Positions

Overview

  • Dr. Rui-Ming Liu received her M.D. and PhD (in Toxicology) degrees from Tongji Medical University, Wuhan, China. She is an American Board of Toxicology certified Toxicologist. Dr. Liu joined the UAB School of Public Health in 1999 as an Assistant Professor and was promoted to Associate Professor in 2005. In 2014, Dr. Liu was promoted to Professor with tenure and moved from School of Public Health to School of Medicine, Pulmonary, Allergy, and Critical Care Division.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's DiseaseJournal of Alzheimer's Disease.  64:447-457. 2018
    2017 NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4Scientific Reports.  7. 2017
    2017 A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 PathwayCellular Physiology and Biochemistry.  43:1152-1167. 2017
    2017 Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosisAJP - Lung Cellular and Molecular Physiology.  313:L834-L844. 2017
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung diseaseAging Cell.  16:1114-1124. 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugsJCI insight.  2. 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctionsAJP - Lung Cellular and Molecular Physiology.  312:L415-L424. 2017
    2017 IP-10/CXCR3 Axis Promotes the Proliferation of Vascular Smooth Muscle Cells through ERK1/2/CREB Signaling PathwayCell Biochemistry and Biophysics.  75:139-147. 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.JCI insight.  2:e91377. 2017
    2017 Exacerbation of diabetic cardiac hypertrophy in OVE26 mice by angiotensin II is associated with JNK/c-Jun/miR-221-mediated autophagy inhibitionOncotarget.  8:106661-106671. 2017
    2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentinAJP - Lung Cellular and Molecular Physiology.  313:L80-L91. 2017
    2016 Chronic hypoxia increases intracellular Ca(2+) concentration and augments proliferation by enhancing store-operated Ca(2+) entry in pulmonary arterial smooth muscle cellsChinese Journal of Internal Medicine.  55:705-709. 2016
    2016 MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiationAmerican Journal of Respiratory Cell and Molecular Biology.  54:843-852. 2016
    2016 The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injuryFederation proceedings.  30:2135-2150. 2016
    2016 Role of further-neighbor interactions in modulating the critical behavior of the Ising model with frustrationPhysical Review E.  93. 2016
    2016 Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinomaScientific Reports.  6. 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthmaAJP - Lung Cellular and Molecular Physiology.  310:L328-L336. 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  192:1462-1474. 2015
    2015 Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosisRedox Biology.  6:565-577. 2015
    2015 Cyclic ozone exposure induces gender-dependent neuropathology and memory decline in an animal model of Alzheimer's diseaseToxicological Sciences.  147:222-234. 2015
    2015 Influence of O2/Ar on structure and optical properties of ZnO: Mg thin films deposited by RF magnetron sputteringGuangdianzi Jiguang ==.  26:883-888. 2015
    2015 Evidence-based clinical guidelines on medication therapy for juvenile idiopathic arthritis: A systematic reviewZhongguo Xunzheng Yixue Zazhi.  15:152-158. 2015
    2015 Evidence-based guidelines on medication therapy for children with rheumatic fever: A systematic reviewZhongguo Xunzheng Yixue Zazhi.  15:23-27. 2015
    2015 Experimental investigations of springing and slamming responses of a ultra-VLCCChuan Bo Li Xue ==.  19:144-151. 2015
    2015 Investigating the Role of the Post-transcriptional Gene Regulator MIR-24-3p in the Proliferation, Migration and Apoptosis of Human Arterial Smooth Muscle Cells in Arteriosclerosis ObliteransCellular Physiology and Biochemistry.  36:1359-1370. 2015
    2015 Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosisExperimental Gerontology.  61:62-75. 2015
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosisJournal of Pharmacology and Experimental Therapeutics.  351:87-95. 2014
    2013 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injuryAmerican Journal of Pathology.  182:1239-1247. 2013
    2013 The progress and development trend of the geoscience information technology viewed from the abstracts submitted to the 34th IGC held in Brisbane, AustraliaGeological Bulletin of China.  32:685-692. 2013
    2013 A new ganoderic acid from Ganoderma lucidum mycelia and its stabilityFitoterapia.  84:115-122. 2013
    2013 [The mechanism of inhibition of the increase in intracellular calcium concentration by the islet amyloid polypeptide in high glucose-stimulated INS-1 cells].Chinese Journal of Internal Medicine.  52:407-411. 2013
    2012 Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis modelFree Radical Biology and Medicine.  53:554-563. 2012
    2012 Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer hela cellsActa Farmaceutica Bonaerense.  31:43-50. 2012
    2012 Corrigendum to "Ozone exposure is a risk factor for Alzheimer's disease" [Free Radical Biology and Medicine (2011) 51 (S68))Free Radical Biology and Medicine.  52:1334. 2012
    2012 Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitroEuropean Journal of Pharmacology.  681:23-33. 2012
    2012 Erratum: Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells (Phytomedicine (2011) 18 (349-355))Phytomedicine.  19:569. 2012
    2012 Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  46:87-95. 2012
    2011 Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in miceInhalation Toxicology.  23:486-494. 2011
    2011 Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's diseaseNeurobiology of Aging.  32:1079-1089. 2011
    2011 Efficacy and safety of mesalazine versus sulfasalazine for ulcerative colitis: A systematic reviewZhongguo Xunzheng Yixue Zazhi.  11:181-186. 2011
    2011 Telbivudine in the treatment of chronic hepatitis B: A systematic reviewZhongguo Xunzheng Yixue Zazhi.  11:101-105. 2011
    2011 Pyrolysis and gasification characteristics of coals in different depositional environmentHuaxue Gongcheng/Chemical Engineering.  39:94-97. 2011
    2011 Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cellsPhytomedicine.  18:349-355. 2011
    2011 Nonlinear superposition formula for SUSY SG/MKdV equations revisitedPhysics Letters A.  375:1286-1294. 2011
    2011 Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's diseaseJournal of Alzheimer's Disease.  26:767-778. 2011
    2010 Hydro-liquefaction behavior of Shengli brown coal in CO/H2O and H2/THN systemsJournal- East China Institute of Chemical Technology.  36:760-754. 2010
    2010 Low-dose and standard-dose cyclosporine immunosuppressive therapy in kidney transplant recipients: A meta-analysis of effectiveness and safetyZhongguo Xunzheng Yixue Zazhi.  10:683-687. 2010
    2010 A new ganoderic acid from Ganoderma lucidum myceliaJournal of Asian Natural Products Research.  12:727-730. 2010
    2010 Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of plasminogen activator inhibitor 1 in fibroblastsJournal of Biological Chemistry.  285:16239-16247. 2010
    2010 Oxidative stress and glutathione in TGF-β-mediated fibrogenesisFree Radical Biology and Medicine.  48:1-15. 2010
    2009 Glimepiride therapy for type 2 diabetes mellitus: A systematic reviewZhongguo Xunzheng Yixue Zazhi.  9:1094-1098. 2009
    2009 Tacrolimus versus cyclosporine A for simultaneous pancreas-kidney transplant recipients: A meta-analysisZhongguo Xunzheng Yixue Zazhi.  9:1214-1219. 2009
    2009 On the design of codebook for space division multiple access systemShanghai Jiao Tong Da Xue Xue Bao ==.  43:385-388. 2009
    2008 Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosisAntioxidants and Redox Signaling.  10:303-319. 2008
    2008 Methodology research of high-speed counter-current chromatography in separation of natural productsChinese Journal of Natural Medicines.  6:13-19. 2008
    2007 Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoterAJP - Lung Cellular and Molecular Physiology.  293. 2007
    2006 γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cellsFree Radical Biology and Medicine.  40:1281-1292. 2006
    2005 Glutathione restores collagen degradation in TGF-β-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogenAJP - Lung Cellular and Molecular Physiology.  289. 2005
    2004 Glutathione regulates transforming growth factor-β-stimulated collagen production in fibroblastsAJP - Lung Cellular and Molecular Physiology.  286. 2004
    2003 Decreased Synthetic Capacity Underlies the Age-Associated Decline in Glutathione Content in Fisher 344 RatsAntioxidants and Redox Signaling.  5:529-536. 2003
    2002 Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during agingJournal of Neuroscience Research.  68:344-351. 2002
    2001 4-Hydroxy-2-nonenal increases γ-glutamylcysteine synthetase gene expression in alveolar epithelial cellsAmerican Journal of Respiratory Cell and Molecular Biology.  24:499-505. 2001
    2001 Oxidant-induced regulation of glutathione synthesis.Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.].  Chapter 6. 2001
    1999 Depletion of glutathione by buthionine sulfoximine is cytotoxic for human neuroblastoma cell lines via apoptosisExperimental Cell Research.  246:183-192. 1999
    1998 Quinones increase γ-glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cellsAJP - Lung Cellular and Molecular Physiology.  274. 1998
    1997 Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cellsBiochemical Pharmacology.  53:987-993. 1997
    1996 Differential Enhancement of γ-Glutamyl Transpeptidase and γ-Glutamylcysteine Synthetase by Tert-butylhydroquinone in Rat Lung Epithelial L2 CellsAmerican Journal of Respiratory Cell and Molecular Biology.  14:186-191. 1996
    1996 Increased γ-Glutamylcysteine Synthetase and γ-Glutamyl Transpeptidase Activities Enhance Resistance of Rat Lung Epithelial L2 Cells to Quinone ToxicityAmerican Journal of Respiratory Cell and Molecular Biology.  14:192-197. 1996
    1994 gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.American Journal of Respiratory Cell and Molecular Biology.  11:586-592. 1994

    Research Overview

  • Dr. Liu’s laboratory research focuses on oxidative stress, aging, and aging-related diseases, mainly Idiopathic Pulmonary Fibrosis (IPF). Her lab is interested in the etiologies and pathogeneses as well as the development of therapeutics for the treatment of these diseases. Specifically, the lab is interested in the mechanism and biological significance of depletion of glutathione (GSH), the most abundant intracellular free thiol and an important antioxidant, during aging and in IPF; the mechanisms whereby plasminogen activator inhibitor 1 (PAI-1), a physiological inhibitor of urokinase type and tissue type plasminogen activators, promotes cell senescence, aging, and fibrosis as well as the therapeutic potential of small molecule of PAI-1 inhibitors for the treatment of lung fibrotic diseases; and Interaction between genetic and environmental factors as well as aging in the onset of Alzheimer’s disease.
  • Education And Training

  • Doctor of Philosophy in Environmental Toxicology, Tongji University 1988
  • Master of Science in Environmental Toxicology, Tongji University 1985
  • Doctor of Medicine, Tongji University 1982
  • Full Name

  • Rui-Ming Liu