Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Erratum to: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion (Nature Communications, (2018), 9, 1, (3698), 10.1038/s41467-018-05853-7) 2019
2019 The expression of MHC class II molecules on murine breast tumors delays T-cell exhaustion, expands the T-cell repertoire, and slows tumor growth 2019
2019 Overcoming immune suppression with epigenetic modification in ovarian cancer 2019
2019 The establishment of resident memory B cells in the lung requires local antigen encounter 2019
2018 Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion 2018
2018 Human leukocyte antigen class I and II knockout human induced pluripotent stem cell–derived cells: Universal donor for cell therapy 2018
2018 Revisiting entinostat as an immune-potentiating adjuvant 2018
2018 The histone demethylase LSD1 regulates B cell proliferation and plasmablast differentiation 2018
2018 EZH2 represses the b cell transcriptional program and regulates antibody-Secreting cell metabolism and antibody production 2018
2018 Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations 2018
2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection 2017
2017 SIgM-fcmr interactions regulate early b cell activation and plasma cell development after influenza virus infection 2017
2017 Pulmonary immunity to viruses 2017
2017 Immunological Functions of the Omentum 2017
2017 Immunization of newborn mice accelerates the architectural maturation of lymph nodes, but AID-dependent IgG responses are still delayed compared to the adult 2017
2017 Fugue G Minor: Getting the Lymph Node Ensemble Together with Circadian Rhythm 2017
2017 Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth 2017
2016 IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice 2016
2016 IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice 2016
2016 Ovarian cancer and the immune system — The role of targeted therapies 2016
2016 Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation 2016
2016 T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite 2016
2015 Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function 2015
2015 IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs 2015
2015 B lymphocytes are required during the early priming of CD4<sup>+</sup> T cells for clearance of pneumocystis infection in mice 2015
2015 The omentum is a site of protective IgM production during intracellular bacterial infection 2015
2014 The biology of the interleukin-2 (IL-2)-Based immunotherapies in cancer and autoimmune disease 2014
2014 Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8+ T Cells 2014
2014 Tertiary lymphoid structures target the antitumor immune response to lung cancer 2014
2014 FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability 2014
2014 Priming of T follicular helper cells by dendritic cells 2014
2014 Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells 2014
2014 The development and function of mucosal lymphoid tissues: A balancing act with micro-organisms 2014
2013 Generation of a dual-functioning antitumor immune response in the peritoneal cavity 2013
2013 Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis 2013
2013 Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation 2013
2013 Neonatal irradiation sensitizes mice to delayed pulmonary challenge 2013
2013 CXCR5+ T helper cells mediate protective immunity against tuberculosis 2013
2012 Lipocalin 2 Regulates Inflammation during Pulmonary Mycobacterial Infections 2012
2012 Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections 2012
2012 Regulation of T H2 development by CXCR5 + dendritic cells and lymphotoxin-expressing B cells 2012
2012 Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation 2012
2012 Stromal cells put the brakes on T-cell responses 2012
2012 Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation 2012
2012 Rangel-Moreno et al. reply: 2012
2011 IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung 2011
2011 Memory: The Incomplete Unhappening of Differentiation 2011
2011 Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus 2011
2011 Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect 2011
2011 Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance 2011
2011 The development of inducible bronchus-associated lymphoid tissue depends on IL-17 2011
2011 Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus 2011
2011 Profiling early lung immune responses in the mouse model of tuberculosis 2011
2010 Adaptive immunity and adipose tissue biology 2010
2010 Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia 2010
2010 Antigen-specific clonal expansion and cytolytic effector function of CD8 + T lymphocytes depend on the transcription factor Bcl11b 2010
2010 Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity 2010
2010 Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis 2010
2010 Erratum: Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza (Nature Immunology (2010) 11 (216-224)) 2010
2010 Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization 2010
2010 Pulmonary dendritic cells: Thinking globally, acting locally 2010
2010 Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+T cell responses to influenza 2010
2010 Bronchus-Associated Lymphoid Tissue (BALT). Structure and function 2010
2009 Insights into the heterogeneity of human B cells: Diverse functions, roles in autoimmunity, and use as therapeutic targets 2009
2009 Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensis 2009
2009 Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses 2009
2009 CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells 2009
2009 Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus 2009
2009 Chemokine cxcl13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation 2009
2008 A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus 2008
2008 Development of secondary lymphoid organs 2008
2008 Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus 2008
2008 Ectopic lymphoid tissues and local immunity 2008
2008 B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms 2008
2007 Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza 2007
2007 IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge 2007
2007 The function of local lymphoid tissues in pulmonary immune responses. 2007
2007 Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract 2007
2006 Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis 2006
2006 Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs 2006
2006 Suppressed insulin signaling and increased apoptosis in Cd38-null islets 2006
2006 B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection 2006
2006 Uneven distribution of MHC class II epitopes within the influenza virus 2006
2005 The complex role of lymphotoxin in immunity 2005
2005 CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection 2005
2005 Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue 2005
2005 Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in schistosoma mansoni 2005
2005 Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen 2005
2005 Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. 2005
2004 Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses 2004
2004 Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13 2004
2004 Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity 2004
2004 Anatomical features of anti-viral immunity in the respiratory tract 2004
2004 Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity 2004
2003 CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly 2003
2003 CD40, but Not CD154, Expression on B Cells is Necessary for Optimal Primary B Cell Responses 2003
2003 CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment 2003
2003 Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P. carinii-specific antibody 2003
2003 Maintenance of long term γ-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells 2003
2003 Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity 2003
2003 Simultaneous detection of EGFP and cell surface markers by fluorescence microscopy in lymphoid tissues 2003
2002 Lymphotoxin-α-deficient mice make delayed, but effective, T and B cell responses to influenza 2002
2002 The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: Reciprocal regulation by interleukin (IL)-4 and IL-12 2002
2002 Cutting edge: Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-γ, but the organization of NALT is LTα dependent 2002
2002 Does neutrophil CD38 have a role in Ca++ signaling triggered by β2 integrin? [1] (multiple letters) 2002
2001 Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo 2001
2001 Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle 2001
1998 Transfer of primitive stem/progenitor bone marrow cells from LTα(-/-) donors to wild-type hosts: Implications for the generation of architectural events in lymphoid B cell domains 1998
1998 Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses 1998
1998 CD38: A new paradigm in lymphocyte activation and signal transduction 1998
1998 Arrest of B lymphocyte terminal differentiation by CD40 signaling: Mechanism for lack of antibody-secreting cells in germinal centers 1998
1998 Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: Resting stem cells or mystery population? 1998
1997 Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment 1997
1996 Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells 1996
1994 Mechanism and subcellular localization of secretory IgM polymer assembly 1994
1994 IgM hexamers? 1994
1994 IgM hexamers? 1994
1993 Interleukin-5 (IL-5) and IL-6 define two molecularly distinct pathways of B-cell differentiation 1993
1993 MHC class II limits the functional expression of endogenous superantigens in B cells 1993
1992 Mouse mammary tumor proviral gene expression in cells of the B lineage 1992
1992 J chain synthesis and secretion of hexameric IgM is differentially regulated by lipopolysaccharide and interleukin 5 1992
1992 Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells 1992
1990 The biological effects of IgM hexamer formation 1990

Chapter

Year Title Altmetric
2015 Structure, Organization, and Development of the Mucosal Immune System of the Respiratory Tract.  43-61. 2015
2014 The biology of the interleukin-2 (IL-2)-based immunotherapies in cancer and autoimmune disease.  31-52. 2014

Education And Training

  • Doctor of Science in Microbiological Sciences and Immunology, Duke University 2011
  • Bachelor of Science or Mathematics in Chemistry, University of Denver 1987
  • Full Name

  • Troy Randall