Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study.

Academic Article

Abstract

  • BACKGROUND: Although long-chain ω-3 (n-3) PUFAs (LCω3PUFAs) have been linked to the prevention of some inflammatory disorders, little is known about the association between these fatty acids and incidence of asthma. OBJECTIVE: The objective was to prospectively investigate the association between LCω3PUFAs and fish intake and incidence of asthma among American young adults. DESIGN: A 20-y follow-up longitudinal analysis was conducted in a biracial cohort of 4162 Americans, aged 18-30 y, with a history of asthma at baseline in 1985. Diet was assessed by a validated interviewer-administered quantitative food-frequency questionnaire at the examinations in 1985, 1992, and 2005. Incident self-reported asthma was defined as having a physician diagnosis of asthma and/or the use of asthma medications between 1985 and 2005. RESULTS: During the 20-y follow-up, 446 incident cases of asthma were identified. LCω3PUFA intake was significantly inversely associated with incidence of asthma after adjustment for sociodemographic, major lifestyle, and dietary confounders. The multivariable-adjusted HR for the highest quintile of LCω3PUFA intake as compared with the lowest quintile was 0.46 (95% CI: 0.33, 0.64; P-trend < 0.01). However, a higher frequency of nonfried fish consumption was not significantly associated with the risk of asthma. DHA showed a greater inverse association than did EPA. The association between LCω3PUFAs and incident asthma was not appreciably modified by sex, race, BMI, smoking status, or atopic status. CONCLUSION: This study showed that intakes of LCω3PUFAs are inversely longitudinally associated with the incidence of asthma in American young adults.
  • Keywords

  • Adolescent, Adult, African Americans, Animals, Asthma, Cardiovascular Diseases, Diet, European Continental Ancestry Group, Fatty Acids, Omega-3, Female, Fishes, Follow-Up Studies, Humans, Incidence, Life Style, Longitudinal Studies, Male, Proportional Hazards Models, Prospective Studies, Risk Factors, Surveys and Questionnaires, United States, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Li J; Xun P; Zamora D; Sood A; Liu K; Daviglus M; Iribarren C; Jacobs D; Shikany JM; He K
  • Start Page

  • 173
  • End Page

  • 178
  • Volume

  • 97
  • Issue

  • 1