Retinotopic patterns of functional connectivity between V1 and large-scale brain networks during resting fixation.

Academic Article

Abstract

  • Psychophysical and neurobiological evidence suggests that central and peripheral vision are specialized for different functions. This specialization of function might be expected to lead to differences in the large-scale functional interactions of early cortical areas that represent central and peripheral visual space. Here, we characterize differences in whole-brain functional connectivity among sectors in primary visual cortex (V1) corresponding to central, near-peripheral, and far-peripheral vision during resting fixation. Importantly, our analyses reveal that eccentricity sectors in V1 have different functional connectivity with non-visual areas associated with large-scale brain networks. Regions associated with the fronto-parietal control network are most strongly connected with central sectors of V1, regions associated with the cingulo-opercular control network are most strongly connected with near-peripheral sectors of V1, and regions associated with the default mode and auditory networks are most strongly connected with far-peripheral sectors of V1. Additional analyses suggest that similar patterns are present during eyes-closed rest. These results suggest that different types of visual information may be prioritized by large-scale brain networks with distinct functional profiles, and provide insights into how the small-scale functional specialization within early visual regions such as V1 relates to the large-scale organization of functionally distinct whole-brain networks.
  • Published In

  • NeuroImage  Journal
  • Keywords

  • Attention, Eccentricity, Primary visual cortex, Top-down control, fMRI, Adult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Photic Stimulation, Visual Cortex, Visual Pathways, Visual Perception, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Griffis JC; Elkhetali AS; Burge WK; Chen RH; Bowman AD; Szaflarski JP; Visscher KM
  • Start Page

  • 1071
  • End Page

  • 1083
  • Volume

  • 146