Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men.

Academic Article

Abstract

  • OBJECTIVE: Multiple studies have shown clear evidence of vitamin D's anti-tumor effects on prostate cancer cells in laboratory experiments, but the evidence has not been consistent in humans. We sought to examine the association between vitamin D and prostate cancer risk in a cohort of older men. METHODS: We conducted a prospective case-cohort study nested within the multicenter Osteoporotic Fractures in Men (MrOS) study. Baseline serum 25-OH vitamin D was measured in a randomly selected sub-cohort of 1,433 men > or = 65 years old without a history of prostate cancer and from all participants with an incident diagnosis of prostate cancer (n = 297). Cox proportional hazards models were used to evaluate the associations between quartiles of total 25-OH vitamin D and incident prostate cancer, as well as Gleason score. RESULTS: In comparison with the lowest quartile of 25-OH vitamin D, the hazard ratio for the highest quartile of 25-OH vitamin D was 1.22 (CI 0.50-1.72, p = 0.25), no trend across quartiles (p = 0.94) or association with Gleason score was observed. Adjustment for covariates did not alter the results. CONCLUSIONS: In this prospective cohort of older men, we found no association between serum 25-OH vitamin D levels and subsequent risk of prostate cancer.
  • Published In

    Keywords

  • Age Factors, Aged, Case-Control Studies, Humans, Male, Proportional Hazards Models, Prospective Studies, Prostatic Neoplasms, Risk Factors, Vitamin D
  • Digital Object Identifier (doi)

    Author List

  • Barnett CM; Nielson CM; Shannon J; Chan JM; Shikany JM; Bauer DC; Hoffman AR; Barrett-Connor E; Orwoll E; Beer TM
  • Start Page

  • 1297
  • End Page

  • 1303
  • Volume

  • 21
  • Issue

  • 8