Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.American Journal of Kidney Diseases2018
2018 Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.Kidney International Reports.  3:1373-1384. 2018
2018 Defining HIV-1 Envelope N-glycan Microdomains Through Site-specific Heterogeneity Profiles.Journal of Virology2018
2018 Aberrant Glycosylation of the IgA1 Molecule in IgA Nephropathy.Seminars in Nephrology.  38:461-476. 2018
2018 Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.PLoS ONE.  13:e0190967. 2018
2017 Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability.G3 : Genes, Genomes, Genetics.  8:27-38. 2017
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.Proceedings of the National Academy of Sciences.  114:E7949-E7958. 2017
2017 Efficient, ultra-high-affinity chromatography in a one-step purification of complex proteins.Proceedings of the National Academy of Sciences.  114:E5138-E5147. 2017
2017 What insights can proteomics give us into IgA nephropathy (Berger's disease)?Expert Review of Proteomics.  14:645-647. 2017
2016 Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy.Journal of the American Society of Nephrology.  27:3278-3284. 2016
2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.Journal of Mass Spectrometry.  51:535-548. 2016
2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.Journal of Mass Spectrometry.  51:ii-iii. 2016
2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.Journal of Mass Spectrometry.  51:461-475. 2016
2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.Journal of Mass Spectrometry.  51:ii-iii. 2016
2016 The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in Immunology.  7:117. 2016
2015 The Serum Very-Low-Density Lipoprotein Serves as a Restriction Factor against Hepatitis C Virus Infection.Journal of Virology.  89:6782-6791. 2015
2015 New Insights into the Pathogenesis of IgA Nephropathy.Kidney Diseases.  1:8-18. 2015
2015 N-acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy.Nephrology Dialysis Transplantation.  30:234-238. 2015
2015 General N-and O-Linked Glycosylation of Lipoproteins in Mycoplasmas and Role of Exogenous Oligosaccharide.PLoS ONE.  10:e0143362. 2015
2015 Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.Redox Biology.  4:346-354. 2015
2014 Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.Proceedings of the National Academy of Sciences.  111:1945-1950. 2014
2014 Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.Journal of Biological Chemistry.  289:814-826. 2014
2014 Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy.PLoS ONE.  9:e99026. 2014
2013 O-linked protein glycosylation in Mycoplasma.Microbiological sciences.  90:1046-1053. 2013
2013 Biomarkers in IgA nephropathy: relationship to pathogenetic hits.Expert Opinion on Medical Diagnostics.  7:615-627. 2013
2013 Elucidating heterogeneity of IgA1 hinge-region O-glycosylation by use of MALDI-TOF/TOF mass spectrometry: role of cysteine alkylation during sample processing.Journal of Biochemical and Biophysical Methods.  92:299-312. 2013
2013 Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.Cell Cycle.  12:3219-3227. 2013
2013 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.Genes and Development.  27:1581-1595. 2013
2013 Pathogenesis of immunoglobulin A nephropathy.Current Opinion in Nephrology and Hypertension.  22:287-294. 2013
2013 IgA nephropathy: molecular mechanisms of the disease.Annual Review of Pathology: Mechanisms of Disease.  8:217-240. 2013
2012 Glycosylation of IgA1 and pathogenesis of IgA nephropathy.Springer Seminars in Immunopathology.  34:365-382. 2012
2012 SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency.Proceedings of the National Academy of Sciences.  109:3772-3777. 2012
2012 Naturally occurring structural isomers in serum IgA1 o-glycosylation.Journal of Proteome Research.  11:692-702. 2012
2012 Production of N-acetylgalactosaminyl-transferase 2 (GalNAc-T2) fused with secretory signal Igκ in insect cells.Protein Expression and Purification.  81:175-180. 2012
2011 The pathophysiology of IgA nephropathy.Journal of the American Society of Nephrology.  22:1795-1803. 2011
2011 Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.Journal of Molecular Biology.  412:94-110. 2011
2011 Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.Journal of Biological Chemistry.  286:7190-7201. 2011
2011 Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid.Biochemistry.  50:93-105. 2011
2010 Clustered O-glycans of IgA1: defining macro- and microheterogeneity by use of electron capture/transfer dissociation.Molecular and Cellular Proteomics.  9:2545-2557. 2010
2010 Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/f rat lenses.Investigative Ophthalmology & Visual Science.  51:5153-5161. 2010
2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition.Journal of Biological Chemistry.  285:20860-20869. 2010
2010 The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.Journal of Biological Chemistry.  285:14152-14159. 2010
2010 Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1.Molecular and Cellular Proteomics.  9:719-727. 2010
2009 Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.PLoS Pathogens.  5:e1000545. 2009
2009 Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex.Cell regulation.  20:270-281. 2009
2008 Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding.Biochemistry.  47:11285-11299. 2008
2008 High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function.Biochemical Society Transactions.  36:1037-1044. 2008
2008 Probing conserved helical modules of portal complexes by mass spectrometry-based hydrogen/deuterium exchange.Journal of Molecular Biology.  381:772-784. 2008
2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation.Nature Medicine.  14:773-777. 2008
2008 Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts.Circulation Research.  102:185-192. 2008
2008 Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal.Journal of Lipid Research.  49:282-294. 2008
2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy.Kidney and Blood Pressure Research.  31:29-37. 2008
2007 Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy.Fresenius' Journal of Analytical Chemistry.  389:1397-1407. 2007
2007 active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: mapping of modified sites by Fourier transform-ion cyclotron resonance mass spectrometry.Chemical Research in Toxicology.  20:1260-1268. 2007
2007 IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells.Contributions to Nephrology.  157:134-138. 2007
2006 Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation.ELECTROPHORESIS.  27:2111-2125. 2006
2005 Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry.Journal of Biological Chemistry.  280:19136-19145. 2005
2005 Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylation.Biochemistry.  44:2732-2745. 2005
2004 Transcription factor B contacts promoter DNA near the transcription start site of the archaeal transcription initiation complex.Journal of Biological Chemistry.  279:2825-2831. 2004
1997 Inductively coupled plasma-atomic emission spectrometric analysis of aqueous slurries of solidsMicrochemical Journal.  56:30-39. 1997

Chapter

Year Title Altmetric
2016 Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy.  53-68. 2016

Research Overview

  • My research involves the analysis of proteins that are glycosylated in the context of human diseases. This includes O-glycosylation of the immunoglobulin IgA1 involved in the pathogenesis of a kidney disease called IgA nephropathy and the multiple N-glycans of the HIV Env glycoprotein which is a target for HIV vaccine design. My lab makes use of high resolution mass spectrometry to gain a better understanding of the range of glycans present on proteins. We then put that knowledge of the characterized glycans into the context of how the various proteins function. Additionally, we make use of a variety of MS based techniques to characterize protein structure and protein complexes.
  • Investigator On

  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Project 2: Design and Developement of Third Generation RXR Rexinoids as Potential Chemoprevention Agents  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2019
  • Elucidating IgA Nephropathy Through Genetic Studies of IgA1 Glycosylation  awarded by Columbia University 2014 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Metabolomics Workshop: From Design to Decision  awarded by National Institute of General Medical Sciences/NIH/DHHS 2012 - 2019
  • Aptamers-Based Arrays for Detection of Pathogenic IgA 1 O-Glycoforms in IgA Nephropathy  awarded by Columbia University 2016 - 2018
  • Novel Therapeutics of Acquired Thrombotic Thrombocytopenic Purpura  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2018
  • GDCN Clinical Center - Advancing Clinical Research in Primary Glomerular Diseases  awarded by University of North Carolina at Chapel Hill 2014 - 2018
  • IgA Nephropathy and the Role of Clustered Glycosylation Initiation by GaINAc-Transferases  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2018
  • Active - Proteomics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by ANTHERA PHARMACEUTICALS, INC 2015 - 2016
  • Private Grant  awarded by Pfizer Pharmaceuticals 2013 - 2015
  • Biological Chemistry of Reactive Nitrogen Species Signaling in Cancer Etiology  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Georgia
  • Full Name

  • Matthew Renfrow
  • Blazerid

  • renfrow