Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study

Academic Article

Abstract

  • © 2016, Société Internationale de Chirurgie. Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery. Methods: Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals. Results: From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560). Conclusions: Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.
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    Digital Object Identifier (doi)

    Author List

  • Abbas Z; Abburu S; Abd Ghaffar MK; Abdelhadi M; Abdikadir HR; Abdulmajid A; Abid H; Abid A; Abuhussein N; Abul MH
  • Start Page

  • 47
  • End Page

  • 55
  • Volume

  • 41
  • Issue

  • 1