Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis

Academic Article

Abstract

  • We report a consecutive series of 59 patients with MDS who underwent reduced-intensity hematopoietic stem cell transplantation (RI-HSCT) with fludarabine/melphalan conditioning and tacrolimus/sirolimus-based GVHD prophylaxis. Two-year OS, EFS, and relapse incidences were 75.1%, 65.2%, and 20.9%, respectively. The cumulative incidence of non-relapse mortality at 100 days, 1 year, and 2 years was 3.4%, 8.5%, and 10.5%, respectively. The incidence of grade II-IV acute GVHD was 35.4%; grade III-IV was 18.6%. Forty of 55 evaluable patients developed chronic GVHD; of these 35 were extensive grade. This RI-HSCT protocol produces encouraging outcomes in MDS patients, and tacrolimus/sirolimus-based GVHD prophylaxis may contribute to that promising result. © 2012 Elsevier Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Nakamura R; Palmer JM; O'Donnell MR; Stiller T; Thomas SH; Chao J; Alvarnas J; Parker PM; Pullarkat V; Maegawa R
  • Start Page

  • 1152
  • End Page

  • 1156
  • Volume

  • 36
  • Issue

  • 9