Positions

Overview

  • My research training began at the NIH (as a HHMI scholar) and continued with a PhD in Immunology following my mentor, Dr. Jeff Bluestone, to the University of Chicago, where I characterized murine peripheral TCR T cell repertoire, phenotype, and effector function. I completed medical school at UCLA and did a Pediatrics residency at Stanford where I gained an interest in Rheumatology. This was followed by a fellowship at the University of Washington in Pediatric Rheumatology. I returned to the lab to study human CD4 T cell effector function regulated at the transcriptional level with Dr. David Lewis. Following Dr. Lewis to Stanford, I completed an HHMI post-doctoral fellowship exploring CD154 dysregulation in systemic lupus erythematosus, as well as HIV-1 transcriptional regulation by NFAT transcription factors. This was the basis for my own lab’s studies at the University of Pennsylvania. I was recruited to UAB in 2007 to begin a division of Pediatric Rheumatology. In general, my lab studies CD4 T cell transcription in primary human CD4 T cells. As such, we have adapted or developed an array of useful methodologies/technologies for studying gene transcription (CD154, HIV-1, and others) in primary murine and human CD4 T cells. In addition, we are exploring the role of the Treg transcription factor, FoxP3, for its ability to inhibit HIV-1 transcription, and for Tregs to inhibit HIV-1 expression in neighboring CD4 T cells and macrophages. In collaboration with the Kutsch lab, we continue to explore transcriptional control of HIV-1 latency. Lastly, we are studying the effect of macrophage activation syndrome (MAS) patient mutations for their ability to decrease perforin-mediated cytolytic activity in NK cells. Many MAS patients have single copy mutations in familial hemophagocytic lymphohistiocytosis genes, and these mutations function as partial dominant negative proteins to inhibit cytolysis.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis.Genes and Immunity.  20:158-166. 2019
    2019 The Immunology of Macrophage Activation Syndrome.Frontiers in Immunology.  10:119. 2019
    2018 Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.Pediatric Rheumatology.  16:71. 2018
    2018 Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy.Arthritis and Rheumatology2018
    2018 Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease.Arthritis and Rheumatology.  70:1508-1518. 2018
    2018 Risk Factors for Intraarticular Heterotopic Bone Formation in the Temporomandibular Joint in Juvenile Idiopathic Arthritis.Journal of Rheumatology.  45:1301-1307. 2018
    2018 Brief Report: Novel UNC13D Intronic Variant Disrupting an NF-κB Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis.Arthritis and Rheumatology.  70:963-970. 2018
    2018 Toward Establishing a Standardized Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic Arthritis.Arthritis Care and Research.  70:758-767. 2018
    2018 Temporomandibular joint arthritis in juvenile idiopathic arthritis, now what?Pediatric Rheumatology.  16:32. 2018
    2018 Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study.Arthritis Research.  20:60. 2018
    2018 Pediatric rheumatology infusion center: report on therapeutic protocols and infusions given over 4 Years with focus on adverse events over 1 Year.Pediatric Rheumatology.  16:16. 2018
    2018 Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteins.Virology.  516:21-29. 2018
    2018 Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus.Journal of Rheumatology.  45:393-396. 2018
    2018 Age and fecal microbial strain-specific differences in patients with spondyloarthritis.Arthritis Research.  20:14. 2018
    2018 Defining the normal appearance of the temporomandibular joints by magnetic resonance imaging with contrast: a comparative study of children with and without juvenile idiopathic arthritis.Pediatric Rheumatology.  16:8. 2018
    2018 Creating the Subspecialty Pediatrics Investigator Network.Journal of Pediatrics.  192:3-4.e2. 2018
    2017 Risk of tuberculosis among Alabama children and adolescents treated with tumor necrosis factor inhibitors: a retrospective study.Pediatric Rheumatology.  15:79. 2017
    2017 Isolated Arthritis of the Temporomandibular Joint as the Initial Manifestation of Juvenile Idiopathic Arthritis.Journal of Rheumatology.  44:1632-1635. 2017
    2017 Malignancy in Pediatric-onset Systemic Lupus Erythematosus.Journal of Rheumatology.  44:1484-1486. 2017
    2017 Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome.Journal of Pediatrics.  189:72-78.e3. 2017
    2017 Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients.Arthritis Care and Research.  69:1088-1094. 2017
    2017 Weathering a Macrophage Storm.Journal of Rheumatology.  44:970-972. 2017
    2017 A review on SLE and malignancy.Best Practice and Research: Clinical Rheumatology.  31:373-396. 2017
    2017 Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis.Arthritis Care and Research.  70:409-419. 2017
    2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages.Virology.  504:79-87. 2017
    2017 Clinical Orofacial Examination in Juvenile Idiopathic Arthritis: International Consensus-based Recommendations for Monitoring Patients in Clinical Practice and Research Studies.Journal of Rheumatology.  44:326-333. 2017
    2016 Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors.Genes and Immunity.  17:400-405. 2016
    2016 Development of spondyloarthropathy following episodes of macrophage activation syndrome in children with heterozygous mutations in haemophagocytic lymphohistiocytosis-associated genes.Clinical and Experimental Rheumatology.  34:953. 2016
    2016 The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target?Current Opinion in Rheumatology.  28:537-543. 2016
    2016 Ustekinumab as a Therapeutic Option for Children With Refractory Enthesitis-Related Arthritis.JCR: Journal of Clinical Rheumatology.  22:282-284. 2016
    2016 Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza.Journal of Infectious Diseases.  213:1180-1188. 2016
    2016 A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.Journal of Immunology.  196:2492-2503. 2016
    2016 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.Annals of the Rheumatic Diseases.  75:481-489. 2016
    2016 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.Arthritis and Rheumatology.  68:566-576. 2016
    2016 Brief Report: Association of Myositis Autoantibodies, Clinical Features, and Environmental Exposures at Illness Onset With Disease Course in Juvenile Myositis.Arthritis and Rheumatology.  68:761-768. 2016
    2016 Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.Critical Care Medicine.  44:275-281. 2016
    2016 Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.RMD Open.  2:e000161. 2016
    2015 Magnetic Resonance Imaging Findings following Intraarticular Infliximab Therapy for Refractory Temporomandibular Joint Arthritis among Children with Juvenile Idiopathic Arthritis.Journal of Rheumatology.  42:2155-2159. 2015
    2015 Macrophage Activation Syndrome.Hematology/Oncology Clinics of North America.  29:927-941. 2015
    2015 Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome?Journal of Rheumatology.  42:1078-1080. 2015
    2015 What investigations are needed to optimally monitor for malignancies in SLE?Lupus.  24:781-787. 2015
    2015 Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.Journal of Rheumatology.  42:994-1001. 2015
    2015 Kill or be killed.Journal of Immunology.  194:5041-5043. 2015
    2015 Safety and efficacy of rituximab in childhood-onset systemic lupus erythematosus and other rheumatic diseases.Journal of Rheumatology.  42:541-546. 2015
    2015 Clinical features and correct diagnosis of macrophage activation syndrome.Expert Review of Clinical Immunology.  11:1043-1053. 2015
    2015 Systemic and intra-articular anti-inflammatory therapy of temporomandibular joint arthritis in children with juvenile idiopathic arthritisSeminars in Orthodontics.  21:125-133. 2015
    2015 Temporomandibular joint arthritis in juvenile idiopathic arthritis: The last frontierInternational Journal of Clinical Rheumatology.  10:273-285. 2015
    2014 Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis.Arthritis Research.  16:486. 2014
    2014 Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients.Arthritis and Rheumatology.  66:3160-3169. 2014
    2014 Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.Arthritis and Rheumatology.  66:2871-2880. 2014
    2014 Systemic lupus erythematosus and malignancies: a review article.Rheumatic Disease Clinics of North America.  40:497-viii. 2014
    2014 The impact of Nucleofection® on the activation state of primary human CD4 T cells.Journal of Immunological Methods.  408:123-131. 2014
    2014 IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter.Genes and Immunity.  15:137-144. 2014
    2014 Results of a multinational survey regarding the diagnosis and treatment of temporomandibular joint involvement in juvenile idiopathic arthritis.Pediatric Rheumatology.  12:6. 2014
    2014 Changes in body mass index in children with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors.Journal of Rheumatology.  41:113-118. 2014
    2014 Genetic defects in cytolysis in macrophage activation syndrome.Current Rheumatology Reports.  16:439. 2014
    2014 High dose Anakinra for treatment of severe neonatal Kawasaki disease: a case report.Pediatric Rheumatology.  12:26. 2014
    2014 Imaging of the temporomandibular joint in juvenile idiopathic arthritis.Arthritis Care and Research.  66:47-54. 2014
    2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.Journal of Virology.  88:364-376. 2014
    2014 Treatment of juvenile idiopathic arthritis: a revolution in care.Pediatric Rheumatology.  12:13. 2014
    2013 Treatment of juvenile idiopathic arthritis in the biologic age.Rheumatic Disease Clinics of North America.  39:751-766. 2013
    2013 High doses of infliximab in the management of juvenile idiopathic arthritis.Journal of Rheumatology.  40:1749-1755. 2013
    2013 MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.Journal of Neuroscience.  33:9592-9600. 2013
    2013 Retinal vasculitis in two pediatric patients with systemic lupus erythematosus: a case report.Pediatric Rheumatology.  11:25. 2013
    2013 Condylar Degeneration and Diseases-Local and Systemic EtiologiesSeminars in Orthodontics.  19:89-96. 2013
    2013 Higher-dose Anakinra is effective in a case of medically refractory macrophage activation syndrome.Journal of Rheumatology.  40:743-744. 2013
    2013 Anaphylaxis to etanercept in two children with juvenile idiopathic arthritis.JCR: Journal of Clinical Rheumatology.  19:129-131. 2013
    2013 Safety and efficacy of intra-articular infliximab therapy for treatment-resistant temporomandibular joint arthritis in children: a retrospective study.Rheumatology.  52:554-559. 2013
    2013 An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection.Journal of Virology.  87:2264-2277. 2013
    2013 Cancer risk in childhood-onset systemic lupus.Arthritis Research.  15:R198. 2013
    2012 Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cells.Journal of Immunology.  189:2746-2757. 2012
    2012 Intensive care requirement, rather than degree of serum ferritin elevation, predicts mortality in macrophage activation syndrome.Pediatric Critical Care Medicine.  13:616. 2012
    2012 Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritis.Journal of Rheumatology.  39:1880-1887. 2012
    2012 Sarcoidosis in a young child with Alagille syndrome: a case report.Pediatric Rheumatology.  10:32. 2012
    2012 Management of temporomandibular joint arthritis in adult rheumatology practices: a survey of adult rheumatologists.Pediatric Rheumatology.  10:26. 2012
    2012 Intra-articular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritis.Journal of Oral and Maxillofacial Surgery.  70:1802-1807. 2012
    2012 Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment.Genes and Immunity.  13:289-298. 2012
    2012 NF-ATc1 levels are increased in murine and human lupus T cells: comment on the article by Kyttaris et al.Arthritis and Rheumatism.  64:1294. 2012
    2011 Attainment of inactive disease status following initiation of TNF-α inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease.Journal of Rheumatology.  38:2675-2681. 2011
    2011 Temporomandibular joint arthritis in pediatric sjogren disease and sarcoidosis.Journal of Rheumatology.  38:2272-2273. 2011
    2011 ReplyArthritis Care and Research.  63:1355. 2011
    2011 High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort.Pediatric Rheumatology.  9:20. 2011
    2011 Brain cavernomas associated with en coup de sabre linear scleroderma: Two case reports.Pediatric Rheumatology.  9:18. 2011
    2011 1.5 Decades Later: Bearing fruits from the ACR/EULAR exchange Program.Pediatric Rheumatology.  9:14. 2011
    2011 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features.Arthritis Care and Research.  63:465-482. 2011
    2011 An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis.Journal of Rheumatology.  38:764-768. 2011
    2011 Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series.Arthritis and Rheumatism.  63:545-555. 2011
    2011 Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature.Pediatric Rheumatology.  9:5. 2011
    2011 Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients.Rheumatology.  50:417-419. 2011
    2011 Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: case report and a review of the pediatric autoimmune pancreatitis literature.Pediatric Rheumatology.  9:1. 2011
    2011 Combination therapy of abatacept and anakinra in children with refractory systemic juvenile idiopathic arthritis: a retrospective case series.Journal of Rheumatology.  38:180-181. 2011
    2010 Guilt by association - what is the true risk of malignancy in children treated with etanercept for JIA?Pediatric Rheumatology.  8:23. 2010
    2010 Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.Arthritis and Rheumatism.  62:2499-2509. 2010
    2010 Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens.Journal of Rheumatology.  37:870-875. 2010
    2009 FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.Journal of Immunology.  183:907-915. 2009
    2009 Rituximab therapy for severe refractory chronic Henoch-Schönlein purpura.Journal of Pediatrics.  155:136-139. 2009
    2009 The temporomandibular joint in juvenile idiopathic arthritis: frequently used and frequently arthritic.Pediatric Rheumatology.  7:11. 2009
    2009 Determinants of the establishment of human immunodeficiency virus type 1 latency.Journal of Virology.  83:3078-3093. 2009
    2009 Rheumatology fellows' perception on training and careers in academia: the American College of Rheumatology Fellow Research and Academic Training Survey.Arthritis and Rheumatism.  61:266-273. 2009
    2008 FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity.Virology.  381:161-167. 2008
    2008 A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter.Genes and Immunity.  9:640-649. 2008
    2008 High prevalence of temporomandibular joint arthritis at disease onset in children with juvenile idiopathic arthritis, as detected by magnetic resonance imaging but not by ultrasound.Arthritis and Rheumatism.  58:1189-1196. 2008
    2008 Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus.Pediatric Rheumatology.  6:5. 2008
    2008 Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR).Journal of Rheumatology.  35:343-348. 2008
    2008 Neither cell-surface nor soluble CD154 levels are associated with coronary artery disease in systemic lupus erythematosus.Journal of Rheumatology.  35:359-360. 2008
    2007 Pediatric rheumatology for the adult rheumatologist II: uveitis in juvenile idiopathic arthritis.JCR: Journal of Clinical Rheumatology.  13:205-210. 2007
    2007 Benefit of fluoroscopically guided intraarticular, long-acting corticosteroid injection for subtalar arthritis in juvenile idiopathic arthritis.Pediatric Radiology.  37:544-548. 2007
    2007 Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis.Journal of Rheumatology.  34:1133-1138. 2007
    2007 Reactive arthritis of the temporomandibular joints and cervical spine in a child.Pediatric Rheumatology.  5:4. 2007
    2007 CT-guided percutaneous steroid injection for management of inflammatory arthropathy of the temporomandibular joint in children.American Journal of Roentgenology.  188:182-186. 2007
    2007 Juvenile idiopathic arthritis classification criteria: loopholes and diagnosis software.Journal of Rheumatology.  34:234. 2007
    2006 Benefit of intraarticular corticosteroid injection under fluoroscopic guidance for subtalar arthritis in juvenile idiopathic arthritis.Journal of Rheumatology.  33:2330-2336. 2006
    2006 Picture of the month: anaplastic large cell lymphoma with hemophagocytic lymphohistiocytosis.Archives of Pediatrics and Adolescent Medicine.  160:1177-1179. 2006
    2006 Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis.Journal of Rheumatology.  33:2081-2084. 2006
    2006 Sjögren syndrome in a child: favorable response of the arthritis to TNFalpha blockade.Clinical Rheumatology.  25:746-748. 2006
    2006 Temporomandibular joint arthritis in juvenile idiopathic arthritis: the forgotten joint.Current Opinion in Rheumatology.  18:490-495. 2006
    2006 Chronic arthritis without uveitis in velocardiofacial syndrome.Journal of Pediatrics.  149:281. 2006
    2006 Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus.Arthritis and Rheumatism.  54:2220-2227. 2006
    2006 Effective gene suppression using small interfering RNA in hard-to-transfect human T cells.Journal of Immunological Methods.  312:1-11. 2006
    2006 Septic abscess in a child with juvenile idiopathic arthritis receiving anti-tumor necrosis factor-alpha.Journal of Rheumatology.  33:825. 2006
    2006 Treatment of pediatric localized scleroderma with methotrexate.Journal of Rheumatology.  33:609-614. 2006
    2006 NFAT transcription factors--new players in the pathogenesis of inflammatory arthropathies?Autoimmunity Reviews.  5:106-110. 2006
    2006 The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.Virology.  344:283-291. 2006
    2006 Early growth response-1 is required for CD154 transcription.Journal of Immunology.  176:811-818. 2006
    2006 Picture of the monthArchives of Pediatrics and Adolescent Medicine.  160:1177-1179. 2006
    2006 The spectrum of renal tubular acidosis in paediatric Sjögren syndrome.Rheumatology.  45:85-91. 2006
    2005 Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritis.Arthritis and Rheumatism.  52:3563-3569. 2005
    2005 A signal achievement in the treatment of arthritis.Arthritis and Rheumatism.  52:2229-2232. 2005
    2005 Pediatric rheumatology for the adult rheumatologist I: therapy and dosing for pediatric rheumatic disorders.JCR: Journal of Clinical Rheumatology.  11:21-33. 2005
    2005 Sweet syndrome as an initial presentation in a child with systemic lupus erythematosus.Lupus.  14:974-975. 2005
    2004 Reciprocal regulation of the nuclear factor of activated T cells and HIV-1.Genes and Immunity.  5:158-167. 2004
    2004 Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cells.Virology.  321:323-331. 2004
    2003 Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation.International Immunology.  15:1461-1472. 2003
    2003 Methotrexate used as a steroid-sparing agent in non-renal chronic Henoch-Schönlein purpura.Clinical and Experimental Rheumatology.  21:767-769. 2003
    2003 Erratum: Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression (Molecular and Cellular Biology (2003) 23:2 (510-525))Molecular and Cellular Biology.  23:6338. 2003
    2003 CD154 transcriptional regulation in primary human CD4 T cells.Immunologic Research.  27:185-202. 2003
    2003 Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression.Molecular and Cellular Biology.  23:510-525. 2003
    2002 Current treatment for chronic arthritis in childhood.Current Opinion in Pediatrics.  14:684-687. 2002
    2002 Regulation of the murine Nfatc1 gene by NFATc2.Journal of Biological Chemistry.  277:10704-10711. 2002
    2002 A T cell-specific enhancer of the human CD40 ligand gene.Journal of Biological Chemistry.  277:7386-7395. 2002
    2001 HIV-1, NFAT, and cyclosporin: immunosuppression for the immunosuppressed?DNA (Mary Ann Liebert, Inc.).  20:761-767. 2001
    2001 Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells.Genes and Immunity.  2:464-468. 2001
    2001 Treatment for JRA in the New Millennium.JCR: Journal of Clinical Rheumatology.  7:283-285. 2001
    2000 Nabumetone induced pseudoporphyria in childhood [3] (multiple letters)Journal of Rheumatology.  27:1817-1818. 2000
    2000 Nabumetone induced pseudoporphyria in childhood.Journal of Rheumatology.  27:1817-1818. 2000
    2000 NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.Clinical Immunology.  94:179-191. 2000
    1999 Current treatment by United States and Canadian pediatric rheumatologists.Journal of Rheumatology.  26:2036-2038. 1999
    1999 T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells.Journal of Immunology.  162:860-870. 1999
    1998 Methotrexate-induced hypersensitivity pneumonitis in a child with juvenile rheumatoid arthritis.Journal of Pediatrics.  132:901-902. 1998
    1997 Childhood sarcoidosis--does age of onset predict clinical manifestations?Journal of Rheumatology.  24:1654-1656. 1997
    1997 Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes.Journal of Immunological Methods.  205:145-150. 1997
    1997 Reactive arthritis to Clostridium difficile in a child.Western Journal of Medicine.  166:419-421. 1997
    1996 Picture of the month. Polyarteritis nodosa with angioedema.Archives of Pediatrics and Adolescent Medicine.  150:875-876. 1996
    1996 Reiter syndrome initially misdiagnosed as Kawasaki disease.Journal of Pediatrics.  128:366-369. 1996
    1996 Picture of the monthArchives of Pediatrics and Adolescent Medicine.  150:875-876. 1996
    1995 The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.Journal of Biological Chemistry.  270:29624-29627. 1995
    1995 Necrobacillosis: an unusual cause of purulent otitis media and sepsis.Pediatric Emergency Care.  11:379-380. 1995
    1995 Reiter's syndrome associated with cryptosporidial gastroenteritis.Journal of Rheumatology.  22:1962-1963. 1995
    1995 Index of suspicion. Case 2. Diagnosis: peritonsillitis.Pediatrics in Review.  16:117-119. 1995
    1994 Scleredema revisited. A poststreptococcal complication.Clinical Pediatrics.  33:606-610. 1994
    1994 Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture.Thymus.  23:131-153. 1994
    1992 Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection.Journal of Immunology.  149:3200-3207. 1992
    1991 Repertoire development and ligand specificity of murine TCR gamma delta cells.Immunological Reviews.  120:5-33. 1991
    1991 Ligand specificity and repertoire development of murine TCR gamma delta cells.Current Topics in Microbiology and Immunology.  173:133-139. 1991
    1990 Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor gamma delta-CD3.Journal of Dermatological Science.  1:459-464. 1990
    1990 T cell receptor delta-gene expression and diversity in the mouse spleen.Journal of Immunology.  145:1311-1317. 1990
    1990 Polymorphisms and diversity of T-cell receptor-gamma proteins expressed in mouse spleen.Immunogenetics.  31:220-228. 1990
    1989 Identification of distinct T cell receptor (TCR)-gamma delta heterodimers using an anti-TCR-gamma variable region serum.Journal of Immunology.  143:3769-3775. 1989
    1989 Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer.Science.  245:746-749. 1989
    1989 Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.Journal of Immunology.  142:3754-3762. 1989
    1989 A TCR gamma delta cell recognizing a novel TL-encoded gene product.Cold Spring Harbor Symposia on Quantitative Biology.  54 Pt 1:45-55. 1989
    1988 Systematic development of distinct T cell receptor-gamma delta T cell subsets during fetal ontogeny.Journal of Immunology.  141:3753-3759. 1988
    1988 Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.Journal of Experimental Medicine.  168:1899-1916. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures.Journal of Immunology.  141:1074-1082. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor γδ structuresJournal of Immunology.  141:1074-1082. 1988
    1987 Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes.Nature.  330:262-264. 1987

    Chapter

    Year Title Altmetric
    2018 Macrophage activation syndrome.  151-182. 2018
    2018 Diskitis.  302-303. 2018
    2018 Sarcoidosis.  814-815. 2018
    2018 Spondyloarthropathy.  872-873. 2018
    2016 Macrophage activation syndrome.  275-292. 2016
    2014 Juvenile Idiopathic Arthritis.  1950-1963. 2014
    2012 Juvenile idiopathic arthritis.  637-647. 2012

    Research Overview

  • Functional Genetics of Macrophage Activation Syndrome
    Temporomandibular Joint Arthritis
  • Investigator On

  • Overcoming HIV-1 Transcriptional Latency in Unresponsive CD4 T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • UAB Multidisciplinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Observational Study of Pediatric Rheumatic Diseases : The CARRA Registry  awarded by Duke University 2015 - 2018
  • Private Grant  awarded by SWEDISH ORPHAN BIOVITRUM AB 2016 - 2017
  • Validation of the Class II MHC Transactivator (CIITA) in Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2014 - 2016
  • Childhood Arthritis and Rheumatology Research Alliance ("CARRA Registry")  awarded by Duke University 2012 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Dermatomyositis Consensus Treatment Plan  awarded by DUKE CLINICAL RESEARCH INSTITUTE 2013 - 2015
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2013 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Idiopathic Arthritis Consensus Treatment Plan  awarded by Duke University 2013 - 2014
  • Improved Understanding of the Biology and use of TNF Inhibition in Children with JIA  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI) 2011 - 2013
  • Teaching Activities

  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • Full Name

  • Randy Cron