Selected Publications

Academic Article

Year Title Altmetric
2022 RORγt-Expressing Pathogenic CD4+ T Cells Cause Brain Inflammation during Chronic ColitisJournal of Immunology.  208:2054-2066. 2022
2021 RORgt promotes Foxp3 expression by antagonizing the effector program in colonic regulatory T cellsJournal of Immunology.  207:2027-2038. 2021
2021 Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal CancerFrontiers in Immunology.  12. 2021
2021 Interleukins and interleukin receptors evolutionary history and origin in relation to cd4+ t cell evolutionGenes.  12. 2021
2020 Retinoid-Related Orphan Receptor RORγt in CD4+ T-Cell–Mediated Intestinal Homeostasis and InflammationAmerican Journal of Pathology.  190:1984-1999. 2020
2017 Cellular and molecular dynamics of Th17 differentiation and its developmental plasticity in the intestinal immune responseFrontiers in Immunology.  8. 2017
2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iT reg cell balanceNature Immunology.  16:286-295. 2015
2013 The Th17 family: Flexibility follows functionImmunological Reviews.  252:89-103. 2013
2012 Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic BacteriaImmunity.  37:1061-1075. 2012
2010 Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activationPLoS Pathogens.  6:1-21. 2010
2009 KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. majorVaccine.  27:1306-1316. 2009
2008 Virulence attenuation of a UDP-galactose/N-acetylglucosamine β1,4 galactosyltransferase expressing Leishmania donovani promastigoteGlycoconjugate Journal.  25:459-472. 2008
2007 Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13Infection and Immunity.  75:5956-5966. 2007
2007 HLA class I-restricted T cell epitopes of the kinetoplastid membrane protein-11 presented by Leishmania donovani-infected human macrophagesJournal of Infectious Diseases.  195:1373-1380. 2007
2006 Mapping the antigenicity of the parasites in Leishmania donovani infection by proteome serologyPLoS ONE.  1. 2006
2005 Identification of new antigens in visceral leishmaniasis by expression cloning and immunoblotting with sera of Kala-Azar patients from Bihar, IndiaInfection and Immunity.  73:7018-7021. 2005
2005 Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: Evidence for mixed Th1- and Th2-like responses in visceral leishmaniasisJournal of Immunology.  174:7160-7171. 2005
2003 Infectivity and attenuation of Leishmania donovani promastigotes II: Association of the loss of parasite infectivity with the terminal galactosylation of precursor acceptors present in virulent parasites by the developmentally regulated galactosyltransferaseParasite Immunology.  25:517-520. 2003
Phylogenetic analysis of molecular pathways in Tregs Suppressor Function
RORγt-Expressing Pathogenic CD4+T Cells Cause Brain Inflammation During Chronic Colitis

Research Overview

  • 1. Novel Function of Tregs in the regulation of host-pathogen interaction and chronic intestinal inflammation: To understand the developmental fate and function of various subsets of regulatory T cells in controlling suppressor function and B cell-mediated antibody response in host-pathogen interaction and chronic intestinal inflammation.

    2. Role of intestinal CD4+T cells in IBD-driven brain inflammation: Understanding the mechanism of IBD-induced neuroinflammation and neurobehavioral changes.

    3. Development of non-pathogenic Th17 cells in pathogen-induced colitis and chronic colitis: Characterizing a new subset of anti-inflammatory Th17 cells in enteropathogenic bacteria-induced infection and chronic colitis.
  • Education And Training

  • Doctor of Philosophy in Biological and Biomedical Sciences, Jadavpur University 2005
  • Full Name

  • Rajatava Basu