A longitudinal study of serum insulin and glucose levels in relation to colorectal cancer risk among postmenopausal women.

Academic Article


  • BACKGROUND: It is unclear whether circulating insulin or glucose levels are associated with increased risk of colorectal cancer. Few prospective studies have examined this question, and only one study had repeated measurements. METHODS: We conducted a prospective study of colorectal cancer risk using the subsample of women in the Women's Health Initiative study whose fasting blood samples, collected at baseline and during follow-up, were analysed for insulin and glucose. Cox proportional hazards models were used to assess associations with colorectal cancer risk in both baseline and time-dependent covariates analyses. RESULTS: Among 4902 non-diabetic women with baseline fasting serum insulin and glucose values, 81 incident cases of colorectal cancer were identified over 12 years of follow-up. Baseline glucose levels were positively associated with colorectal cancer and colon cancer risk: multivariable-adjusted hazard ratio (HR) comparing the highest (≥99.5 mg dl(-1)) with the lowest tertile (<89.5 mg dl(-1)): 1.74, 95% confidence interval (CI) 0.97-3.15 and 2.25, 95% CI: 1.12-4.51, respectively. Serum insulin and homeostasis model assessment were not associated with risk. Analyses of repeated measurements supported the baseline results. CONCLUSION: These data suggest that elevated serum glucose levels may be a risk factor for colorectal cancer in postmenopausal women.
  • Published In


  • Aged, Blood Glucose, Colorectal Neoplasms, Female, Humans, Insulin, Longitudinal Studies, Middle Aged, Postmenopause, Proportional Hazards Models, Prospective Studies
  • Digital Object Identifier (doi)

    Author List

  • Kabat GC; Kim MY; Strickler HD; Shikany JM; Lane D; Luo J; Ning Y; Gunter MJ; Rohan TE
  • Start Page

  • 227
  • End Page

  • 232
  • Volume

  • 106
  • Issue

  • 1