Models to Study Chronic Myeloid Leukemia Cancer Stem Cells

Chapter

Abstract

  • © 2014 by John Wiley & Sons, Inc. All rights reserved. Cancer stem cells (CSC) comprise a specialized neoplastic population and are responsible for maintaining tumors in several cancers. Cancer stem cells, like normal stem cells, can undergo processes modulating self-renewal and differentiation or commitment. Relapse in treated oncology patients is thought to arise from a pool of resistant cells, and this residual cell population has key significance because it is responsible for disease re-initiation. If the CSC constitutes this resistant population, they should be the dominant population in minimal residual disease, and it is critical to study them.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9781118356166
  • Start Page

  • 119
  • End Page

  • 131
  • Volume

  • 9781118356166