Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 The in vivo specificity of synaptic Gβ and Gγ subunits to the α 2a adrenergic receptor at CNS synapsesScientific Reports.  9. 2019
2019 Complex noradrenergic dysfunction in Alzheimer's disease: Low norepinephrine input is not always to blameBrain Research.  1702:12-16. 2019
2017 Effective attenuation of adenosine a1r signaling by neurabin requires oligomerization of neurabinMolecular Pharmacology.  92:630-639. 2017
2017 The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitmentFederation proceedings.  31:4434-4446. 2017
2017 Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystoniaExperimental Neurology.  295:162-175. 2017
2017 Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilinPLoS ONE.  12. 2017
2017 Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletionExperimental Neurology.  292:179-192. 2017
2017 Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α 2A adrenergic receptor ligandsNeuropharmacology.  116:38-49. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceCardiovascular Research.  112:532-542. 2016
2015 Spinophilin is indispensable for the α<inf>2B</inf> adrenergic receptor-elicited hypertensive responsePLoS ONE.  10. 2015
2015 Noradrenergic dysfunction in Alzheimer's diseaseFrontiers in Neuroscience.  9. 2015
2015 Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer’s diseaseJournal of Neuroscience.  35:6221-6230. 2015
2014 α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interactionProceedings of the National Academy of Sciences.  111:17296-17301. 2014
2014 Cannabinoid modulation of alpha2 adrenergic receptor function in rodent medial prefrontal cortexEuropean Journal of Neuroscience.  40:3202-3214. 2014
2014 Tricyclic antidepressants exhibit variable pharmacological profiles at the α2A adrenergic receptorBiochemical and Biophysical Research Communications.  451:461-466. 2014
2014 Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesisCardiovascular Research.  103:258-267. 2014
2014 CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in miceHuman Molecular Genetics.  23:2145-2156. 2014
2014 The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsyAnnals of Neurology.  75:77-87. 2014
2014 α2A-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalisJournal of Neuroscience.  34:9319-9331. 2014
2013 Cross-talk from β-adrenergic receptors modulates α 2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilinJournal of Biological Chemistry.  288:29193-29205. 2013
2012 Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilinNeuropharmacology.  62:2353-2361. 2012
2012 Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the α 2A adrenergic receptorBiochemical and Biophysical Research Communications.  420:161-165. 2012
2012 Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosineJournal of Neuroscience.  32:2683-2695. 2012
2012 Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilinNeuropharmacology.  62:2354-2362. 2012
2012 α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapyNeuroscience and Biobehavioral Reviews.  36:2214-2225. 2012
2011 Adrenergic receptors. Preface.Current Topics in Membranes.  67. 2011
2011 The antidepressant desipramine is an arrestin-biased ligand at the α 2A-adrenergic receptor driving receptor down-regulation in vitro and in vivoJournal of Biological Chemistry.  286:36063-36075. 2011
2011 Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factorBiochemical and Biophysical Research Communications.  409:338-343. 2011
2011 Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodelingCells Tissues Organs.  193:393-403. 2011
2011 Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesisMechanisms of Development.  128:200-207. 2011
2011 Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryosDevelopmental Dynamics.  240:211-220. 2011
2011 Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downsMethods in Molecular Biology.  746:347-355. 2011
2010 Enhanced hypotensive, bradycardic, and hypnotic responses to α2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the α2A-adrenergic receptorMolecular Pharmacology.  78:279-286. 2010
2009 α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalisNeuroscience.  163:339-351. 2009
2009 Epitope-tagged receptor knock-in mice reveal that differential desensitization of α2-adrenergic responses is because of ligand-selective internalizationJournal of Biological Chemistry.  284:13233-13243. 2009
2009 Knockout of spinophilin, an endogenous antagonist of arrestin-dependent α2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differencesBehavioural Brain Research.  197:457-461. 2009
2008 Protein kinase A phosphorylation of spinophilin modulates its interaction with the α2A-adrenergic receptor (AR) and alters temporal properties of α2AAR internalizationJournal of Biological Chemistry.  283:14516-14523. 2008
2008 Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defectsDevelopmental Biology.  316:417-430. 2008
2007 Myocardial Smad4 is essential for cardiogenesis in mouse embryosCirculation Research.  101:277-285. 2007
2007 Regulation of α2AR trafficking and signaling by interacting proteinsBiochemical Pharmacology.  73:1135-1145. 2007
2006 Arrestin serves as a molecular switch, linking endogenous α2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activationJournal of Biological Chemistry.  281:25948-25955. 2006
2005 Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.Molecular Pharmacology.  67:1690-1696. 2005
2004 Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.Science.  304:1940-1944. 2004
2003 Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.Journal of Biological Chemistry.  278:32405-32412. 2003
2002 Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3.Journal of Biological Chemistry.  277:50589-50596. 2002
2001 Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.Journal of Biological Chemistry.  276:15003-15008. 2001

Book

Year Title Altmetric
2011 Genetic Variations of α2-Adrenergic Receptors Illuminate the Diversity of Receptor Functions.  Ed. 67.  2011

Chapter

Year Title Altmetric
2015 α2 adrenergic receptor trafficking as a therapeutic target in antidepressant drug action.  207-225. 2015
2012 α2-Adrenergic Receptors.  55-58. 2012

Education And Training

  • Doctor of Philosophy in Biology / Biological Sciences, University of Iowa 1999
  • Doctor of Medicine in Medical Basic Sciences, 1992
  • Full Name

  • Qin Wang