Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Dysregulation of T follicular helper cells in lupus 2019
2018 Cutting edge: Intracellular IFN-β and distinct type i IFN expression patterns in circulating systemic lupus erythematosus B cells 2018
2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5 2018
2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases 2018
2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosus 2018
2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cells 2017
2016 Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer 2016
2015 General approach for tetramer-based identification of autoantigen-reactive B cells: Characterization of La- and snRNP-reactive B cells in autoimmune BXD2 mice 2015
2015 Identification of follicular T helper cells in tissue sections 2015
2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus 2015
2014 Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus 2014
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt 2014
2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis 2014
2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice 2014
2013 The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases. 2013
2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis 2013
2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice 2013
2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells 2013
2013 Cutting edge: Defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice 2013
2013 Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging. 2013
2012 Managing macrophages in rheumatoid arthritis by reform or removal 2012
2012 Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity gene 2012
2012 A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells 2012
2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model. 2012
2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adults 2011
2011 Reply 2011
2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice 2011
2011 Type i interferon-dependent CD86high marginal zone precursor b cells are potent T cell costimulators in mice 2011
2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease. 2011
2010 Metabolic syndrome, hormones, and maintenance of T cells during aging 2010
2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16 2010
2010 Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3 2010
2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity 2010
2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model 2010
2009 Assessment of genetic shielding for adenovirus vectors 2009
2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis 2009
2008 Regulation of estrogenic effects by beclin 1 in breast cancer cells 2008
2008 Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach 2008
2008 Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession 2008
2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice 2008
2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies 2007
2007 Quantitative trait locus (QTL) mapping in aging systems 2007
2007 Quantitative trait locus (QTL) mapping in aging systems. 2007
2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in mice 2006
2006 Phenotype of genetically regulated thymic involution in young BXD RI strains of mice 2006
2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforin 2006
2006 CD8 T-cell immune phenotype of successful aging 2006
2006 Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy 2006
2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis 2006
2006 Tumor necrosis factor ligand-receptor superfamily and arthritis. 2006
2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function 2005
2005 Rheumatoid arthritis: safe and sound. 2005
2005 Safe and sound 2005
2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis 2005
2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
2005 Genetic analysis of the antibody response to AAV2 and factor IX 2005
2005 Impaired apoptosis and immune senescence - Cause or effect? 2005
2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice 2005
2005 Genetic regulation of thymic involution 2005
2004 Nur77 family of nuclear hormone receptors 2004
2004 Defective clearance of adenovirus in IRF-1-/- mice associated with defects in NK and T cells but not macrophages 2004
2004 Regulation of apoptosis proteins in cancer cells by ubiquitin 2004
2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte Proliferation 2004
2004 Novel Tumor Necrosis Factor α-Regulated Genes in Rheumatoid Arthritis 2004
2004 Identification of multiple genetic loci that regulate adenovirus gene therapy 2004
2004 The Collaborative Cross, a community resource for the genetic analysis of complex traits 2004
2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis 2003
2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. 2003
2003 The nature and identification of quantitative trait loci: A community's view 2003
2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 2003
2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422)) 2003
2003 Cellular mechanism of thymic involution 2003
2003 Impact of immune senescence on human aging 2003
2003 Origin of late-onset autoimmune disease 2003
2002 Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production 2002
2002 Molecular imaging: New applications for biochemistry 2002
2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells 2002
2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model 2002
2002 Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ culture 2002
2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver 2002
2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11 2002
2002 Beneficial influences of systemic cooperation and sociological behavior on longevity 2002
2002 Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice 2002
2002 Molecular imaging: new applications for biochemistry. 2002
2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells 2002
2001 Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles 2001
2001 Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death 2001
2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis Infection 2001
2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection. 2001
2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt 2001
2001 Genetic dissection of age-related changes of immune function in mice 2001
2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. 2001
2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus 2001
2001 Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8+ T cells 2001
2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer 2001
2001 Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to γ-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice 2001
2001 Apoptosis and rheumatoid arthritis: past, present, and future directions. 2001
2001 The Fas signaling connection between autoimmunity and embryonic lethality 2001
2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor α and reduces arthritis 2000
2000 Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice 2000
1999 Apoptosis and cell death in the endocrine system 1999
1999 Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signaling 1999
1999 Polyamine-fas interactions: Inhibition of polyamine biosynthesis in MRL-lpr/lpr mice is associated with the up-regulation of fas mRNA in thymocytes 1999
1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic mice 1999
1998 Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell line 1998
1997 Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescence 1997
1997 Increased Acute-Phase Response and Renal Amyloidosis in Aged CD2-fas-Transgenic Mice 1997
1997 Increased apoptosis of CD45RO- T cells with aging 1997
1997 Clinical features associated with correction of T-cell senescence: Increased acute-phase response, amyloidosis and arthritis 1997
1996 CD2-FAS transgene increases t cell immune response and elevates amyloidosis in the kidney of aged CD-I mice 1996
1995 Cyclins and autoimmunity: Cyclin b1 gene expression and restriction fragment length polymorphism in lupus-prone mice 1995
1994 Regulation of ornithine decarboxylase in the kidney of autoimmune mice with the lpr gene 1994
1993 Studies on the effects of an ornithine decarboxylase inhibitor on lupus nephritis reveal a post-transcriptional modification of the enzyme 1993
1992 Ethanol intake in the chicken and its effect on body temperature and hypothalamic serotonin 1992
1991 Roles of in vitro- and in vivo-administered histamine and serotonin in compound 48/80-induced gastric acid secretion in isolated, perfused rat stomach 1991
1991 Suppression of Ethanol Intake in Chickens by Fenfluramine and Dietary Tryptophan 1991
1990 Inhibition of gastric acid secretion in the rat by high calcium 1990

Chapter

Year Title Altmetric
2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
2009 Gene therapy and immune senescence.  1629-1646. 2009

Research Overview

  • We have identified that autoimmune BXD2 mice exhibit unique features, including spontaneous formation of germinal centers, increased expression of activation-induced cytidine deaminase (AID), increased production of pathogenic autoantibodies that are polyreactive, significantly increased percentage of IL-17high CD4 TH cells (TH-17) and IL-17Rhigh B cells, and significantly increased numbers of type I interferon producing plasmacytoid dendritic cells in the spleens of these mice. We are currently studying the inter-connection of high IL-17, high type I IFN and the development of autoreactive B cells related to B-cell tolerance loss at the transitional stage and the germinal center stage in BXD2 mice.

    We currently study the close interaction between spleen marginal zone (MZ) B cells and MZ macrophages, and the implication of disrupting this close interaction in disease relapse following B-cell depletion therapy (BCDT) in systemic lupus erythematosus (SLE). In healthy individuals, the MZ B cells provide essential signals to maintain MZM survival and tolerogenic signaling to apoptotic debris derived autoantigens (AC-Ags) in the spleen MZ barrier. In SLE, a deficiency of tolerogenic MZMs occurs which disrupts the barrier and promotes an immunogenic environment including accumulation of uncleared AC-Ags and production of type I IFNs. Based on these results, we propose that BCDT in lupus, through depletion of the MZ B cells leads to a secondary depletion of the MZMs which may enable immunogenic responses to ACs in certain SLE patients. During deep B-cell depletion, when there are minimal B cells, this effect is not apparent. However, as B-cell repopulation occurs, the B cells are immediately subject to the immunogenic MZ microenvironment resulting in formation of autoreactive B cells and disease flares. We are currently developing strategies to overcome the loss of tolerogenic MZM barrier following BCDT with an ultimate goal to re-set B-cell tolerogenic state to achieve long-term remission. This work is currently supported by the Lupus Research Institute. http://lupusresearchinstitute.org/lupus-research/grant-recipients/hsu/hui-chen
  • Education And Training

  • Doctor of Philosophy in Nutrition Sciences, Rutgers University : New Brunswick 1995
  • Full Name

  • Hui-Chen Hsu
  • Fax

  • 205-975-6648