IgM Memory Cells: First Responders in Malaria

Academic Article


  • Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM+ memory B cells function as first responders by rapidly differentiating into T-cell-dependent plasmablasts and T-cell-independent plasma cells.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Stone SL; Lund FE
  • Start Page

  • 235
  • End Page

  • 237
  • Volume

  • 45
  • Issue

  • 2