Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Transgenic Expression of Nrf2 Induces a Pro-Reductive Stress and Adaptive Cardiac Remodeling in the MouseGenes.  13. 2022
2022 Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress CardiomyopathyFrontiers in Cardiovascular Medicine.  9. 2022
2022 Editorial: Metabolic and Redox Regulation at the Center of Aging.Frontiers in Aging.  3:858295. 2022
2021 Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stressScientific Reports.  11. 2021
2021 Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathyFree Radical Biology and Medicine.  169:317-342. 2021
2021 Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluationFood Research International.  140. 2021
2021 Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.Theranostics.  11:2742-2754. 2021
2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy.  17:1-382. 2021
2021 Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular diseasePlacenta.  103:226-231. 2021
2021 Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium. 2021
2021 microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice.Frontiers in Cardiovascular Medicine.  8:737826. 2021
2020 Reductive stress promotes protein aggregation and impairs neurogenesisRedox Biology.  37. 2020
2020 Reductive stress impairs myogenic differentiationRedox Biology.  34. 2020
2020 Reductive Stress: Neglected Science.Antioxidants and Redox Signaling2020
2020 Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic DysfunctionAntioxidants and Redox Signaling.  32:1293-1312. 2020
2020 Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss 2020
2020 DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes 2020
2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
2019 Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.Cardioscience.  115:1986-1997. 2019
2019 Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in miceRedox Biology.  27. 2019
2019 Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial RepairCirculation.  140:520-522. 2019
2019 OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signallingClinical and Experimental Pharmacology and Physiology.  46:743-751. 2019
2019 Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological RemodelingFrontiers in Cardiovascular Medicine.  6. 2019
2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture modelJournal of Heart and Lung Transplantation.  38:456-465. 2019
2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart FailureCirculation Research.  124:161-169. 2019
2019 Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male ratFree Radical Biology and Medicine.  130:592-600. 2019
2019 Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway.Oxidative Medicine and Cellular Longevity.  2019:2761041. 2019
2018 Evidence for a hyper-reductive redox in a sub-set of heart failure patientsJournal of Translational Medicine.  16. 2018
2018 Recurrent heat shock impairs the proliferation and differentiation of C2C12 myoblastsCell Stress and Chaperones.  23:399-410. 2018
2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
2018 Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation 2018
2018 Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial DysfunctionMolecular Nutrition and Food Research.  62. 2018
2017 Identification of transcriptome signature for myocardial reductive stressRedox Biology.  13:568-580. 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 TNF-alpha Is not a Miscreant: A Hero for Basal Nrf2-Antioxidant Signaling. 2017
2017 Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardiumRedox Biology.  12:937-945. 2017
2017 Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout miceBMC Genomics.  18. 2017
2017 Chronic endurance exercise impairs cardiac structure and function in middle-aged mice with impaired Nrf2 signalingFrontiers in Physiology.  8. 2017
2017 Cardiac aging – benefits of exercise, Nrf2 activation and antioxidant signalingAdvances in Experimental Medicine and Biology.  999:231-255. 2017
2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
2016 A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytesRedox Biology.  9:77-89. 2016
2016 Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular functionJournal of Thoracic and Cardiovascular Surgery.  152:1059-1070.e2. 2016
2016 Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and functionJournal of Heart and Lung Transplantation.  35:930-932. 2016
2016 Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung FibrosisAmerican Journal of Pathology.  186:1712-1723. 2016
2016 Exercise, Nrf2 and antioxidant signaling in cardiac agingFrontiers in Physiology.  7. 2016
2016 Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: A mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle 2016
2016 Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stressJournal of Translational Medicine.  14. 2016
2015 Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355))Biochemical Journal.  471:431. 2015
2015 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicityBiochemical Journal.  469:347-355. 2015
2015 Nickel elution properties of contemporary interatrial shunt closure devices 2015
2015 Redox Signaling and the Cardiovascular and Skeletal Muscle SystemOxidative Medicine and Cellular Longevity.  2015. 2015
2015 Reductive potential - A savior turns stressor in protein aggregation cardiomyopathy 2015
2014 Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophagesCell.  156:1223-1234. 2014
2014 Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cellsFree Radical Biology and Medicine.  71:402-414. 2014
2013 Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.Cardioscience.  100:63-73. 2013
2013 The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.PLoS Genetics.  9:e1003544. 2013
2012 Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. 2012
2012 Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.Free Radical Biology and Medicine.  52:366-376. 2012
2012 Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.PLoS One.  7:e45697. 2012
2011 Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.Antioxidants and Redox Signaling.  14:957-971. 2011
2010 Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways.Journal of Molecular and Cellular Cardiology.  49:918-930. 2010
2008 Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice.Physiological Genomics.  35:165-172. 2008
2008 Autophagy is an adaptive response in desmin-related cardiomyopathy. 2008
2008 Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. 2008
2007 CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. 2007
2007 TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. 2007
2007 Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.Cell.  130:427-439. 2007
2005 Effects of the antioxidant properties of millet species on oxidative stress and glycemic status in alloxan-induced ratsProgress in food & nutrition science.  25:1109-1120. 2005
2005 Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy. 2005
2005 Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney.Antioxidants and Redox Signaling.  7:465-471. 2005
2004 The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats. 2004
2004 Modulation of rat erythrocyte antioxidant defense system by buthionine sulfoximine and its reversal by glutathione monoester therapy. 2004
2004 Vitamin E prevents buthionine sulfoximine-induced biochemical disorders in the rat.Journal of Pharmacy and Pharmacology.  56:91-99. 2004
2002 The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver.Journal of Nutritional Biochemistry.  13:302-306. 2002

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Madras 2001
  • Full Name

  • Rajasekaran Namakkal Soorappan