Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Erratum: Relational mobility predicts social behaviors in 39 countries and is tied to historical farming and threat (Proceedings of the National Academy of Sciences of the United States of America (2019) 115 (7521–7526) DOI: 10.1073/pnas.1713191115)Proceedings of the National Academy of Sciences.  116:8082. 2019
2018 Factors associated with physical inactivity in adult breast cancer survivors—A population-based studyCancer Medicine.  7:6331-6339. 2018
2017 Clinical and genetic risk prediction of subsequent CNS tumors in survivors of childhood cancer: A report fromthe COG ALTE03N1 studyJournal of Clinical Oncology.  35:3688-3696. 2017
2017 Abundance and molecular diversity of thraustochytrids in coastal waters of southern ChinaFEMS Microbiology Ecology.  93. 2017
2016 High type I error and misrepresentations in search for transgenerational epigenetic inheritance: Response to Guerrero-BosagnaGenome Biology.  17. 2016
2016 CELF4 variant and anthracycline-related cardiomyopathy: A children's oncology group genome-wide association studyJournal of Clinical Oncology.  34:863-870. 2016
2015 Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogrammingGenome Biology.  16. 2015
2014 Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencingNucleic Acids Research.  42:1772-1783. 2014
2013 De Novo DNA Methylation in the Male Germ Line Occurs by Default but Is Excluded at Sites of H3K4 MethylationCell Reports.  4:205-219. 2013
2012 More than insulator: Multiple roles of CTCF at the H19-Igf2 imprinted domainFrontiers in Genetics.  3. 2012
2012 Chromatin immunoprecipitation to characterize the epigenetic profiles of imprinted domainsMethods in Molecular Biology.  925:159-172. 2012
2012 Chromatin immunoprecipitation to characterize the epigenetic profiles of imprinted domains.Methods in Molecular Biology.  925:159-172. 2012
2011 Chromosome-wide analysis of parental allele-specific chromatin and DNA methylationMolecular and Cellular Biology.  31:1757-1770. 2011
2011 Effects of endocrine disruptors on imprinted gene expression in the mouse embryoEpigenetics.  6:937-950. 2011
2011 MIRA-SNuPE, a quantitative, multiplex method for measuring allele-specific DNA methylationEpigenetics.  6:212-223. 2011
2010 Coordinated allele-specific histone acetylation at the differentially methylated regions of imprinted genesNucleic Acids Research.  38:7974-7990. 2010
2010 CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-igf2 imprinting control region in prospermatogoniaPLoS Genetics.  6. 2010
2010 Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethalityPLoS ONE.  5:1-11. 2010
2010 Allele-specific H3K79 di- versus trimethylation distinguishes opposite parental alleles at imprinted regionsMolecular and Cellular Biology.  30:2693-2707. 2010
2009 The 3′-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysisJournal of Biological Chemistry.  284:22184-22194. 2009
2008 Overexpression and hypomethylation of Flap endonuclease 1 gene in breast and other cancersCell Growth and Differentiation.  6:1710-1717. 2008
2008 Comprehensive Mapping of the C-Terminus of Flap Endonuclease-1 Reveals Distinct Interaction Sites for Five Proteins That Represent Different DNA Replication and Repair PathwaysJournal of Molecular Biology.  377:679-690. 2008
2007 Fen1 mutations result in autoimmunity, chronic inflammation and cancersNature Medicine.  13:812-819. 2007
2007 Concerted action of exonuclease and gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG) n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragmentsJournal of Biological Chemistry.  282:3465-3477. 2007
2005 Characterization of the 3′ → 5′ exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologuesBiochemistry.  44:15774-15786. 2005
2005 Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseasesBioEssays.  27:717-729. 2005
2005 Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radioduransDNA Repair.  4:671-678. 2005
2003 Enhanced transformation of plant cells following co-bombardment of VirE2 protein of Agrobacterium tumefaciens with DNA substrateCurrent Science.  85:1343-1347. 2003
2003 Transient expression of foreign genes in mature wheat embryo explants following particle bombardmentPhysiology and Molecular Biology of Plants.  9:217-223. 2003

Chapter

Year Title Altmetric
2007 Nucleases in DNA repair, replication and recombination: Flap endonuclease-1 as a paradigm.  267-300. 2007

Research Overview

  • As an integral member of the Institute for Cancer Outcomes and Survivorship at UAB, my goal is to understand the molecular and epigenetic basis of adverse outcomes in childhood cancer survivors. Anthracycline-related cardiomyopathy and congestive heart failure is the leading cause of late morbidity in survivors of childhood cancers. There is a dose-dependent association between anthracycline exposure and cardiomyopathy risk, suggesting that genetic predisposition possibly modifies this association. I am following an integrative genomics approach to understand whether genetic and epigenetic predisposition can place childhood cancer survivors at an increased risk for developing treatment-related complications and therefore allow for targeted therapy, thus reducing morbidity in children with cancer.
  • Investigator On

  • Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors  awarded by National Cancer Institute/NIH/DHHS 2018 - 2025
  • BMT Survivor Study-2 (BMTSS-2)  awarded by National Cancer Institute/NIH/DHHS 2019 - 2024
  • City of Hope Lymphoma SPORE  awarded by BECKMAN RESEARCH INSTITUTE (CITY OF HOPE) 2018 - 2023
  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2019 - 2020
  • St. Baldrick's Foundation Supplemental Reimbursement  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2018 - 2020
  • (PQB-1) Telomere Maintenance Defects and Thyroid Second Cancer in Childhood Cancer Survivors  awarded by Baylor College of Medicine 2015 - 2019
  • Per Case Reimbursement: COG NCORP Research Base  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2017 - 2019
  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2018 - 2019
  • A Comprehensive Investigation of Outcome Disparities in Children, Adolescents and Young Adults with Cancer  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2016 - 2018
  • Novel Methods to Detect Gene-Environment Interactions in Treatment-Related Brain Tumors Among Childhood Cancer Survivors  awarded by University of Wisconsin-Milwaukee 2015 - 2016
  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2014 - 2015
  • Education And Training

  • Doctor of Philosophy in Molecular Biology, 2001
  • Full Name

  • Purnima Singh
  • Fax

  • 205-638-2121