Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.

Academic Article


  • There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
  • Published In


  • Notch1, Notch1 activating compound, Raf-1, ZM336372, achaete scute complex-like 1, medullary thyroid cancer
  • Author List

  • Kunnimalaiyaan M; Haymart MR; Chen H
  • Start Page

  • 43
  • End Page

  • 47
  • Volume

  • 2