The LRF transcription factor regulates mature B cell development and the germinal center response in mice

Academic Article

Abstract

  • B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell-specific conditional knockout mice, we have demonstrated here that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. Moreover, LRF inactivation in transformed B cells attenuated their growth rate. These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Sakurai N; Maeda M; Lee SU; Ishikawa Y; Li M; Williams JC; Wang L; Su L; Suzuki M; Saito TI
  • Start Page

  • 2583
  • End Page

  • 2598
  • Volume

  • 121
  • Issue

  • 7