1. Novel Function of Tregs in the regulation of host-pathogen interaction and chronic intestinal inflammation: To understand the developmental fate and function of various subsets of regulatory T cells in controlling suppressor function and B cell-mediated antibody response in host-pathogen interaction and chronic intestinal inflammation.
2. Role of intestinal CD4+T cells in IBD-driven brain inflammation: Understanding the mechanism of IBD-induced neuroinflammation and neurobehavioral changes.
3. Development of non-pathogenic Th17 cells in pathogen-induced colitis and chronic colitis: Characterizing a new subset of anti-inflammatory Th17 cells in enteropathogenic bacteria-induced infection and chronic colitis.