Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection

Academic Article


  • The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8+ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8+ T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8+ T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8+ T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
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    Digital Object Identifier (doi)

    Author List

  • Cella M; Presti R; Vermi W; Lavender K; Turnbull E; Ochsenbauer-Jambor C; Kappes JC; Ferrari G; Kessels L; Williams I
  • Start Page

  • 949
  • End Page

  • 954
  • Volume

  • 40
  • Issue

  • 4