Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Dysregulation of T follicular helper cells in lupusJournal of Immunology.  202:1649-1658. 2019
2018 Cutting edge: Intracellular IFN-β and distinct type i IFN expression patterns in circulating systemic lupus erythematosus B cellsJournal of Immunology.  201:2203-2208. 2018
2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and DiseasesCell Chemical Biology.  25:499-512. 2018
2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosusDiscovery medicine.  25:21-29. 2018
2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cellsJournal of Immunology.  199:2618-2623. 2017
2016 Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancerAmino Acids.  48:2293-2302. 2016
2015 General approach for tetramer-based identification of autoantigen-reactive B cells: Characterization of La- and snRNP-reactive B cells in autoimmune BXD2 miceJournal of Immunology.  194:5022-5034. 2015
2015 Identification of follicular T helper cells in tissue sectionsMethods in Molecular Biology.  1291:13-25. 2015
2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupusJournal of Clinical Investigation.  125:2877-2890. 2015
2014 Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupusPLoS ONE.  9. 2014
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγtNature Communications.  5. 2014
2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritisArthritis and Rheumatology.  66:2368-2379. 2014
2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 miceArthritis and Rheumatology.  66:2601-2612. 2014
2013 The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.Journal of Orthopedics & Rheumatology.  1:4. 2013
2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritisArthritis and Rheumatism.  65:2594-2605. 2013
2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 miceArthritis and Rheumatism.  65:2703-2712. 2013
2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cellsJournal of Immunology.  191:1614-1624. 2013
2013 Cutting edge: Defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 miceJournal of Immunology.  190:4465-4469. 2013
2013 Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.Advances in Aging Research.  2:72-80. 2013
2012 Managing macrophages in rheumatoid arthritis by reform or removalCurrent Rheumatology Reports.  14:445-454. 2012
2012 Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity geneArthritis and Rheumatism.  64:609-612. 2012
2012 A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cellsAmino Acids.  42:899-911. 2012
2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.Arthritis and Rheumatism.  64:1098-1109. 2012
2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adultsJournal of Applied Biobehavioral Research.  16:187-211. 2011
2011 ReplyArthritis and Rheumatism.  63:3175-3177. 2011
2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 miceArthritis and Rheumatism.  63:2038-2048. 2011
2011 Type i interferon-dependent CD86high marginal zone precursor b cells are potent T cell costimulators in miceArthritis and Rheumatism.  63:1054-1064. 2011
2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.Discovery medicine.  11:76-85. 2011
2010 Metabolic syndrome, hormones, and maintenance of T cells during agingCurrent Opinion in Immunology.  22:541-548. 2010
2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16Journal of Immunology.  184:2289-2296. 2010
2010 Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3Mechanisms of Ageing and Development.  131:29-37. 2010
2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunityJournal of Immunology.  184:442-451. 2010
2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging modelBritish Journal of Dermatology.  162:487-496. 2010
2009 Assessment of genetic shielding for adenovirus vectorsOpen Gene Therapy Journal.  2:1-11. 2009
2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritisScandinavian Journal of Immunology.  70:309-316. 2009
2008 Regulation of estrogenic effects by beclin 1 in breast cancer cellsCancer Research.  68:7855-7863. 2008
2008 Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approachVirology Journal.  5. 2008
2008 Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid successionMolecular Therapy.  16:1500-1506. 2008
2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceNature Immunology.  9:166-175. 2008
2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodiesJournal of Immunology.  178:5357-5365. 2007
2007 Quantitative trait locus (QTL) mapping in aging systemsMethods in Molecular Biology.  371:321-348. 2007
2007 Quantitative trait locus (QTL) mapping in aging systems.Methods in Molecular Biology.  371:321-348. 2007
2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in miceHereditas.  143:189-197. 2006
2006 Phenotype of genetically regulated thymic involution in young BXD RI strains of miceScandinavian Journal of Immunology.  64:287-294. 2006
2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforinHuman Gene Therapy.  17:669-682. 2006
2006 CD8 T-cell immune phenotype of successful agingMechanisms of Ageing and Development.  127:231-239. 2006
2006 Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapyMolecular Therapy.  13:260-269. 2006
2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisArthritis and Rheumatism.  54:343-355. 2006
2006 Tumor necrosis factor ligand-receptor superfamily and arthritis.Current Directions in Autoimmunity.  9:37-54. 2006
2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system functionNature Genetics.  37:233-242. 2005
2005 Rheumatoid arthritis: safe and sound.Gene Therapy.  12:1542-1543. 2005
2005 Safe and soundGene Therapy.  12:1542-1543. 2005
2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritisArthritis and Rheumatism.  52:3257-3268. 2005
2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevationGene Therapy.  12:1079-1088. 2005
2005 Genetic analysis of the antibody response to AAV2 and factor IXMolecular Therapy.  11:866-874. 2005
2005 Impaired apoptosis and immune senescence - Cause or effect?Immunological Reviews.  205:130-146. 2005
2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of miceScandinavian Journal of Immunology.  61:128-138. 2005
2005 Genetic regulation of thymic involutionMechanisms of Ageing and Development.  126:87-97. 2005
2004 Nur77 family of nuclear hormone receptorsCurrent Drug Targets -Inflammation and Allergy-.  3:413-423. 2004
2004 Defective clearance of adenovirus in IRF-1 -/- mice associated with defects in NK and T cells but not macrophagesScandinavian Journal of Immunology.  60:89-99. 2004
2004 Regulation of apoptosis proteins in cancer cells by ubiquitinOncogene.  23:2009-2015. 2004
2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte ProliferationJournal of Immunology.  172:2909-2916. 2004
2004 Novel Tumor Necrosis Factor α-Regulated Genes in Rheumatoid ArthritisArthritis and Rheumatism.  50:420-431. 2004
2004 Identification of multiple genetic loci that regulate adenovirus gene therapyGene Therapy.  11:4-14. 2004
2004 The Collaborative Cross, a community resource for the genetic analysis of complex traitsNature Genetics.  36:1133-1137. 2004
2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritisJournal of Clinical Investigation.  112:1332-1341. 2003
2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.Journal of Clinical Investigation.  112:1332-1341. 2003
2003 The nature and identification of quantitative trait loci: A community's viewNature Reviews Genetics.  4:911-916. 2003
2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10Genes and Immunity.  4:402-410. 2003
2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422))Scandinavian Journal of Immunology.  58:118. 2003
2003 Cellular mechanism of thymic involutionScandinavian Journal of Immunology.  57:410-422. 2003
2003 Impact of immune senescence on human agingImmunology and Allergy Clinics of North America.  23. 2003
2003 Origin of late-onset autoimmune diseaseImmunology and Allergy Clinics of North America.  23:65-82. 2003
2002 Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or productionJournal of Virology.  76:12023-12031. 2002
2002 Molecular imaging: New applications for biochemistryJournal of Cellular Biochemistry.  162-171. 2002
2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cellsImmunologic Research.  26:235-246. 2002
2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor modelInternational Journal of Cancer.  101:270-279. 2002
2002 Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ cultureScandinavian Journal of Immunology.  56:174-184. 2002
2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liverJournal of Virology.  76:5692-5700. 2002
2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11Mechanisms of Ageing and Development.  123:1145-1158. 2002
2002 Beneficial influences of systemic cooperation and sociological behavior on longevityMechanisms of Ageing and Development.  123:963-973. 2002
2002 Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j miceJournal of Immunology.  168:4164-4172. 2002
2002 Molecular imaging: new applications for biochemistry.Journal of Cellular Biochemistry -Supplement-.  39:162-171. 2002
2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cellsCell Death and Differentiation.  9:626-635. 2002
2001 Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticlesJournal of Immunological Methods.  256:89-105. 2001
2001 Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell deathMechanisms of Ageing and Development.  122:1663-1684. 2001
2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis InfectionArthritis and Rheumatism.  44:2146-2159. 2001
2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection.Arthritis and Rheumatism.  44:2146-2159. 2001
2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase AktArthritis and Rheumatism.  44:1555-1567. 2001
2001 Genetic dissection of age-related changes of immune function in miceScandinavian Journal of Immunology.  54:10-20. 2001
2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.Arthritis and Rheumatism.  44:1555-1567. 2001
2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virusGene Therapy.  8:704-712. 2001
2001 Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8+ T cellsMechanisms of Ageing and Development.  122:305-326. 2001
2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transferArthritis and Rheumatism.  44:964-973. 2001
2001 Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to γ-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant miceJournal of Immunology.  166:772-780. 2001
2001 Apoptosis and rheumatoid arthritis: past, present, and future directions.Current Rheumatology Reports.  3:70-78. 2001
2001 The Fas signaling connection between autoimmunity and embryonic lethalityJournal of Clinical Immunology.  21:1-14. 2001
2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor α and reduces arthritisHuman Gene Therapy.  11:2431-2442. 2000
2000 Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient miceJournal of Clinical Investigation.  105:813-821. 2000
1999 Apoptosis and cell death in the endocrine systemRecent Progress in Hormone Research.  54:235-269. 1999
1999 Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signalingViral Immunology.  12:263-275. 1999
1999 Polyamine-fas interactions: Inhibition of polyamine biosynthesis in MRL-lpr/lpr mice is associated with the up-regulation of fas mRNA in thymocytesAutoimmunity.  29:299-309. 1999
1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic miceInternational Reviews of Immunology.  18:309-327. 1999
1998 Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell lineProceedings of the Association of American Physicians.  110:218-225. 1998
1997 Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescenceImmunological Reviews.  160:19-30. 1997
1997 Increased Acute-Phase Response and Renal Amyloidosis in Aged CD2-fas-Transgenic MiceJournal of Immunology.  158:5988-5996. 1997
1997 Increased apoptosis of CD45RO- T cells with agingMechanisms of Ageing and Development.  94:123-134. 1997
1997 Clinical features associated with correction of T-cell senescence: Increased acute-phase response, amyloidosis and arthritisDevelopmental and Comparative Immunology.  21:509-523. 1997
1996 CD2-FAS transgene increases t cell immune response and elevates amyloidosis in the kidney of aged CD-I miceFederation proceedings.  10. 1996
1995 Cyclins and autoimmunity: Cyclin b1 gene expression and restriction fragment length polymorphism in lupus-prone miceAutoimmunity.  22:17-26. 1995
1994 Regulation of ornithine decarboxylase in the kidney of autoimmune mice with the lpr geneAutoimmunity.  19:253-264. 1994
1993 Studies on the effects of an ornithine decarboxylase inhibitor on lupus nephritis reveal a post-transcriptional modification of the enzymeAgents and actions.  39. 1993
1992 Ethanol intake in the chicken and its effect on body temperature and hypothalamic serotoninNutrition Research.  12:629-642. 1992
1991 Roles of in vitro- and in vivo-administered histamine and serotonin in compound 48/80-induced gastric acid secretion in isolated, perfused rat stomachDigestive Diseases and Sciences.  36:1708-1714. 1991
1991 Suppression of Ethanol Intake in Chickens by Fenfluramine and Dietary TryptophanAlcoholism: Clinical and Experimental Research.  15:1056-1059. 1991
1990 Inhibition of gastric acid secretion in the rat by high calciumNutrition Research.  10:1441-1453. 1990

Chapter

Year Title Altmetric
2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
2009 Gene therapy and immune senescence.  1629-1646. 2009

Research Overview

  • We have identified that autoimmune BXD2 mice exhibit unique features, including spontaneous formation of germinal centers, increased expression of activation-induced cytidine deaminase (AID), increased production of pathogenic autoantibodies that are polyreactive, significantly increased percentage of IL-17high CD4 TH cells (TH-17) and IL-17Rhigh B cells, and significantly increased numbers of type I interferon producing plasmacytoid dendritic cells in the spleens of these mice. We are currently studying the inter-connection of high IL-17, high type I IFN and the development of autoreactive B cells related to B-cell tolerance loss at the transitional stage and the germinal center stage in BXD2 mice.

    We currently study the close interaction between spleen marginal zone (MZ) B cells and MZ macrophages, and the implication of disrupting this close interaction in disease relapse following B-cell depletion therapy (BCDT) in systemic lupus erythematosus (SLE). In healthy individuals, the MZ B cells provide essential signals to maintain MZM survival and tolerogenic signaling to apoptotic debris derived autoantigens (AC-Ags) in the spleen MZ barrier. In SLE, a deficiency of tolerogenic MZMs occurs which disrupts the barrier and promotes an immunogenic environment including accumulation of uncleared AC-Ags and production of type I IFNs. Based on these results, we propose that BCDT in lupus, through depletion of the MZ B cells leads to a secondary depletion of the MZMs which may enable immunogenic responses to ACs in certain SLE patients. During deep B-cell depletion, when there are minimal B cells, this effect is not apparent. However, as B-cell repopulation occurs, the B cells are immediately subject to the immunogenic MZ microenvironment resulting in formation of autoreactive B cells and disease flares. We are currently developing strategies to overcome the loss of tolerogenic MZM barrier following BCDT with an ultimate goal to re-set B-cell tolerogenic state to achieve long-term remission. This work is currently supported by the Lupus Research Institute. http://lupusresearchinstitute.org/lupus-research/grant-recipients/hsu/hui-chen
  • Education And Training

  • Doctor of Philosophy in Nutrition Sciences, Rutgers University : New Brunswick 1995
  • Full Name

  • Hui-Chen Hsu
  • Fax

  • 205-975-6648