© 2016 Elsevier Inc. Objectives To discuss the relationship between weight management and diet and cancer prevention, current nutritional guidelines, and evidence-based strategies to reduce cancer risk. Data Sources Current nutritional guidelines, journal articles published between 2012 and 2015, and internet resources. Conclusion Evidence indicates that attaining and/or maintaining a healthy weight and adopting a diet that is primarily plant-based, low in red and processed meats, simple sugars, and refined carbohydrates, limits alcohol, and relies on food for nutrients can aid in preventing cancer. Implications for Nursing Practice Nurses can take the lead to educate patients and families about weight management and diet and to promote adherence to nutritional guidelines.