokine production and in vivo toxicity 1992
    1992 Isolation and characterization of a novel streptococcal superantigen. 1992
    1992 Specialized role for a murine class I-b MHC molecule in prokaryotic host defenses 1992
    1991 Specialized function of the nonclassical MHC class I molecule Hmt: A specific receptor for N-formylated peptides 1991
    1991 Staphylococcal toxins bind to different sites on HLA-DR 1991
    1991 Specialized functions of major histocompatibility complex class i molecules. ii. hmt binds n-formylated peptides of mitochondrial and prokaryotic origin 1991
    1991 Staphylococcal exotoxin activation of T cells: Role of exotoxin-MHC class II binding affinity and class II isotype 1991
    1991 Distinct biochemical features of interferon gamma receptors on human T lymphocytes 1991
    1991 Molecular biology and immunology: An introduction 1991
    1991 Mutation of the disulfide loop in staphylococcal enterotoxin A: Consequences for T cell recognition 1991
    1991 Mutational analysis of regulation of MHC and anti-viral genes 1991
    1990 Dissociation of the Stimulatory Activities of Staphylococcal Enterotoxins for T Cells and Monocytes 1990
    1990 Specialized functions of MHC class i molecules: I. An n-formyl peptide receptor is required for construction of the class i antigen Mta 1990
    1990 MHC class II molecules transduce signals in monocytes in response to bound staphylococcal enterotoxins and toxic shock syndrome toxin. 1990
    1990 Retrovirus-Mediated Insertional Mutagenesis: Phagemid Rescue of Flanking DNA by Selecting Plasmid ori 1990
    1990 The role of physical forces on cytotoxic T cell-target cell conjugate stability 1990
    1989 An unexpectedly labile mitochondrially encoded protein is required for Mta expression 1989
    1989 Class II MHC molecules are specific receptors for Staphylococcus enterotoxin A 1989
    1989 Prostaglandin E2 selectively increases interferon gamma receptor expression on human CD8+ lymphocytes 1989
    1989 Superantigens: interaction of staphylococcal enterotoxins with MHC class II molecules. 1989
    1988 Induction of suppressor T cells by cytokines 1988
    1988 Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm 1988
    1988 Polymorphic Bgl II restriction sites of DR α demarcate a novel HLA-DR1 antigen 1988
    1988 Human immunodeficiency virus-induced pathology favored by cellular transmission and activation 1988
    1988 Shear Stress Effects on Human T Cell Function 1988
    1987 Differential presentation of HLA-DR, DQ, and DP restriction elements by interferon-γ-treated dermal fibroblasts 1987
    1987 Suppressor cell growth factor and anti-CD3 antibodies stimulate reciprocal subsets of T lymphocytes 1987
    1987 Unusual functional and biochemical properties of DR molecules from the HLA-DR1, B14 haplotype 1987
    1987 Unglycosylated Mtaa expresses an Mtab-like determinant 1987
    1987 Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA 1987
    1987 Unusual functional and biochemical properties of DR molecules from the HLA-DR1, B14 haplotype. 1987
    1987 Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency 1987
    1987 Differential antigen-presenting cell requirements of hapten-specific T cell lines restricted to class II determinants 1987
    1987 Human suppressor T lymphocyte growth and differentiation. 1987
    1987 Sequential effects of prostaglandins and interferon-γ on differentiation of CD8+suppressor cells 1987
    1987 Trinitrophenyl reactive T-cell clones in functional and molecular analysis of the HLA-D region. 1987
    1986 Opposing immunoregulatory functions of CD8+lymphocytes: A requirement for monocytes in suppressor cell induction 1986
    1986 Molecular characterization of a subtype of DQw1 recognized by hapten-specific T cells 1986
    1986 Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire: Definition of the Qa-1(d) and Qa-1(c) alloantigens and cross-reactivity with H-21 1986
    1986 Human suppressor T cells: Induction, differentiation, and regulatory functions 1986
    1986 Maternally Transmitted Antigen 1986
    1986 Proliferative signals for suppressor T cells. Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor 1986
    1986 Regulation of primary cytotoxic T lymphocyte responses generated during mixed leukocyte culture with H-2(d) identical Qa-1 disparate cells 1986
    1985 Dissociation of proliferative and differentiative signals for human suppressor T cells. 1985
    1985 Multiparameter analysis of human lymphocyte subpopulations using flow cytometry. 1985
    1985 Oligosaccharide-dependent and independent Qa-1 determinants 1985
    1985 The Qa-1 alloantigens: III. Biochemical analysis of the structure and extent of polymorphism of the Qa-1 allelic products 1985
    1985 Mitochondrial modulation of maternally transmitted antigen: Analysis of cell hybrids 1985
    1985 Cellular requirements for the generation of primary cell-mediated lympholysis responses to Qa-1 antigens 1985
    1985 Polymorphism and tissue distribution of maternally transmitted antigen defined by cytotoxic T lymphocyte lines 1985
    1985 Analysis of the Qa-4 allodeterminant 1985
    1985 Correlation of Qa-1 determinants defined by antisera and by cytotoxic T lymphocytes 1985
    1985 Class II determinants recognized by TNP-specific cloned human T cell lines 1985
    1985 Class II positive human dermal fibroblasts restimulate cloned allospecific T cells but fail to stimulate primary allogeneic lymphoproliferation 1985
    1985 Cytotoxic T lymphocyte (CTL) definition of Qa-1 determinants 1985
    1985 Differential glycosylation requirements for the cell surface expression of class I molecules 1985
    1985 Disproportionate expansion of a minor t cell subset in patients with lymphadenopathy syndrome and acquired immunodeficiency syndrome 1985
    1985 HLA restriction patterns of trinitrophenyl-specific proliferative human T cell clones 1985
    1985 Ia expression and antigen presenting functions of cloned TNP-specific human T cell lines 1985
    1985 Maternally transmitted antigen: Analysis by cloned cytotoxic T lymphocytes 1985
    1985 Pokeweed mitogen activated helper cells produce a suppressor cell growth factor 1985
    1985 The hla complex and the pathogenesis of infectious diseases 1985
    1984 Lymphocyte subsets in patients with acquired immunodeficiency syndrome (AIDS), aids-related complex (ARC), and acute viral infections. 1984
    1984 Cellular requirements for induction of human primary proliferative responses to trinitrophenyl-modified cells 1984
    1984 Biochemical characterization of the Qa-1 alloantigens 1984
    1984 Cloned human T cells synthetize Ia molecules and can function as antigen presenting cells 1984
    1984 Regulatory interactions governing the proliferation of T cell subsets stimulated with pokeweed mitogen 1984
    1983 Mitochondria control expression of a murine cell surface antigen 1983
    1983 Differences in maternal lineages of new zealand black mice defined by restriction endonuclease analysis of mitochondrial dna and by expression of maternally transmitted antigen 1983
    1983 Cytotoxicity by NK-like cells from hepatitis B-immune patients to a human hepatoma cell line secreting HBsAg 1983
    1983 Antigen presentation to human T lymphocytes. II. Requirements for Mac-120+ macrophages and responsiveness to interleukin 2 1983
    1983 Characterization of determinants encoded by four Qa-1 genotypes and their recognition by cloned cytotoxic T lymphocytes 1983
    1983 T-T cell interactions in cell-mediated immune responses to major histocompatibility complex antigens. 1983
    1983 The Qa-1 alloantigens. II. Evidence for the expression of Qa-1 molecules by the Qa-1(d) genotype and for cross-reactivity between Qa-1 and H-2K(f) 1983
    1982 Primary cell-mediated lympholysis response to a maternally transmitted antigen 1982
    1982 Bromodeoxyuridine and light treatment enhances responsiveness of pokeweed mitogen-stimulated human lymphocytes to autologous and allogeneic determinants 1982
    1982 Qa-1-associated antigens: IV. Evidence for additional Qa-1 polymorphism defined biochemically and by cytotoxic T lymphocyte recognition 1982
    1981 Antigen presentation to human t lymphocytes: I. different requirements for stimulation by hapten-modified cells vs. cell sonicates 1981
    1981 Divalent cations and cytochalasin B-sensitive processes in activation, synthesis, and release of mixed leukocyte reaction suppressor factor 1981
    1981 Cellular and antigenic requirements for production of mixed leukocyte reaction suppressor factor 1981
    1981 Regulatory mechanisms in tumor immunity: introduction and summary. 1981
    1981 Role of calcium and magnesium and of cytochalasin-sensitive processes in lectin-stimulated lymphocyte activation 1981
    1981 The Qa-1 alloantigens. I. Identification and molecular weight characterization of glycoproteins controlled by the Qa-1(a) and Qa-1(b) alleles 1981
    1980 Qa-1-associated antigens. III. Distribution of Qa-1 region antigens on lymphoid subpopulations 1980
    1980 Role of Ia-positive cells in induction of secondary human immune responses to haptens in vitro 1980
    1980 Role of Ia-positive cells in induction of secondary human immune responses to haptens in vitro. 1980
    1979 Interaction between T cells and non-T cells in suppression of cytotoxic lymphocyte responses 1979
    1979 Primary in vitro cytotoxic response of nzb spleen cells to qa-lb-associated antigenic determinants 1979
    1979 Requlation of cytotoxic lymphocyte responses in New Zealand mice by alloantigen-activated spleen cells. 1979
    1979 H-2-nonrestricted cytotoxic responses to an antigen encoded telomeric to H-2D 1979
    1979 Human immune responses to hapten-conjugated cells. II. The roles of autologous and allogeneic histocompatibility determinants in proliferative responses in vitro 1979
    1979 Physiology of mixed leukocyte reaction suppressor factor. I. Role of cytoskeleton and protein synthesis in production and secretion 1979
    1979 Prenatal diagnosis of congenital adrenal hyperplasia 1979
    1979 Qa-1-associated antigens. I. Generation of H-2-nonrestricted cytotoxic T lymphocytes specific for determinants of the Qa-1 region 1979
    1979 Qa-1-associated antigens. II. Evidence for functional differentiation from H-2K and H-2D antigens 1979
    1979 Recognition of hapten-modified cells in vitro by human T lymphocytes 1979
    1979 Regulation of cytotoxic lymphocyte responses in New Zealand mice by alloantigen-activated spleen cells 1979
    1979 Regulatory mechanisms in cell-mediated immune responses: VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor* 1979
    1978 Regulation of alloantigen-induced cytotoxic responses by concanavalin A-activated lymphoid cells: suppression by antigen elimination 1978
    1978 Suppression of cytotoxic lymphocyte responses in vitro by soluble products of alloantigen-activated spleen cells 1978
    1978 Suppressor factor activity in cell mediated immune responses 1978
    1978 Human immune responses to hapten-conjugated cells: I. Primary and secondary proliferative responses in vitro* 1978
    1978 Mechanism of suppression of alloantigen-induced cytotoxic responses by concanavalin A-activated lymphoid cells 1978
    1978 Suppressor T cells in the regulation of immune responses to allogeneic tissues 1978
    1977 Regulation of cytotoxic lymphocyte responses in vitro by alloantigen activated spleen cells 1977
    1977 Regulatory mechanisms in cell-mediated immune responses: VI. Interaction of H-2 and Non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor* 1977
    1977 Regulatory mechanisms in cell-mediated immune responses: V. H-2 homology requirements for the production of a minor locus-induced suppressor factor* 1977
    1977 Aspirin and Delayed Type Hypersensitivity 1977
    1977 Fractionation of lymphocyte subpopulations which regulate mixed lymphocyte reactions 1977
    1977 Migratory properties of normal lymphoid cells with different concanavalin A-binding capacities 1977
    1977 Modulation of immunity by thymus-derived lymphocytes 1977
    1976 Regulatory mechanisms in cell-mediated immune responses: IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes* 1976
    1976 Suppression of mixed lymphocyte reactions by alloantigen-activated spleen-localizing thymocytes 1976
    1976 Regulatory mechanisms in cell-mediated immune responses: III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions* 1976
    1976 Biological expression of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A activated spleen cells 1976
    1976 Immune mechanisms in systemic lupus erythematosus. 1976
    1975 Biological expressions of lymphocyte activation. IV. Concanavalin A activated suppressor cells in mouse mixed lymphocyte reactions 1975
    1975 Determinants of differential migration of mouse spleen cells treated with Concanavalin A 1975
    1975 Regulatory mechanisms in cell mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen activated spleen cells 1975
    1975 Antibody synthesis and immunological memory in concanavalin A-treated mice 1975
    1975 Determinants of differential migration of concanavalin A activated lymphocytes 1975
    1975 Migration and activation of regulatory T cells for mouse mixed lymphocyte reactions 1975
    1975 Scanning electron microscopy of normal and mitogen-stimulated mouse lymphoid cells 1975
    1975 Suppression of mixed lymphocyte reaction by factors released from alloantigen activated spleen cells 1975
    1974 Regulatory mechanisms in cell-mediated immune responses: I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes 1974
    1974 Biological expressions of lymphocyte activation. III. Suppression of plaque forming cell responses in vitro by supernatant fluids from concanavalin A activated spleen cell cultures 1974
    1974 Concanavalin A induced modulation of antibody synthesis in vivo 1974
    1974 Migration of concanavalin A activated lymphocytes 1974
    1973 Immunological and clinical effects of transfer factor in anergic subjects. 1973
    1973 Therapy of sarcoidosis initiated with alternate day prednisone 1973
    1973 Biological expressions of lymphocyte activation: II. generation of a population of thymus-derived suppressor lymphocytes 1973
    1973 Biological expressions of lymphocyte activation: I. Effects of phytomitogens on antibody synthesis in vitro 1973
    1973 Mechanism of allergy to components of commercial bovine thyrotropin 1973
    1973 Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis 1973
    1972 Effect of transfer factor on lymphocyte function in anergic patients. 1972
    1972 Simultaneous suppression of responses to allogeneic tissue in vitro and in vivo 1972
    1971 Treatment of chronic mucocutaneous moniliasis by immunologic reconstitution. 1971
    1971 Chronic mucocutaneous candidiasis: model-building in cellular immunity. 1971
    1971 Inhibition of growth of candida albicans by iron-unsaturated lactoferrin: Relation to host-defense mechanisms in chronic mucocutaneous candidiasis 1971
    1971 Photosensitive cheilitis. Clinical and pathogenetic considerations. 1971
    1970 TREATMENT OF CHRONIC MONILIASIS WITH LYMPHOCYTE TRANSFUSIONS 1970
    1965 Mesenchymal metaplasia of the chick chorioallantoic membrane; a non-specific response to selected stimuli 1965

    Book

    Year Title Altmetric
    2012 Clinical immunology: Principles and practice: Fourth edition 2012
    2012 Preface to the first edition 2012
    2012 Preface to the fourth edition 2012
    2008 Clinical Immunology 2008
    2008 Preface to the first edition 2008
    2008 Preface to the third edition 2008
    2008 Clinical Immunology 2008

    Chapter

    Year Title Altmetric
    2012 Antigens and antigen presentation.  77-89. 2012
    2012 The human immune response.  3-13. 2012
    2008 Antigens and antigen processing.  91-101. 2008
    2008 The human immune response.  3-16. 2008

    Full Name

  • Robert Rich