The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationale.

Academic Article

Abstract

  • BACKGROUND: The association between hyperuricemia and hypertension is controversial. Animal models, epidemiological data, and small clinical trials have favored a causative role for hyperuricemia in hypertension but more studies are necessary to elucidate putative mechanisms, population susceptibility, and potential for urate-lowering therapies (ULT) to decrease blood pressure (BP). PURPOSE: To describe the background and design of the Serum Urate Reduction to Prevent Hypertension (SURPHER) study. METHODS: SURPHER is a single center, double-blinded, crossover trial in which participants are randomly assigned to allopurinol (300mg) or placebo. Enrollment focused on adults 18-40years old with baseline systolic blood pressure≥120 and <160mmHg or diastolic blood pressure≥80 and <100mmHg, and serum urate ≥5.0mg/dL or ≥4.0mg/dL for men or women, respectively. SURPHER recruitment targets participants without chronic kidney disease (estimated glomerular filtration rate>60mL/min/1.73m2), and without prior diagnosis of gout or use of ULT to treat gout. The primary outcome is change from baseline in blood pressure assessed by 24hour ambulatory blood pressure monitoring and mechanistic outcomes include changes in endothelial function as measured by flow-mediated dilation, as well as C-reactive protein levels. RESULTS: Since June 16, 2014 until present, SURPHER is recruiting participants in the city of Birmingham, Alabama. LIMITATIONS: The study aims to enroll otherwise healthy young adults for a pharmacological intervention study with multiple study-related procedures. Challenges related to recruitment are anticipated and multiple strategies for increasing recruitment and retention are planned if necessary.
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    Keywords

  • Allopurinol, Blood pressure, Endothelial function, Hypertension, Hyperuricemia, Prehypertension, Serum urate, Urate lowering therapy (ULT), Uric acid, Adolescent, Adult, African Americans, Allopurinol, Blood Pressure, Cross-Over Studies, Double-Blind Method, Endothelium, Vascular, Female, Gout Suppressants, Humans, Hyperuricemia, Inflammation Mediators, Male, Research Design, Sex Factors, Uric Acid, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Saddekni MB; Saag KG; Dudenbostel T; Oparil S; Calhoun DA; Sattui SE; Feig DI; Muntner P; Redden DT; Foster PJ
  • Start Page

  • 238
  • End Page

  • 244
  • Volume

  • 50