Regulation of differentiation by TGF-β

Academic Article

Abstract

  • Recent experiments in neural, skeletal, endothelial, and hematopoietic tissues have provided new insights into the way members of the transforming growth factor-β (TGF-β) superfamily regulate cellular differentiation. TGF-βs regulate the fate of multipotential stem cells instructively (in the neural crest) by regulating the expression or function of tissue-specific transcription factors, as well as selectively (in the mesenchyme) by regulating the expression of required growth factors and their receptors. During skeletal development, TGF-βs have unique functions and act sequentially to modulate chondrocyte and osteoblast differentiation. Responsiveness to TGF-βs changes as cells differentiate and evidence now suggests that changes in TGF-β receptor profile may account for some of these differences. Drosophila and transgenic mouse models are now providing useful insights into mechanisms of TGF-β action in vivo.
  • Digital Object Identifier (doi)

    Author List

  • Moses HL; Serra R
  • Start Page

  • 581
  • End Page

  • 586
  • Volume

  • 6
  • Issue

  • 5