The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias

Academic Article

Abstract

  • The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mellentin JD; Murre C; Donlon TA; Mccaw PS; Smith SD; Carroll AJ; Mcdonald ME; Baltimore D; Cleary ML
  • Start Page

  • 379
  • End Page

  • 382
  • Volume

  • 246
  • Issue

  • 4928